# genes

id: YNL165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YNL165W is not an essential gene","secondary_identifier":"SGD:S000005109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL165W"}


id: YNL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNI5","product":"Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis","secondary_identifier":"SGD:S000005110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL166C"}


id: YNL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00266":null,"SJAG_00979":null,"YNL167C":null},"has_protein_features":false,"name":"SKO1","ortholog_annotations":[{"gene_uniquename":"YNL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00266","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00979","reference_uniquename":"PMID:26896847"}],"product":"Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL167C"}


id: YNL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00493":null,"YNL168C":null},"has_protein_features":false,"name":"FMP41","ortholog_annotations":[{"gene_uniquename":"YNL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00493","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00493","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL168C"}


id: YNL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02980":null,"SJAG_03524":null,"YNL169C":null},"has_protein_features":false,"name":"PSD1","ortholog_annotations":[{"gene_uniquename":"YNL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02980","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03524","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03524","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL169C"}


id: YNL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL170W"}


id: YNL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL171C"}


id: YNL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05329":null,"YNL172W":null},"has_protein_features":false,"name":"APC1","ortholog_annotations":[{"gene_uniquename":"YNL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05329","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05329","reference_uniquename":"PMID:26896847"}],"product":"Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL172W"}


id: YNL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDG1","product":"Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL173C"}


id: YNL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C","secondary_identifier":"SGD:S000005118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL174W"}


id: YNL175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01650":null,"YNL175C":null},"has_protein_features":false,"name":"NOP13","ortholog_annotations":[{"gene_uniquename":"YNL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01650","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01650","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL175C"}


id: YNL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TDA7","product":"Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL176C"}


id: YNL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03192":null,"YNL177C":null},"has_protein_features":false,"name":"MRPL22","ortholog_annotations":[{"gene_uniquename":"YNL177C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03192","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL177C"}


id: YNL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04814":null,"YNL178W":null},"has_protein_features":false,"name":"RPS3","ortholog_annotations":[{"gene_uniquename":"YNL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04814","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL178W"}


id: YNL179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000005123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL179C"}


id: YNL180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RHO5","product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; necessary for oxidant and ramped heat stress-induced cell death; ortholog of mammalian RAC1","secondary_identifier":"SGD:S000005124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL180C"}


id: YNL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03251":null,"YNL181W":null},"has_protein_features":false,"name":"PBR1","ortholog_annotations":[{"gene_uniquename":"YNL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03251","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03251","reference_uniquename":"PMID:26896847"}],"product":"Putative oxidoreductase; required for cell viability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL181W"}


id: YNL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04062":null,"YNL182C":null},"has_protein_features":false,"name":"IPI3","ortholog_annotations":[{"gene_uniquename":"YNL182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04062","reference_uniquename":"PMID:26896847"}],"product":"Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL182C"}


id: YNL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YNL183C":null},"has_protein_features":false,"name":"NPR1","ortholog_annotations":[{"gene_uniquename":"YNL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL183C"}


id: YNL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL184C"}


id: YNL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03297":null,"YNL185C":null},"has_protein_features":false,"name":"MRPL19","ortholog_annotations":[{"gene_uniquename":"YNL185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03297","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03297","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL185C"}


id: YNL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00764":null,"YNL186W":null},"has_protein_features":false,"name":"UBP10","ortholog_annotations":[{"gene_uniquename":"YNL186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00764","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00764","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL186W"}


id: YNL187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SWT21","product":"Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats","secondary_identifier":"SGD:S000005131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL187W"}


id: YNL188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KAR1","product":"Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene","secondary_identifier":"SGD:S000005132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL188W"}


id: YNL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00840":null,"SJAG_04411":null,"YNL189W":null},"has_protein_features":false,"name":"SRP1","ortholog_annotations":[{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00840","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04411","reference_uniquename":"PMID:26896847"}],"product":"Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL189W"}


id: YNL190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site","secondary_identifier":"SGD:S000005134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL190W"}


id: YNL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUG3","product":"Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)","secondary_identifier":"SGD:S000005135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL191W"}


id: YNL192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00442":null,"SJAG_04868":null,"YNL192W":null},"has_protein_features":false,"name":"CHS1","ortholog_annotations":[{"gene_uniquename":"YNL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00442","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04868","reference_uniquename":"PMID:29761456"}],"product":"Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL192W"}


id: YNL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01666":null,"YNL193W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01666","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL193W"}


id: YNL194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL194C"}


id: YNL195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL195C"}


id: YNL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SLZ1","product":"Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during the induction of sporulation; homologous to human ZCH13H3, a subunit of the mammalian m6A methyltransferase complex","secondary_identifier":"SGD:S000005140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL196C"}


id: YNL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01843":null,"SJAG_02554":null,"YNL197C":null},"has_protein_features":false,"name":"WHI3","ortholog_annotations":[{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein that modulates mRNA stability; regulates cell cycle, sister chromatid cohesion, and stress response genes; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules to regulate target mRNAs; regulates cell fate and critical cell size for Start passage; regulates ploidy; self-templating mnemon that forms inactive super-assemblies, preventing G1 arrest in mother cells after unsuccessful mating and causing sterility in old cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL197C"}


id: YNL198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL198C"}


id: YNL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GCR2","product":"Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p","secondary_identifier":"SGD:S000005143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL199C"}


id: YNL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02462":null,"YNL200C":null},"has_protein_features":false,"name":"NNR1","ortholog_annotations":[{"gene_uniquename":"YNL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02462","reference_uniquename":"PMID:29761456"}],"product":"NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL200C"}


id: YNL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00369":null,"YNL201C":null},"has_protein_features":false,"name":"PSY2","ortholog_annotations":[{"gene_uniquename":"YNL201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00369","reference_uniquename":"PMID:26896847"}],"product":"Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL201C"}


id: YNL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPS19","product":"Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate","secondary_identifier":"SGD:S000005146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL202W"}


id: YNL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL203C"}


id: YNL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03268":null,"YNL204C":null},"has_protein_features":false,"name":"SPS18","ortholog_annotations":[{"gene_uniquename":"YNL204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03268","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL204C"}


id: YNL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL205C"}


id: YNL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT106","product":"Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)","secondary_identifier":"SGD:S000005150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL206C"}


id: YNL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01618":null,"YNL207W":null},"has_protein_features":false,"name":"RIO2","ortholog_annotations":[{"gene_uniquename":"YNL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01618","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01618","reference_uniquename":"PMID:26896847"}],"product":"Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL207W"}


id: YNL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi","secondary_identifier":"SGD:S000005152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL208W"}


id: YNL209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01874":null,"SJAG_03237":null,"YNL209W":null},"has_protein_features":false,"name":"SSB2","ortholog_annotations":[{"gene_uniquename":"YNL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01874","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03237","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL209W"}


id: YNL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MER1","product":"mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22","secondary_identifier":"SGD:S000005154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL210W"}


id: YNL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX7","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene","secondary_identifier":"SGD:S000005155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL211C"}


id: YNL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02337":null,"YNL212W":null},"has_protein_features":false,"name":"VID27","ortholog_annotations":[{"gene_uniquename":"YNL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02337","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL212W"}


id: YNL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRG9","product":"Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL213C"}


id: YNL214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX17","product":"Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis","secondary_identifier":"SGD:S000005158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL214W"}


id: YNL215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04989":null,"YNL215W":null},"has_protein_features":false,"name":"IES2","ortholog_annotations":[{"gene_uniquename":"YNL215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04989","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL215W"}


id: YNL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03092":null,"YNL216W":null},"has_protein_features":false,"name":"RAP1","ortholog_annotations":[{"gene_uniquename":"YNL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03092","reference_uniquename":"PMID:29761456"}],"product":"Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL216W"}


id: YNL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00132":null,"YNL217W":null},"has_protein_features":false,"name":"PPN2","ortholog_annotations":[{"gene_uniquename":"YNL217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00132","reference_uniquename":"PMID:29761456"}],"product":"Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL217W"}


id: YNL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02199":null,"YNL218W":null},"has_protein_features":false,"name":"MGS1","ortholog_annotations":[{"gene_uniquename":"YNL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02199","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02199","reference_uniquename":"PMID:26896847"}],"product":"Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL218W"}


id: YNL219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00334":null,"YNL219C":null},"has_protein_features":false,"name":"ALG9","ortholog_annotations":[{"gene_uniquename":"YNL219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00334","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00334","reference_uniquename":"PMID:26896847"}],"product":"Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL219C"}


id: YNL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00044":null,"YNL220W":null},"has_protein_features":false,"name":"ADE12","ortholog_annotations":[{"gene_uniquename":"YNL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00044","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00044","reference_uniquename":"PMID:26896847"}],"product":"Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL220W"}


id: YNL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04582":null,"YNL221C":null},"has_protein_features":false,"name":"POP1","ortholog_annotations":[{"gene_uniquename":"YNL221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04582","reference_uniquename":"PMID:26896847"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL221C"}


id: YNL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03624":null,"YNL222W":null},"has_protein_features":false,"name":"SSU72","ortholog_annotations":[{"gene_uniquename":"YNL222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03624","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03624","reference_uniquename":"PMID:26896847"}],"product":"Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL222W"}


id: YNL223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01283":null,"YNL223W":null},"has_protein_features":false,"name":"ATG4","ortholog_annotations":[{"gene_uniquename":"YNL223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01283","reference_uniquename":"PMID:26896847"}],"product":"Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL223W"}


id: YNL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02256":null,"YNL224C":null},"has_protein_features":false,"name":"SQS1","ortholog_annotations":[{"gene_uniquename":"YNL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02256","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02256","reference_uniquename":"PMID:26896847"}],"product":"Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL224C"}


id: YNL225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01464":null,"YNL225C":null},"has_protein_features":false,"name":"CNM67","ortholog_annotations":[{"gene_uniquename":"YNL225C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01464","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL225C"}


id: YNL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C","secondary_identifier":"SGD:S000005170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL226W"}


id: YNL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04991":null,"YNL227C":null},"has_protein_features":false,"name":"JJJ1","ortholog_annotations":[{"gene_uniquename":"YNL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04991","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04991","reference_uniquename":"PMID:26896847"}],"product":"Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL227C"}


id: YNL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1","secondary_identifier":"SGD:S000005172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL228W"}


id: YNL229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00179":null,"SJAG_00238":null,"YNL229C":null},"has_protein_features":false,"name":"URE2","ortholog_annotations":[{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00179","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00179","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00179","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00238","reference_uniquename":"PMID:26896847"}],"product":"Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL229C"}


id: YNL230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00540":null,"YNL230C":null},"has_protein_features":false,"name":"ELA1","ortholog_annotations":[{"gene_uniquename":"YNL230C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00540","reference_uniquename":"PMID:29761456"}],"product":"Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL230C"}


id: YNL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03721":null,"YNL231C":null},"has_protein_features":false,"name":"PDR16","ortholog_annotations":[{"gene_uniquename":"YNL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03721","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL231C"}


id: YNL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01818":null,"YNL232W":null},"has_protein_features":false,"name":"CSL4","ortholog_annotations":[{"gene_uniquename":"YNL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01818","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01818","reference_uniquename":"PMID:26896847"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL232W"}


id: YNL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNI4","product":"Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly","secondary_identifier":"SGD:S000005177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL233W"}


id: YNL234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1","secondary_identifier":"SGD:S000005178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL234W"}


id: YNL235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex","secondary_identifier":"SGD:S000005179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL235C"}


id: YNL236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIN4","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription","secondary_identifier":"SGD:S000005180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL236W"}


id: YNL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YTP1","product":"Probable type-III integral membrane protein of unknown function; has regions of similarity to mitochondrial electron transport proteins","secondary_identifier":"SGD:S000005181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL237W"}


id: YNL238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04398":null,"YNL238W":null},"has_protein_features":false,"name":"KEX2","ortholog_annotations":[{"gene_uniquename":"YNL238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04398","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04398","reference_uniquename":"PMID:26896847"}],"product":"Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL238W"}


id: YNL239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LAP3","product":"Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; targeted to vacuole via CVT pathway; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH","secondary_identifier":"SGD:S000005183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL239W"}


id: YNL240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02497":null,"YNL240C":null},"has_protein_features":false,"name":"NAR1","ortholog_annotations":[{"gene_uniquename":"YNL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02497","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02497","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL240C"}


id: YNL241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02148":null,"SJAG_02297":null,"SJAG_02696":null,"YNL241C":null},"has_protein_features":false,"name":"ZWF1","ortholog_annotations":[{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02148","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02297","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02696","reference_uniquename":"PMID:29761456"}],"product":"Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL241C"}


id: YNL242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03851":null,"YNL242W":null},"has_protein_features":false,"name":"ATG2","ortholog_annotations":[{"gene_uniquename":"YNL242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03851","reference_uniquename":"PMID:26896847"}],"product":"Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL242W"}


id: YNL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00152":null,"YNL243W":null},"has_protein_features":false,"name":"SLA2","ortholog_annotations":[{"gene_uniquename":"YNL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00152","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL243W"}


id: YNL244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01117":null,"YNL244C":null},"has_protein_features":false,"name":"SUI1","ortholog_annotations":[{"gene_uniquename":"YNL244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01117","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01117","reference_uniquename":"PMID:26896847"}],"product":"Translation initiation factor eIF1; component of complex involved in recognition of initiator codon; modulates translation accuracy at initiation phase by discriminating against suboptimal initiation sites to prevent excessive uORF translation genome-wide","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL244C"}


id: YNL245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03993":null,"YNL245C":null},"has_protein_features":false,"name":"CWC25","ortholog_annotations":[{"gene_uniquename":"YNL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03993","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03993","reference_uniquename":"PMID:26896847"}],"product":"Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL245C"}


id: YNL246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00170":null,"YNL246W":null},"has_protein_features":false,"name":"VPS75","ortholog_annotations":[{"gene_uniquename":"YNL246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00170","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00170","reference_uniquename":"PMID:26896847"}],"product":"NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL246W"}


id: YNL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00420":null,"YNL247W":null},"has_protein_features":false,"name":"CRS1","ortholog_annotations":[{"gene_uniquename":"YNL247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00420","reference_uniquename":"PMID:26896847"}],"product":"Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL247W"}


id: YNL248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03956":null,"YNL248C":null},"has_protein_features":false,"name":"RPA49","ortholog_annotations":[{"gene_uniquename":"YNL248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03956","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03956","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL248C"}


id: YNL249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPA43","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL249C"}


id: YNL250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01677":null,"YNL250W":null},"has_protein_features":false,"name":"RAD50","ortholog_annotations":[{"gene_uniquename":"YNL250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01677","reference_uniquename":"PMID:29761456"}],"product":"Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL250W"}


id: YNL251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04942":null,"YNL251C":null},"has_protein_features":false,"name":"NRD1","ortholog_annotations":[{"gene_uniquename":"YNL251C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04942","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL251C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04942","reference_uniquename":"PMID:26896847"}],"product":"RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL251C"}


id: YNL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00086":null,"YNL252C":null},"has_protein_features":false,"name":"MRPL17","ortholog_annotations":[{"gene_uniquename":"YNL252C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00086","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL252C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00086","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL252C"}


id: YNL253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05328":null,"YNL253W":null},"has_protein_features":false,"name":"TEX1","ortholog_annotations":[{"gene_uniquename":"YNL253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05328","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mRNA export; component of the transcription export (TREX) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL253W"}


id: YNL254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTC4","product":"Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000005198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL254C"}


id: YNL255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02043":null,"YNL255C":null},"has_protein_features":false,"name":"GIS2","ortholog_annotations":[{"gene_uniquename":"YNL255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02043","reference_uniquename":"PMID:29761456"}],"product":"Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL255C"}


id: YNL256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00815":null,"YNL256W":null},"has_protein_features":false,"name":"FOL1","ortholog_annotations":[{"gene_uniquename":"YNL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00815","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL256W"}


id: YNL257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03247":null,"YNL257C":null},"has_protein_features":false,"name":"SIP3","ortholog_annotations":[{"gene_uniquename":"YNL257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:26896847"}],"product":"Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL257C"}


id: YNL258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DSL1","product":"Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene","secondary_identifier":"SGD:S000005202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL258C"}


id: YNL259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03231":null,"YNL259C":null},"has_protein_features":false,"name":"ATX1","ortholog_annotations":[{"gene_uniquename":"YNL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03231","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03231","reference_uniquename":"PMID:26896847"}],"product":"Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL259C"}


id: YNL260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02745":null,"YNL260C":null},"has_protein_features":false,"name":"LTO1","ortholog_annotations":[{"gene_uniquename":"YNL260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02745","reference_uniquename":"PMID:29761456"}],"product":"Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL260C"}


id: YNL261W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03451":null,"YNL261W":null},"has_protein_features":false,"name":"ORC5","ortholog_annotations":[{"gene_uniquename":"YNL261W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03451","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL261W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03451","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL261W"}


id: YNL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02908":null,"YNL262W":null},"has_protein_features":false,"name":"POL2","ortholog_annotations":[{"gene_uniquename":"YNL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02908","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02908","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL262W"}


id: YNL263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01642":null,"YNL263C":null},"has_protein_features":false,"name":"YIF1","ortholog_annotations":[{"gene_uniquename":"YNL263C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01642","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL263C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01642","reference_uniquename":"PMID:26896847"}],"product":"Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL263C"}


id: YNL264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03721":null,"YNL264C":null},"has_protein_features":false,"name":"PDR17","ortholog_annotations":[{"gene_uniquename":"YNL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03721","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL264C"}


id: YNL265C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05303":null,"YNL265C":null},"has_protein_features":false,"name":"IST1","ortholog_annotations":[{"gene_uniquename":"YNL265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05303","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in recycling of membrane transporters from endosome to plasma membrane; plays a role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL265C"}


id: YNL266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C","secondary_identifier":"SGD:S000005210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL266W"}


id: YNL267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05330":null,"YNL267W":null},"has_protein_features":false,"name":"PIK1","ortholog_annotations":[{"gene_uniquename":"YNL267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05330","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05330","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL267W"}


id: YNL268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YNL268W":null},"has_protein_features":false,"name":"LYP1","ortholog_annotations":[{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL268W"}


id: YNL269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC4","product":"Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment","secondary_identifier":"SGD:S000005213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL269W"}


id: YNL270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YNL270C":null},"has_protein_features":false,"name":"ALP1","ortholog_annotations":[{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL270C"}


id: YNL271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00279":null,"YNL271C":null},"has_protein_features":false,"name":"BNI1","ortholog_annotations":[{"gene_uniquename":"YNL271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00279","reference_uniquename":"PMID:29761456"}],"product":"Formin; polarisome component; nucleates the formation of linear actin filaments, involved in budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; some functional redundancy with BNR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL271C"}


id: YNL272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02368":null,"YNL272C":null},"has_protein_features":false,"name":"SEC2","ortholog_annotations":[{"gene_uniquename":"YNL272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02368","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02368","reference_uniquename":"PMID:26896847"}],"product":"Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL272C"}


id: YNL273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02724":null,"YNL273W":null},"has_protein_features":false,"name":"TOF1","ortholog_annotations":[{"gene_uniquename":"YNL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02724","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02724","reference_uniquename":"PMID:26896847"}],"product":"Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL273W"}


id: YNL274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00281":null,"SJAG_01432":null,"YNL274C":null},"has_protein_features":false,"name":"GOR1","ortholog_annotations":[{"gene_uniquename":"YNL274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00281","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01432","reference_uniquename":"PMID:26896847"}],"product":"Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL274C"}


id: YNL275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01183":null,"YNL275W":null},"has_protein_features":false,"name":"BOR1","ortholog_annotations":[{"gene_uniquename":"YNL275W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01183","reference_uniquename":"PMID:29761456"}],"product":"Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL275W"}


id: YNL276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W","secondary_identifier":"SGD:S000005220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL276C"}


id: YNL277W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00395":null,"YNL277W":null},"has_protein_features":false,"name":"MET2","ortholog_annotations":[{"gene_uniquename":"YNL277W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00395","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL277W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00395","reference_uniquename":"PMID:26896847"}],"product":"L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL277W"}


id: YNL277W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL277W-A"}


id: YNL278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02878":null,"YNL278W":null},"has_protein_features":false,"name":"CAF120","ortholog_annotations":[{"gene_uniquename":"YNL278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:29761456"}],"product":"Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL278W"}


id: YNL279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00870":null,"YNL279W":null},"has_protein_features":false,"name":"PRM1","ortholog_annotations":[{"gene_uniquename":"YNL279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00870","reference_uniquename":"PMID:26896847"}],"product":"Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL279W"}


id: YNL280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04810":null,"YNL280C":null},"has_protein_features":false,"name":"ERG24","ortholog_annotations":[{"gene_uniquename":"YNL280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04810","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04810","reference_uniquename":"PMID:26896847"}],"product":"C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL280C"}


id: YNL281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HCH1","product":"Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL281W"}


id: YNL282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02553":null,"YNL282W":null},"has_protein_features":false,"name":"POP3","ortholog_annotations":[{"gene_uniquename":"YNL282W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02553","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; increases the activity and thermal stability of the RNase P complex, along with Pop2p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL282W"}


id: YNL283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YNL283C":null},"has_protein_features":false,"name":"WSC2","ortholog_annotations":[{"gene_uniquename":"YNL283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL283C"}


id: YNL284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03459":null,"YNL284C":null},"has_protein_features":false,"name":"MRPL10","ortholog_annotations":[{"gene_uniquename":"YNL284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03459","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03459","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL284C"}


id: YNL285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL285W"}


id: YNL286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01452":null,"YNL286W":null},"has_protein_features":false,"name":"CUS2","ortholog_annotations":[{"gene_uniquename":"YNL286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01452","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01452","reference_uniquename":"PMID:26896847"}],"product":"Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL286W"}


id: YNL287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01508":null,"YNL287W":null},"has_protein_features":false,"name":"SEC21","ortholog_annotations":[{"gene_uniquename":"YNL287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01508","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01508","reference_uniquename":"PMID:26896847"}],"product":"Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL287W"}


id: YNL288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00285":null,"YNL288W":null},"has_protein_features":false,"name":"CAF40","ortholog_annotations":[{"gene_uniquename":"YNL288W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00285","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL288W"}


id: YNL289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL1","product":"Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth","secondary_identifier":"SGD:S000005233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL289W"}


id: YNL290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02182":null,"YNL290W":null},"has_protein_features":false,"name":"RFC3","ortholog_annotations":[{"gene_uniquename":"YNL290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02182","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02182","reference_uniquename":"PMID:26896847"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL290W"}


id: YNL291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02877":null,"YNL291C":null},"has_protein_features":false,"name":"MID1","ortholog_annotations":[{"gene_uniquename":"YNL291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02877","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02877","reference_uniquename":"PMID:26896847"}],"product":"Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL291C"}


id: YNL292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04065":null,"YNL292W":null},"has_protein_features":false,"name":"PUS4","ortholog_annotations":[{"gene_uniquename":"YNL292W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04065","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL292W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04065","reference_uniquename":"PMID:26896847"}],"product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL292W"}


id: YNL293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01048":null,"YNL293W":null},"has_protein_features":false,"name":"MSB3","ortholog_annotations":[{"gene_uniquename":"YNL293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:26896847"}],"product":"Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL293W"}


id: YNL294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM21","product":"pH sensor molecule, component of RIM101 pathway; positive regulator of cell size; has role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH","secondary_identifier":"SGD:S000005238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL294C"}


id: YNL295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00077":null,"YNL295W":null},"has_protein_features":false,"name":"MRX6","ortholog_annotations":[{"gene_uniquename":"YNL295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00077","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL295W"}


id: YNL296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog","secondary_identifier":"SGD:S000005240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL296W"}


id: YNL297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01030":null,"YNL297C":null},"has_protein_features":false,"name":"MON2","ortholog_annotations":[{"gene_uniquename":"YNL297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01030","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01030","reference_uniquename":"PMID:26896847"}],"product":"Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL297C"}


id: YNL298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CLA4","product":"Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL298W"}


id: YNL299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01176":null,"YNL299W":null},"has_protein_features":false,"name":"TRF5","ortholog_annotations":[{"gene_uniquename":"YNL299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:26896847"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL299W"}


id: YNL300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOS6","product":"Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid","secondary_identifier":"SGD:S000005244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL300W"}


id: YNL301C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YNL301C":null},"has_protein_features":false,"name":"RPL18B","ortholog_annotations":[{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL301C"}


id: YNL302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YNL302C":null},"has_protein_features":false,"name":"RPS19B","ortholog_annotations":[{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL302C"}


id: YNL303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL303W"}


id: YNL304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPT11","product":"Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed","secondary_identifier":"SGD:S000005248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL304W"}


id: YNL305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04471":null,"YNL305C":null},"has_protein_features":false,"name":"BXI1","ortholog_annotations":[{"gene_uniquename":"YNL305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04471","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL305C"}


id: YNL306W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02777":null,"YNL306W":null},"has_protein_features":false,"name":"MRPS18","ortholog_annotations":[{"gene_uniquename":"YNL306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02777","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02777","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL306W"}


id: YNL307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YNL307C":null},"has_protein_features":false,"name":"MCK1","ortholog_annotations":[{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Dual-specificity S/T and tyrosine protein kinase; spindle position checkpoint component that works in parallel with Kin4p to prevent mitotic exit network (MEN) activation by the Cdc14 early anaphase release (FEAR) network; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent degradation of Rcn1p and Cdc6p, inhibition of protein kinase A, transcriptional regulation, inhibition of RNAPIII, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL307C"}


id: YNL308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00965":null,"YNL308C":null},"has_protein_features":false,"name":"KRI1","ortholog_annotations":[{"gene_uniquename":"YNL308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00965","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00965","reference_uniquename":"PMID:26896847"}],"product":"Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL308C"}


id: YNL309W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB1","product":"Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL309W"}


id: YNL310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04336":null,"YNL310C":null},"has_protein_features":false,"name":"ZIM17","ortholog_annotations":[{"gene_uniquename":"YNL310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04336","reference_uniquename":"PMID:29761456"}],"product":"Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL310C"}


id: YNL311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKP2","product":"F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000005255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL311C"}


id: YNL312W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01698":null,"YNL312W":null},"has_protein_features":false,"name":"RFA2","ortholog_annotations":[{"gene_uniquename":"YNL312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01698","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01698","reference_uniquename":"PMID:26896847"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL312W"}


id: YNL313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01291":null,"YNL313C":null},"has_protein_features":false,"name":"EMW1","ortholog_annotations":[{"gene_uniquename":"YNL313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01291","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01291","reference_uniquename":"PMID:26896847"}],"product":"Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL313C"}


id: YNL314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL82","product":"Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain","secondary_identifier":"SGD:S000005258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL314W"}


id: YNL315C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04899":null,"YNL315C":null},"has_protein_features":false,"name":"ATP11","ortholog_annotations":[{"gene_uniquename":"YNL315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04899","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04899","reference_uniquename":"PMID:26896847"}],"product":"Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL315C"}


id: YNL316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03124":null,"YNL316C":null},"has_protein_features":false,"name":"PHA2","ortholog_annotations":[{"gene_uniquename":"YNL316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03124","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03124","reference_uniquename":"PMID:26896847"}],"product":"Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL316C"}


id: YNL317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01175":null,"YNL317W":null},"has_protein_features":false,"name":"PFS2","ortholog_annotations":[{"gene_uniquename":"YNL317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01175","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01175","reference_uniquename":"PMID:26896847"}],"product":"Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL317W"}


id: YNL318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNL318C":null},"has_protein_features":false,"name":"HXT14","ortholog_annotations":[{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL318C"}


id: YNL319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14","secondary_identifier":"SGD:S000005263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL319W"}


id: YNL320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00774":null,"YNL320W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00774","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00774","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL320W"}


id: YNL321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04028":null,"YNL321W":null},"has_protein_features":false,"name":"VNX1","ortholog_annotations":[{"gene_uniquename":"YNL321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04028","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04028","reference_uniquename":"PMID:26896847"}],"product":"Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL321W"}


id: YNL322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KRE1","product":"Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor","secondary_identifier":"SGD:S000005266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL322C"}


id: YNL323W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNL323W":null},"has_protein_features":false,"name":"LEM3","ortholog_annotations":[{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:26896847"}],"product":"Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL323W"}


id: YNL324W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL324W"}


id: YNL325C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02289":null,"YNL325C":null},"has_protein_features":false,"name":"FIG4","ortholog_annotations":[{"gene_uniquename":"YNL325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02289","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02289","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL325C"}


id: YNL326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01299":null,"YNL326C":null},"has_protein_features":false,"name":"PFA3","ortholog_annotations":[{"gene_uniquename":"YNL326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01299","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01299","reference_uniquename":"PMID:26896847"}],"product":"Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL326C"}


id: YNL327W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGT2","product":"Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner","secondary_identifier":"SGD:S000005271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL327W"}


id: YNL328C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01597":null,"YNL328C":null},"has_protein_features":false,"name":"MDJ2","ortholog_annotations":[{"gene_uniquename":"YNL328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:26896847"}],"product":"Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL328C"}


id: YNL329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02997":null,"YNL329C":null},"has_protein_features":false,"name":"PEX6","ortholog_annotations":[{"gene_uniquename":"YNL329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02997","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02997","reference_uniquename":"PMID:26896847"}],"product":"AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL329C"}


id: YNL330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00581":null,"YNL330C":null},"has_protein_features":false,"name":"RPD3","ortholog_annotations":[{"gene_uniquename":"YNL330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00581","reference_uniquename":"PMID:29761456"}],"product":"Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL330C"}


id: YNL331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD14","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL331C"}


id: YNL332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YNL332W":null},"has_protein_features":false,"name":"THI12","ortholog_annotations":[{"gene_uniquename":"YNL332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL332W"}


id: YNL333W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YNL333W":null},"has_protein_features":false,"name":"SNZ2","ortholog_annotations":[{"gene_uniquename":"YNL333W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL333W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL333W"}


id: YNL334C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YNL334C":null},"has_protein_features":false,"name":"SNO2","ortholog_annotations":[{"gene_uniquename":"YNL334C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL334C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL334C"}


id: YNL335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDI2","product":"Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p","secondary_identifier":"SGD:S000005279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL335W"}


id: YNL336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS1","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL336W"}


id: YNL337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL337W"}


id: YNL338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element core sequence on the left arm of chromosome XIV","secondary_identifier":"SGD:S000005282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL338W"}


id: YNL339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-6","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000005283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339C"}


id: YNL339W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-A"}


id: YNL339W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-B"}


id: YNR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01922":null,"YNR001C":null},"has_protein_features":false,"name":"CIT1","ortholog_annotations":[{"gene_uniquename":"YNR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01922","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001C"}


id: YNR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by homology","secondary_identifier":"SGD:S000007625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001W-A"}


id: YNR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01505":null,"YNR002C":null},"has_protein_features":false,"name":"ATO2","ortholog_annotations":[{"gene_uniquename":"YNR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR002C"}


id: YNR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03181":null,"YNR003C":null},"has_protein_features":false,"name":"RPC34","ortholog_annotations":[{"gene_uniquename":"YNR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03181","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03181","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003C"}


id: YNR003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C","secondary_identifier":"SGD:S000028705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003W-A"}


id: YNR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SWM2","product":"Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p","secondary_identifier":"SGD:S000005287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR004W"}


id: YNR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR005C"}


id: YNR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03250":null,"YNR006W":null},"has_protein_features":false,"name":"VPS27","ortholog_annotations":[{"gene_uniquename":"YNR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03250","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03250","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin binding protein involved in endosomal protein sorting; K48-, K63-Ub chain binding protein that preferentially binds K63-linked chains in vitro; subunit of the ESCRT-0 complex that binds to ubiquitin via two ubiquitin-interacting motifs (UIMs) and is involved in sorting cargo into multivesicular bodies; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR006W"}


id: YNR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01561":null,"YNR007C":null},"has_protein_features":false,"name":"ATG3","ortholog_annotations":[{"gene_uniquename":"YNR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01561","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01561","reference_uniquename":"PMID:26896847"}],"product":"E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR007C"}


id: YNR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03162":null,"YNR008W":null},"has_protein_features":false,"name":"LRO1","ortholog_annotations":[{"gene_uniquename":"YNR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03162","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03162","reference_uniquename":"PMID:26896847"}],"product":"Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR008W"}


id: YNR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04381":null,"YNR009W":null},"has_protein_features":false,"name":"NRM1","ortholog_annotations":[{"gene_uniquename":"YNR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04381","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR009W"}


id: YNR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03590":null,"YNR010W":null},"has_protein_features":false,"name":"CSE2","ortholog_annotations":[{"gene_uniquename":"YNR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03590","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR010W"}


id: YNR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01315":null,"YNR011C":null},"has_protein_features":false,"name":"PRP2","ortholog_annotations":[{"gene_uniquename":"YNR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01315","reference_uniquename":"PMID:29761456"}],"product":"RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR011C"}


id: YNR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03708":null,"YNR012W":null},"has_protein_features":false,"name":"URK1","ortholog_annotations":[{"gene_uniquename":"YNR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03708","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03708","reference_uniquename":"PMID:26896847"}],"product":"Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR012W"}


id: YNR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01059":null,"YNR013C":null},"has_protein_features":false,"name":"PHO91","ortholog_annotations":[{"gene_uniquename":"YNR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR013C"}


id: YNR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR014W"}


id: YNR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03236":null,"YNR015W":null},"has_protein_features":false,"name":"SMM1","ortholog_annotations":[{"gene_uniquename":"YNR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03236","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR015W"}


id: YNR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03313":null,"YNR016C":null},"has_protein_features":false,"name":"ACC1","ortholog_annotations":[{"gene_uniquename":"YNR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03313","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR016C"}


id: YNR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04218":null,"YNR017W":null},"has_protein_features":false,"name":"TIM23","ortholog_annotations":[{"gene_uniquename":"YNR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04218","reference_uniquename":"PMID:29761456"}],"product":"Essential core component of the TIM23 complex; subunit of the translocase of the inner mitochondrial membrane involved in protein import into the mitochondrial matrix and inner membrane; provides a structural role, contributing to the architecture of the import channel; functions as a voltage sensor and pre-sequence receptor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR017W"}


id: YNR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03337":null,"YNR018W":null},"has_protein_features":false,"name":"RCF2","ortholog_annotations":[{"gene_uniquename":"YNR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03337","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03337","reference_uniquename":"PMID:26896847"}],"product":"Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; antagonistic with Min8p to control ETC assembly member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR018W"}


id: YNR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YNR019W":null},"has_protein_features":false,"name":"ARE2","ortholog_annotations":[{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:26896847"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR019W"}


id: YNR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01838":null,"YNR020C":null},"has_protein_features":false,"name":"ATP23","ortholog_annotations":[{"gene_uniquename":"YNR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01838","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01838","reference_uniquename":"PMID:26896847"}],"product":"Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR020C"}


id: YNR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03930":null,"YNR021W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03930","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03930","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR021W"}


id: YNR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04207":null,"YNR022C":null},"has_protein_features":false,"name":"MRPL50","ortholog_annotations":[{"gene_uniquename":"YNR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04207","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR022C"}


id: YNR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00739":null,"YNR023W":null},"has_protein_features":false,"name":"SNF12","ortholog_annotations":[{"gene_uniquename":"YNR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:26896847"}],"product":"73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR023W"}


id: YNR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01431":null,"YNR024W":null},"has_protein_features":false,"name":"MPP6","ortholog_annotations":[{"gene_uniquename":"YNR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01431","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR024W"}


id: YNR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase","secondary_identifier":"SGD:S000005308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR025C"}


id: YNR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04615":null,"YNR026C":null},"has_protein_features":false,"name":"SEC12","ortholog_annotations":[{"gene_uniquename":"YNR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04615","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR026C"}


id: YNR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00252":null,"SJAG_01383":null,"YNR027W":null},"has_protein_features":false,"name":"BUD17","ortholog_annotations":[{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01383","reference_uniquename":"PMID:29761456"}],"product":"Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR027W"}


id: YNR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CPR8","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR028W"}


id: YNR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00923":null,"YNR029C":null},"has_protein_features":false,"name":"ZNG1","ortholog_annotations":[{"gene_uniquename":"YNR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00923","reference_uniquename":"PMID:26896847"}],"product":"GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR029C"}


id: YNR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00437":null,"YNR030W":null},"has_protein_features":false,"name":"ALG12","ortholog_annotations":[{"gene_uniquename":"YNR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00437","reference_uniquename":"PMID:26896847"}],"product":"Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR030W"}


id: YNR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YNR031C":null},"has_protein_features":false,"name":"SSK2","ortholog_annotations":[{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:26896847"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR031C"}


id: YNR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03849":null,"YNR032C-A":null},"has_protein_features":false,"name":"HUB1","ortholog_annotations":[{"gene_uniquename":"YNR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03849","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03849","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032C-A"}


id: YNR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01790":null,"YNR032W":null},"has_protein_features":false,"name":"PPG1","ortholog_annotations":[{"gene_uniquename":"YNR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01790","reference_uniquename":"PMID:26896847"}],"product":"Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032W"}


id: YNR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02408":null,"YNR033W":null},"has_protein_features":false,"name":"ABZ1","ortholog_annotations":[{"gene_uniquename":"YNR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02408","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02408","reference_uniquename":"PMID:26896847"}],"product":"Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR033W"}


id: YNR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YNR034W":null},"has_protein_features":false,"name":"SOL1","ortholog_annotations":[{"gene_uniquename":"YNR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W"}


id: YNR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGO4","product":"Protein of unknown function; expressed during diauxic shift and stationary phase, and negatively regulated by glucose; expression is regulated by Msn2p/Msn4p; overexpression slows down progression through meiosis and improves fermentative efficiency; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W-A"}


id: YNR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01384":null,"YNR035C":null},"has_protein_features":false,"name":"ARC35","ortholog_annotations":[{"gene_uniquename":"YNR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01384","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR035C"}


id: YNR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04173":null,"SJAG_04494":null,"YNR036C":null},"has_protein_features":false,"name":"MRPS12","ortholog_annotations":[{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04173","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04173","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04494","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04494","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR036C"}


id: YNR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04918":null,"YNR037C":null},"has_protein_features":false,"name":"RSM19","ortholog_annotations":[{"gene_uniquename":"YNR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04918","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR037C"}


id: YNR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03479":null,"YNR038W":null},"has_protein_features":false,"name":"DBP6","ortholog_annotations":[{"gene_uniquename":"YNR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03479","reference_uniquename":"PMID:26896847"}],"product":"Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR038W"}


id: YNR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03528":null,"YNR039C":null},"has_protein_features":false,"name":"ZRG17","ortholog_annotations":[{"gene_uniquename":"YNR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03528","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03528","reference_uniquename":"PMID:26896847"}],"product":"Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR039C"}


id: YNR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX15","product":"Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","secondary_identifier":"SGD:S000005323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR040W"}


id: YNR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06603":null,"YNR041C":null},"has_protein_features":false,"name":"COQ2","ortholog_annotations":[{"gene_uniquename":"YNR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06603","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06603","reference_uniquename":"PMID:26896847"}],"product":"Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR041C"}


id: YNR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2","secondary_identifier":"SGD:S000005325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR042W"}


id: YNR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03349":null,"YNR043W":null},"has_protein_features":false,"name":"MVD1","ortholog_annotations":[{"gene_uniquename":"YNR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03349","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03349","reference_uniquename":"PMID:26896847"}],"product":"Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR043W"}


id: YNR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGA1","product":"Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR044W"}


id: YNR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET494","product":"Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000005328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR045W"}


id: YNR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04890":null,"YNR046W":null},"has_protein_features":false,"name":"TRM112","ortholog_annotations":[{"gene_uniquename":"YNR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04890","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR046W"}


id: YNR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YNR047W":null},"has_protein_features":false,"name":"FPK1","ortholog_annotations":[{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR047W"}


id: YNR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNR048W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR048W"}


id: YNR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00280":null,"YNR049C":null},"has_protein_features":false,"name":"MSO1","ortholog_annotations":[{"gene_uniquename":"YNR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00280","reference_uniquename":"PMID:29761456"}],"product":"Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR049C"}


id: YNR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01061":null,"YNR050C":null},"has_protein_features":false,"name":"LYS9","ortholog_annotations":[{"gene_uniquename":"YNR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01061","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR050C"}


id: YNR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02663":null,"YNR051C":null},"has_protein_features":false,"name":"BRE5","ortholog_annotations":[{"gene_uniquename":"YNR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02663","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the ER and Golgi compartments, deubiquitinating COPII and COPI vesicle coat constituents, Sec23p and Sec27p; involved along with Ubp3p in the steady-state retention of Golgi membrane proteins, such as glycosyltransferases; null is sensitive to brefeldin A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR051C"}


id: YNR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04407":null,"YNR052C":null},"has_protein_features":false,"name":"POP2","ortholog_annotations":[{"gene_uniquename":"YNR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04407","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04407","reference_uniquename":"PMID:26896847"}],"product":"Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR052C"}


id: YNR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01391":null,"YNR053C":null},"has_protein_features":false,"name":"NOG2","ortholog_annotations":[{"gene_uniquename":"YNR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01391","reference_uniquename":"PMID:26896847"}],"product":"Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR053C"}


id: YNR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04524":null,"YNR054C":null},"has_protein_features":false,"name":"ESF2","ortholog_annotations":[{"gene_uniquename":"YNR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04524","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR054C"}


id: YNR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04134":null,"YNR055C":null},"has_protein_features":false,"name":"HOL1","ortholog_annotations":[{"gene_uniquename":"YNR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04134","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04134","reference_uniquename":"PMID:26896847"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR055C"}


id: YNR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_06598":null,"YNR056C":null},"has_protein_features":false,"name":"BIO5","ortholog_annotations":[{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR056C"}


id: YNR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BIO4","product":"Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels","secondary_identifier":"SGD:S000005340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR057C"}


id: YNR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00673":null,"YNR058W":null},"has_protein_features":false,"name":"BIO3","ortholog_annotations":[{"gene_uniquename":"YNR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00673","reference_uniquename":"PMID:26896847"}],"product":"7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR058W"}


id: YNR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNT4","product":"Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000005342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR059W"}


id: YNR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YNR060W":null},"has_protein_features":false,"name":"FRE4","ortholog_annotations":[{"gene_uniquename":"YNR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR060W"}


id: YNR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000005344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR061C"}


id: YNR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUL3","product":"Putative pulcherrimin transporter; involved in uptake of iron-transporting siderophore, pulcherrimin","secondary_identifier":"SGD:S000005345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR062C"}


id: YNR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUL4","product":"Putative zinc-cluster transcription factor; involved in utilization of iron-transporting siderophore pulcherrimin","secondary_identifier":"SGD:S000005346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR063W"}


id: YNR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides","secondary_identifier":"SGD:S000005347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR064C"}


id: YNR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YNR065C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR065C"}


id: YNR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative membrane-localized protein of unknown function","secondary_identifier":"SGD:S000005349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR066C"}


id: YNR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YNR067C":null},"has_protein_features":false,"name":"DSE4","ortholog_annotations":[{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:26896847"}],"product":"Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR067C"}


id: YNR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form","secondary_identifier":"SGD:S000005351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR068C"}


id: YNR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC5","product":"Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro","secondary_identifier":"SGD:S000005352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR069C"}


id: YNR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YNR070W":null},"has_protein_features":false,"name":"PDR18","ortholog_annotations":[{"gene_uniquename":"YNR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR070W"}


id: YNR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative aldose 1-epimerase","secondary_identifier":"SGD:S000005354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR071C"}


id: YNR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNR072W":null},"has_protein_features":false,"name":"HXT17","ortholog_annotations":[{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR072W"}


id: YNR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAN2","product":"Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication","secondary_identifier":"SGD:S000005356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR073C"}


id: YNR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02016":null,"YNR074C":null},"has_protein_features":false,"name":"AIF1","ortholog_annotations":[{"gene_uniquename":"YNR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02016","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR074C"}


id: YNR075C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075C-A"}


id: YNR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS10","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075W"}


id: YNR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU6","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p","secondary_identifier":"SGD:S000005359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR076W"}


id: YNR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function, abundance changes with carbon source","secondary_identifier":"SGD:S000005360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR077C"}


id: YOL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO80","product":"Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling","secondary_identifier":"SGD:S000005361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL001W"}


id: YOL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02847":null,"YOL002C":null},"has_protein_features":false,"name":"IZH2","ortholog_annotations":[{"gene_uniquename":"YOL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02847","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL002C"}


id: YOL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFA4","product":"Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases","secondary_identifier":"SGD:S000005363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL003C"}


id: YOL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00441":null,"SJAG_01804":null,"SJAG_02846":null,"YOL004W":null},"has_protein_features":false,"name":"SIN3","ortholog_annotations":[{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00441","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01804","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02846","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL004W"}


id: YOL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04894":null,"YOL005C":null},"has_protein_features":false,"name":"RPB11","ortholog_annotations":[{"gene_uniquename":"YOL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04894","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04894","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL005C"}


id: YOL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05193":null,"YOL006C":null},"has_protein_features":false,"name":"TOP1","ortholog_annotations":[{"gene_uniquename":"YOL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05193","reference_uniquename":"PMID:26896847"}],"product":"Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL006C"}


id: YOL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSI2","product":"Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene","secondary_identifier":"SGD:S000005367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL007C"}


id: YOL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04223":null,"YOL008W":null},"has_protein_features":false,"name":"COQ10","ortholog_annotations":[{"gene_uniquename":"YOL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04223","reference_uniquename":"PMID:29761456"}],"product":"Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL008W"}


id: YOL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03710":null,"YOL009C":null},"has_protein_features":false,"name":"MDM12","ortholog_annotations":[{"gene_uniquename":"YOL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03710","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03710","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; localizes to mitochondria–ER contact sites; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL009C"}


id: YOL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01476":null,"YOL010W":null},"has_protein_features":false,"name":"RCL1","ortholog_annotations":[{"gene_uniquename":"YOL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01476","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01476","reference_uniquename":"PMID:26896847"}],"product":"Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL010W"}


id: YOL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YOL011W":null},"has_protein_features":false,"name":"PLB3","ortholog_annotations":[{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL011W"}


id: YOL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03047":null,"YOL012C":null},"has_protein_features":false,"name":"HTZ1","ortholog_annotations":[{"gene_uniquename":"YOL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03047","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03047","reference_uniquename":"PMID:26896847"}],"product":"Histone variant H2A.Z; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL012C"}


id: YOL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05274":null,"YOL013C":null},"has_protein_features":false,"name":"HRD1","ortholog_annotations":[{"gene_uniquename":"YOL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05274","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05274","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013C"}


id: YOL013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE; overlaps tRNA-Pro/YNCO0011W","secondary_identifier":"SGD:S000028811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-A"}


id: YOL013W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element","secondary_identifier":"SGD:S000007252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-B"}


id: YOL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus","secondary_identifier":"SGD:S000005374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL014W"}


id: YOL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC10","product":"Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000005375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL015W"}


id: YOL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02858":null,"YOL016C":null},"has_protein_features":false,"name":"CMK2","ortholog_annotations":[{"gene_uniquename":"YOL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02858","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL016C"}


id: YOL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ESC8","product":"Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL017W"}


id: YOL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04978":null,"YOL018C":null},"has_protein_features":false,"name":"TLG2","ortholog_annotations":[{"gene_uniquename":"YOL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04978","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04978","reference_uniquename":"PMID:26896847"}],"product":"Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL018C"}


id: YOL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YOL019W":null},"has_protein_features":false,"name":"TOS7","ortholog_annotations":[{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W"}


id: YOL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W-A"}


id: YOL020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YOL020W":null},"has_protein_features":false,"name":"TAT2","ortholog_annotations":[{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL020W"}


id: YOL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04006":null,"YOL021C":null},"has_protein_features":false,"name":"DIS3","ortholog_annotations":[{"gene_uniquename":"YOL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04006","reference_uniquename":"PMID:29761456"}],"product":"Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL021C"}


id: YOL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02911":null,"SJAG_03857":null,"YOL022C":null},"has_protein_features":false,"name":"TSR4","ortholog_annotations":[{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02911","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03857","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL022C"}


id: YOL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02856":null,"YOL023W":null},"has_protein_features":false,"name":"IFM1","ortholog_annotations":[{"gene_uniquename":"YOL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02856","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02856","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial translation initiation factor 2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL023W"}


id: YOL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL024W"}


id: YOL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LAG2","product":"Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1","secondary_identifier":"SGD:S000005385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL025W"}


id: YOL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00569":null,"YOL026C":null},"has_protein_features":false,"name":"MIM1","ortholog_annotations":[{"gene_uniquename":"YOL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00569","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL026C"}


id: YOL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01806":null,"YOL027C":null},"has_protein_features":false,"name":"MDM38","ortholog_annotations":[{"gene_uniquename":"YOL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:26896847"}],"product":"Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL027C"}


id: YOL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP7","product":"Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL028C"}


id: YOL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens","secondary_identifier":"SGD:S000005389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL029C"}


id: YOL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00218":null,"SJAG_04483":null,"YOL030W":null},"has_protein_features":false,"name":"GAS5","ortholog_annotations":[{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00218","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04483","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04483","reference_uniquename":"PMID:26896847"}],"product":"1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL030W"}


id: YOL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIL1","product":"Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein","secondary_identifier":"SGD:S000005391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL031C"}


id: YOL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00586":null,"YOL032W":null},"has_protein_features":false,"name":"OPI10","ortholog_annotations":[{"gene_uniquename":"YOL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00586","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00586","reference_uniquename":"PMID:26896847"}],"product":"Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL032W"}


id: YOL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03071":null,"YOL033W":null},"has_protein_features":false,"name":"MSE1","ortholog_annotations":[{"gene_uniquename":"YOL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03071","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03071","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL033W"}


id: YOL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03436":null,"YOL034W":null},"has_protein_features":false,"name":"SMC5","ortholog_annotations":[{"gene_uniquename":"YOL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03436","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03436","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL034W"}


id: YOL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL035C"}


id: YOL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL036W"}


id: YOL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W","secondary_identifier":"SGD:S000005397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL037C"}


id: YOL038C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE analysis","secondary_identifier":"SGD:S000028812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038C-A"}


id: YOL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04306":null,"YOL038W":null},"has_protein_features":false,"name":"PRE6","ortholog_annotations":[{"gene_uniquename":"YOL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04306","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04306","reference_uniquename":"PMID:26896847"}],"product":"Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038W"}


id: YOL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01128":null,"SJAG_02871":null,"YOL039W":null},"has_protein_features":false,"name":"RPP2A","ortholog_annotations":[{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL039W"}


id: YOL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02870":null,"SJAG_04256":null,"YOL040C":null},"has_protein_features":false,"name":"RPS15","ortholog_annotations":[{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02870","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04256","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04256","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04256","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL040C"}


id: YOL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05190":null,"YOL041C":null},"has_protein_features":false,"name":"NOP12","ortholog_annotations":[{"gene_uniquename":"YOL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05190","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05190","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL041C"}


id: YOL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NGL1","product":"Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL042W"}


id: YOL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03724":null,"YOL043C":null},"has_protein_features":false,"name":"NTG2","ortholog_annotations":[{"gene_uniquename":"YOL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03724","reference_uniquename":"PMID:29761456"}],"product":"DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL043C"}


id: YOL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05950":null,"YOL044W":null},"has_protein_features":false,"name":"PEX15","ortholog_annotations":[{"gene_uniquename":"YOL044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05950","reference_uniquename":"PMID:29761456"}],"product":"Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL044W"}


id: YOL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01376":null,"YOL045W":null},"has_protein_features":false,"name":"PSK2","ortholog_annotations":[{"gene_uniquename":"YOL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01376","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01376","reference_uniquename":"PMID:26896847"}],"product":"PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL045W"}


id: YOL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W","secondary_identifier":"SGD:S000005406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL046C"}


id: YOL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDS2","product":"Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000005407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL047C"}


id: YOL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT8","product":"Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL048C"}


id: YOL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01351":null,"YOL049W":null},"has_protein_features":false,"name":"GSH2","ortholog_annotations":[{"gene_uniquename":"YOL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01351","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01351","reference_uniquename":"PMID:26896847"}],"product":"Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL049W"}


id: YOL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000005410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL050C"}


id: YOL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03981":null,"YOL051W":null},"has_protein_features":false,"name":"GAL11","ortholog_annotations":[{"gene_uniquename":"YOL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03981","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL051W"}


id: YOL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03632":null,"YOL052C":null},"has_protein_features":false,"name":"SPE2","ortholog_annotations":[{"gene_uniquename":"YOL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03632","reference_uniquename":"PMID:26896847"}],"product":"S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C"}


id: YOL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDR2","product":"Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C-A"}


id: YOL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM39","product":"Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss; localizes to mitochondria, cytosol and to the peroxisome in a Pex5p-dependent manner in glucose","secondary_identifier":"SGD:S000005414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL053W"}


id: YOL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01854":null,"SJAG_03615":null,"YOL054W":null},"has_protein_features":false,"name":"PSH1","ortholog_annotations":[{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03615","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03615","reference_uniquename":"PMID:26896847"}],"product":"E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p; ubiquitination of Cse4p may be antagonized by Scm3p; interacts with the FACT complex preventing mislocalization of Cse4p to euchromatin independent of Slx5p; formyl-methionine/N-recognin component of N-end rule pathway mediating destruction of formylated cytosolic proteins elevated in response to starvation or stationary phase entry","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL054W"}


id: YOL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YOL055C":null},"has_protein_features":false,"name":"THI20","ortholog_annotations":[{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:26896847"}],"product":"Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL055C"}


id: YOL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02009":null,"YOL056W":null},"has_protein_features":false,"name":"GPM3","ortholog_annotations":[{"gene_uniquename":"YOL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:26896847"}],"product":"Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL056W"}


id: YOL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers","secondary_identifier":"SGD:S000005418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL057W"}


id: YOL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04577":null,"YOL058W":null},"has_protein_features":false,"name":"ARG1","ortholog_annotations":[{"gene_uniquename":"YOL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04577","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04577","reference_uniquename":"PMID:26896847"}],"product":"Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL058W"}


id: YOL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00409":null,"SJAG_01012":null,"YOL059W":null},"has_protein_features":false,"name":"GPD2","ortholog_annotations":[{"gene_uniquename":"YOL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00409","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01012","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL059W"}


id: YOL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04111":null,"YOL060C":null},"has_protein_features":false,"name":"MAM3","ortholog_annotations":[{"gene_uniquename":"YOL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04111","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04111","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL060C"}


id: YOL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04882":null,"YOL061W":null},"has_protein_features":false,"name":"PRS5","ortholog_annotations":[{"gene_uniquename":"YOL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04882","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04882","reference_uniquename":"PMID:26896847"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL061W"}


id: YOL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00800":null,"YOL062C":null},"has_protein_features":false,"name":"APM4","ortholog_annotations":[{"gene_uniquename":"YOL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00800","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00800","reference_uniquename":"PMID:26896847"}],"product":"Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL062C"}


id: YOL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03507":null,"YOL063C":null},"has_protein_features":false,"name":"CRT10","ortholog_annotations":[{"gene_uniquename":"YOL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03507","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL063C"}


id: YOL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01702":null,"YOL064C":null},"has_protein_features":false,"name":"MET22","ortholog_annotations":[{"gene_uniquename":"YOL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01702","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01702","reference_uniquename":"PMID:26896847"}],"product":"Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL064C"}


id: YOL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INP54","product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins","secondary_identifier":"SGD:S000005426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL065C"}


id: YOL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01054":null,"YOL066C":null},"has_protein_features":false,"name":"RIB2","ortholog_annotations":[{"gene_uniquename":"YOL066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01054","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL066C"}


id: YOL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTG1","product":"Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization","secondary_identifier":"SGD:S000005428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL067C"}


id: YOL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04186":null,"YOL068C":null},"has_protein_features":false,"name":"HST1","ortholog_annotations":[{"gene_uniquename":"YOL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:26896847"}],"product":"NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL068C"}


id: YOL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00794":null,"YOL069W":null},"has_protein_features":false,"name":"NUF2","ortholog_annotations":[{"gene_uniquename":"YOL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00794","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00794","reference_uniquename":"PMID:26896847"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL069W"}


id: YOL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NBA1","product":"Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited by Aim44p and Nap1p to the cell cortex and to cytokinesis remnants (bud scars) where it prevents Rsr1p-mediated activation of Cdc24p, the Cdc42p GEF; localizes to the cytoplasm, and the cell division site prior to being stably recruited to cytokinesis remnants; establishes the transient localization of Rga1p, a Cdc42p GAP, at bud scars along with Nis1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL070C"}


id: YOL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01895":null,"YOL071W":null},"has_protein_features":false,"name":"SDH5","ortholog_annotations":[{"gene_uniquename":"YOL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01895","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01895","reference_uniquename":"PMID:26896847"}],"product":"Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL071W"}


id: YOL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00298":null,"YOL072W":null},"has_protein_features":false,"name":"THP1","ortholog_annotations":[{"gene_uniquename":"YOL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00298","reference_uniquename":"PMID:29761456"}],"product":"Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL072W"}


id: YOL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03302":null,"YOL073C":null},"has_protein_features":false,"name":"DSC2","ortholog_annotations":[{"gene_uniquename":"YOL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03302","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03302","reference_uniquename":"PMID:26896847"}],"product":"Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL073C"}


id: YOL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YOL075C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOL075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Putative ABC transporter","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL075C"}


id: YOL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03045":null,"YOL076W":null},"has_protein_features":false,"name":"MDM20","ortholog_annotations":[{"gene_uniquename":"YOL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03045","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL076W"}


id: YOL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02508":null,"YOL077C":null},"has_protein_features":false,"name":"BRX1","ortholog_annotations":[{"gene_uniquename":"YOL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02508","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077C"}


id: YOL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07003":null,"YOL077W-A":null},"has_protein_features":false,"name":"ATP19","ortholog_annotations":[{"gene_uniquename":"YOL077W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07003","reference_uniquename":"PMID:29761456"}],"product":"Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077W-A"}


id: YOL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00117":null,"YOL078W":null},"has_protein_features":false,"name":"AVO1","ortholog_annotations":[{"gene_uniquename":"YOL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00117","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00117","reference_uniquename":"PMID:26896847"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; C-terminal PH domain binds to phosphoinositide-(4,5)-bisphosphate (PI(4,5)P2); binds directly to Ypk2p a Tor2p substrate and downstream TORC2 effector through a conserved central CRIM domain; acts with Tsc11p as a scaffold important for the integrity of the TORC2 complex; dispensable for PM localization of TORC2; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL078W"}


id: YOL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL079W"}


id: YOL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00841":null,"YOL080C":null},"has_protein_features":false,"name":"REX4","ortholog_annotations":[{"gene_uniquename":"YOL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00841","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL080C"}


id: YOL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRA2","product":"GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis","secondary_identifier":"SGD:S000005441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL081W"}


id: YOL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03976":null,"YOL082W":null},"has_protein_features":false,"name":"ATG19","ortholog_annotations":[{"gene_uniquename":"YOL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03976","reference_uniquename":"PMID:29761456"}],"product":"Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL082W"}


id: YOL083C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083C-A"}


id: YOL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG34","product":"Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog","secondary_identifier":"SGD:S000005443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083W"}


id: YOL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHM7","product":"Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL084W"}


id: YOL085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A","secondary_identifier":"SGD:S000005445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085C"}


id: YOL085W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C","secondary_identifier":"SGD:S000028708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085W-A"}


id: YOL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YOL086C":null},"has_protein_features":false,"name":"ADH1","ortholog_annotations":[{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086C"}


id: YOL086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00935":null,"YOL086W-A":null},"has_protein_features":false,"name":"MHF1","ortholog_annotations":[{"gene_uniquename":"YOL086W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00935","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL086W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00935","reference_uniquename":"PMID:26896847"}],"product":"Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086W-A"}


id: YOL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00805":null,"YOL087C":null},"has_protein_features":false,"name":"DUF1","ortholog_annotations":[{"gene_uniquename":"YOL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00805","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00805","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL087C"}


id: YOL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03414":null,"YOL088C":null},"has_protein_features":false,"name":"MPD2","ortholog_annotations":[{"gene_uniquename":"YOL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03414","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL088C"}


id: YOL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAL9","product":"Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL089C"}


id: YOL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02226":null,"YOL090W":null},"has_protein_features":false,"name":"MSH2","ortholog_annotations":[{"gene_uniquename":"YOL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02226","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02226","reference_uniquename":"PMID:26896847"}],"product":"Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL090W"}


id: YOL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO21","product":"Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL091W"}


id: YOL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YOL092W":null},"has_protein_features":false,"name":"YPQ1","ortholog_annotations":[{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL092W"}


id: YOL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04993":null,"YOL093W":null},"has_protein_features":false,"name":"TRM10","ortholog_annotations":[{"gene_uniquename":"YOL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04993","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04993","reference_uniquename":"PMID:26896847"}],"product":"tRNA methyltransferase; methylates the N-1 of guanine at position 9 in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer ncRNA originates from the TRM10 locus; genetic analysis shows the 18-mer ncRNA is a translational regulator; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL093W"}


id: YOL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00729":null,"YOL094C":null},"has_protein_features":false,"name":"RFC4","ortholog_annotations":[{"gene_uniquename":"YOL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00729","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL094C"}


id: YOL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMI1","product":"Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD","secondary_identifier":"SGD:S000005455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL095C"}


id: YOL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01911":null,"SJAG_04642":null,"YOL096C":null},"has_protein_features":false,"name":"COQ3","ortholog_annotations":[{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04642","reference_uniquename":"PMID:29761456"}],"product":"O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL096C"}


id: YOL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01522":null,"YOL097C":null},"has_protein_features":false,"name":"WRS1","ortholog_annotations":[{"gene_uniquename":"YOL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01522","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097C"}


id: YOL097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097W-A"}


id: YOL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03393":null,"YOL098C":null},"has_protein_features":false,"name":"SDD3","ortholog_annotations":[{"gene_uniquename":"YOL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03393","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL098C"}


id: YOL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes","secondary_identifier":"SGD:S000005459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL099C"}


id: YOL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02468":null,"SJAG_05290":null,"YOL100W":null},"has_protein_features":false,"name":"PKH2","ortholog_annotations":[{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:26896847"}],"product":"Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL100W"}


id: YOL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IZH4","product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL101C"}


id: YOL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03913":null,"YOL102C":null},"has_protein_features":false,"name":"TPT1","ortholog_annotations":[{"gene_uniquename":"YOL102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:26896847"}],"product":"tRNA 2'-phosphotransferase; catalyzes the final step in tRNA splicing, transferring the 2'-PO(4) from the splice junction to NAD(+), forming ADP-ribose 1''-2''cyclic phosphate and nicotinamide; ADP-ribosyltransferase that ADP-ribosylates 5'-phosphorylated ssDNA and ssRNAs; human and mouse orthologs complement the inviability of the yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL102C"}


id: YOL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YOL103W":null},"has_protein_features":false,"name":"ITR2","ortholog_annotations":[{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:26896847"}],"product":"Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL103W"}


id: YOL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NDJ1","product":"Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement","secondary_identifier":"SGD:S000005464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL104C"}


id: YOL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YOL105C":null},"has_protein_features":false,"name":"WSC3","ortholog_annotations":[{"gene_uniquename":"YOL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL105C"}


id: YOL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL106W"}


id: YOL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01927":null,"YOL107W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01927","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL107W"}


id: YOL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INO4","product":"Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain","secondary_identifier":"SGD:S000005468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL108C"}


id: YOL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZEO1","product":"Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria","secondary_identifier":"SGD:S000005469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL109W"}


id: YOL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01349":null,"YOL110W":null},"has_protein_features":false,"name":"SHR5","ortholog_annotations":[{"gene_uniquename":"YOL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01349","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL110W"}


id: YOL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDY2","product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes","secondary_identifier":"SGD:S000005471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL111C"}


id: YOL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01048":null,"YOL112W":null},"has_protein_features":false,"name":"MSB4","ortholog_annotations":[{"gene_uniquename":"YOL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:26896847"}],"product":"GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL112W"}


id: YOL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02878":null,"YOL113W":null},"has_protein_features":false,"name":"SKM1","ortholog_annotations":[{"gene_uniquename":"YOL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:29761456"}],"product":"Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL113W"}


id: YOL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05221":null,"YOL114C":null},"has_protein_features":false,"name":"PTH4","ortholog_annotations":[{"gene_uniquename":"YOL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05221","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05221","reference_uniquename":"PMID:26896847"}],"product":"Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL114C"}


id: YOL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01176":null,"YOL115W":null},"has_protein_features":false,"name":"PAP2","ortholog_annotations":[{"gene_uniquename":"YOL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:26896847"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL115W"}


id: YOL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSN1","product":"Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000005476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL116W"}


id: YOL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRI2","product":"Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response","secondary_identifier":"SGD:S000005477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL117W"}


id: YOL118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL118C"}


id: YOL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCH4","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL119C"}


id: YOL120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YOL120C":null},"has_protein_features":false,"name":"RPL18A","ortholog_annotations":[{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL120C"}


id: YOL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YOL121C":null},"has_protein_features":false,"name":"RPS19A","ortholog_annotations":[{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL121C"}


id: YOL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YOL122C":null},"has_protein_features":false,"name":"SMF1","ortholog_annotations":[{"gene_uniquename":"YOL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:26896847"}],"product":"Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL122C"}


id: YOL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03853":null,"YOL123W":null},"has_protein_features":false,"name":"HRP1","ortholog_annotations":[{"gene_uniquename":"YOL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03853","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL123W"}


id: YOL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04181":null,"YOL124C":null},"has_protein_features":false,"name":"TRM11","ortholog_annotations":[{"gene_uniquename":"YOL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04181","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; contains a THUMP domain and a methyltransferase domain; methyltransferase complex also contains Trm112p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL124C"}


id: YOL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01375":null,"YOL125W":null},"has_protein_features":false,"name":"TRM13","ortholog_annotations":[{"gene_uniquename":"YOL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01375","reference_uniquename":"PMID:26896847"}],"product":"2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL125W"}


id: YOL126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDH2","product":"Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy","secondary_identifier":"SGD:S000005486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL126C"}


id: YOL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02840":null,"SJAG_04304":null,"YOL127W":null},"has_protein_features":false,"name":"RPL25","ortholog_annotations":[{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02840","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04304","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04304","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04304","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL127W"}


id: YOL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YGK3","product":"Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL128C"}


id: YOL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03511":null,"YOL129W":null},"has_protein_features":false,"name":"VPS68","ortholog_annotations":[{"gene_uniquename":"YOL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03511","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL129W"}


id: YOL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03516":null,"YOL130W":null},"has_protein_features":false,"name":"ALR1","ortholog_annotations":[{"gene_uniquename":"YOL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL130W"}


id: YOL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YOL131W has a paralog, STB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL131W"}


id: YOL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01835":null,"YOL132W":null},"has_protein_features":false,"name":"GAS4","ortholog_annotations":[{"gene_uniquename":"YOL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:26896847"}],"product":"1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL132W"}


id: YOL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00341":null,"YOL133W":null},"has_protein_features":false,"name":"HRT1","ortholog_annotations":[{"gene_uniquename":"YOL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00341","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00341","reference_uniquename":"PMID:26896847"}],"product":"RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL133W"}


id: YOL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit","secondary_identifier":"SGD:S000005494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL134C"}


id: YOL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02849":null,"YOL135C":null},"has_protein_features":false,"name":"MED7","ortholog_annotations":[{"gene_uniquename":"YOL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02849","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02849","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL135C"}


id: YOL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFK27","product":"6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A","secondary_identifier":"SGD:S000005496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL136C"}


id: YOL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC6","product":"Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression","secondary_identifier":"SGD:S000005497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL137W"}


id: YOL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04496":null,"YOL138C":null},"has_protein_features":false,"name":"RTC1","ortholog_annotations":[{"gene_uniquename":"YOL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04496","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04496","reference_uniquename":"PMID:26896847"}],"product":"Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL138C"}


id: YOL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00507":null,"SJAG_03223":null,"YOL139C":null},"has_protein_features":false,"name":"CDC33","ortholog_annotations":[{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00507","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00507","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03223","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03223","reference_uniquename":"PMID:26896847"}],"product":"Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL139C"}


id: YOL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01019":null,"YOL140W":null},"has_protein_features":false,"name":"ARG8","ortholog_annotations":[{"gene_uniquename":"YOL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01019","reference_uniquename":"PMID:26896847"}],"product":"Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL140W"}


id: YOL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01261":null,"YOL141W":null},"has_protein_features":false,"name":"PPM2","ortholog_annotations":[{"gene_uniquename":"YOL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01261","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01261","reference_uniquename":"PMID:26896847"}],"product":"AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL141W"}


id: YOL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04321":null,"YOL142W":null},"has_protein_features":false,"name":"RRP40","ortholog_annotations":[{"gene_uniquename":"YOL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04321","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04321","reference_uniquename":"PMID:26896847"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL142W"}


id: YOL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02360":null,"YOL143C":null},"has_protein_features":false,"name":"RIB4","ortholog_annotations":[{"gene_uniquename":"YOL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02360","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02360","reference_uniquename":"PMID:26896847"}],"product":"Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL143C"}


id: YOL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04610":null,"YOL144W":null},"has_protein_features":false,"name":"NOP8","ortholog_annotations":[{"gene_uniquename":"YOL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04610","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL144W"}


id: YOL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00139":null,"YOL145C":null},"has_protein_features":false,"name":"CTR9","ortholog_annotations":[{"gene_uniquename":"YOL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00139","reference_uniquename":"PMID:26896847"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL145C"}


id: YOL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00536":null,"YOL146W":null},"has_protein_features":false,"name":"PSF3","ortholog_annotations":[{"gene_uniquename":"YOL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00536","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00536","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL146W"}


id: YOL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02788":null,"SJAG_04146":null,"YOL147C":null},"has_protein_features":false,"name":"PEX11","ortholog_annotations":[{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02788","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04146","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04146","reference_uniquename":"PMID:26896847"}],"product":"Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL147C"}


id: YOL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01658":null,"YOL148C":null},"has_protein_features":false,"name":"SPT20","ortholog_annotations":[{"gene_uniquename":"YOL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01658","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL148C"}


id: YOL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05694":null,"YOL149W":null},"has_protein_features":false,"name":"DCP1","ortholog_annotations":[{"gene_uniquename":"YOL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05694","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL149W"}


id: YOL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL150C"}


id: YOL151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YOL151W":null},"has_protein_features":false,"name":"GRE2","ortholog_annotations":[{"gene_uniquename":"YOL151W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL151W"}


id: YOL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YOL152W":null},"has_protein_features":false,"name":"FRE7","ortholog_annotations":[{"gene_uniquename":"YOL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL152W"}


id: YOL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Blocked reading frame, contains two in-frame stops in translation; this ORF is conserved, without the stops, in Saccharomyces paradoxus, S. mikatae, and S. bayanus; RNA sequencing data indicate the presence of a transcription unit at this reading frame","secondary_identifier":"SGD:S000005513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL153C"}


id: YOL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZPS1","product":"Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH","secondary_identifier":"SGD:S000005514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL154W"}


id: YOL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HPF1","product":"Haze-protective mannoprotein; reduces particle size of aggregated proteins in white wines, thereby decreasing turbidity; intragenic repeat expansion controls chronological aging; expansion of intragenic tandem repeats within N-terminus sufficient to cause pronounced life span shortening; repeat expansion shifts cells from sedentary to buoyant, thereby increasing exposure to oxygen, altering methionine, lipid, and purine metabolism","secondary_identifier":"SGD:S000005515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155C"}


id: YOL155W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155W-A"}


id: YOL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YOL156W":null},"has_protein_features":false,"name":"HXT11","ortholog_annotations":[{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL156W"}


id: YOL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA2","product":"Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose","secondary_identifier":"SGD:S000005517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL157C"}


id: YOL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YOL158C":null},"has_protein_features":false,"name":"ENB1","ortholog_annotations":[{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Ferric enterobactin transmembrane transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL158C"}


id: YOL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS3","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA","secondary_identifier":"SGD:S000005519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C"}


id: YOL159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C-A"}


id: YOL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL160W"}


id: YOL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU20","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation","secondary_identifier":"SGD:S000005521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL161C"}


id: YOL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL163W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL162W"}


id: YOL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL162W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL163W"}


id: YOL164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BDS1","product":"Bacterially-derived sulfatase; required for use of alkyl sulfates as sulfur source","secondary_identifier":"SGD:S000005524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W"}


id: YOL164W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W-A"}


id: YOL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD15","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL165C"}


id: YOL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166C"}


id: YOL166W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166W-A"}


id: YOR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03745":null,"YOR001W":null},"has_protein_features":false,"name":"RRP6","ortholog_annotations":[{"gene_uniquename":"YOR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03745","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03745","reference_uniquename":"PMID:26896847"}],"product":"Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR001W"}


id: YOR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03656":null,"YOR002W":null},"has_protein_features":false,"name":"ALG6","ortholog_annotations":[{"gene_uniquename":"YOR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03656","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03656","reference_uniquename":"PMID:26896847"}],"product":"ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR002W"}


id: YOR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02432":null,"SJAG_04785":null,"YOR003W":null},"has_protein_features":false,"name":"YSP3","ortholog_annotations":[{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:26896847"}],"product":"Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR003W"}


id: YOR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00253":null,"YOR004W":null},"has_protein_features":false,"name":"UTP23","ortholog_annotations":[{"gene_uniquename":"YOR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00253","reference_uniquename":"PMID:26896847"}],"product":"Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR004W"}


id: YOR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02527":null,"YOR005C":null},"has_protein_features":false,"name":"DNL4","ortholog_annotations":[{"gene_uniquename":"YOR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02527","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02527","reference_uniquename":"PMID:26896847"}],"product":"DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR005C"}


id: YOR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03755":null,"YOR006C":null},"has_protein_features":false,"name":"TSR3","ortholog_annotations":[{"gene_uniquename":"YOR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03755","reference_uniquename":"PMID:26896847"}],"product":"Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR006C"}


id: YOR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01496":null,"YOR007C":null},"has_protein_features":false,"name":"SGT2","ortholog_annotations":[{"gene_uniquename":"YOR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01496","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01496","reference_uniquename":"PMID:26896847"}],"product":"Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR007C"}


id: YOR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YOR008C":null},"has_protein_features":false,"name":"SLG1","ortholog_annotations":[{"gene_uniquename":"YOR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C"}


id: YOR008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000006431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C-A"}


id: YOR008W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008W-B"}


id: YOR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR4","product":"Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000005535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR009W"}


id: YOR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR2","product":"Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR010C"}


id: YOR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YOR011W":null},"has_protein_features":false,"name":"AUS1","ortholog_annotations":[{"gene_uniquename":"YOR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W"}


id: YOR011W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W-A"}


id: YOR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01619":null,"YOR012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01619","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR012W"}


id: YOR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC11","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR013W"}


id: YOR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03353":null,"SJAG_03681":null,"YOR014W":null},"has_protein_features":false,"name":"RTS1","ortholog_annotations":[{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03353","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03681","reference_uniquename":"PMID:26896847"}],"product":"B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR014W"}


id: YOR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene","secondary_identifier":"SGD:S000005541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR015W"}


id: YOR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03270":null,"YOR016C":null},"has_protein_features":false,"name":"ERP4","ortholog_annotations":[{"gene_uniquename":"YOR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:26896847"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR016C"}


id: YOR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02526":null,"YOR017W":null},"has_protein_features":false,"name":"PET127","ortholog_annotations":[{"gene_uniquename":"YOR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02526","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02526","reference_uniquename":"PMID:26896847"}],"product":"Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR017W"}


