# genes

id: YCR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04917":null,"YCR042C":null},"has_protein_features":false,"name":"TAF2","ortholog_annotations":[{"gene_uniquename":"YCR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04917","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04917","reference_uniquename":"PMID:26896847"}],"product":"TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR042C"}


id: YCR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene","secondary_identifier":"SGD:S000000639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR043C"}


id: YCR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04975":null,"YCR044C":null},"has_protein_features":false,"name":"PER1","ortholog_annotations":[{"gene_uniquename":"YCR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04975","reference_uniquename":"PMID:29761456"}],"product":"Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR044C"}


id: YCR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT12","product":"Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores","secondary_identifier":"SGD:S000000641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045C"}


id: YCR045W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045W-A"}


id: YCR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01473":null,"YCR046C":null},"has_protein_features":false,"name":"IMG1","ortholog_annotations":[{"gene_uniquename":"YCR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01473","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR046C"}


id: YCR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02281":null,"YCR047C":null},"has_protein_features":false,"name":"BUD23","ortholog_annotations":[{"gene_uniquename":"YCR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02281","reference_uniquename":"PMID:29761456"}],"product":"Ribosome biogenesis factor; methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; required for recruitment of Rps2p; functions with DEAH-box RNA helicase Ecm16p; diploid mutant displays random budding pattern; functional homolog of human WBSCR22","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047C"}


id: YCR047W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047W-A"}


id: YCR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YCR048W":null},"has_protein_features":false,"name":"ARE1","ortholog_annotations":[{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:26896847"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR048W"}


id: YCR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR049C"}


id: YCR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein","secondary_identifier":"SGD:S000000646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR050C"}


id: YCR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01812":null,"YCR051W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01812","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01812","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR051W"}


id: YCR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00739":null,"YCR052W":null},"has_protein_features":false,"name":"RSC6","ortholog_annotations":[{"gene_uniquename":"YCR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:26896847"}],"product":"Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR052W"}


id: YCR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00432":null,"YCR053W":null},"has_protein_features":false,"name":"THR4","ortholog_annotations":[{"gene_uniquename":"YCR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00432","reference_uniquename":"PMID:26896847"}],"product":"Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR053W"}


id: YCR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03692":null,"YCR054C":null},"has_protein_features":false,"name":"CTR86","ortholog_annotations":[{"gene_uniquename":"YCR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03692","reference_uniquename":"PMID:26896847"}],"product":"Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR054C"}


id: YCR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR055C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR055C"}


id: YCR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR056W"}


id: YCR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00572":null,"YCR057C":null},"has_protein_features":false,"name":"PWP2","ortholog_annotations":[{"gene_uniquename":"YCR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00572","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00572","reference_uniquename":"PMID:26896847"}],"product":"Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR057C"}


id: YCR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR058C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR058C"}


id: YCR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04873":null,"YCR059C":null},"has_protein_features":false,"name":"YIH1","ortholog_annotations":[{"gene_uniquename":"YCR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04873","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04873","reference_uniquename":"PMID:26896847"}],"product":"Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR059C"}


id: YCR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAH1","product":"Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants","secondary_identifier":"SGD:S000000656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR060W"}


id: YCR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TVS1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; induced by treatment with 8-methoxypsoralen and UVA irradiation; contains 10-11 predicted transmembrane domains","secondary_identifier":"SGD:S000000657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR061W"}


id: YCR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR062W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR061W","secondary_identifier":"SGD:S000000658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR062W"}


id: YCR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02227":null,"YCR063W":null},"has_protein_features":false,"name":"BUD31","ortholog_annotations":[{"gene_uniquename":"YCR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02227","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02227","reference_uniquename":"PMID:26896847"}],"product":"Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR063W"}


id: YCR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BUD31","secondary_identifier":"SGD:S000000660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR064C"}


id: YCR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03143":null,"SJAG_05288":null,"YCR065W":null},"has_protein_features":false,"name":"HCM1","ortholog_annotations":[{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03143","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03143","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05288","reference_uniquename":"PMID:29761456"}],"product":"Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources, NAD synthesis, oxidative stress resistance; regulated by cell wall integrity checkpoint; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR065W"}


id: YCR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00819":null,"YCR066W":null},"has_protein_features":false,"name":"RAD18","ortholog_annotations":[{"gene_uniquename":"YCR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00819","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00819","reference_uniquename":"PMID:26896847"}],"product":"E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR066W"}


id: YCR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SED4","product":"Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR067C"}


id: YCR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02100":null,"YCR068W":null},"has_protein_features":false,"name":"ATG15","ortholog_annotations":[{"gene_uniquename":"YCR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02100","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B; hydrolyses phosphatidylserine; minor activity against cardiolipin and PtdEtn; required for lysis of autophagic and CVT bodies; targeted to the vacuole via the Pep1p-dependent endosomal VPS pathway; targeted to intravacuolar vesicles during autophagy by the MVB pathway; maintains lipid droplet quantity after the diauxic shift; regulates lipolysis; single membrane spanning protein with cytosolic N-term and the rest in the ER lumen; expression regulated by Yap1p during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR068W"}


id: YCR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CPR4","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR069W"}


id: YCR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted open reading frame; YCR070W was originally annotated as an ORF, but upon further review was deleted from the genome annotation","secondary_identifier":"SGD:S000000666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR070W"}


id: YCR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMG2","product":"Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49","secondary_identifier":"SGD:S000000667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR071C"}


id: YCR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02754":null,"YCR072C":null},"has_protein_features":false,"name":"RSA4","ortholog_annotations":[{"gene_uniquename":"YCR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02754","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02754","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal large subunit (60S) assembly factor; association of the N-terminal ubiquitin-like (UBL) domain of this preribosomal factor with the MIDAS domain in the Rea1p tail, promoted by the GTPase Nog2p, is required for the ATP-dependent dissociation of preribosomal factors including the Rix1p subcomplex, Rea1p, Nog2p and Rsa1p itself prior to nuclear export of pre-60S particles; contains WD-repeats and a UBL domain; localizes to the nucleolus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR072C"}


id: YCR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YCR073C":null},"has_protein_features":false,"name":"SSK22","ortholog_annotations":[{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:26896847"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073C"}


id: YCR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YCR073W-A":null},"has_protein_features":false,"name":"SOL2","ortholog_annotations":[{"gene_uniquename":"YCR073W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073W-A"}


id: YCR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later withdrawn","secondary_identifier":"SGD:S000119982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR074C"}


id: YCR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERS1","product":"Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS","secondary_identifier":"SGD:S000000671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075C"}


id: YCR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGO2","product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; identified by homology to Ashbya gossypii; EGO2 has a paralog, EGO4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075W-A"}


id: YCR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04633":null,"YCR076C":null},"has_protein_features":false,"name":"FUB1","ortholog_annotations":[{"gene_uniquename":"YCR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04633","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04633","reference_uniquename":"PMID:29761456"}],"product":"Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; specifically blocks all three proteasome active sites; exhibits boundary activity which inhibits the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR076C"}


id: YCR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02213":null,"YCR077C":null},"has_protein_features":false,"name":"PAT1","ortholog_annotations":[{"gene_uniquename":"YCR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02213","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02213","reference_uniquename":"PMID:26896847"}],"product":"Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR077C"}


id: YCR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02433":null,"YCR079W":null},"has_protein_features":false,"name":"PTC6","ortholog_annotations":[{"gene_uniquename":"YCR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02433","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02433","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR079W"}


id: YCR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR080W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR081W","secondary_identifier":"SGD:S000000676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR080W"}


id: YCR081C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081C-A"}


id: YCR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00156":null,"YCR081W":null},"has_protein_features":false,"name":"SRB8","ortholog_annotations":[{"gene_uniquename":"YCR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00156","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00156","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081W"}


id: YCR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AHC2","product":"Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex","secondary_identifier":"SGD:S000000678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR082W"}


id: YCR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00614":null,"SJAG_04953":null,"YCR083W":null},"has_protein_features":false,"name":"TRX3","ortholog_annotations":[{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00614","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR083W"}


id: YCR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00290":null,"SJAG_04921":null,"YCR084C":null},"has_protein_features":false,"name":"TUP1","ortholog_annotations":[{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00290","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00290","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04921","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional regulator; functions primarily as a transcriptional co-repressor with Cyc8p but can also function as a co-activator, recruiting SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Tup1p or Cyc8p, subject to redundant repression, or in some cases de-repression of target genes in a tup1 mutant is dependent upon CYC8 and vice versa; establishes a repressive chromatin structure via histone H3/H4 interactions and stabilizing nucleosomes over promoters","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR084C"}


id: YCR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR085W is not an essential gene","secondary_identifier":"SGD:S000000681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR085W"}


id: YCR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00207":null,"YCR086W":null},"has_protein_features":false,"name":"CSM1","ortholog_annotations":[{"gene_uniquename":"YCR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00207","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR086W"}


id: YCR087C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00410":null,"YCR087C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR087C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00410","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR087C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00410","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; binds zinc; phosphomutants exhibit phenotypes, suggesting functionality of phosphosites; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087C-A"}


id: YCR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene","secondary_identifier":"SGD:S000000683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087W"}


id: YCR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02566":null,"YCR088W":null},"has_protein_features":false,"name":"ABP1","ortholog_annotations":[{"gene_uniquename":"YCR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02566","reference_uniquename":"PMID:26896847"}],"product":"Actin-binding protein of the cortical actin cytoskeleton; important for activation of actin nucleation mediated by the Arp2/Arp3 complex; inhibits actin filament elongation at the barbed-end; phosphorylation within its proline-rich region, mediated by Cdc28p and Pho85p, protects Abp1p from PEST sequence-mediated proteolysis; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR088W"}


id: YCR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIG2","product":"Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR089W"}


id: YCR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01266":null,"YCR090C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01266","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01266","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR090C"}


id: YCR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YCR091W":null},"has_protein_features":false,"name":"KIN82","ortholog_annotations":[{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR091W"}


id: YCR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01419":null,"YCR092C":null},"has_protein_features":false,"name":"MSH3","ortholog_annotations":[{"gene_uniquename":"YCR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01419","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01419","reference_uniquename":"PMID:26896847"}],"product":"Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR092C"}


id: YCR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03597":null,"YCR093W":null},"has_protein_features":false,"name":"CDC39","ortholog_annotations":[{"gene_uniquename":"YCR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03597","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR093W"}


id: YCR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YCR094W":null},"has_protein_features":false,"name":"CDC50","ortholog_annotations":[{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR094W"}


id: YCR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OCA4","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000000691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095C"}


id: YCR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000029724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095W-A"}


id: YCR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMRA2","product":"Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system","secondary_identifier":"SGD:S000000692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR096C"}


id: YCR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMRA1","product":"Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells","secondary_identifier":"SGD:S000000694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W"}


id: YCR097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein","secondary_identifier":"SGD:S000007632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W-A"}


id: YCR097WA
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; YCR097WA refers to an incorrect annotation of HMRA1 that appeared in the original version of Chromosome III (1996) but was later withdrawn and subsequently removed from SGD","secondary_identifier":"SGD:S000000693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097WA"}


id: YCR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00232":null,"SJAG_03644":null,"SJAG_05325":null,"YCR098C":null},"has_protein_features":false,"name":"GIT1","ortholog_annotations":[{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00232","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03644","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05325","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR098C"}


id: YCR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR099C"}


id: YCR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EMA35","product":"Protein involved in protein sorting; involved in targeting mitochondrial membrane proteins to mitochondrial translocation system; mutation causes respiration defects","secondary_identifier":"SGD:S000000697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR100C"}


id: YCR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene","secondary_identifier":"SGD:S000000698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR101C"}


id: YCR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative quinone oxidoreductase; overexpression improves ethanol production and acid stress resistance; involved in copper metabolism; similar to Cochliobolus carbonum toxD gene","secondary_identifier":"SGD:S000000699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR102C"}


id: YCR102W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR102W-A"}


id: YCR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this ORF was removed when a sequence update created a stop codon after residue 45","secondary_identifier":"SGD:S000000700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR103C"}


id: YCR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU3","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000000701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR104W"}


id: YCR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02963":null,"YCR105W":null},"has_protein_features":false,"name":"ADH7","ortholog_annotations":[{"gene_uniquename":"YCR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02963","reference_uniquename":"PMID:26896847"}],"product":"NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR105W"}


id: YCR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RDS1","product":"Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide","secondary_identifier":"SGD:S000000703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR106W"}


id: YCR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD3","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000000704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR107W"}


id: YCR108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR108C"}


id: YCRX01W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX01W"}


id: YCRX02C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX02C"}


id: YCRX03C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX03C"}


id: YCRX04W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX04W"}


id: YCRX05W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX05W"}


id: YCRX06W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX06W"}


id: YCRX07W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX07W"}


id: YCRX08W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX08W"}


id: YCRX09C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX09C"}


id: YCRX10W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX10W"}


id: YCRX11W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX11W"}


id: YCRX12W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX12W"}


id: YCRX14W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX14W"}


id: YCRX15W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX15W"}


id: YCRX16C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX16C"}


id: YCRX17W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX17W"}


id: YCRX18C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX18C"}


id: YCRX19W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX19W"}


id: YCRX20C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX20C"}


id: YCRX21C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX21C"}


id: YDL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YDL001W":null},"has_protein_features":false,"name":"RMD1","ortholog_annotations":[{"gene_uniquename":"YDL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic protein required for sporulation; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL001W"}


id: YDL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05020":null,"YDL002C":null},"has_protein_features":false,"name":"NHP10","ortholog_annotations":[{"gene_uniquename":"YDL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05020","reference_uniquename":"PMID:29761456"}],"product":"Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL002C"}


id: YDL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01067":null,"YDL003W":null},"has_protein_features":false,"name":"MCD1","ortholog_annotations":[{"gene_uniquename":"YDL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01067","reference_uniquename":"PMID:26896847"}],"product":"Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL003W"}


id: YDL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03114":null,"YDL004W":null},"has_protein_features":false,"name":"ATP16","ortholog_annotations":[{"gene_uniquename":"YDL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03114","reference_uniquename":"PMID:26896847"}],"product":"Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL004W"}


id: YDL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MED2","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000002163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL005C"}


id: YDL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03185":null,"YDL006W":null},"has_protein_features":false,"name":"PTC1","ortholog_annotations":[{"gene_uniquename":"YDL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03185","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03185","reference_uniquename":"PMID:26896847"}],"product":"Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating the osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; involved in myosin-V dependent inheritance of mitochondria, peroxisomes, vacuoles and secretory vesicles; localizes to the nucleus, cytoplasm and peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL006W"}


id: YDL007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000113557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL007C-A"}


id: YDL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00712":null,"YDL007W":null},"has_protein_features":false,"name":"RPT2","ortholog_annotations":[{"gene_uniquename":"YDL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00712","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00712","reference_uniquename":"PMID:26896847"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL007W"}


id: YDL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05236":null,"YDL008W":null},"has_protein_features":false,"name":"APC11","ortholog_annotations":[{"gene_uniquename":"YDL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05236","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05236","reference_uniquename":"PMID:26896847"}],"product":"Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL008W"}


id: YDL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene","secondary_identifier":"SGD:S000002167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL009C"}


id: YDL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02495":null,"YDL010W":null},"has_protein_features":false,"name":"GRX6","ortholog_annotations":[{"gene_uniquename":"YDL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02495","reference_uniquename":"PMID:29761456"}],"product":"Cis-Golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL010W"}


id: YDL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W","secondary_identifier":"SGD:S000002169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL011C"}


id: YDL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02333":null,"YDL012C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02333","reference_uniquename":"PMID:29761456"}],"product":"Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL012C"}


id: YDL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01572":null,"SJAG_05012":null,"YDL013W":null},"has_protein_features":false,"name":"SLX5","ortholog_annotations":[{"gene_uniquename":"YDL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01572","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05012","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL013W"}


id: YDL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00943":null,"YDL014W":null},"has_protein_features":false,"name":"NOP1","ortholog_annotations":[{"gene_uniquename":"YDL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00943","reference_uniquename":"PMID:29761456"}],"product":"Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL014W"}


id: YDL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02717":null,"YDL015C":null},"has_protein_features":false,"name":"TSC13","ortholog_annotations":[{"gene_uniquename":"YDL015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02717","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02717","reference_uniquename":"PMID:26896847"}],"product":"Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL015C"}


id: YDL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication","secondary_identifier":"SGD:S000002174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL016C"}


id: YDL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00486":null,"SJAG_03160":null,"YDL017W":null},"has_protein_features":false,"name":"CDC7","ortholog_annotations":[{"gene_uniquename":"YDL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00486","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00486","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03160","reference_uniquename":"PMID:29761456"}],"product":"S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45 to drive assembly of the pre-IC and the CMG helicase; maintains Cse4p at kinetochores through phosphorylation to regulate chromosome segregation, regulates pre-meiotic replication, meiotic DSB formation, monopolar attachment of homologs during MI through monopolin recruitment and middle meiotic gene expression; HsCDC7 and DBF4 complement","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL017W"}


id: YDL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03270":null,"YDL018C":null},"has_protein_features":false,"name":"ERP3","ortholog_annotations":[{"gene_uniquename":"YDL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:26896847"}],"product":"Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL018C"}


id: YDL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01722":null,"YDL019C":null},"has_protein_features":false,"name":"OSH2","ortholog_annotations":[{"gene_uniquename":"YDL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01722","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01722","reference_uniquename":"PMID:26896847"}],"product":"Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL019C"}


id: YDL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00304":null,"YDL020C":null},"has_protein_features":false,"name":"RPN4","ortholog_annotations":[{"gene_uniquename":"YDL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00304","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00304","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL020C"}


id: YDL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02009":null,"YDL021W":null},"has_protein_features":false,"name":"GPM2","ortholog_annotations":[{"gene_uniquename":"YDL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:26896847"}],"product":"Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL021W"}


id: YDL022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000028537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL022C-A"}


id: YDL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00409":null,"SJAG_01012":null,"YDL022W":null},"has_protein_features":false,"name":"GPD1","ortholog_annotations":[{"gene_uniquename":"YDL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00409","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01012","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL022W"}


id: YDL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000002181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL023C"}


id: YDL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YDL024C":null},"has_protein_features":false,"name":"DIA3","ortholog_annotations":[{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; involved in invasive and pseudohyphal growth","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL024C"}


id: YDL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YDL025C":null},"has_protein_features":false,"name":"RTK1","ortholog_annotations":[{"gene_uniquename":"YDL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL025C"}


id: YDL025W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL025W-A"}


id: YDL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL026W"}


id: YDL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX9","product":"Mitochondrial inner membrane protein; high copy suppressor of ER stress-mediated cell death; overexpression increases O2 consumption, impairs processing of COB and COX1 RNAs encoding mitochondrial oxidative phosphorylation factors, and impacts the transition from fermentative to respiratory metabolism","secondary_identifier":"SGD:S000002185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL027C"}


id: YDL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04126":null,"YDL028C":null},"has_protein_features":false,"name":"MPS1","ortholog_annotations":[{"gene_uniquename":"YDL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04126","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04126","reference_uniquename":"PMID:26896847"}],"product":"Dual-specificity kinase; required for SPB duplication and spindle checkpoint function in mitosis and meiosis; contributes to bi-orientation, promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; autophosphorylation required for function; substrates include SPB proteins (Spc42p, Spc110p, Spc98p), mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); detected in peroxisomes; similar to human Mps1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL028C"}


id: YDL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01964":null,"YDL029W":null},"has_protein_features":false,"name":"ARP2","ortholog_annotations":[{"gene_uniquename":"YDL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01964","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL029W"}


id: YDL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00577":null,"YDL030W":null},"has_protein_features":false,"name":"PRP9","ortholog_annotations":[{"gene_uniquename":"YDL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00577","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00577","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL030W"}


id: YDL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00798":null,"YDL031W":null},"has_protein_features":false,"name":"DBP10","ortholog_annotations":[{"gene_uniquename":"YDL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00798","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00798","reference_uniquename":"PMID:26896847"}],"product":"Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL031W"}


id: YDL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene","secondary_identifier":"SGD:S000002190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL032W"}


id: YDL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00358":null,"YDL033C":null},"has_protein_features":false,"name":"SLM3","ortholog_annotations":[{"gene_uniquename":"YDL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00358","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00358","reference_uniquename":"PMID:26896847"}],"product":"tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL033C"}


id: YDL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene","secondary_identifier":"SGD:S000002192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL034W"}


id: YDL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01699":null,"YDL035C":null},"has_protein_features":false,"name":"GPR1","ortholog_annotations":[{"gene_uniquename":"YDL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01699","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01699","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL035C"}


id: YDL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01172":null,"YDL036C":null},"has_protein_features":false,"name":"PUS9","ortholog_annotations":[{"gene_uniquename":"YDL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01172","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL036C"}


id: YDL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC1","product":"Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the gene IMI1","secondary_identifier":"SGD:S000002195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL037C"}


id: YDL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YDL038C was originally annotated as an independent ORF, but as a result of a sequence correction, was merged with adjacent ORF PRM7/YDL039C into a single open reading frame","secondary_identifier":"SGD:S000002196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL038C"}


id: YDL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM7","product":"Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1","secondary_identifier":"SGD:S000002197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL039C"}


id: YDL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02920":null,"SJAG_04179":null,"YDL040C":null},"has_protein_features":false,"name":"NAT1","ortholog_annotations":[{"gene_uniquename":"YDL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02920","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02920","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04179","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL040C"}


id: YDL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C","secondary_identifier":"SGD:S000002199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL041W"}


id: YDL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04186":null,"YDL042C":null},"has_protein_features":false,"name":"SIR2","ortholog_annotations":[{"gene_uniquename":"YDL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:26896847"}],"product":"Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL042C"}


id: YDL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00498":null,"YDL043C":null},"has_protein_features":false,"name":"PRP11","ortholog_annotations":[{"gene_uniquename":"YDL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00498","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00498","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL043C"}


id: YDL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01517":null,"YDL044C":null},"has_protein_features":false,"name":"MTF2","ortholog_annotations":[{"gene_uniquename":"YDL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01517","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL044C"}


id: YDL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01937":null,"YDL045C":null},"has_protein_features":false,"name":"FAD1","ortholog_annotations":[{"gene_uniquename":"YDL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01937","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01937","reference_uniquename":"PMID:26896847"}],"product":"Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL045C"}


id: YDL045W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01767":null,"YDL045W-A":null},"has_protein_features":false,"name":"MRP10","ortholog_annotations":[{"gene_uniquename":"YDL045W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01767","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL045W-A"}


id: YDL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01407":null,"YDL046W":null},"has_protein_features":false,"name":"NPC2","ortholog_annotations":[{"gene_uniquename":"YDL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01407","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01407","reference_uniquename":"PMID:26896847"}],"product":"Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general “lipid solubilizer”, binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL046W"}


id: YDL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01187":null,"YDL047W":null},"has_protein_features":false,"name":"SIT4","ortholog_annotations":[{"gene_uniquename":"YDL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01187","reference_uniquename":"PMID:29761456"}],"product":"Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL047W"}


id: YDL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STP4","product":"Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL048C"}


id: YDL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04073":null,"YDL049C":null},"has_protein_features":false,"name":"KNH1","ortholog_annotations":[{"gene_uniquename":"YDL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04073","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL049C"}


id: YDL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL050C"}


id: YDL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00195":null,"YDL051W":null},"has_protein_features":false,"name":"LHP1","ortholog_annotations":[{"gene_uniquename":"YDL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00195","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00195","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL051W"}


id: YDL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01957":null,"YDL052C":null},"has_protein_features":false,"name":"SLC1","ortholog_annotations":[{"gene_uniquename":"YDL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01957","reference_uniquename":"PMID:29761456"}],"product":"1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL052C"}


id: YDL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PBP4","product":"Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes","secondary_identifier":"SGD:S000002211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL053C"}


id: YDL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCH1","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000002212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL054C"}


id: YDL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03188":null,"YDL055C":null},"has_protein_features":false,"name":"PSA1","ortholog_annotations":[{"gene_uniquename":"YDL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03188","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03188","reference_uniquename":"PMID:26896847"}],"product":"GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL055C"}


id: YDL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00693":null,"SJAG_00987":null,"YDL056W":null},"has_protein_features":false,"name":"MBP1","ortholog_annotations":[{"gene_uniquename":"YDL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00693","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00987","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00987","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL056W"}


id: YDL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YDL057W is not an essential gene","secondary_identifier":"SGD:S000002215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL057W"}


id: YDL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01633":null,"YDL058W":null},"has_protein_features":false,"name":"USO1","ortholog_annotations":[{"gene_uniquename":"YDL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01633","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01633","reference_uniquename":"PMID:26896847"}],"product":"Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL058W"}


id: YDL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RAD59","product":"Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; regulates replication fork progression in DNA ligase I-deficient cells; paralog of Rad52p","secondary_identifier":"SGD:S000002217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL059C"}


id: YDL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00344":null,"YDL060W":null},"has_protein_features":false,"name":"TSR1","ortholog_annotations":[{"gene_uniquename":"YDL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00344","reference_uniquename":"PMID:26896847"}],"product":"Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL060W"}


id: YDL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03254":null,"YDL061C":null},"has_protein_features":false,"name":"RPS29B","ortholog_annotations":[{"gene_uniquename":"YDL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03254","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL061C"}


id: YDL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential","secondary_identifier":"SGD:S000002220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL062W"}


id: YDL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01621":null,"YDL063C":null},"has_protein_features":false,"name":"SYO1","ortholog_annotations":[{"gene_uniquename":"YDL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01621","reference_uniquename":"PMID:26896847"}],"product":"Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL063C"}


id: YDL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02082":null,"YDL064W":null},"has_protein_features":false,"name":"UBC9","ortholog_annotations":[{"gene_uniquename":"YDL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02082","reference_uniquename":"PMID:29761456"}],"product":"SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL064W"}


id: YDL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03781":null,"YDL065C":null},"has_protein_features":false,"name":"PEX19","ortholog_annotations":[{"gene_uniquename":"YDL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03781","reference_uniquename":"PMID:29761456"}],"product":"Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL065C"}


id: YDL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04362":null,"YDL066W":null},"has_protein_features":false,"name":"IDP1","ortholog_annotations":[{"gene_uniquename":"YDL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL066W"}


id: YDL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07007":null,"YDL067C":null},"has_protein_features":false,"name":"COX9","ortholog_annotations":[{"gene_uniquename":"YDL067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07007","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL067C"}


id: YDL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL068W"}


id: YDL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBS1","product":"Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader","secondary_identifier":"SGD:S000002227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL069C"}


id: YDL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02500":null,"SJAG_02701":null,"YDL070W":null},"has_protein_features":false,"name":"BDF2","ortholog_annotations":[{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02500","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02701","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02701","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL070W"}


id: YDL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W","secondary_identifier":"SGD:S000002229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL071C"}


id: YDL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03244":null,"YDL072C":null},"has_protein_features":false,"name":"YET3","ortholog_annotations":[{"gene_uniquename":"YDL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL072C"}


id: YDL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04503":null,"YDL073W":null},"has_protein_features":false,"name":"AHK1","ortholog_annotations":[{"gene_uniquename":"YDL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04503","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL073W"}


id: YDL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02319":null,"SJAG_03006":null,"YDL074C":null},"has_protein_features":false,"name":"BRE1","ortholog_annotations":[{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02319","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03006","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03006","reference_uniquename":"PMID:26896847"}],"product":"E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL074C"}


id: YDL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01676":null,"SJAG_02755":null,"YDL075W":null},"has_protein_features":false,"name":"RPL31A","ortholog_annotations":[{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01676","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01676","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02755","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL075W"}


id: YDL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00868":null,"YDL076C":null},"has_protein_features":false,"name":"RXT3","ortholog_annotations":[{"gene_uniquename":"YDL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00868","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL076C"}


id: YDL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05184":null,"YDL077C":null},"has_protein_features":false,"name":"VAM6","ortholog_annotations":[{"gene_uniquename":"YDL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05184","reference_uniquename":"PMID:26896847"}],"product":"Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL077C"}


id: YDL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDH3","product":"Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; mutation in human homolog MDH2 causes early-onset severe encephalopathy","secondary_identifier":"SGD:S000002236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL078C"}


id: YDL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YDL079C":null},"has_protein_features":false,"name":"MRK1","ortholog_annotations":[{"gene_uniquename":"YDL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:26896847"}],"product":"Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL079C"}


id: YDL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YDL080C":null},"has_protein_features":false,"name":"THI3","ortholog_annotations":[{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:26896847"}],"product":"Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL080C"}


id: YDL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01411":null,"SJAG_04020":null,"YDL081C":null},"has_protein_features":false,"name":"RPP1A","ortholog_annotations":[{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL081C"}


id: YDL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01608":null,"SJAG_03423":null,"YDL082W":null},"has_protein_features":false,"name":"RPL13A","ortholog_annotations":[{"gene_uniquename":"YDL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03423","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL082W"}


id: YDL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01609":null,"SJAG_03422":null,"YDL083C":null},"has_protein_features":false,"name":"RPS16B","ortholog_annotations":[{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03422","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03422","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL083C"}


id: YDL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04589":null,"YDL084W":null},"has_protein_features":false,"name":"SUB2","ortholog_annotations":[{"gene_uniquename":"YDL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04589","reference_uniquename":"PMID:26896847"}],"product":"Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL084W"}


id: YDL085C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04436":null,"YDL085C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL085C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04436","reference_uniquename":"PMID:29761456"}],"product":"Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Aβ40 and α-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL085C-A"}


id: YDL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01539":null,"YDL085W":null},"has_protein_features":false,"name":"NDE2","ortholog_annotations":[{"gene_uniquename":"YDL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01539","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL085W"}


id: YDL086C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL086C-A"}


id: YDL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene","secondary_identifier":"SGD:S000002244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL086W"}


id: YDL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04214":null,"YDL087C":null},"has_protein_features":false,"name":"LUC7","ortholog_annotations":[{"gene_uniquename":"YDL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04214","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04214","reference_uniquename":"PMID:26896847"}],"product":"Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL087C"}


id: YDL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03593":null,"YDL088C":null},"has_protein_features":false,"name":"ASM4","ortholog_annotations":[{"gene_uniquename":"YDL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03593","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03593","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL088C"}


id: YDL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01050":null,"YDL089W":null},"has_protein_features":false,"name":"NUR1","ortholog_annotations":[{"gene_uniquename":"YDL089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01050","reference_uniquename":"PMID:29761456"}],"product":"Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; involved in regulating mitotic exit; dephosphorylated by Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p and Lrs4p; null mutant has elevated levels of unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery; Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL089W"}


id: YDL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02583":null,"YDL090C":null},"has_protein_features":false,"name":"RAM1","ortholog_annotations":[{"gene_uniquename":"YDL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02583","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02583","reference_uniquename":"PMID:26896847"}],"product":"Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL090C"}


id: YDL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01585":null,"YDL091C":null},"has_protein_features":false,"name":"UBX3","ortholog_annotations":[{"gene_uniquename":"YDL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01585","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01585","reference_uniquename":"PMID:26896847"}],"product":"Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL091C"}


id: YDL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01282":null,"YDL092W":null},"has_protein_features":false,"name":"SRP14","ortholog_annotations":[{"gene_uniquename":"YDL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01282","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL092W"}


id: YDL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04316":null,"YDL093W":null},"has_protein_features":false,"name":"PMT5","ortholog_annotations":[{"gene_uniquename":"YDL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:26896847"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL093W"}


id: YDL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential","secondary_identifier":"SGD:S000002252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL094C"}


id: YDL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04316":null,"YDL095W":null},"has_protein_features":false,"name":"PMT1","ortholog_annotations":[{"gene_uniquename":"YDL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:26896847"}],"product":"Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; functions as a heterodimer with Pmt2p but can also pair with Pmt3p; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL095W"}


id: YDL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI6","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential","secondary_identifier":"SGD:S000002254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL096C"}


id: YDL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00738":null,"YDL097C":null},"has_protein_features":false,"name":"RPN6","ortholog_annotations":[{"gene_uniquename":"YDL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00738","reference_uniquename":"PMID:29761456"}],"product":"Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL097C"}


id: YDL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00989":null,"YDL098C":null},"has_protein_features":false,"name":"SNU23","ortholog_annotations":[{"gene_uniquename":"YDL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00989","reference_uniquename":"PMID:29761456"}],"product":"Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL098C"}


id: YDL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUG1","product":"Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes","secondary_identifier":"SGD:S000002257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL099W"}


id: YDL100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01240":null,"YDL100C":null},"has_protein_features":false,"name":"GET3","ortholog_annotations":[{"gene_uniquename":"YDL100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01240","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01240","reference_uniquename":"PMID:26896847"}],"product":"Guanine nucleotide exchange factor for Gpa1p; amplifies G-protein signaling; subunit of the GET complex involved in ATP-dependent Golgi-to-ER trafficking; binds as a dimer to the transmembrane domain of tail-anchored proteins in the cytosol, shielding them from aqueous solvent until the Get1p/Get2p heterodimer releases the substrate and inserts it into the ER membrane; acts as a chaperone under ATP-depleted oxidative stress conditions; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL100C"}


id: YDL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUN1","product":"Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role","secondary_identifier":"SGD:S000002259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL101C"}


id: YDL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02818":null,"YDL102W":null},"has_protein_features":false,"name":"POL3","ortholog_annotations":[{"gene_uniquename":"YDL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02818","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL102W"}


id: YDL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01443":null,"YDL103C":null},"has_protein_features":false,"name":"QRI1","ortholog_annotations":[{"gene_uniquename":"YDL103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01443","reference_uniquename":"PMID:29761456"}],"product":"UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL103C"}


id: YDL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00865":null,"YDL104C":null},"has_protein_features":false,"name":"QRI7","ortholog_annotations":[{"gene_uniquename":"YDL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00865","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00865","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL104C"}


id: YDL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01332":null,"YDL105W":null},"has_protein_features":false,"name":"NSE4","ortholog_annotations":[{"gene_uniquename":"YDL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01332","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01332","reference_uniquename":"PMID:26896847"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL105W"}


id: YDL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05006":null,"YDL106C":null},"has_protein_features":false,"name":"PHO2","ortholog_annotations":[{"gene_uniquename":"YDL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05006","reference_uniquename":"PMID:26896847"}],"product":"Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL106C"}


id: YDL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS2","product":"Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p","secondary_identifier":"SGD:S000002265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL107W"}


id: YDL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00150":null,"YDL108W":null},"has_protein_features":false,"name":"KIN28","ortholog_annotations":[{"gene_uniquename":"YDL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00150","reference_uniquename":"PMID:26896847"}],"product":"Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL108W"}


id: YDL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04105":null,"SJAG_04973":null,"YDL109C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04105","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:26896847"}],"product":"Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL109C"}


id: YDL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA17","product":"Regulatory gamma subunit of fatty acid synthase (FAS); ATPase dedicated chaperone that adapts proteasome assembly to stress; induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion","secondary_identifier":"SGD:S000002268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL110C"}


id: YDL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04818":null,"YDL111C":null},"has_protein_features":false,"name":"RRP42","ortholog_annotations":[{"gene_uniquename":"YDL111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04818","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04818","reference_uniquename":"PMID:26896847"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL111C"}


id: YDL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TRM3","product":"2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs","secondary_identifier":"SGD:S000002270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL112W"}


id: YDL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04219":null,"YDL113C":null},"has_protein_features":false,"name":"ATG20","ortholog_annotations":[{"gene_uniquename":"YDL113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04219","reference_uniquename":"PMID:26896847"}],"product":"Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway, endosomal sorting and selective autophagy; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL113C"}


id: YDL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00593":null,"YDL114W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00593","reference_uniquename":"PMID:29761456"}],"product":"Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL114W"}


id: YDL114W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts","secondary_identifier":"SGD:S000007598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL114W-A"}


id: YDL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00383":null,"YDL115C":null},"has_protein_features":false,"name":"IWR1","ortholog_annotations":[{"gene_uniquename":"YDL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00383","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL115C"}


id: YDL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04148":null,"YDL116W":null},"has_protein_features":false,"name":"NUP84","ortholog_annotations":[{"gene_uniquename":"YDL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04148","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04148","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL116W"}


id: YDL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03379":null,"YDL117W":null},"has_protein_features":false,"name":"CYK3","ortholog_annotations":[{"gene_uniquename":"YDL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03379","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03379","reference_uniquename":"PMID:26896847"}],"product":"SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL117W"}


id: YDL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein","secondary_identifier":"SGD:S000002276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL118W"}


id: YDL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04984":null,"YDL119C":null},"has_protein_features":false,"name":"HEM25","ortholog_annotations":[{"gene_uniquename":"YDL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04984","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04984","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL119C"}


id: YDL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03862":null,"YDL120W":null},"has_protein_features":false,"name":"YFH1","ortholog_annotations":[{"gene_uniquename":"YDL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03862","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03862","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL120W"}


id: YDL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EXP1","product":"A cargo receptor protein for Pma1p; works with Psg1p to promote the transport and maturation of Pma1p; localizes to the ER and COPII vesicles; a non-essential protein","secondary_identifier":"SGD:S000002279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL121C"}


id: YDL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBP1","product":"Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains","secondary_identifier":"SGD:S000002280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL122W"}


id: YDL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00372":null,"YDL123W":null},"has_protein_features":false,"name":"SNA4","ortholog_annotations":[{"gene_uniquename":"YDL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; localized to the vacuolar outer membrane; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL123W"}


id: YDL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01869":null,"YDL124W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01869","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01869","reference_uniquename":"PMID:26896847"}],"product":"NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL124W"}


id: YDL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01231":null,"YDL125C":null},"has_protein_features":false,"name":"HNT1","ortholog_annotations":[{"gene_uniquename":"YDL125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01231","reference_uniquename":"PMID:29761456"}],"product":"Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL125C"}


id: YDL126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03345":null,"YDL126C":null},"has_protein_features":false,"name":"CDC48","ortholog_annotations":[{"gene_uniquename":"YDL126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03345","reference_uniquename":"PMID:29761456"}],"product":"AAA ATPase with protein-unfoldase activity; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL126C"}


id: YDL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL2","product":"Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL127W"}


id: YDL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04698":null,"YDL128W":null},"has_protein_features":false,"name":"VCX1","ortholog_annotations":[{"gene_uniquename":"YDL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04698","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04698","reference_uniquename":"PMID:26896847"}],"product":"Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL128W"}


id: YDL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000002287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL129W"}


id: YDL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01411":null,"SJAG_04020":null,"YDL130W":null},"has_protein_features":false,"name":"RPP1B","ortholog_annotations":[{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL130W"}


id: YDL130W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04422":null,"YDL130W-A":null},"has_protein_features":false,"name":"STF1","ortholog_annotations":[{"gene_uniquename":"YDL130W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04422","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL130W-A"}


id: YDL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04688":null,"YDL131W":null},"has_protein_features":false,"name":"LYS21","ortholog_annotations":[{"gene_uniquename":"YDL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04688","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04688","reference_uniquename":"PMID:26896847"}],"product":"Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL131W"}


id: YDL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02591":null,"YDL132W":null},"has_protein_features":false,"name":"CDC53","ortholog_annotations":[{"gene_uniquename":"YDL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02591","reference_uniquename":"PMID:29761456"}],"product":"Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL132W"}


id: YDL133C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07013":null,"SJAG_07014":null,"YDL133C-A":null},"has_protein_features":false,"name":"RPL41B","ortholog_annotations":[{"gene_uniquename":"YDL133C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07013","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL133C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07014","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL133C-A"}


id: YDL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRF1","product":"Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients","secondary_identifier":"SGD:S000002291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL133W"}


id: YDL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00600":null,"YDL134C":null},"has_protein_features":false,"name":"PPH21","ortholog_annotations":[{"gene_uniquename":"YDL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL134C"}


id: YDL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03361":null,"YDL135C":null},"has_protein_features":false,"name":"RDI1","ortholog_annotations":[{"gene_uniquename":"YDL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03361","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03361","reference_uniquename":"PMID:26896847"}],"product":"Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL135C"}


id: YDL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00749":null,"YDL136W":null},"has_protein_features":false,"name":"RPL35B","ortholog_annotations":[{"gene_uniquename":"YDL136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00749","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL136W"}


id: YDL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01456":null,"SJAG_02824":null,"YDL137W":null},"has_protein_features":false,"name":"ARF2","ortholog_annotations":[{"gene_uniquename":"YDL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01456","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02824","reference_uniquename":"PMID:29761456"}],"product":"ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL137W"}


id: YDL138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGT2","product":"Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL138W"}


id: YDL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SCM3","product":"Non-histone component of centromeric chromatin; acts as a Cse4p specific chaperone that recognizes the centromere-targeting domain in the HFD of histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP","secondary_identifier":"SGD:S000002298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL139C"}


id: YDL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01713":null,"YDL140C":null},"has_protein_features":false,"name":"RPO21","ortholog_annotations":[{"gene_uniquename":"YDL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01713","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01713","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL140C"}


id: YDL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03069":null,"YDL141W":null},"has_protein_features":false,"name":"BPL1","ortholog_annotations":[{"gene_uniquename":"YDL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03069","reference_uniquename":"PMID:26896847"}],"product":"Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL141W"}


id: YDL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04317":null,"YDL142C":null},"has_protein_features":false,"name":"CRD1","ortholog_annotations":[{"gene_uniquename":"YDL142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04317","reference_uniquename":"PMID:29761456"}],"product":"Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL142C"}


id: YDL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04121":null,"YDL143W":null},"has_protein_features":false,"name":"CCT4","ortholog_annotations":[{"gene_uniquename":"YDL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04121","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04121","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL143W"}


id: YDL144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000002303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL144C"}


id: YDL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04569":null,"YDL145C":null},"has_protein_features":false,"name":"COP1","ortholog_annotations":[{"gene_uniquename":"YDL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04569","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04569","reference_uniquename":"PMID:26896847"}],"product":"Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL145C"}


id: YDL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02228":null,"YDL146W":null},"has_protein_features":false,"name":"LDB17","ortholog_annotations":[{"gene_uniquename":"YDL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02228","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02228","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL146W"}


id: YDL147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03321":null,"YDL147W":null},"has_protein_features":false,"name":"RPN5","ortholog_annotations":[{"gene_uniquename":"YDL147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03321","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03321","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03321","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL147W"}


id: YDL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03654":null,"YDL148C":null},"has_protein_features":false,"name":"NOP14","ortholog_annotations":[{"gene_uniquename":"YDL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03654","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03654","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL148C"}


id: YDL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03100":null,"YDL149W":null},"has_protein_features":false,"name":"ATG9","ortholog_annotations":[{"gene_uniquename":"YDL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03100","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03100","reference_uniquename":"PMID:26896847"}],"product":"Lipid scramblase that mediates autophagosomal membrane expansion; translocates phospholipids between outer and inner leaflets of liposomes; transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between phagophore assembly site (PAS) and other cytosolic punctate structures","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL149W"}


id: YDL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04408":null,"YDL150W":null},"has_protein_features":false,"name":"RPC53","ortholog_annotations":[{"gene_uniquename":"YDL150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04408","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C53","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL150W"}


id: YDL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD30","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000002310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL151C"}


id: YDL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome","secondary_identifier":"SGD:S000002311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL152W"}


id: YDL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01907":null,"YDL153C":null},"has_protein_features":false,"name":"SAS10","ortholog_annotations":[{"gene_uniquename":"YDL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01907","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01907","reference_uniquename":"PMID:26896847"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL153C"}


id: YDL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSH5","product":"Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans","secondary_identifier":"SGD:S000002313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL154W"}


id: YDL155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03525":null,"SJAG_03699":null,"YDL155W":null},"has_protein_features":false,"name":"CLB3","ortholog_annotations":[{"gene_uniquename":"YDL155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03699","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03699","reference_uniquename":"PMID:26896847"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL155W"}


id: YDL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CMR1","product":"Nuclear protein with role in transcription, protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; also localizes to coding regions of transcribed genes; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions","secondary_identifier":"SGD:S000002315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL156W"}


id: YDL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06468":null,"YDL157C":null},"has_protein_features":false,"name":"DMO2","ortholog_annotations":[{"gene_uniquename":"YDL157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06468","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; localizes to the ER and peroxisomes; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL157C"}


id: YDL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL158C"}


id: YDL159C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL159C-B"}


id: YDL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00993":null,"YDL159W":null},"has_protein_features":false,"name":"STE7","ortholog_annotations":[{"gene_uniquename":"YDL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00993","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00993","reference_uniquename":"PMID:26896847"}],"product":"Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL159W"}


id: YDL159W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL159W-A"}


id: YDL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03157":null,"YDL160C":null},"has_protein_features":false,"name":"DHH1","ortholog_annotations":[{"gene_uniquename":"YDL160C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03157","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL160C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03157","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic DEAD-box helicase and mRNA decapping activator; interacts with decapping and deadenylase complexes to coordinate mRNA decapping and decay; regulates general translational repression; translational activator of select mRNAs during filamentous growth, mating and autophagy; cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body assembly, while ATPase stimulation by Not1p promotes disassembly; forms cytoplasmic foci on replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL160C"}


id: YDL160C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02465":null,"YDL160C-A":null},"has_protein_features":false,"name":"MHF2","ortholog_annotations":[{"gene_uniquename":"YDL160C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02465","reference_uniquename":"PMID:29761456"}],"product":"Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL160C-A"}


id: YDL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04644":null,"YDL161W":null},"has_protein_features":false,"name":"ENT1","ortholog_annotations":[{"gene_uniquename":"YDL161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:26896847"}],"product":"Epsin-like protein involved in endocytosis and actin patch assembly; K63-specific Ub chain binding protein that functions as an endocytic adaptor; binds clathrin via a clathrin-binding domain motif at C-terminus; contains two ubiquitin-interacting motifs (UIMs); functionally redundant with Ent2p; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL161W"}


id: YDL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly","secondary_identifier":"SGD:S000002321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL162C"}


id: YDL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase","secondary_identifier":"SGD:S000002322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL163W"}


id: YDL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00198":null,"YDL164C":null},"has_protein_features":false,"name":"CDC9","ortholog_annotations":[{"gene_uniquename":"YDL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00198","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00198","reference_uniquename":"PMID:26896847"}],"product":"DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL164C"}


id: YDL165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01053":null,"YDL165W":null},"has_protein_features":false,"name":"CDC36","ortholog_annotations":[{"gene_uniquename":"YDL165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01053","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01053","reference_uniquename":"PMID:26896847"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL165W"}


id: YDL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03798":null,"YDL166C":null},"has_protein_features":false,"name":"FAP7","ortholog_annotations":[{"gene_uniquename":"YDL166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03798","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03798","reference_uniquename":"PMID:26896847"}],"product":"Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL166C"}


id: YDL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02381":null,"YDL167C":null},"has_protein_features":false,"name":"NRP1","ortholog_annotations":[{"gene_uniquename":"YDL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02381","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02381","reference_uniquename":"PMID:26896847"}],"product":"Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL167C"}


id: YDL168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01457":null,"SJAG_04063":null,"YDL168W":null},"has_protein_features":false,"name":"SFA1","ortholog_annotations":[{"gene_uniquename":"YDL168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01457","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04063","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL168W"}


id: YDL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UGX2","product":"Protein of unknown function; transcript accumulates in response to any combination of stress conditions","secondary_identifier":"SGD:S000002328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL169C"}


id: YDL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UGA3","product":"Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4","secondary_identifier":"SGD:S000002329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL170W"}


id: YDL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04054":null,"YDL171C":null},"has_protein_features":false,"name":"GLT1","ortholog_annotations":[{"gene_uniquename":"YDL171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04054","reference_uniquename":"PMID:29761456"}],"product":"NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL171C"}


id: YDL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL172C"}


id: YDL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAR32","product":"Low complexity protein; mediates inhibition of Mep1p and Mep3p activity; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylation and localization regulated by TORC1-effector kinase, Npr1p","secondary_identifier":"SGD:S000002332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL173W"}


id: YDL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DLD1","product":"Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000002333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL174C"}


id: YDL175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03984":null,"YDL175C":null},"has_protein_features":false,"name":"AIR2","ortholog_annotations":[{"gene_uniquename":"YDL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03984","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03984","reference_uniquename":"PMID:26896847"}],"product":"RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL175C"}


id: YDL176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GID12","product":"Protein of unknown function involved in regulating assembly of Gid4p into the GID E3 ligase complex; interacts with GID complex components; involved in actin patch formation; computationally predicted to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; non-essential gene","secondary_identifier":"SGD:S000002335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL176W"}


id: YDL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04873":null,"YDL177C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL177C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04873","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL177C"}


id: YDL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03804":null,"YDL178W":null},"has_protein_features":false,"name":"DLD2","ortholog_annotations":[{"gene_uniquename":"YDL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03804","reference_uniquename":"PMID:29761456"}],"product":"D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL178W"}


id: YDL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL9","product":"Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL179W"}


id: YDL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIT1","product":"G protein-coupled receptor-like protein; involved in negatively regulating TORC1 activity; green fluorescent protein (GFP)-fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000002339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL180W"}


id: YDL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04422":null,"YDL181W":null},"has_protein_features":false,"name":"INH1","ortholog_annotations":[{"gene_uniquename":"YDL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04422","reference_uniquename":"PMID:29761456"}],"product":"Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL181W"}


id: YDL182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04688":null,"YDL182W":null},"has_protein_features":false,"name":"LYS20","ortholog_annotations":[{"gene_uniquename":"YDL182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04688","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04688","reference_uniquename":"PMID:26896847"}],"product":"Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL182W"}


id: YDL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02445":null,"YDL183C":null},"has_protein_features":false,"name":"MRX19","ortholog_annotations":[{"gene_uniquename":"YDL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02445","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02445","reference_uniquename":"PMID:26896847"}],"product":"Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL183C"}


id: YDL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07013":null,"SJAG_07014":null,"YDL184C":null},"has_protein_features":false,"name":"RPL41A","ortholog_annotations":[{"gene_uniquename":"YDL184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07013","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07014","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL184C"}


id: YDL185C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL185C-A"}


id: YDL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01471":null,"YDL185W":null},"has_protein_features":false,"name":"VMA1","ortholog_annotations":[{"gene_uniquename":"YDL185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01471","reference_uniquename":"PMID:26896847"}],"product":"Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL185W"}


id: YDL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YDL186W is not an essential gene","secondary_identifier":"SGD:S000002345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL186W"}


id: YDL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL187C"}


id: YDL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00600":null,"YDL188C":null},"has_protein_features":false,"name":"PPH22","ortholog_annotations":[{"gene_uniquename":"YDL188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00600","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL188C"}


id: YDL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RBS1","product":"Protein involved in assembly of the RNA Pol III complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain; capable of forming the prion [VTS1+]","secondary_identifier":"SGD:S000002348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL189W"}


id: YDL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02685":null,"YDL190C":null},"has_protein_features":false,"name":"UFD2","ortholog_annotations":[{"gene_uniquename":"YDL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02685","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02685","reference_uniquename":"PMID:26896847"}],"product":"Conserved ubiquitin (Ub) chain assembly factor (E4); forms branched Ub chains on substrates destined for degradation, catalyzing K48-linked multi-monoubiquitination of K29-linked Ub chains assembled by Ub-ligase Ufd4p; involved in Ub-fusion degradation pathway, OLE membrane fluidity pathway, stress response survival, and ERAD pathway for misfolded proteins where it promotes ubiquitination and transfer of ERAD substrates to Rad23p; U-box family member; homologous to human Ufd2a, Ufd2b","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL190C"}


id: YDL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00749":null,"YDL191W":null},"has_protein_features":false,"name":"RPL35A","ortholog_annotations":[{"gene_uniquename":"YDL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00749","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL191W"}


id: YDL192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01456":null,"SJAG_02824":null,"YDL192W":null},"has_protein_features":false,"name":"ARF1","ortholog_annotations":[{"gene_uniquename":"YDL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01456","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02824","reference_uniquename":"PMID:29761456"}],"product":"ADP-ribosylation factor; GTPase of the Ras superfamily that regulates coated vesicle formation during intracellular trafficking within the Golgi; regulates mitochondrial fission, fusion and function, controlling the flow of fatty acids and metabolites from lipid droplets to peroxisomes and mitochondria; localizes to the Golgi apparatus and the active form to ER and lipid droplets; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL192W"}


id: YDL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00554":null,"YDL193W":null},"has_protein_features":false,"name":"NUS1","ortholog_annotations":[{"gene_uniquename":"YDL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00554","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00554","reference_uniquename":"PMID:26896847"}],"product":"Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL193W"}


id: YDL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SNF3","product":"Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL194W"}


id: YDL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03558":null,"YDL195W":null},"has_protein_features":false,"name":"SEC31","ortholog_annotations":[{"gene_uniquename":"YDL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03558","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03558","reference_uniquename":"PMID:26896847"}],"product":"Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL195W"}


id: YDL196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31","secondary_identifier":"SGD:S000002355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL196W"}


id: YDL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASF2","product":"Anti-silencing protein; causes derepression of silent loci when overexpressed","secondary_identifier":"SGD:S000002356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL197C"}


id: YDL198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00760":null,"YDL198C":null},"has_protein_features":false,"name":"GGC1","ortholog_annotations":[{"gene_uniquename":"YDL198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00760","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL198C"}


id: YDL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative transporter; member of the sugar porter family","secondary_identifier":"SGD:S000002358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL199C"}


id: YDL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04778":null,"YDL200C":null},"has_protein_features":false,"name":"MGT1","ortholog_annotations":[{"gene_uniquename":"YDL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04778","reference_uniquename":"PMID:29761456"}],"product":"DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; localizes to the peroxisome in a Pex5p-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL200C"}


id: YDL201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04680":null,"YDL201W":null},"has_protein_features":false,"name":"TRM8","ortholog_annotations":[{"gene_uniquename":"YDL201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04680","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL201W"}


id: YDL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04889":null,"YDL202W":null},"has_protein_features":false,"name":"MRPL11","ortholog_annotations":[{"gene_uniquename":"YDL202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04889","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04889","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL202W"}


id: YDL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02733":null,"SJAG_04595":null,"YDL203C":null},"has_protein_features":false,"name":"ACK1","ortholog_annotations":[{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02733","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04595","reference_uniquename":"PMID:26896847"}],"product":"Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL203C"}


id: YDL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01848":null,"YDL204W":null},"has_protein_features":false,"name":"RTN2","ortholog_annotations":[{"gene_uniquename":"YDL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01848","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01848","reference_uniquename":"PMID:26896847"}],"product":"Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL204W"}


id: YDL204W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function, translated but not conserved; translation inhibition causes strong growth phenotypes","secondary_identifier":"SGD:S000350094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL204W-A"}


id: YDL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02896":null,"YDL205C":null},"has_protein_features":false,"name":"HEM3","ortholog_annotations":[{"gene_uniquename":"YDL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02896","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02896","reference_uniquename":"PMID:26896847"}],"product":"Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL205C"}


id: YDL206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04892":null,"YDL206W":null},"has_protein_features":false,"name":"YCX1","ortholog_annotations":[{"gene_uniquename":"YDL206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04892","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in calcium-induced activation of calcineurin; homologous to proteins in Candida and Cryptococcus; YCX1 is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL206W"}


id: YDL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03847":null,"YDL207W":null},"has_protein_features":false,"name":"GLE1","ortholog_annotations":[{"gene_uniquename":"YDL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03847","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03847","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL207W"}


id: YDL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00083":null,"YDL208W":null},"has_protein_features":false,"name":"NHP2","ortholog_annotations":[{"gene_uniquename":"YDL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00083","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00083","reference_uniquename":"PMID:26896847"}],"product":"Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL208W"}


id: YDL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04898":null,"YDL209C":null},"has_protein_features":false,"name":"CWC2","ortholog_annotations":[{"gene_uniquename":"YDL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04898","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04898","reference_uniquename":"PMID:26896847"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL209C"}


id: YDL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YDL210W":null},"has_protein_features":false,"name":"UGA4","ortholog_annotations":[{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL210W"}


id: YDL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL211C"}


id: YDL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04684":null,"YDL212W":null},"has_protein_features":false,"name":"SHR3","ortholog_annotations":[{"gene_uniquename":"YDL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04684","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL212W"}


id: YDL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01201":null,"YDL213C":null},"has_protein_features":false,"name":"NOP6","ortholog_annotations":[{"gene_uniquename":"YDL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01201","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01201","reference_uniquename":"PMID:26896847"}],"product":"rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL213C"}


id: YDL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YDL214C":null},"has_protein_features":false,"name":"PRR2","ortholog_annotations":[{"gene_uniquename":"YDL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL214C"}


id: YDL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GDH2","product":"NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis","secondary_identifier":"SGD:S000002374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL215C"}


id: YDL216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00720":null,"YDL216C":null},"has_protein_features":false,"name":"RRI1","ortholog_annotations":[{"gene_uniquename":"YDL216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00720","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00720","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL216C"}


id: YDL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01640":null,"YDL217C":null},"has_protein_features":false,"name":"TIM22","ortholog_annotations":[{"gene_uniquename":"YDL217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01640","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01640","reference_uniquename":"PMID:26896847"}],"product":"Essential core component of mitochondrial TIM22 complex; involved in insertion of polytopic proteins into inner membrane; forms channel through which proteins are imported; different regions of Tim22p have functionally diverse roles in recruiting partner subunits to core channel","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL217C"}


id: YDL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin","secondary_identifier":"SGD:S000002377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL218W"}


id: YDL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01248":null,"YDL219W":null},"has_protein_features":false,"name":"DTD1","ortholog_annotations":[{"gene_uniquename":"YDL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01248","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01248","reference_uniquename":"PMID:26896847"}],"product":"D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL219W"}


id: YDL220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02194":null,"YDL220C":null},"has_protein_features":false,"name":"CDC13","ortholog_annotations":[{"gene_uniquename":"YDL220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02194","reference_uniquename":"PMID:29761456"}],"product":"Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles regulating telomerase, telomere end protection, and telomere replication; can dynamically intermolecularly exchange between telomeric single-stranded DNA molecules; essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL220C"}


id: YDL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13","secondary_identifier":"SGD:S000002380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL221W"}


id: YDL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP45","product":"Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL222C"}


id: YDL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HBT1","product":"Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL223C"}


id: YDL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01843":null,"SJAG_02554":null,"YDL224C":null},"has_protein_features":false,"name":"WHI4","ortholog_annotations":[{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:26896847"}],"product":"Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL224C"}


id: YDL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01769":null,"YDL225W":null},"has_protein_features":false,"name":"SHS1","ortholog_annotations":[{"gene_uniquename":"YDL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01769","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL225W"}


id: YDL226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03268":null,"YDL226C":null},"has_protein_features":false,"name":"GCS1","ortholog_annotations":[{"gene_uniquename":"YDL226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03268","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03268","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL226C"}


id: YDL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HO","product":"Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p","secondary_identifier":"SGD:S000002386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL227C"}


id: YDL228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1","secondary_identifier":"SGD:S000002387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL228C"}


id: YDL229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03237":null,"YDL229W":null},"has_protein_features":false,"name":"SSB1","ortholog_annotations":[{"gene_uniquename":"YDL229W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03237","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL229W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03237","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL229W"}


id: YDL230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00214":null,"YDL230W":null},"has_protein_features":false,"name":"PTP1","ortholog_annotations":[{"gene_uniquename":"YDL230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00214","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00214","reference_uniquename":"PMID:26896847"}],"product":"Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL230W"}


id: YDL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02011":null,"SJAG_04423":null,"YDL231C":null},"has_protein_features":false,"name":"BRE4","ortholog_annotations":[{"gene_uniquename":"YDL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02011","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04423","reference_uniquename":"PMID:29761456"}],"product":"Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL231C"}


id: YDL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05348":null,"YDL232W":null},"has_protein_features":false,"name":"OST4","ortholog_annotations":[{"gene_uniquename":"YDL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05348","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL232W"}


id: YDL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02255":null,"YDL233W":null},"has_protein_features":false,"name":"MFG1","ortholog_annotations":[{"gene_uniquename":"YDL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02255","reference_uniquename":"PMID:29761456"}],"product":"Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL233W"}


id: YDL234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03021":null,"YDL234C":null},"has_protein_features":false,"name":"GYP7","ortholog_annotations":[{"gene_uniquename":"YDL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03021","reference_uniquename":"PMID:26896847"}],"product":"GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; regulates Ypt7p activity on late endosomes; contains a PH-like domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL234C"}


id: YDL235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06592":null,"YDL235C":null},"has_protein_features":false,"name":"YPD1","ortholog_annotations":[{"gene_uniquename":"YDL235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06592","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06592","reference_uniquename":"PMID:26896847"}],"product":"Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL235C"}


id: YDL236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03108":null,"YDL236W":null},"has_protein_features":false,"name":"PHO13","ortholog_annotations":[{"gene_uniquename":"YDL236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03108","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03108","reference_uniquename":"PMID:26896847"}],"product":"Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL236W"}


id: YDL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM6","product":"Protein of unknown function; required for respiratory growth; YDL237W is not an essential gene","secondary_identifier":"SGD:S000002396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL237W"}


id: YDL238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01997":null,"YDL238C":null},"has_protein_features":false,"name":"GUD1","ortholog_annotations":[{"gene_uniquename":"YDL238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01997","reference_uniquename":"PMID:29761456"}],"product":"Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL238C"}


id: YDL239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01464":null,"YDL239C":null},"has_protein_features":false,"name":"ADY3","ortholog_annotations":[{"gene_uniquename":"YDL239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01464","reference_uniquename":"PMID:29761456"}],"product":"Protein required for spore wall formation; subunit of leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms ring-like structure at leading edge of prospore membrane during meiosis II; mediates assembly of LEP complex, formation of ring-like structure via interaction with spindle pole body components, and prospore membrane maturation; also detected in peroxisomes; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL239C"}


id: YDL240C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL240C-A"}


id: YDL240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00551":null,"SJAG_03655":null,"YDL240W":null},"has_protein_features":false,"name":"LRG1","ortholog_annotations":[{"gene_uniquename":"YDL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00551","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03655","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL240W"}


id: YDL241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene","secondary_identifier":"SGD:S000002400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL241W"}


id: YDL242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000002401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL242W"}


id: YDL243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD4","product":"Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000002402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL243C"}


id: YDL244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YDL244W":null},"has_protein_features":false,"name":"THI13","ortholog_annotations":[{"gene_uniquename":"YDL244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL244W"}


id: YDL245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDL245C":null},"has_protein_features":false,"name":"HXT15","ortholog_annotations":[{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL245C"}


id: YDL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00237":null,"YDL246C":null},"has_protein_features":false,"name":"SOR2","ortholog_annotations":[{"gene_uniquename":"YDL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL246C"}


id: YDL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPH2","product":"Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication","secondary_identifier":"SGD:S000002406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL247W"}


id: YDL247W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL247W-A"}


id: YDL248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS7","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000002407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL248W"}


id: YDR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04859":null,"YDR001C":null},"has_protein_features":false,"name":"NTH1","ortholog_annotations":[{"gene_uniquename":"YDR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04859","reference_uniquename":"PMID:29761456"}],"product":"Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR001C"}


id: YDR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02520":null,"YDR002W":null},"has_protein_features":false,"name":"YRB1","ortholog_annotations":[{"gene_uniquename":"YDR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02520","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02520","reference_uniquename":"PMID:26896847"}],"product":"Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR002W"}


id: YDR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01258":null,"YDR003W":null},"has_protein_features":false,"name":"RCR2","ortholog_annotations":[{"gene_uniquename":"YDR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01258","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar ubiquitin ligase-substrate adaptor; delivered to vacuole using ubiquitin as a sorting signal; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR003W"}


id: YDR003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR003W-A"}


id: YDR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00757":null,"YDR004W":null},"has_protein_features":false,"name":"RAD57","ortholog_annotations":[{"gene_uniquename":"YDR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00757","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00757","reference_uniquename":"PMID:26896847"}],"product":"Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR004W"}


id: YDR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02898":null,"YDR005C":null},"has_protein_features":false,"name":"MAF1","ortholog_annotations":[{"gene_uniquename":"YDR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02898","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02898","reference_uniquename":"PMID:26896847"}],"product":"Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR005C"}


id: YDR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOK1","product":"Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13","secondary_identifier":"SGD:S000002413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR006C"}


id: YDR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TRP1","product":"Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303","secondary_identifier":"SGD:S000002414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR007W"}


id: YDR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps TRP1/YDR007W on opposite strand","secondary_identifier":"SGD:S000002415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR008C"}


id: YDR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02950":null,"YDR009W":null},"has_protein_features":false,"name":"GAL3","ortholog_annotations":[{"gene_uniquename":"YDR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02950","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02950","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR009W"}


id: YDR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000002417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR010C"}


id: YDR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YDR011W":null},"has_protein_features":false,"name":"SNQ2","ortholog_annotations":[{"gene_uniquename":"YDR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR011W"}


id: YDR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06612":null,"YDR012W":null},"has_protein_features":false,"name":"RPL4B","ortholog_annotations":[{"gene_uniquename":"YDR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06612","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06612","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR012W"}


id: YDR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00874":null,"YDR013W":null},"has_protein_features":false,"name":"PSF1","ortholog_annotations":[{"gene_uniquename":"YDR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00874","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00874","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR013W"}


id: YDR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02606":null,"YDR014W":null},"has_protein_features":false,"name":"RAD61","ortholog_annotations":[{"gene_uniquename":"YDR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02606","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR014W"}


id: YDR014W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HED1","product":"Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of synaptonemal complex; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene, transcribed specifically during meiotic prophase","secondary_identifier":"SGD:S000113613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR014W-A"}


id: YDR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A","secondary_identifier":"SGD:S000002422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR015C"}


id: YDR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01775":null,"YDR016C":null},"has_protein_features":false,"name":"DAD1","ortholog_annotations":[{"gene_uniquename":"YDR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01775","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR016C"}


id: YDR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02321":null,"YDR017C":null},"has_protein_features":false,"name":"KCS1","ortholog_annotations":[{"gene_uniquename":"YDR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02321","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02321","reference_uniquename":"PMID:26896847"}],"product":"Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; phosphorylated by the AMPK Snf1p, leading to reduced levels of pyrophosphorylated IP7, increased filamentous and invasive growth and increased cell elongation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR017C"}


id: YDR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03935":null,"YDR018C":null},"has_protein_features":false,"name":"MLG1","ortholog_annotations":[{"gene_uniquename":"YDR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03935","reference_uniquename":"PMID:29761456"}],"product":"Lysolipid acyltransferase; involved in the synthesis of phosphatidic acid from 1-acyl-2-hydroxy-sn-glycero-3-phosphate using oleoyl-CoA as acyl donor and in phospholipid remodeling, incorporating palmitic acid into the sn-1 position of phosphatidylserine and phosphatidylethanolamine; localizes to ER membranes associated with mitochondria (MAMs); contains three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR018C"}


id: YDR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02901":null,"YDR019C":null},"has_protein_features":false,"name":"GCV1","ortholog_annotations":[{"gene_uniquename":"YDR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02901","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02901","reference_uniquename":"PMID:26896847"}],"product":"T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR019C"}


id: YDR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAS2","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases","secondary_identifier":"SGD:S000002427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR020C"}


id: YDR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02879":null,"YDR021W":null},"has_protein_features":false,"name":"FAL1","ortholog_annotations":[{"gene_uniquename":"YDR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02879","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02879","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR021W"}


id: YDR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG31","product":"Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion","secondary_identifier":"SGD:S000002429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR022C"}


id: YDR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04762":null,"YDR023W":null},"has_protein_features":false,"name":"SES1","ortholog_annotations":[{"gene_uniquename":"YDR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04762","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04762","reference_uniquename":"PMID:26896847"}],"product":"Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; copurifies with Abp140p in an RNA-dependent manner and stimulates 3-methylcytidine (m3C) modification of residue 32 of the tRNA anticodon loop of tRNA-Ser; interacts with peroxin Pex21p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR023W"}


id: YDR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FYV1","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin","secondary_identifier":"SGD:S000002431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR024W"}


id: YDR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00069":null,"SJAG_00503":null,"YDR025W":null},"has_protein_features":false,"name":"RPS11A","ortholog_annotations":[{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00503","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00503","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR025W"}


id: YDR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00073":null,"SJAG_02922":null,"SJAG_04855":null,"YDR026C":null},"has_protein_features":false,"name":"NSI1","ortholog_annotations":[{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00073","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00073","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02922","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04855","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04855","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR026C"}


id: YDR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03963":null,"YDR027C":null},"has_protein_features":false,"name":"VPS54","ortholog_annotations":[{"gene_uniquename":"YDR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03963","reference_uniquename":"PMID:26896847"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR027C"}


id: YDR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00534":null,"YDR028C":null},"has_protein_features":false,"name":"REG1","ortholog_annotations":[{"gene_uniquename":"YDR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00534","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00534","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR028C"}


id: YDR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR029W is not an essential gene","secondary_identifier":"SGD:S000002436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR029W"}


id: YDR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04540":null,"YDR030C":null},"has_protein_features":false,"name":"RAD28","ortholog_annotations":[{"gene_uniquename":"YDR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04540","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04540","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR030C"}


id: YDR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIX14","product":"Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000002438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR031W"}


id: YDR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02697":null,"YDR032C":null},"has_protein_features":false,"name":"PST2","ortholog_annotations":[{"gene_uniquename":"YDR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:26896847"}],"product":"FMN-dependent NAD(P)H:quinone oxidoreductase; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR032C"}


id: YDR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02533":null,"YDR033W":null},"has_protein_features":false,"name":"MRH1","ortholog_annotations":[{"gene_uniquename":"YDR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR033W"}


id: YDR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LYS14","product":"Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer","secondary_identifier":"SGD:S000002441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034C"}


id: YDR034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7","secondary_identifier":"SGD:S000007233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034C-A"}


id: YDR034W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CPP3","product":"Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; also localizes to the vacuolar membrane; may be involved in response to stress; upregulated by toxic concentrations of heavy metal ions and alkali; contains a conserved cysteine rich palmitoylated domain (CYSPD, aka CYSTM); CPP3 has a paralog, MNC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034W-B"}


id: YDR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00224":null,"SJAG_03580":null,"YDR035W":null},"has_protein_features":false,"name":"ARO3","ortholog_annotations":[{"gene_uniquename":"YDR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00224","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03580","reference_uniquename":"PMID:29761456"}],"product":"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR035W"}


id: YDR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00944":null,"YDR036C":null},"has_protein_features":false,"name":"EHD3","ortholog_annotations":[{"gene_uniquename":"YDR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00944","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00944","reference_uniquename":"PMID:26896847"}],"product":"3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR036C"}


id: YDR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00488":null,"YDR037W":null},"has_protein_features":false,"name":"KRS1","ortholog_annotations":[{"gene_uniquename":"YDR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00488","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00488","reference_uniquename":"PMID:26896847"}],"product":"Lysyl-tRNA synthetase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR037W"}


id: YDR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR038C":null},"has_protein_features":false,"name":"ENA5","ortholog_annotations":[{"gene_uniquename":"YDR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR038C"}


id: YDR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR039C":null},"has_protein_features":false,"name":"ENA2","ortholog_annotations":[{"gene_uniquename":"YDR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR039C"}


id: YDR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR040C":null},"has_protein_features":false,"name":"ENA1","ortholog_annotations":[{"gene_uniquename":"YDR040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR040C"}


id: YDR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00860":null,"YDR041W":null},"has_protein_features":false,"name":"RSM10","ortholog_annotations":[{"gene_uniquename":"YDR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00860","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00860","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR041W"}


id: YDR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression is increased in ssu72-ts69 mutant","secondary_identifier":"SGD:S000002449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR042C"}


id: YDR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00124":null,"YDR043C":null},"has_protein_features":false,"name":"NRG1","ortholog_annotations":[{"gene_uniquename":"YDR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00124","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR043C"}


id: YDR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04944":null,"YDR044W":null},"has_protein_features":false,"name":"HEM13","ortholog_annotations":[{"gene_uniquename":"YDR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04944","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04944","reference_uniquename":"PMID:26896847"}],"product":"Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR044W"}


id: YDR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03761":null,"YDR045C":null},"has_protein_features":false,"name":"RPC11","ortholog_annotations":[{"gene_uniquename":"YDR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03761","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03761","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR045C"}


id: YDR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YDR046C":null},"has_protein_features":false,"name":"BAP3","ortholog_annotations":[{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR046C"}


id: YDR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04109":null,"YDR047W":null},"has_protein_features":false,"name":"HEM12","ortholog_annotations":[{"gene_uniquename":"YDR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04109","reference_uniquename":"PMID:26896847"}],"product":"Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR047W"}


id: YDR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF VMS1/YDR049W","secondary_identifier":"SGD:S000002455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR048C"}


id: YDR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00948":null,"YDR049W":null},"has_protein_features":false,"name":"VMS1","ortholog_annotations":[{"gene_uniquename":"YDR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00948","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00948","reference_uniquename":"PMID:26896847"}],"product":"Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, component of a Cdc48p-complex; involved in protein quality control; exhibits cytosolic and ER-membrane localization; contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; translocates to mitochondria under oxidative stress and forms a complex with Cdc48p and Npl4p that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR049W"}


id: YDR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04192":null,"YDR050C":null},"has_protein_features":false,"name":"TPI1","ortholog_annotations":[{"gene_uniquename":"YDR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04192","reference_uniquename":"PMID:29761456"}],"product":"Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR050C"}


id: YDR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DET1","product":"Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel","secondary_identifier":"SGD:S000002458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR051C"}


id: YDR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03090":null,"SJAG_03695":null,"YDR052C":null},"has_protein_features":false,"name":"DBF4","ortholog_annotations":[{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03090","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03090","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03695","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03695","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR052C"}


id: YDR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex","secondary_identifier":"SGD:S000002460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR053W"}


id: YDR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00300":null,"YDR054C":null},"has_protein_features":false,"name":"CDC34","ortholog_annotations":[{"gene_uniquename":"YDR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00300","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR054C"}


id: YDR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YDR055W":null},"has_protein_features":false,"name":"PST1","ortholog_annotations":[{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:26896847"}],"product":"Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR055W"}


id: YDR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01999":null,"YDR056C":null},"has_protein_features":false,"name":"EMC10","ortholog_annotations":[{"gene_uniquename":"YDR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01999","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR056C"}


id: YDR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00530":null,"YDR057W":null},"has_protein_features":false,"name":"YOS9","ortholog_annotations":[{"gene_uniquename":"YDR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00530","reference_uniquename":"PMID:29761456"}],"product":"ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR057W"}


id: YDR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TGL2","product":"Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli","secondary_identifier":"SGD:S000002465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR058C"}


id: YDR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04573":null,"YDR059C":null},"has_protein_features":false,"name":"UBC5","ortholog_annotations":[{"gene_uniquename":"YDR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04573","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR059C"}


id: YDR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01275":null,"SJAG_01779":null,"YDR060W":null},"has_protein_features":false,"name":"MAK21","ortholog_annotations":[{"gene_uniquename":"YDR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01275","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01275","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01779","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR060W"}


id: YDR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03948":null,"YDR061W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03948","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03948","reference_uniquename":"PMID:26896847"}],"product":"Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR061W"}


id: YDR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02305":null,"YDR062W":null},"has_protein_features":false,"name":"LCB2","ortholog_annotations":[{"gene_uniquename":"YDR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02305","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02305","reference_uniquename":"PMID:26896847"}],"product":"Serine palmitoyltransferase component; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR062W"}


id: YDR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03455":null,"YDR063W":null},"has_protein_features":false,"name":"AIM7","ortholog_annotations":[{"gene_uniquename":"YDR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03455","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03455","reference_uniquename":"PMID:26896847"}],"product":"Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR063W"}


id: YDR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01132":null,"SJAG_01387":null,"YDR064W":null},"has_protein_features":false,"name":"RPS13","ortholog_annotations":[{"gene_uniquename":"YDR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01387","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR064W"}


id: YDR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRG1","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; required for vacuolar acidification; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000002472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR065W"}


id: YDR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTR2","product":"Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR066C"}


id: YDR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OCA6","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT","secondary_identifier":"SGD:S000002474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR067C"}


id: YDR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00791":null,"YDR068W":null},"has_protein_features":false,"name":"DOS2","ortholog_annotations":[{"gene_uniquename":"YDR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00791","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR068W"}


id: YDR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03429":null,"YDR069C":null},"has_protein_features":false,"name":"DOA4","ortholog_annotations":[{"gene_uniquename":"YDR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03429","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR069C"}


id: YDR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP16","product":"Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000002477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR070C"}


id: YDR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02296":null,"YDR071C":null},"has_protein_features":false,"name":"PAA1","ortholog_annotations":[{"gene_uniquename":"YDR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02296","reference_uniquename":"PMID:29761456"}],"product":"Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR071C"}


id: YDR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00506":null,"YDR072C":null},"has_protein_features":false,"name":"IPT1","ortholog_annotations":[{"gene_uniquename":"YDR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00506","reference_uniquename":"PMID:29761456"}],"product":"Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR072C"}


id: YDR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00743":null,"YDR073W":null},"has_protein_features":false,"name":"SNF11","ortholog_annotations":[{"gene_uniquename":"YDR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00743","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR073W"}


id: YDR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01646":null,"SJAG_01862":null,"YDR074W":null},"has_protein_features":false,"name":"TPS2","ortholog_annotations":[{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01646","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01646","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01862","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01862","reference_uniquename":"PMID:26896847"}],"product":"Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in the synthesis of storage carbohydrate trehalose; positive regulator of autophagy involved in the dephosphorylation of Rim15p leading to ATG8 induction; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR074W"}


id: YDR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00823":null,"YDR075W":null},"has_protein_features":false,"name":"PPH3","ortholog_annotations":[{"gene_uniquename":"YDR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00823","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00823","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR075W"}


id: YDR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02708":null,"YDR076W":null},"has_protein_features":false,"name":"RAD55","ortholog_annotations":[{"gene_uniquename":"YDR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02708","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR076W"}


id: YDR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SED1","product":"Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR077W"}


id: YDR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03051":null,"YDR078C":null},"has_protein_features":false,"name":"SHU2","ortholog_annotations":[{"gene_uniquename":"YDR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03051","reference_uniquename":"PMID:29761456"}],"product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR078C"}


id: YDR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01207":null,"YDR079C-A":null},"has_protein_features":false,"name":"TFB5","ortholog_annotations":[{"gene_uniquename":"YDR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01207","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01207","reference_uniquename":"PMID:26896847"}],"product":"Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR079C-A"}


id: YDR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET100","product":"Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme","secondary_identifier":"SGD:S000002486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR079W"}


id: YDR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00380":null,"YDR080W":null},"has_protein_features":false,"name":"VPS41","ortholog_annotations":[{"gene_uniquename":"YDR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00380","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00380","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR080W"}


id: YDR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDC2","product":"Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions","secondary_identifier":"SGD:S000002488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR081C"}


id: YDR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02362":null,"YDR082W":null},"has_protein_features":false,"name":"STN1","ortholog_annotations":[{"gene_uniquename":"YDR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02362","reference_uniquename":"PMID:29761456"}],"product":"Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR082W"}


id: YDR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03713":null,"YDR083W":null},"has_protein_features":false,"name":"RRP8","ortholog_annotations":[{"gene_uniquename":"YDR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03713","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03713","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with gar1 mutation; deletion disrupts telomere maintenance by influencing expression of neighboring gene STN1; mammalian homolog nucleomethylin has been linked to nutrient availability signaling pathways and obesity","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR083W"}


id: YDR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00553":null,"YDR084C":null},"has_protein_features":false,"name":"TVP23","ortholog_annotations":[{"gene_uniquename":"YDR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00553","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00553","reference_uniquename":"PMID:26896847"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR084C"}


id: YDR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFR1","product":"Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR085C"}


id: YDR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00959":null,"YDR086C":null},"has_protein_features":false,"name":"SSS1","ortholog_annotations":[{"gene_uniquename":"YDR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00959","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00959","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR086C"}


id: YDR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03458":null,"YDR087C":null},"has_protein_features":false,"name":"RRP1","ortholog_annotations":[{"gene_uniquename":"YDR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03458","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03458","reference_uniquename":"PMID:26896847"}],"product":"Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR087C"}


id: YDR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01200":null,"YDR088C":null},"has_protein_features":false,"name":"SLU7","ortholog_annotations":[{"gene_uniquename":"YDR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01200","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01200","reference_uniquename":"PMID:26896847"}],"product":"RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR088C"}


id: YDR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VTC5","product":"Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000002496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR089W"}


id: YDR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YDR090C":null},"has_protein_features":false,"name":"ILT1","ortholog_annotations":[{"gene_uniquename":"YDR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; deletion confers sensitivity to cationic compounds; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR090C"}


id: YDR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03658":null,"YDR091C":null},"has_protein_features":false,"name":"RLI1","ortholog_annotations":[{"gene_uniquename":"YDR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03658","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03658","reference_uniquename":"PMID:26896847"}],"product":"Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR091C"}


id: YDR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00208":null,"YDR092W":null},"has_protein_features":false,"name":"UBC13","ortholog_annotations":[{"gene_uniquename":"YDR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00208","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00208","reference_uniquename":"PMID:26896847"}],"product":"E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR092W"}


id: YDR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01731":null,"SJAG_02897":null,"YDR093W":null},"has_protein_features":false,"name":"DNF2","ortholog_annotations":[{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:26896847"}],"product":"Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR093W"}


id: YDR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W","secondary_identifier":"SGD:S000002501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR094W"}


id: YDR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR095C"}


id: YDR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03041":null,"YDR096W":null},"has_protein_features":false,"name":"GIS1","ortholog_annotations":[{"gene_uniquename":"YDR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03041","reference_uniquename":"PMID:29761456"}],"product":"Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR096W"}


id: YDR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02748":null,"YDR097C":null},"has_protein_features":false,"name":"MSH6","ortholog_annotations":[{"gene_uniquename":"YDR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02748","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02748","reference_uniquename":"PMID:26896847"}],"product":"Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; contains PIP motif that binds PCNA (Pol30p) and Rev1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR097C"}


id: YDR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00822":null,"YDR098C":null},"has_protein_features":false,"name":"GRX3","ortholog_annotations":[{"gene_uniquename":"YDR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:26896847"}],"product":"Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx4p and Grx5p; redundantly protects cells from oxidative damage along with GRX4 and GRX5; with Grx4p, promotes the dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx4p in the deglutathionylation of Sir2p, restoring deacetylase activity after disulfide stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR098C"}


id: YDR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02266":null,"SJAG_02576":null,"YDR099W":null},"has_protein_features":false,"name":"BMH2","ortholog_annotations":[{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:26896847"}],"product":"14-3-3 protein, minor isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates multiple processes including exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; abundance relative to Bmh1p increases during sporulation; similar to several human 14-3-3 proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR099W"}


id: YDR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03368":null,"YDR100W":null},"has_protein_features":false,"name":"TVP15","ortholog_annotations":[{"gene_uniquename":"YDR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03368","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03368","reference_uniquename":"PMID:26896847"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR100W"}


