# genes

id: YPL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YPL058C":null},"has_protein_features":false,"name":"PDR12","ortholog_annotations":[{"gene_uniquename":"YPL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL058C"}


id: YPL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01417":null,"YPL059W":null},"has_protein_features":false,"name":"GRX5","ortholog_annotations":[{"gene_uniquename":"YPL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01417","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL059W"}


id: YPL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01639":null,"YPL060W":null},"has_protein_features":false,"name":"MFM1","ortholog_annotations":[{"gene_uniquename":"YPL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL060W"}


id: YPL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03786":null,"YPL061W":null},"has_protein_features":false,"name":"ALD6","ortholog_annotations":[{"gene_uniquename":"YPL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL061W"}


id: YPL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; deletion decreases transcription of downstream gene ALD6; YPL062W is not an essential gene; null mutant shows decrease in terpenoid production; homozygous diploid mutant shows a decrease in glycogen accumulation","secondary_identifier":"SGD:S000005983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL062W"}


id: YPL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03560":null,"YPL063W":null},"has_protein_features":false,"name":"TIM50","ortholog_annotations":[{"gene_uniquename":"YPL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03560","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03560","reference_uniquename":"PMID:26896847"}],"product":"Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL063W"}


id: YPL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00602":null,"YPL064C":null},"has_protein_features":false,"name":"CWC27","ortholog_annotations":[{"gene_uniquename":"YPL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00602","reference_uniquename":"PMID:29761456"}],"product":"Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL064C"}


id: YPL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04349":null,"YPL065W":null},"has_protein_features":false,"name":"VPS28","ortholog_annotations":[{"gene_uniquename":"YPL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04349","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04349","reference_uniquename":"PMID:26896847"}],"product":"Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL065W"}


id: YPL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02215":null,"YPL066W":null},"has_protein_features":false,"name":"RGL1","ortholog_annotations":[{"gene_uniquename":"YPL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02215","reference_uniquename":"PMID:29761456"}],"product":"Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL066W"}


id: YPL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HTC1","product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene","secondary_identifier":"SGD:S000005988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL067C"}


id: YPL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000005989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL068C"}


id: YPL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BTS1","product":"Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic","secondary_identifier":"SGD:S000005990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL069C"}


id: YPL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MUK1","product":"Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain","secondary_identifier":"SGD:S000005991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL070W"}


id: YPL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000005992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL071C"}


id: YPL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01312":null,"YPL072W":null},"has_protein_features":false,"name":"UBP16","ortholog_annotations":[{"gene_uniquename":"YPL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01312","reference_uniquename":"PMID:29761456"}],"product":"Putative deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL072W"}


id: YPL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments","secondary_identifier":"SGD:S000005994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL073C"}


id: YPL074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YPL074W":null},"has_protein_features":false,"name":"YTA6","ortholog_annotations":[{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:26896847"}],"product":"Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL074W"}


id: YPL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GCR1","product":"Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability","secondary_identifier":"SGD:S000005996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL075W"}


id: YPL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04119":null,"YPL076W":null},"has_protein_features":false,"name":"GPI2","ortholog_annotations":[{"gene_uniquename":"YPL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04119","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04119","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL076W"}


id: YPL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL077C"}


id: YPL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00836":null,"YPL078C":null},"has_protein_features":false,"name":"ATP4","ortholog_annotations":[{"gene_uniquename":"YPL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00836","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00836","reference_uniquename":"PMID:26896847"}],"product":"Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL078C"}


id: YPL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YPL079W":null},"has_protein_features":false,"name":"RPL21B","ortholog_annotations":[{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL079W"}


id: YPL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000006001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL080C"}


id: YPL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YPL081W":null},"has_protein_features":false,"name":"RPS9A","ortholog_annotations":[{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL081W"}


id: YPL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00650":null,"YPL082C":null},"has_protein_features":false,"name":"MOT1","ortholog_annotations":[{"gene_uniquename":"YPL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00650","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00650","reference_uniquename":"PMID:26896847"}],"product":"Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL082C"}


id: YPL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00754":null,"YPL083C":null},"has_protein_features":false,"name":"SEN54","ortholog_annotations":[{"gene_uniquename":"YPL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00754","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00754","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL083C"}


id: YPL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02584":null,"YPL084W":null},"has_protein_features":false,"name":"BRO1","ortholog_annotations":[{"gene_uniquename":"YPL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; required for ESCRT-dependent transport of ubiquitinated cargo to the vacuole; localizes to extracellular vesicles during heat conditioning with proposed function in thermotolerance; orthologous to mammalian ESCRT-associated protein ALIX (PDCD6IP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL084W"}


id: YPL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00284":null,"YPL085W":null},"has_protein_features":false,"name":"SEC16","ortholog_annotations":[{"gene_uniquename":"YPL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00284","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00284","reference_uniquename":"PMID:26896847"}],"product":"COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL085W"}


id: YPL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04756":null,"YPL086C":null},"has_protein_features":false,"name":"ELP3","ortholog_annotations":[{"gene_uniquename":"YPL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04756","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL086C"}


id: YPL087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YDC1","product":"Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL087W"}


id: YPL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance","secondary_identifier":"SGD:S000006009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL088W"}


id: YPL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YPL089C":null},"has_protein_features":false,"name":"RLM1","ortholog_annotations":[{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL089C"}


id: YPL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YPL090C":null},"has_protein_features":false,"name":"RPS6A","ortholog_annotations":[{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL090C"}


id: YPL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01162":null,"YPL091W":null},"has_protein_features":false,"name":"GLR1","ortholog_annotations":[{"gene_uniquename":"YPL091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01162","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01162","reference_uniquename":"PMID:26896847"}],"product":"Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL091W"}


id: YPL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSU1","product":"Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein","secondary_identifier":"SGD:S000006013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL092W"}


id: YPL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04940":null,"YPL093W":null},"has_protein_features":false,"name":"NOG1","ortholog_annotations":[{"gene_uniquename":"YPL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04940","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL093W"}


id: YPL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02588":null,"YPL094C":null},"has_protein_features":false,"name":"SEC62","ortholog_annotations":[{"gene_uniquename":"YPL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02588","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL094C"}


id: YPL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EEB1","product":"Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL095C"}


id: YPL096C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06383":null,"YPL096C-A":null},"has_protein_features":false,"name":"ERI1","ortholog_annotations":[{"gene_uniquename":"YPL096C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06383","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096C-A"}


id: YPL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03227":null,"YPL096W":null},"has_protein_features":false,"name":"PNG1","ortholog_annotations":[{"gene_uniquename":"YPL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03227","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03227","reference_uniquename":"PMID:26896847"}],"product":"Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096W"}


id: YPL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04473":null,"YPL097W":null},"has_protein_features":false,"name":"MSY1","ortholog_annotations":[{"gene_uniquename":"YPL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04473","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial tyrosyl-tRNA synthetase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL097W"}


id: YPL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01120":null,"YPL098C":null},"has_protein_features":false,"name":"MGR2","ortholog_annotations":[{"gene_uniquename":"YPL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01120","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01120","reference_uniquename":"PMID:26896847"}],"product":"Core component of the TIM23 protein translocase complex; couples Tim21 with the core Tim23 translocase; provides quality control for membrane protein insertion, regulating their release into the inner membrane by the TIM23 complex; required for mitochondrial import of presequence-containing proteins at elevated temperature; forms the translocation path with Tim17p, sealing the lateral opening of the Tim17p cavity; required for viability of cells lacking the mitochondrial genome (petite-negative)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL098C"}


id: YPL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07008":null,"YPL099C":null},"has_protein_features":false,"name":"INA17","ortholog_annotations":[{"gene_uniquename":"YPL099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07008","reference_uniquename":"PMID:29761456"}],"product":"F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL099C"}


id: YPL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG21","product":"Phosphoinositide binding protein; required for vesicle formation in cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both Atg12-Atg5-Atg16 complex and Atg8p at pre-autophagosomal structure; necessary for oxidant-induced cell death; targeted to vacuole via AP-3 pathway; WD-40 repeat containing PROPPIN family member","secondary_identifier":"SGD:S000006021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL100W"}


id: YPL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03677":null,"YPL101W":null},"has_protein_features":false,"name":"ELP4","ortholog_annotations":[{"gene_uniquename":"YPL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03677","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03677","reference_uniquename":"PMID:26896847"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL101W"}


id: YPL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4","secondary_identifier":"SGD:S000006023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL102C"}


id: YPL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP30","product":"Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D","secondary_identifier":"SGD:S000006024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL103C"}


id: YPL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04094":null,"YPL104W":null},"has_protein_features":false,"name":"MSD1","ortholog_annotations":[{"gene_uniquename":"YPL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04094","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04094","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL104W"}


id: YPL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01279":null,"YPL105C":null},"has_protein_features":false,"name":"SYH1","ortholog_annotations":[{"gene_uniquename":"YPL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL105C"}


id: YPL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04511":null,"YPL106C":null},"has_protein_features":false,"name":"SSE1","ortholog_annotations":[{"gene_uniquename":"YPL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:26896847"}],"product":"ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL106C"}


id: YPL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02559":null,"YPL107W":null},"has_protein_features":false,"name":"DPC25","ortholog_annotations":[{"gene_uniquename":"YPL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02559","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02559","reference_uniquename":"PMID:26896847"}],"product":"Putative mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; DPC25 is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL107W"}


id: YPL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000006029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL108W"}


id: YPL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00496":null,"YPL109C":null},"has_protein_features":false,"name":"CQD1","ortholog_annotations":[{"gene_uniquename":"YPL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00496","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00496","reference_uniquename":"PMID:26896847"}],"product":"UbiB protein kinase-like family member; mitochondrial inner membrane protein that interacts with outer membrane proteins Por1p and Om14p to form a MICOS-independent mitochondrial contact site; role in mitochondrial organization; contributes to mitochondrial lipid homeostasis; controls the cellular distribution of coenzyme Q (CoQ); contains a potential mitochondrial targeting sequence and predicted transmembrane domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL109C"}


id: YPL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00622":null,"YPL110C":null},"has_protein_features":false,"name":"GDE1","ortholog_annotations":[{"gene_uniquename":"YPL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00622","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00622","reference_uniquename":"PMID:26896847"}],"product":"Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL110C"}


id: YPL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03398":null,"YPL111W":null},"has_protein_features":false,"name":"CAR1","ortholog_annotations":[{"gene_uniquename":"YPL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03398","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03398","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03398","reference_uniquename":"PMID:26896847"}],"product":"Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL111W"}


id: YPL112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX25","product":"Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL112C"}


id: YPL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene","secondary_identifier":"SGD:S000006034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL113C"}


id: YPL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index","secondary_identifier":"SGD:S000006035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL114W"}


id: YPL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02278":null,"YPL115C":null},"has_protein_features":false,"name":"BEM3","ortholog_annotations":[{"gene_uniquename":"YPL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02278","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02278","reference_uniquename":"PMID:26896847"}],"product":"Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL115C"}


id: YPL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOS3","product":"Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats","secondary_identifier":"SGD:S000006037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL116W"}


id: YPL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04307":null,"YPL117C":null},"has_protein_features":false,"name":"IDI1","ortholog_annotations":[{"gene_uniquename":"YPL117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04307","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04307","reference_uniquename":"PMID:26896847"}],"product":"Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL117C"}


id: YPL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00105":null,"SJAG_02201":null,"YPL118W":null},"has_protein_features":false,"name":"MRP51","ortholog_annotations":[{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00105","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02201","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL118W"}


id: YPL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00786":null,"YPL119C":null},"has_protein_features":false,"name":"DBP1","ortholog_annotations":[{"gene_uniquename":"YPL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:26896847"}],"product":"ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C"}


id: YPL119C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C-A"}


id: YPL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01876":null,"YPL120W":null},"has_protein_features":false,"name":"VPS30","ortholog_annotations":[{"gene_uniquename":"YPL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01876","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01876","reference_uniquename":"PMID:26896847"}],"product":"Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL120W"}


id: YPL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01495":null,"SJAG_01708":null,"YPL121C":null},"has_protein_features":false,"name":"MEI5","ortholog_annotations":[{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01495","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01708","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL121C"}


id: YPL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00901":null,"YPL122C":null},"has_protein_features":false,"name":"TFB2","ortholog_annotations":[{"gene_uniquename":"YPL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00901","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00901","reference_uniquename":"PMID:26896847"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL122C"}


id: YPL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RNY1","product":"Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity","secondary_identifier":"SGD:S000006044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL123C"}


id: YPL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPC29","product":"Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication","secondary_identifier":"SGD:S000006045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL124W"}


id: YPL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01083":null,"YPL125W":null},"has_protein_features":false,"name":"KAP120","ortholog_annotations":[{"gene_uniquename":"YPL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01083","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01083","reference_uniquename":"PMID:26896847"}],"product":"Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL125W"}


id: YPL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01764":null,"YPL126W":null},"has_protein_features":false,"name":"NAN1","ortholog_annotations":[{"gene_uniquename":"YPL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01764","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01764","reference_uniquename":"PMID:26896847"}],"product":"U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; localizes to nucleolus and peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL126W"}


id: YPL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HHO1","product":"Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination","secondary_identifier":"SGD:S000006048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL127C"}


id: YPL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02212":null,"YPL128C":null},"has_protein_features":false,"name":"TBF1","ortholog_annotations":[{"gene_uniquename":"YPL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02212","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02212","reference_uniquename":"PMID:26896847"}],"product":"Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; involved in nucleosome displacement during double-strand break repair","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL128C"}


id: YPL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00735":null,"YPL129W":null},"has_protein_features":false,"name":"TAF14","ortholog_annotations":[{"gene_uniquename":"YPL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:26896847"}],"product":"Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; serves as an additional DNA binding domain for the complex; contains a YEATS domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL129W"}


id: YPL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO19","product":"Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL130W"}


id: YPL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01568":null,"SJAG_04066":null,"YPL131W":null},"has_protein_features":false,"name":"RPL5","ortholog_annotations":[{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04066","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04066","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL131W"}


id: YPL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03322":null,"YPL132W":null},"has_protein_features":false,"name":"COX11","ortholog_annotations":[{"gene_uniquename":"YPL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:26896847"}],"product":"Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; involved in oxidative stress response; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL132W"}


id: YPL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RDS2","product":"Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole","secondary_identifier":"SGD:S000006054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL133C"}


id: YPL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00522":null,"YPL134C":null},"has_protein_features":false,"name":"ODC1","ortholog_annotations":[{"gene_uniquename":"YPL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL134C"}


id: YPL135C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135C-A"}


id: YPL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00532":null,"YPL135W":null},"has_protein_features":false,"name":"ISU1","ortholog_annotations":[{"gene_uniquename":"YPL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:26896847"}],"product":"Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135W"}


id: YPL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C","secondary_identifier":"SGD:S000006057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL136W"}


id: YPL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIP3","product":"Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL137C"}


id: YPL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01325":null,"YPL138C":null},"has_protein_features":false,"name":"SPP1","ortholog_annotations":[{"gene_uniquename":"YPL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01325","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01325","reference_uniquename":"PMID:26896847"}],"product":"Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL138C"}


id: YPL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04758":null,"YPL139C":null},"has_protein_features":false,"name":"UME1","ortholog_annotations":[{"gene_uniquename":"YPL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL139C"}


id: YPL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01181":null,"YPL140C":null},"has_protein_features":false,"name":"MKK2","ortholog_annotations":[{"gene_uniquename":"YPL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:26896847"}],"product":"MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL140C"}


id: YPL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04507":null,"YPL141C":null},"has_protein_features":false,"name":"FRK1","ortholog_annotations":[{"gene_uniquename":"YPL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04507","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; minor role relative to Kin4p in regulating peroxisomal transport and vacuolar inheritance; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL141C"}


id: YPL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit","secondary_identifier":"SGD:S000006063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL142C"}


id: YPL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00166":null,"SJAG_04414":null,"YPL143W":null},"has_protein_features":false,"name":"RPL33A","ortholog_annotations":[{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL143W"}


id: YPL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04197":null,"YPL144W":null},"has_protein_features":false,"name":"POC4","ortholog_annotations":[{"gene_uniquename":"YPL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04197","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL144W"}


id: YPL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YPL145C":null},"has_protein_features":false,"name":"KES1","ortholog_annotations":[{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger; one of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL145C"}


id: YPL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00323":null,"YPL146C":null},"has_protein_features":false,"name":"NOP53","ortholog_annotations":[{"gene_uniquename":"YPL146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00323","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL146C"}


id: YPL147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PXA1","product":"Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant","secondary_identifier":"SGD:S000006068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL147W"}


id: YPL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03180":null,"YPL148C":null},"has_protein_features":false,"name":"PPT2","ortholog_annotations":[{"gene_uniquename":"YPL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03180","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL148C"}


id: YPL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00059":null,"YPL149W":null},"has_protein_features":false,"name":"ATG5","ortholog_annotations":[{"gene_uniquename":"YPL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00059","reference_uniquename":"PMID:26896847"}],"product":"Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL149W"}


id: YPL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02760":null,"YPL150W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02760","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02760","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL150W"}


id: YPL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04694":null,"YPL151C":null},"has_protein_features":false,"name":"PRP46","ortholog_annotations":[{"gene_uniquename":"YPL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04694","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04694","reference_uniquename":"PMID:26896847"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL151C"}


id: YPL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00078":null,"YPL152W":null},"has_protein_features":false,"name":"RRD2","ortholog_annotations":[{"gene_uniquename":"YPL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00078","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00078","reference_uniquename":"PMID:26896847"}],"product":"Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W"}


id: YPL152W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W-A"}


id: YPL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04287":null,"YPL153C":null},"has_protein_features":false,"name":"RAD53","ortholog_annotations":[{"gene_uniquename":"YPL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04287","reference_uniquename":"PMID:26896847"}],"product":"DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL153C"}


id: YPL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEP4","product":"Vacuolar aspartyl protease (proteinase A); required for post-translational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway","secondary_identifier":"SGD:S000006075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL154C"}


id: YPL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00851":null,"SJAG_01297":null,"SJAG_02336":null,"YPL155C":null},"has_protein_features":false,"name":"KIP2","ortholog_annotations":[{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01297","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02336","reference_uniquename":"PMID:26896847"}],"product":"Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL155C"}


id: YPL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM4","product":"Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift","secondary_identifier":"SGD:S000006077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL156C"}


id: YPL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03901":null,"YPL157W":null},"has_protein_features":false,"name":"TGS1","ortholog_annotations":[{"gene_uniquename":"YPL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03901","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03901","reference_uniquename":"PMID:26896847"}],"product":"Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL157W"}


id: YPL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM44","product":"Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress","secondary_identifier":"SGD:S000006079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL158C"}


id: YPL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET20","product":"Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome; subunit of a complex containing Mrx6p, Pim1p, and Mam33p that may regulate mtDNA replication","secondary_identifier":"SGD:S000006080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL159C"}


id: YPL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02015":null,"YPL160W":null},"has_protein_features":false,"name":"CDC60","ortholog_annotations":[{"gene_uniquename":"YPL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02015","reference_uniquename":"PMID:26896847"}],"product":"Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL160W"}


id: YPL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04653":null,"YPL161C":null},"has_protein_features":false,"name":"BEM4","ortholog_annotations":[{"gene_uniquename":"YPL161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04653","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishment of cell polarity and bud emergence; regulates filamentous-growth mitogen-activated protein kinase (MAPK) pathway; interacts with the Rho1p small GTP-binding protein, the pleckstrin homology (PH) domain of Cdc24p, and with the Rho-type GTPase Cdc42p; stabilizes Cdc42p levels, resulting in elevated fMAPK pathway signaling; involved in maintenance of proper telomere length","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL161C"}


id: YPL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology","secondary_identifier":"SGD:S000006083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL162C"}


id: YPL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SVS1","product":"Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL163C"}


id: YPL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLH3","product":"Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability","secondary_identifier":"SGD:S000006085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL164C"}


id: YPL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02659":null,"YPL165C":null},"has_protein_features":false,"name":"SET6","ortholog_annotations":[{"gene_uniquename":"YPL165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02659","reference_uniquename":"PMID:29761456"}],"product":"SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL165C"}


id: YPL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG29","product":"Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000006087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL166W"}


id: YPL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00153":null,"YPL167C":null},"has_protein_features":false,"name":"REV3","ortholog_annotations":[{"gene_uniquename":"YPL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00153","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00153","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of DNA polymerase zeta (pol zeta); involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev7p, Pol31p and Pol32p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL167C"}


id: YPL168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX4","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated","secondary_identifier":"SGD:S000006089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL168W"}


id: YPL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00178":null,"YPL169C":null},"has_protein_features":false,"name":"MEX67","ortholog_annotations":[{"gene_uniquename":"YPL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00178","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00178","reference_uniquename":"PMID:26896847"}],"product":"Poly(A) RNA binding protein involved in nuclear mRNA export; component of the nuclear pore and nuclear RNA export factor; ubiquitin-associated (UBA) domain interacts with Mip6p; ortholog of human TAP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL169C"}


id: YPL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02982":null,"YPL170W":null},"has_protein_features":false,"name":"DAP1","ortholog_annotations":[{"gene_uniquename":"YPL170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02982","reference_uniquename":"PMID:29761456"}],"product":"Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL170W"}


id: YPL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OYE3","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death","secondary_identifier":"SGD:S000006092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL171C"}


id: YPL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03173":null,"YPL172C":null},"has_protein_features":false,"name":"COX10","ortholog_annotations":[{"gene_uniquename":"YPL172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03173","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03173","reference_uniquename":"PMID:26896847"}],"product":"Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL172C"}


id: YPL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04490":null,"YPL173W":null},"has_protein_features":false,"name":"MRPL40","ortholog_annotations":[{"gene_uniquename":"YPL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04490","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL173W"}


id: YPL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00140":null,"YPL174C":null},"has_protein_features":false,"name":"NIP100","ortholog_annotations":[{"gene_uniquename":"YPL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00140","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00140","reference_uniquename":"PMID:26896847"}],"product":"Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL174C"}


id: YPL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04881":null,"YPL175W":null},"has_protein_features":false,"name":"SPT14","ortholog_annotations":[{"gene_uniquename":"YPL175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04881","reference_uniquename":"PMID:29761456"}],"product":"UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL175W"}


id: YPL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02117":null,"YPL176C":null},"has_protein_features":false,"name":"TRE1","ortholog_annotations":[{"gene_uniquename":"YPL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:26896847"}],"product":"Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL176C"}


id: YPL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CUP9","product":"Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000006098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL177C"}


id: YPL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01064":null,"YPL178W":null},"has_protein_features":false,"name":"CBC2","ortholog_annotations":[{"gene_uniquename":"YPL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01064","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL178W"}


id: YPL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04426":null,"YPL179W":null},"has_protein_features":false,"name":"PPQ1","ortholog_annotations":[{"gene_uniquename":"YPL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL179W"}


id: YPL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01703":null,"YPL180W":null},"has_protein_features":false,"name":"TCO89","ortholog_annotations":[{"gene_uniquename":"YPL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01703","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL180W"}


id: YPL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03255":null,"YPL181W":null},"has_protein_features":false,"name":"CTI6","ortholog_annotations":[{"gene_uniquename":"YPL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03255","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03255","reference_uniquename":"PMID:26896847"}],"product":"Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL181W"}


id: YPL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W","secondary_identifier":"SGD:S000006103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL182C"}


id: YPL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02352":null,"YPL183C":null},"has_protein_features":false,"name":"RTT10","ortholog_annotations":[{"gene_uniquename":"YPL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02352","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02352","reference_uniquename":"PMID:26896847"}],"product":"WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183C"}


id: YPL183W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03040":null,"YPL183W-A":null},"has_protein_features":false,"name":"RTC6","ortholog_annotations":[{"gene_uniquename":"YPL183W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03040","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183W-A"}


id: YPL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRN1","product":"mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation","secondary_identifier":"SGD:S000006105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL184C"}


id: YPL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C","secondary_identifier":"SGD:S000006106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL185W"}


id: YPL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UIP4","product":"Protein required for nuclear envelope integrity; involved in distribution of nuclear pore complexes; interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope","secondary_identifier":"SGD:S000006107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL186C"}


id: YPL187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MF(ALPHA)1","product":"Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions","secondary_identifier":"SGD:S000006108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL187W"}


id: YPL188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03946":null,"YPL188W":null},"has_protein_features":false,"name":"POS5","ortholog_annotations":[{"gene_uniquename":"YPL188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03946","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL188W"}


id: YPL189C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COA2","product":"Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p","secondary_identifier":"SGD:S000028527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189C-A"}


id: YPL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04337":null,"YPL189W":null},"has_protein_features":false,"name":"GUP2","ortholog_annotations":[{"gene_uniquename":"YPL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04337","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04337","reference_uniquename":"PMID:26896847"}],"product":"Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189W"}


id: YPL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03747":null,"YPL190C":null},"has_protein_features":false,"name":"NAB3","ortholog_annotations":[{"gene_uniquename":"YPL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03747","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03747","reference_uniquename":"PMID:26896847"}],"product":"RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL190C"}


id: YPL191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01481":null,"YPL191C":null},"has_protein_features":false,"name":"MIY2","ortholog_annotations":[{"gene_uniquename":"YPL191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01481","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01481","reference_uniquename":"PMID:26896847"}],"product":"K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL191C"}


id: YPL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM3","product":"Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body","secondary_identifier":"SGD:S000006113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL192C"}


id: YPL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05679":null,"YPL193W":null},"has_protein_features":false,"name":"RSA1","ortholog_annotations":[{"gene_uniquename":"YPL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05679","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL193W"}


id: YPL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01605":null,"YPL194W":null},"has_protein_features":false,"name":"DDC1","ortholog_annotations":[{"gene_uniquename":"YPL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01605","reference_uniquename":"PMID:29761456"}],"product":"DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL194W"}


id: YPL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00108":null,"YPL195W":null},"has_protein_features":false,"name":"APL5","ortholog_annotations":[{"gene_uniquename":"YPL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00108","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00108","reference_uniquename":"PMID:26896847"}],"product":"Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL195W"}


id: YPL196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02470":null,"YPL196W":null},"has_protein_features":false,"name":"OXR1","ortholog_annotations":[{"gene_uniquename":"YPL196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02470","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02470","reference_uniquename":"PMID:26896847"}],"product":"Protein that regulates the vacuolar V-ATPase; inhibits V1-ATPase activity and triggers ATP-dependent disassembly of the V-ATPase holoenzyme, counteracting the function of the RAVE complex; localizes to the cytoplasm; required for retention of the vacuolar-ATPase V0 domain subunit Stv1p in pre-vacuolar compartments; involved in resistance to oxidative damage; member of a conserved family of TLDc domain proteins found in eukaryotes; contains an N-terminal EF-hand-like domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL196W"}


id: YPL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPL7B","secondary_identifier":"SGD:S000006118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL197C"}


id: YPL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01551":null,"SJAG_03425":null,"YPL198W":null},"has_protein_features":false,"name":"RPL7B","ortholog_annotations":[{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL198W"}


id: YPL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01979":null,"YPL199C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL199C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01979","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL199C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01979","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in nonstop mRNA decay; predicted to be palmitoylated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL199C"}


id: YPL200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSM4","product":"Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL200W"}


id: YPL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YIG1","product":"Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol","secondary_identifier":"SGD:S000006122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL201C"}


id: YPL202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFT2","product":"Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL202C"}


id: YPL203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04312":null,"YPL203W":null},"has_protein_features":false,"name":"TPK2","ortholog_annotations":[{"gene_uniquename":"YPL203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; promotes nutrient responsive growth via the Ras-cAMP signaling pathway; phosphorylates and inhibits histone demethylase Jhd2p in response to glucose, promoting H3K4 trimethylation and maintaining H3K14 acetylation by preventing chromatin binding of Rpd3p; required for Sfl1p-mediated pseudohyphal growth; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL203W"}


id: YPL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02104":null,"SJAG_04457":null,"YPL204W":null},"has_protein_features":false,"name":"HRR25","ortholog_annotations":[{"gene_uniquename":"YPL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02104","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04457","reference_uniquename":"PMID:29761456"}],"product":"Conserved casein kinase, monopolin subunit; regulates diverse events including vesicular traffic, DNA repair, CVT pathway, cohesion cleavage, attachment of sister kinetochores at meiosis I, exit from meiosis II, and ribosomal subunit biogenesis; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p; homolog of mammalian CK1delta","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL204W"}


id: YPL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Hypothetical protein; deletion of locus affects telomere length","secondary_identifier":"SGD:S000006126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL205C"}


id: YPL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02161":null,"YPL206C":null},"has_protein_features":false,"name":"PGC1","ortholog_annotations":[{"gene_uniquename":"YPL206C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02161","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL206C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02161","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL206C"}


id: YPL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04265":null,"YPL207W":null},"has_protein_features":false,"name":"TYW1","ortholog_annotations":[{"gene_uniquename":"YPL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04265","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04265","reference_uniquename":"PMID:26896847"}],"product":"Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL207W"}


id: YPL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YPL208W":null},"has_protein_features":false,"name":"RKM1","ortholog_annotations":[{"gene_uniquename":"YPL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:26896847"}],"product":"SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL208W"}


id: YPL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01837":null,"YPL209C":null},"has_protein_features":false,"name":"IPL1","ortholog_annotations":[{"gene_uniquename":"YPL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01837","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01837","reference_uniquename":"PMID:26896847"}],"product":"Aurora kinase of the chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in MI, and kinetochore release from SPB clusters during meiotic exit; maintains meiotic spindle checkpoint delay in a mek1 null; maintains condensed chromosomes in anaphase; required for SPB cohesion and preventing multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; inhibits Pse1p upon SAC arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL209C"}


id: YPL210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01840":null,"YPL210C":null},"has_protein_features":false,"name":"SRP72","ortholog_annotations":[{"gene_uniquename":"YPL210C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL210C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01840","reference_uniquename":"PMID:26896847"}],"product":"Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL210C"}


id: YPL211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01839":null,"YPL211W":null},"has_protein_features":false,"name":"NIP7","ortholog_annotations":[{"gene_uniquename":"YPL211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01839","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL211W"}


id: YPL212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00088":null,"SJAG_00319":null,"YPL212C":null},"has_protein_features":false,"name":"PUS1","ortholog_annotations":[{"gene_uniquename":"YPL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00088","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:26896847"}],"product":"tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL212C"}


id: YPL213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03210":null,"YPL213W":null},"has_protein_features":false,"name":"LEA1","ortholog_annotations":[{"gene_uniquename":"YPL213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03210","reference_uniquename":"PMID:26896847"}],"product":"Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL213W"}


id: YPL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00381":null,"YPL214C":null},"has_protein_features":false,"name":"THI6","ortholog_annotations":[{"gene_uniquename":"YPL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00381","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00381","reference_uniquename":"PMID:26896847"}],"product":"Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL214C"}


id: YPL215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01141":null,"YPL215W":null},"has_protein_features":false,"name":"CBP3","ortholog_annotations":[{"gene_uniquename":"YPL215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01141","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL215W"}


id: YPL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL216W"}


id: YPL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03846":null,"YPL217C":null},"has_protein_features":false,"name":"BMS1","ortholog_annotations":[{"gene_uniquename":"YPL217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03846","reference_uniquename":"PMID:29761456"}],"product":"GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL217C"}


id: YPL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00906":null,"YPL218W":null},"has_protein_features":false,"name":"SAR1","ortholog_annotations":[{"gene_uniquename":"YPL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00906","reference_uniquename":"PMID:29761456"}],"product":"ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL218W"}


id: YPL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL8","product":"Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL219W"}


id: YPL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02531":null,"SJAG_03122":null,"YPL220W":null},"has_protein_features":false,"name":"RPL1A","ortholog_annotations":[{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02531","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02531","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03122","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03122","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL220W"}


id: YPL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02727":null,"SJAG_04668":null,"YPL221W":null},"has_protein_features":false,"name":"FLC1","ortholog_annotations":[{"gene_uniquename":"YPL221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02727","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:26896847"}],"product":"Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL221W"}


id: YPL222C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL222C-A"}


id: YPL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP40","product":"Mitochondrial AMPylator in the pseudokinase selenoprotein-O family; role in the oxidative stress response, transferring AMP from ATP to protein substrates (AMPylation) involved in redox homeostasis; regulates S-glutathionylation levels; proposed involvement in the environmental stress response","secondary_identifier":"SGD:S000006143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL222W"}


id: YPL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GRE1","product":"Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL223C"}


id: YPL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04260":null,"YPL224C":null},"has_protein_features":false,"name":"MMT2","ortholog_annotations":[{"gene_uniquename":"YPL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04260","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04260","reference_uniquename":"PMID:26896847"}],"product":"Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL224C"}


id: YPL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02030":null,"YPL225W":null},"has_protein_features":false,"name":"CHP1","ortholog_annotations":[{"gene_uniquename":"YPL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02030","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02030","reference_uniquename":"PMID:26896847"}],"product":"Chaperone for eEF1A; ribosome-associated chaperone dedicated to facilitating high-level expression of eEF1A; transiently binds nascent GTPase domain of eEF1A as soon as it emerges from ribosome tunnel; forms complex with NAC by binding UBA domain of Egd2p; inactivation results in disturbed proteostasis and Hsf1p activation due to abberant eEF1A biogenesis; overlapping phenotypes support notion that Chp1p functions in same eEF1A biogenesis pathway as chaperone Zpr1p-Aim29p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL225W"}


id: YPL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02704":null,"YPL226W":null},"has_protein_features":false,"name":"NEW1","ortholog_annotations":[{"gene_uniquename":"YPL226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02704","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02704","reference_uniquename":"PMID:26896847"}],"product":"Translation termination and ribosome biogenesis factor; ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL226W"}


id: YPL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00394":null,"YPL227C":null},"has_protein_features":false,"name":"ALG5","ortholog_annotations":[{"gene_uniquename":"YPL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00394","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00394","reference_uniquename":"PMID:26896847"}],"product":"UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL227C"}


id: YPL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04488":null,"YPL228W":null},"has_protein_features":false,"name":"CET1","ortholog_annotations":[{"gene_uniquename":"YPL228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04488","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04488","reference_uniquename":"PMID:26896847"}],"product":"RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL228W"}


id: YPL229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL229W"}


id: YPL230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"USV1","product":"Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL230W"}


id: YPL231W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04972":null,"YPL231W":null},"has_protein_features":false,"name":"FAS2","ortholog_annotations":[{"gene_uniquename":"YPL231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04972","reference_uniquename":"PMID:26896847"}],"product":"Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL231W"}


id: YPL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03536":null,"YPL232W":null},"has_protein_features":false,"name":"SSO1","ortholog_annotations":[{"gene_uniquename":"YPL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03536","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03536","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL232W"}


id: YPL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01228":null,"YPL233W":null},"has_protein_features":false,"name":"NSL1","ortholog_annotations":[{"gene_uniquename":"YPL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01228","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL233W"}


id: YPL234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03406":null,"YPL234C":null},"has_protein_features":false,"name":"VMA11","ortholog_annotations":[{"gene_uniquename":"YPL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03406","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03406","reference_uniquename":"PMID:26896847"}],"product":"Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL234C"}


id: YPL235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03036":null,"YPL235W":null},"has_protein_features":false,"name":"RVB2","ortholog_annotations":[{"gene_uniquename":"YPL235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03036","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL235W"}


id: YPL236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03386":null,"YPL236C":null},"has_protein_features":false,"name":"ENV7","ortholog_annotations":[{"gene_uniquename":"YPL236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03386","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03386","reference_uniquename":"PMID:26896847"}],"product":"Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; targeted to vacuole via AP-3 pathway; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL236C"}


id: YPL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05003":null,"YPL237W":null},"has_protein_features":false,"name":"SUI3","ortholog_annotations":[{"gene_uniquename":"YPL237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05003","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05003","reference_uniquename":"PMID:26896847"}],"product":"Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL237W"}


id: YPL238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W","secondary_identifier":"SGD:S000006159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL238C"}


id: YPL239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04611":null,"YPL239W":null},"has_protein_features":false,"name":"YAR1","ortholog_annotations":[{"gene_uniquename":"YPL239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04611","reference_uniquename":"PMID:29761456"}],"product":"Nucleocytoplasmic shuttling assembly chaperone; co-translationally associates with nascent Rps3p in the cytoplasm and delivers it to pre-ribosomal subunits in the nucleus; required for 40S ribosomal subunit nuclear export, biogenesis and adaptation to osmotic and oxidative stress;  contains ankyrin-repeats; expression repressed by heat shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL239W"}


id: YPL240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01664":null,"YPL240C":null},"has_protein_features":false,"name":"HSP82","ortholog_annotations":[{"gene_uniquename":"YPL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01664","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01664","reference_uniquename":"PMID:26896847"}],"product":"Hsp90 chaperone; functionally redundant with Hsc82p; required for pheromone signaling; negative regulator of the Hsf1p-dependent heat shock response with Cpr7p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; promotes solubility of chaperone-substrate complexes; DNA damage induced nuclear import is Aha1p dependent; protein abundance increases in response to DNA replication stress; human homolog, HSP90AB1, complements null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL240C"}


id: YPL241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01526":null,"YPL241C":null},"has_protein_features":false,"name":"CIN2","ortholog_annotations":[{"gene_uniquename":"YPL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01526","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL241C"}


id: YPL242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02379":null,"SJAG_04080":null,"SJAG_04498":null,"YPL242C":null},"has_protein_features":false,"name":"IQG1","ortholog_annotations":[{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02379","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04080","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04498","reference_uniquename":"PMID:29761456"}],"product":"Actin filament binding protein that enhances actin ring formation; IQGAP family member required for assembly and contraction of the AMR, prior to cytokinesis; localizes to the contractile ring during anaphase in an Mlc1p-dependent manner, recruiting Myo1p and Hof1p to the site, and promoting cytokinetic core complex assembly; specifies bud-site selection, localizing axial markers Bud4p and Cdc12p; regulated by Cdc28p; relocalizes from the bud neck to the cytoplasm upon replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL242C"}


id: YPL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01759":null,"YPL243W":null},"has_protein_features":false,"name":"SRP68","ortholog_annotations":[{"gene_uniquename":"YPL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01759","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01759","reference_uniquename":"PMID:26896847"}],"product":"Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL243W"}


id: YPL244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04162":null,"YPL244C":null},"has_protein_features":false,"name":"HUT1","ortholog_annotations":[{"gene_uniquename":"YPL244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04162","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL244C"}


id: YPL245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm","secondary_identifier":"SGD:S000006166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL245W"}


id: YPL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01285":null,"SJAG_05286":null,"YPL246C":null},"has_protein_features":false,"name":"RBD2","ortholog_annotations":[{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01285","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01285","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05286","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05286","reference_uniquename":"PMID:26896847"}],"product":"Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL246C"}


id: YPL247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04087":null,"YPL247C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04087","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL247C"}


id: YPL248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAL4","product":"DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p","secondary_identifier":"SGD:S000006169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL248C"}


id: YPL249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00092":null,"SJAG_02012":null,"YPL249C":null},"has_protein_features":false,"name":"GYP5","ortholog_annotations":[{"gene_uniquename":"YPL249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00092","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02012","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL249C"}


id: YPL249C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02121":null,"SJAG_03133":null,"YPL249C-A":null},"has_protein_features":false,"name":"RPL36B","ortholog_annotations":[{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02121","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02121","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03133","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL249C-A"}


id: YPL250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG41","product":"Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL250C"}


id: YPL250W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL250W-A"}


id: YPL251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C","secondary_identifier":"SGD:S000006172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL251W"}


id: YPL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04397":null,"YPL252C":null},"has_protein_features":false,"name":"YAH1","ortholog_annotations":[{"gene_uniquename":"YPL252C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04397","reference_uniquename":"PMID:29761456"}],"product":"Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL252C"}


id: YPL253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VIK1","product":"Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL253C"}


id: YPL254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03776":null,"YPL254W":null},"has_protein_features":false,"name":"HFI1","ortholog_annotations":[{"gene_uniquename":"YPL254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03776","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03776","reference_uniquename":"PMID:26896847"}],"product":"Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL254W"}


id: YPL255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BBP1","product":"Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p","secondary_identifier":"SGD:S000006176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL255W"}


id: YPL256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CLN2","product":"G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1","secondary_identifier":"SGD:S000006177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL256C"}


id: YPL257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene","secondary_identifier":"SGD:S000006178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL257W"}


id: YPL258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YPL258C":null},"has_protein_features":false,"name":"THI21","ortholog_annotations":[{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:26896847"}],"product":"Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL258C"}


id: YPL259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04609":null,"YPL259C":null},"has_protein_features":false,"name":"APM1","ortholog_annotations":[{"gene_uniquename":"YPL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04609","reference_uniquename":"PMID:26896847"}],"product":"Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL259C"}


id: YPL260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00049":null,"YPL260W":null},"has_protein_features":false,"name":"CUB1","ortholog_annotations":[{"gene_uniquename":"YPL260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00049","reference_uniquename":"PMID:26896847"}],"product":"Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL260W"}


id: YPL261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W","secondary_identifier":"SGD:S000006182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL261C"}


id: YPL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04843":null,"YPL262W":null},"has_protein_features":false,"name":"FUM1","ortholog_annotations":[{"gene_uniquename":"YPL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04843","reference_uniquename":"PMID:26896847"}],"product":"Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL262W"}


id: YPL263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KEL3","product":"Cytoplasmic protein of unknown function","secondary_identifier":"SGD:S000006184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL263C"}


id: YPL264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01177":null,"SJAG_04697":null,"YPL264C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01177","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04697","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL264C"}


id: YPL265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02955":null,"YPL265W":null},"has_protein_features":false,"name":"DIP5","ortholog_annotations":[{"gene_uniquename":"YPL265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02955","reference_uniquename":"PMID:29761456"}],"product":"Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL265W"}


id: YPL266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02821":null,"YPL266W":null},"has_protein_features":false,"name":"DIM1","ortholog_annotations":[{"gene_uniquename":"YPL266W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02821","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL266W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02821","reference_uniquename":"PMID:26896847"}],"product":"Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL266W"}


id: YPL267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ACM1","product":"Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C","secondary_identifier":"SGD:S000006188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL267W"}


id: YPL268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00321":null,"YPL268W":null},"has_protein_features":false,"name":"PLC1","ortholog_annotations":[{"gene_uniquename":"YPL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00321","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00321","reference_uniquename":"PMID:26896847"}],"product":"Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL268W"}


id: YPL269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KAR9","product":"Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli","secondary_identifier":"SGD:S000006190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL269W"}


id: YPL270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDL2","product":"Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis","secondary_identifier":"SGD:S000006191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL270W"}


id: YPL271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00915":null,"YPL271W":null},"has_protein_features":false,"name":"ATP15","ortholog_annotations":[{"gene_uniquename":"YPL271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00915","reference_uniquename":"PMID:29761456"}],"product":"Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL271W"}


id: YPL272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PBI1","product":"Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene","secondary_identifier":"SGD:S000006193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL272C"}


id: YPL273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04425":null,"YPL273W":null},"has_protein_features":false,"name":"SAM4","ortholog_annotations":[{"gene_uniquename":"YPL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:26896847"}],"product":"S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL273W"}


id: YPL274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAM3","product":"High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p","secondary_identifier":"SGD:S000006195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL274W"}


id: YPL277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels","secondary_identifier":"SGD:S000006198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL277C"}


id: YPL278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; gene expression regulated by copper levels","secondary_identifier":"SGD:S000006199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL278C"}


id: YPL279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01973":null,"YPL279C":null},"has_protein_features":false,"name":"FEX2","ortholog_annotations":[{"gene_uniquename":"YPL279C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL279C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL279C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL279C"}


id: YPL280W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YPL280W":null},"has_protein_features":false,"name":"HSP32","ortholog_annotations":[{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:26896847"}],"product":"Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL280W"}


id: YPL281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YPL281C":null},"has_protein_features":false,"name":"ERR2","ortholog_annotations":[{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:26896847"}],"product":"Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL281C"}


id: YPL282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU22","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; identical to Pau21p; encodes two proteins that are translated from two different start codons","secondary_identifier":"SGD:S000006203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL282C"}


id: YPL283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-7","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000006204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283C"}


id: YPL283W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283W-A"}


id: YPL283W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283W-B"}


id: YPR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIT3","product":"Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate","secondary_identifier":"SGD:S000006205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR001W"}


id: YPR002C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12","secondary_identifier":"SGD:S000007254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR002C-A"}


id: YPR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDH1","product":"Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate","secondary_identifier":"SGD:S000006206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR002W"}


id: YPR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01941":null,"YPR003C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01941","reference_uniquename":"PMID:29761456"}],"product":"Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR003C"}


id: YPR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM45","product":"Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit","secondary_identifier":"SGD:S000006208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR004C"}


id: YPR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAL1","product":"Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p","secondary_identifier":"SGD:S000006209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR005C"}


id: YPR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICL2","product":"2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol","secondary_identifier":"SGD:S000006210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR006C"}


id: YPR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03926":null,"YPR007C":null},"has_protein_features":false,"name":"REC8","ortholog_annotations":[{"gene_uniquename":"YPR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03926","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR007C"}


id: YPR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00802":null,"SJAG_01694":null,"YPR008W":null},"has_protein_features":false,"name":"HAA1","ortholog_annotations":[{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR008W"}


id: YPR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUT2","product":"Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR009W"}


id: YPR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03578":null,"YPR010C":null},"has_protein_features":false,"name":"RPA135","ortholog_annotations":[{"gene_uniquename":"YPR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03578","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03578","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase I second largest subunit A135","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR010C"}


id: YPR010C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04450":null,"SJAG_06392":null,"YPR010C-A":null},"has_protein_features":false,"name":"MRA1","ortholog_annotations":[{"gene_uniquename":"YPR010C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04450","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR010C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06392","reference_uniquename":"PMID:29761456"}],"product":"Protein that negatively regulates respiratory complex assembly; associated with the inner mitochondrial membrane; antagonistic with Rcf2p to control ETC assembly; conserved among Saccharomyces sensu stricto species","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000122558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR010C-A"}


id: YPR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03334":null,"YPR011C":null},"has_protein_features":false,"name":"MRX21","ortholog_annotations":[{"gene_uniquename":"YPR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03334","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03334","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR011C"}


id: YPR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene","secondary_identifier":"SGD:S000006216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR012W"}


id: YPR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CMR3","product":"Putative zinc finger protein; YPR013C is not an essential gene","secondary_identifier":"SGD:S000006217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR013C"}


id: YPR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YPR014C is not an essential gene","secondary_identifier":"SGD:S000006218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR014C"}


id: YPR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000006219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR015C"}


id: YPR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03012":null,"YPR016C":null},"has_protein_features":false,"name":"TIF6","ortholog_annotations":[{"gene_uniquename":"YPR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03012","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR016C"}


id: YPR016W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR016W-A"}


id: YPR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03142":null,"YPR017C":null},"has_protein_features":false,"name":"DSS4","ortholog_annotations":[{"gene_uniquename":"YPR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03142","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR017C"}


id: YPR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04272":null,"YPR018W":null},"has_protein_features":false,"name":"RLF2","ortholog_annotations":[{"gene_uniquename":"YPR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04272","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04272","reference_uniquename":"PMID:26896847"}],"product":"Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of  DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR018W"}


id: YPR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04210":null,"YPR019W":null},"has_protein_features":false,"name":"MCM4","ortholog_annotations":[{"gene_uniquename":"YPR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04210","reference_uniquename":"PMID:26896847"}],"product":"Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR019W"}


id: YPR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00985":null,"YPR020W":null},"has_protein_features":false,"name":"ATP20","ortholog_annotations":[{"gene_uniquename":"YPR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00985","reference_uniquename":"PMID:29761456"}],"product":"Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR020W"}


id: YPR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGC1","product":"Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant","secondary_identifier":"SGD:S000006225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR021C"}


id: YPR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00163":null,"YPR022C":null},"has_protein_features":false,"name":"SDD4","ortholog_annotations":[{"gene_uniquename":"YPR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00163","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00163","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR022C"}


id: YPR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00349":null,"YPR023C":null},"has_protein_features":false,"name":"EAF3","ortholog_annotations":[{"gene_uniquename":"YPR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00349","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00349","reference_uniquename":"PMID:26896847"}],"product":"Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR023C"}


id: YPR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01816":null,"YPR024W":null},"has_protein_features":false,"name":"YME1","ortholog_annotations":[{"gene_uniquename":"YPR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01816","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01816","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR024W"}


id: YPR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04614":null,"YPR025C":null},"has_protein_features":false,"name":"CCL1","ortholog_annotations":[{"gene_uniquename":"YPR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04614","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04614","reference_uniquename":"PMID:26896847"}],"product":"Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly;  human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR025C"}


id: YPR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATH1","product":"Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress","secondary_identifier":"SGD:S000006230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR026W"}


id: YPR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000006231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR027C"}


id: YPR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03795":null,"YPR028W":null},"has_protein_features":false,"name":"YOP1","ortholog_annotations":[{"gene_uniquename":"YPR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03795","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03795","reference_uniquename":"PMID:26896847"}],"product":"Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR028W"}


id: YPR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01809":null,"YPR029C":null},"has_protein_features":false,"name":"APL4","ortholog_annotations":[{"gene_uniquename":"YPR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01809","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01809","reference_uniquename":"PMID:26896847"}],"product":"Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR029C"}


id: YPR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSR2","product":"Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR030W"}


id: YPR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02629":null,"YPR031W":null},"has_protein_features":false,"name":"NTO1","ortholog_annotations":[{"gene_uniquename":"YPR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02629","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR031W"}


id: YPR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03754":null,"YPR032W":null},"has_protein_features":false,"name":"SRO7","ortholog_annotations":[{"gene_uniquename":"YPR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03754","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03754","reference_uniquename":"PMID:26896847"}],"product":"Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR032W"}


id: YPR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00103":null,"YPR033C":null},"has_protein_features":false,"name":"HTS1","ortholog_annotations":[{"gene_uniquename":"YPR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00103","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00103","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR033C"}


id: YPR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03058":null,"YPR034W":null},"has_protein_features":false,"name":"ARP7","ortholog_annotations":[{"gene_uniquename":"YPR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03058","reference_uniquename":"PMID:26896847"}],"product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000006238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR034W"}


id: YPR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00359":null,"YPR035W":null},"has_protein_features":false,"name":"GLN1","ortholog_annotations":[{"gene_uniquename":"YPR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00359","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00359","reference_uniquename":"PMID:26896847"}],"product":"Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR035W"}


id: YPR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04955":null,"YPR036W":null},"has_protein_features":false,"name":"VMA13","ortholog_annotations":[{"gene_uniquename":"YPR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04955","reference_uniquename":"PMID:29761456"}],"product":"Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR036W"}


id: YPR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO24","product":"Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed beginning in mid-meiosis, regulated by two MSEs (middle sporulation elements), and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p","secondary_identifier":"SGD:S000028425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR036W-A"}


id: YPR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03992":null,"YPR037C":null},"has_protein_features":false,"name":"ERV2","ortholog_annotations":[{"gene_uniquename":"YPR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03992","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03992","reference_uniquename":"PMID:26896847"}],"product":"Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR037C"}


id: YPR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC16","product":"Putative protein of unknown function; partially overlaps verified gene ERV2/YPR037C but doesn't share phenotypes; also overlaps dubious ORF YPR039W; null mutant displays increased levels of spontaneous Rad52p foci, increased biofilm information, different altered sensitivities to various chemcicals","secondary_identifier":"SGD:S000006242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR038W"}


id: YPR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W","secondary_identifier":"SGD:S000006243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR039W"}


id: YPR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01142":null,"YPR040W":null},"has_protein_features":false,"name":"TIP41","ortholog_annotations":[{"gene_uniquename":"YPR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01142","reference_uniquename":"PMID:26896847"}],"product":"Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR040W"}


id: YPR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02390":null,"YPR041W":null},"has_protein_features":false,"name":"TIF5","ortholog_annotations":[{"gene_uniquename":"YPR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02390","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02390","reference_uniquename":"PMID:26896847"}],"product":"Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR041W"}


id: YPR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00391":null,"SJAG_16457":null,"YPR042C":null},"has_protein_features":false,"name":"PUF2","ortholog_annotations":[{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00391","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16457","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16457","reference_uniquename":"PMID:26896847"}],"product":"PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR042C"}


id: YPR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02510":null,"SJAG_03043":null,"YPR043W":null},"has_protein_features":false,"name":"RPL43A","ortholog_annotations":[{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR043W"}


id: YPR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI11","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000006248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR044C"}


id: YPR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00560":null,"YPR045C":null},"has_protein_features":false,"name":"THP3","ortholog_annotations":[{"gene_uniquename":"YPR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00560","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00560","reference_uniquename":"PMID:26896847"}],"product":"Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR045C"}


id: YPR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02664":null,"YPR046W":null},"has_protein_features":false,"name":"MCM16","ortholog_annotations":[{"gene_uniquename":"YPR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02664","reference_uniquename":"PMID:29761456"}],"product":"Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR046W"}


id: YPR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02615":null,"YPR047W":null},"has_protein_features":false,"name":"MSF1","ortholog_annotations":[{"gene_uniquename":"YPR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02615","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02615","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR047W"}


id: YPR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00972":null,"YPR048W":null},"has_protein_features":false,"name":"TAH18","ortholog_annotations":[{"gene_uniquename":"YPR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00972","reference_uniquename":"PMID:26896847"}],"product":"Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR048W"}


id: YPR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04502":null,"YPR049C":null},"has_protein_features":false,"name":"ATG11","ortholog_annotations":[{"gene_uniquename":"YPR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04502","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04502","reference_uniquename":"PMID:26896847"}],"product":"Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR049C"}


id: YPR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W","secondary_identifier":"SGD:S000006254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR050C"}


id: YPR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04131":null,"YPR051W":null},"has_protein_features":false,"name":"MAK3","ortholog_annotations":[{"gene_uniquename":"YPR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04131","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04131","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR051W"}


id: YPR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03603":null,"YPR052C":null},"has_protein_features":false,"name":"NHP6A","ortholog_annotations":[{"gene_uniquename":"YPR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03603","reference_uniquename":"PMID:29761456"}],"product":"High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR052C"}


id: YPR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPR053C is not an essential gene; partially overlaps verified ORF NHP6A/YPR052C","secondary_identifier":"SGD:S000006257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR053C"}


id: YPR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMK1","product":"Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; promotes deposition of the glucan layer of the spore wall by regulating the localization of Gsc2p to sites of spore wall assembly in postmeiotic cells; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II","secondary_identifier":"SGD:S000006258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR054W"}


id: YPR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02320":null,"YPR055W":null},"has_protein_features":false,"name":"SEC8","ortholog_annotations":[{"gene_uniquename":"YPR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02320","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02320","reference_uniquename":"PMID:26896847"}],"product":"Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR055W"}


id: YPR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04368":null,"YPR056W":null},"has_protein_features":false,"name":"TFB4","ortholog_annotations":[{"gene_uniquename":"YPR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04368","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04368","reference_uniquename":"PMID:26896847"}],"product":"Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR056W"}


id: YPR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BRR1","product":"snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed","secondary_identifier":"SGD:S000006261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR057W"}


id: YPR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00626":null,"YPR058W":null},"has_protein_features":false,"name":"YMC1","ortholog_annotations":[{"gene_uniquename":"YPR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00626","reference_uniquename":"PMID:26896847"}],"product":"Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR058W"}


id: YPR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W","secondary_identifier":"SGD:S000006263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR059C"}


id: YPR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00518":null,"YPR060C":null},"has_protein_features":false,"name":"ARO7","ortholog_annotations":[{"gene_uniquename":"YPR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00518","reference_uniquename":"PMID:29761456"}],"product":"Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR060C"}


id: YPR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00627":null,"YPR061C":null},"has_protein_features":false,"name":"JID1","ortholog_annotations":[{"gene_uniquename":"YPR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00627","reference_uniquename":"PMID:29761456"}],"product":"Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR061C"}


id: YPR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY1","product":"Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)","secondary_identifier":"SGD:S000006266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR062W"}


id: YPR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05414":null,"YPR063C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05414","reference_uniquename":"PMID:29761456"}],"product":"ER-localized protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR063C"}


id: YPR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene","secondary_identifier":"SGD:S000006268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR064W"}


id: YPR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ROX1","product":"Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance","secondary_identifier":"SGD:S000006269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR065W"}


id: YPR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00878":null,"YPR066W":null},"has_protein_features":false,"name":"UBA3","ortholog_annotations":[{"gene_uniquename":"YPR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00878","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00878","reference_uniquename":"PMID:26896847"}],"product":"Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR066W"}


id: YPR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04016":null,"YPR067W":null},"has_protein_features":false,"name":"ISA2","ortholog_annotations":[{"gene_uniquename":"YPR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04016","reference_uniquename":"PMID:29761456"}],"product":"Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR067W"}


id: YPR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOS1","product":"Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex","secondary_identifier":"SGD:S000006272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR068C"}


id: YPR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04481":null,"YPR069C":null},"has_protein_features":false,"name":"SPE3","ortholog_annotations":[{"gene_uniquename":"YPR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:26896847"}],"product":"Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR069C"}


id: YPR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02391":null,"YPR070W":null},"has_protein_features":false,"name":"MED1","ortholog_annotations":[{"gene_uniquename":"YPR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02391","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR070W"}


id: YPR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication","secondary_identifier":"SGD:S000006275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR071W"}


id: YPR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04350":null,"YPR072W":null},"has_protein_features":false,"name":"NOT5","ortholog_annotations":[{"gene_uniquename":"YPR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04350","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR072W"}


id: YPR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01667":null,"YPR073C":null},"has_protein_features":false,"name":"LTP1","ortholog_annotations":[{"gene_uniquename":"YPR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01667","reference_uniquename":"PMID:26896847"}],"product":"Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR073C"}


id: YPR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03934":null,"YPR074C":null},"has_protein_features":false,"name":"TKL1","ortholog_annotations":[{"gene_uniquename":"YPR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03934","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03934","reference_uniquename":"PMID:26896847"}],"product":"Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR074C"}


id: YPR074W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Hypothetical protein identified by homology","secondary_identifier":"SGD:S000007631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR074W-A"}


id: YPR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPY2","product":"Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000006279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR075C"}


id: YPR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR076W"}


id: YPR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1","secondary_identifier":"SGD:S000006281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR077C"}


id: YPR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible","secondary_identifier":"SGD:S000006282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR078C"}


id: YPR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02049":null,"YPR079W":null},"has_protein_features":false,"name":"MRL1","ortholog_annotations":[{"gene_uniquename":"YPR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02049","reference_uniquename":"PMID:26896847"}],"product":"Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR079W"}


id: YPR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01851":null,"SJAG_02180":null,"SJAG_04157":null,"YPR080W":null},"has_protein_features":false,"name":"TEF1","ortholog_annotations":[{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"}],"product":"Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR080W"}


id: YPR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01352":null,"YPR081C":null},"has_protein_features":false,"name":"GRS2","ortholog_annotations":[{"gene_uniquename":"YPR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01352","reference_uniquename":"PMID:29761456"}],"product":"Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR081C"}


id: YPR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04222":null,"YPR082C":null},"has_protein_features":false,"name":"DIB1","ortholog_annotations":[{"gene_uniquename":"YPR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04222","reference_uniquename":"PMID:29761456"}],"product":"17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR082C"}


id: YPR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDM36","product":"Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-anchor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission","secondary_identifier":"SGD:S000006287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR083W"}


id: YPR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000006288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR084W"}


id: YPR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04784":null,"YPR085C":null},"has_protein_features":false,"name":"ASA1","ortholog_annotations":[{"gene_uniquename":"YPR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04784","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR085C"}


id: YPR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01523":null,"YPR086W":null},"has_protein_features":false,"name":"SUA7","ortholog_annotations":[{"gene_uniquename":"YPR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01523","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01523","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR086W"}


id: YPR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS69","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect","secondary_identifier":"SGD:S000006291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR087W"}


id: YPR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03684":null,"YPR088C":null},"has_protein_features":false,"name":"SRP54","ortholog_annotations":[{"gene_uniquename":"YPR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03684","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03684","reference_uniquename":"PMID:26896847"}],"product":"Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR088C"}


id: YPR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02974":null,"YPR089W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02974","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02974","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR089W"}


id: YPR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YPR090W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YPR089W","secondary_identifier":"SGD:S000006294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR090W"}


id: YPR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01116":null,"YPR091C":null},"has_protein_features":false,"name":"NVJ2","ortholog_annotations":[{"gene_uniquename":"YPR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01116","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01116","reference_uniquename":"PMID:26896847"}],"product":"Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); involved in nonvesicular transfer of ceramides from ER to Golgi during ER stress; may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR091C"}


id: YPR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR092W"}


id: YPR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01992":null,"YPR093C":null},"has_protein_features":false,"name":"ASR1","ortholog_annotations":[{"gene_uniquename":"YPR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01992","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR093C"}


id: YPR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03245":null,"YPR094W":null},"has_protein_features":false,"name":"RDS3","ortholog_annotations":[{"gene_uniquename":"YPR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03245","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03245","reference_uniquename":"PMID:26896847"}],"product":"Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR094W"}


id: YPR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02004":null,"SJAG_03246":null,"YPR095C":null},"has_protein_features":false,"name":"SYT1","ortholog_annotations":[{"gene_uniquename":"YPR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02004","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02004","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03246","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03246","reference_uniquename":"PMID:26896847"}],"product":"Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR095C"}


id: YPR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000006300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR096C"}


id: YPR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02492":null,"SJAG_02728":null,"YPR097W":null},"has_protein_features":false,"name":"LEC1","ortholog_annotations":[{"gene_uniquename":"YPR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02492","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02492","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02728","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide-binding regulator of ergosterol distribution; contains PX (Phox homology) domain; associated with ER-lipid droplet contact site; may facilitate ergosterol transport between plasma membrane and lipid droplets","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR097W"}


id: YPR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMH18","product":"Mitochondrial protein of unknown function; localized to the mitochondrial outer membrane","secondary_identifier":"SGD:S000006302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR098C"}


id: YPR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Mitochondrial protein of unknown function; null mutant has a respiratory growth defect and displays reduced peroxide-induced mitochondrial ROS; partially overlaps the verified gene MRPL51/YPR100W","secondary_identifier":"SGD:S000006303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR099C"}


id: YPR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01303":null,"YPR100W":null},"has_protein_features":false,"name":"MRPL51","ortholog_annotations":[{"gene_uniquename":"YPR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01303","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit; required for mitochondrial genome integrity, respiratory growth, and mitochondrial redox homeostasis, partially overlaps verified gene YPR099C","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR100W"}


id: YPR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03711":null,"YPR101W":null},"has_protein_features":false,"name":"SNT309","ortholog_annotations":[{"gene_uniquename":"YPR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03711","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR101W"}


id: YPR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00465":null,"SJAG_02280":null,"YPR102C":null},"has_protein_features":false,"name":"RPL11A","ortholog_annotations":[{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR102C"}


id: YPR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04969":null,"YPR103W":null},"has_protein_features":false,"name":"PRE2","ortholog_annotations":[{"gene_uniquename":"YPR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04969","reference_uniquename":"PMID:29761456"}],"product":"Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; localizes to peroxisomes in oleate-growing cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR103W"}


id: YPR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01243":null,"YPR104C":null},"has_protein_features":false,"name":"FHL1","ortholog_annotations":[{"gene_uniquename":"YPR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01243","reference_uniquename":"PMID:26896847"}],"product":"Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR104C"}


id: YPR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01071":null,"YPR105C":null},"has_protein_features":false,"name":"COG4","ortholog_annotations":[{"gene_uniquename":"YPR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01071","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01071","reference_uniquename":"PMID:26896847"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR105C"}


id: YPR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISR1","product":"Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S","secondary_identifier":"SGD:S000006310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR106W"}


id: YPR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00527":null,"YPR107C":null},"has_protein_features":false,"name":"YTH1","ortholog_annotations":[{"gene_uniquename":"YPR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00527","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00527","reference_uniquename":"PMID:26896847"}],"product":"Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR107C"}


id: YPR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04144":null,"YPR108W":null},"has_protein_features":false,"name":"RPN7","ortholog_annotations":[{"gene_uniquename":"YPR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04144","reference_uniquename":"PMID:26896847"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR108W"}


id: YPR108W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; overlaps tRNA-Thr/YNCP0016W","secondary_identifier":"SGD:S000028590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR108W-A"}


id: YPR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLD1","product":"Component of Dsc E3 ligase complex in Golgi and endosomes; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index","secondary_identifier":"SGD:S000006313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR109W"}


id: YPR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01444":null,"YPR110C":null},"has_protein_features":false,"name":"RPC40","ortholog_annotations":[{"gene_uniquename":"YPR110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01444","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01444","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR110C"}


id: YPR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02736":null,"SJAG_04597":null,"YPR111W":null},"has_protein_features":false,"name":"DBF20","ortholog_annotations":[{"gene_uniquename":"YPR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02736","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04597","reference_uniquename":"PMID:26896847"}],"product":"Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR111W"}


id: YPR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01169":null,"YPR112C":null},"has_protein_features":false,"name":"MRD1","ortholog_annotations":[{"gene_uniquename":"YPR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01169","reference_uniquename":"PMID:29761456"}],"product":"Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR112C"}


id: YPR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00999":null,"YPR113W":null},"has_protein_features":false,"name":"PIS1","ortholog_annotations":[{"gene_uniquename":"YPR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00999","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00999","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR113W"}


id: YPR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01912":null,"YPR114W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01912","reference_uniquename":"PMID:26896847"}],"product":"Protein distantly similar to ceramide synthases, Lag1p and Lac1p; mutation confers sensitivity to inhibitors of sphingolipid biosynthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR114W"}


id: YPR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGC1","product":"Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000006319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR115W"}


id: YPR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRG8","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000006320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR116W"}


id: YPR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01564":null,"YPR117W":null},"has_protein_features":false,"name":"HOB2","ortholog_annotations":[{"gene_uniquename":"YPR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01564","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01564","reference_uniquename":"PMID:26896847"}],"product":"Modulator of cellular lipid distribution; localizes to ER-PM and ER-mitochondria contact sites; shares homology with lipid transfer proteins Vps13p and Atg2p; homolog of D. melanogaster Hobbit protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR117W"}


id: YPR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03614":null,"YPR118W":null},"has_protein_features":false,"name":"MRI1","ortholog_annotations":[{"gene_uniquename":"YPR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03614","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03614","reference_uniquename":"PMID:26896847"}],"product":"5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR118W"}


id: YPR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01401":null,"SJAG_04140":null,"YPR119W":null},"has_protein_features":false,"name":"CLB2","ortholog_annotations":[{"gene_uniquename":"YPR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01401","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04140","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; also involved in response to DNA damage; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR119W"}


id: YPR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03525":null,"YPR120C":null},"has_protein_features":false,"name":"CLB5","ortholog_annotations":[{"gene_uniquename":"YPR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:26896847"}],"product":"B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000006324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR120C"}


id: YPR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YPR121W":null},"has_protein_features":false,"name":"THI22","ortholog_annotations":[{"gene_uniquename":"YPR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:26896847"}],"product":"Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR121W"}


id: YPR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01430":null,"YPR122W":null},"has_protein_features":false,"name":"AXL1","ortholog_annotations":[{"gene_uniquename":"YPR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01430","reference_uniquename":"PMID:26896847"}],"product":"Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000006326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR122W"}


id: YPR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR","secondary_identifier":"SGD:S000006327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR123C"}


id: YPR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTR1","product":"High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion","secondary_identifier":"SGD:S000006328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR124W"}


id: YPR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01806":null,"YPR125W":null},"has_protein_features":false,"name":"YLH47","ortholog_annotations":[{"gene_uniquename":"YPR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR125W"}


id: YPR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR126C"}


id: YPR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01543":null,"YPR127W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01543","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01543","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01543","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01543","reference_uniquename":"PMID:26896847"}],"product":"Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR127W"}


id: YPR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ANT1","product":"Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation","secondary_identifier":"SGD:S000006332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR128C"}


id: YPR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02638":null,"YPR129W":null},"has_protein_features":false,"name":"SCD6","ortholog_annotations":[{"gene_uniquename":"YPR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02638","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02638","reference_uniquename":"PMID:26896847"}],"product":"Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR129W"}


id: YPR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR130C"}


id: YPR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01826":null,"YPR131C":null},"has_protein_features":false,"name":"NAT3","ortholog_annotations":[{"gene_uniquename":"YPR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01826","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01826","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR131C"}


id: YPR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01632":null,"SJAG_02682":null,"SJAG_03568":null,"YPR132W":null},"has_protein_features":false,"name":"RPS23B","ortholog_annotations":[{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR132W"}


id: YPR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02209":null,"YPR133C":null},"has_protein_features":false,"name":"SPN1","ortholog_annotations":[{"gene_uniquename":"YPR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02209","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in RNA polymerase II transcription; also required for histone modifications and splicing; constitutively recruited to the CYC1 promoter and required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain is highly conserved throughout eukaryotes; mutations confer an Spt- phenotype","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR133C"}


id: YPR133W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05259":null,"YPR133W-A":null},"has_protein_features":false,"name":"TOM5","ortholog_annotations":[{"gene_uniquename":"YPR133W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05259","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR133W-A"}


id: YPR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS18","product":"Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions","secondary_identifier":"SGD:S000006338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR134W"}


id: YPR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00618":null,"YPR135W":null},"has_protein_features":false,"name":"CTF4","ortholog_annotations":[{"gene_uniquename":"YPR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00618","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00618","reference_uniquename":"PMID:26896847"}],"product":"Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p); recruits Mms22p to replication forks during S phase, and may link DNA synthesis to sister chromatid cohesion","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR135W"}


id: YPR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9","secondary_identifier":"SGD:S000006340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR136C"}


id: YPR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03028":null,"YPR137W":null},"has_protein_features":false,"name":"RRP9","ortholog_annotations":[{"gene_uniquename":"YPR137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03028","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03028","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processome; ortholog of the human U3-55k protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR137W"}


id: YPR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04136":null,"SJAG_04731":null,"YPR138C":null},"has_protein_features":false,"name":"MEP3","ortholog_annotations":[{"gene_uniquename":"YPR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04136","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04731","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04731","reference_uniquename":"PMID:26896847"}],"product":"Ammonium permease of high capacity and low affinity; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation ammonia permease activity regulated by TORC1 effectors, Npr1p and Par32p; MEP3 has a paralog, MEP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR138C"}


id: YPR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04041":null,"YPR139C":null},"has_protein_features":false,"name":"LOA1","ortholog_annotations":[{"gene_uniquename":"YPR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04041","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04041","reference_uniquename":"PMID:26896847"}],"product":"Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR139C"}


id: YPR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAZ1","product":"Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant","secondary_identifier":"SGD:S000006344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR140W"}


id: YPR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01546":null,"SJAG_01613":null,"YPR141C":null},"has_protein_features":false,"name":"KAR3","ortholog_annotations":[{"gene_uniquename":"YPR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01546","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01613","reference_uniquename":"PMID:29761456"}],"product":"Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR141C"}


id: YPR142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing","secondary_identifier":"SGD:S000006346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR142C"}


id: YPR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04330":null,"YPR143W":null},"has_protein_features":false,"name":"RRP15","ortholog_annotations":[{"gene_uniquename":"YPR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04330","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04330","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR143W"}


id: YPR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00838":null,"YPR144C":null},"has_protein_features":false,"name":"NOC4","ortholog_annotations":[{"gene_uniquename":"YPR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00838","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00838","reference_uniquename":"PMID:26896847"}],"product":"Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR144C"}


id: YPR145C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000113589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR145C-A"}


id: YPR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04549":null,"YPR145W":null},"has_protein_features":false,"name":"ASN1","ortholog_annotations":[{"gene_uniquename":"YPR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04549","reference_uniquename":"PMID:29761456"}],"product":"Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR145W"}


id: YPR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR146C"}


id: YPR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Bifunctional triacylglycerol lipase and short chain ester hydrolase; null mutant results in the accumulation of both triacylglycerol and fatty acids derived from neutral lipids and phospholipids as well as an increase in the quantity of lipid droplets; contains an alpha/beta hydrolase domain with a conserved GXSXG lipase motif; localizes to lipid droplets; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000006351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR147C"}


id: YPR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000006352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR148C"}


id: YPR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02338":null,"YPR149W":null},"has_protein_features":false,"name":"NCE102","ortholog_annotations":[{"gene_uniquename":"YPR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02338","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02338","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in regulation of pheromone response and mating; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR149W"}


id: YPR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C","secondary_identifier":"SGD:S000006354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR150W"}


id: YPR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUE1","product":"Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria","secondary_identifier":"SGD:S000006355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR151C"}


id: YPR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00809":null,"YPR152C":null},"has_protein_features":false,"name":"URN1","ortholog_annotations":[{"gene_uniquename":"YPR152C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00809","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR152C"}


id: YPR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAY24","product":"Peripheral ER membrane protein; putative ER chaperone required for the stability and function of nutrient permeases exposed to high pressure","secondary_identifier":"SGD:S000006357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR153W"}


id: YPR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04554":null,"YPR154W":null},"has_protein_features":false,"name":"PIN3","ortholog_annotations":[{"gene_uniquename":"YPR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04554","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04554","reference_uniquename":"PMID:26896847"}],"product":"Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR154W"}


id: YPR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00428":null,"YPR155C":null},"has_protein_features":false,"name":"NCA2","ortholog_annotations":[{"gene_uniquename":"YPR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00428","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00428","reference_uniquename":"PMID:26896847"}],"product":"Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR155C"}


id: YPR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02344":null,"YPR156C":null},"has_protein_features":false,"name":"TPO3","ortholog_annotations":[{"gene_uniquename":"YPR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:26896847"}],"product":"Polyamine transporter of major facilitator superfamily; member of 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to plasma membrane; targeted to vacuole via AP-3 pathway; TPO3 has a paralog, TPO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR156C"}


id: YPR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TDA6","product":"Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR157W"}


id: YPR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CUR1","product":"Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR158W"}


id: YPR159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR159C-A"}


id: YPR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02446":null,"SJAG_02590":null,"SJAG_04690":null,"YPR159W":null},"has_protein_features":false,"name":"KRE6","ortholog_annotations":[{"gene_uniquename":"YPR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02446","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02446","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02590","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04690","reference_uniquename":"PMID:29761456"}],"product":"Glucosyl hydrolase required for beta-1,6-glucan biosynthesis; type II integral membrane protein that localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR159W"}


id: YPR160C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR160C-A"}


id: YPR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPH1","product":"Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway","secondary_identifier":"SGD:S000006364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR160W"}


id: YPR160W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR160W-A"}


id: YPR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03061":null,"YPR161C":null},"has_protein_features":false,"name":"SGV1","ortholog_annotations":[{"gene_uniquename":"YPR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03061","reference_uniquename":"PMID:29761456"}],"product":"Cyclin (Bur2p)-dependent protein kinase; subunit of the CDK-cyclin BUR kinase complex with Bur2p; regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; stimulates recruitment of the PAF complex through Spt5p CTD phosphorylation; recruits Spt6p to the CTD at the onset of transcription; regulates telomere elongation; regulated by Cak1p; similar to metazoan CDK9 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR161C"}


id: YPR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02394":null,"YPR162C":null},"has_protein_features":false,"name":"ORC4","ortholog_annotations":[{"gene_uniquename":"YPR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02394","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02394","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR162C"}


id: YPR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03433":null,"YPR163C":null},"has_protein_features":false,"name":"TIF3","ortholog_annotations":[{"gene_uniquename":"YPR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03433","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03433","reference_uniquename":"PMID:26896847"}],"product":"Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR163C"}


id: YPR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03728":null,"YPR164W":null},"has_protein_features":false,"name":"MMS1","ortholog_annotations":[{"gene_uniquename":"YPR164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03728","reference_uniquename":"PMID:29761456"}],"product":"Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR164W"}


id: YPR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02684":null,"SJAG_04666":null,"YPR165W":null},"has_protein_features":false,"name":"RHO1","ortholog_annotations":[{"gene_uniquename":"YPR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02684","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04666","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein of the rho subfamily of Ras-like small GTPases; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p); positive regulatory subunit of the 1,3-beta-D-glucan synthase complex, activating 1,3-beta-glucan synthase (Fks1p and Gsc2p), an enzyme involved in cell wall biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR165W"}


id: YPR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02452":null,"YPR166C":null},"has_protein_features":false,"name":"MRP2","ortholog_annotations":[{"gene_uniquename":"YPR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02452","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02452","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR166C"}


id: YPR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04060":null,"YPR167C":null},"has_protein_features":false,"name":"MET16","ortholog_annotations":[{"gene_uniquename":"YPR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04060","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04060","reference_uniquename":"PMID:26896847"}],"product":"3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR167C"}


id: YPR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00909":null,"YPR168W":null},"has_protein_features":false,"name":"NUT2","ortholog_annotations":[{"gene_uniquename":"YPR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00909","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00909","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR168W"}


id: YPR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02094":null,"YPR169W":null},"has_protein_features":false,"name":"JIP5","ortholog_annotations":[{"gene_uniquename":"YPR169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02094","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02094","reference_uniquename":"PMID:26896847"}],"product":"Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR169W"}


id: YPR169W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B","secondary_identifier":"SGD:S000028591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR169W-A"}


id: YPR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORFs YPR169W-A and YPR170W-B","secondary_identifier":"SGD:S000006374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR170C"}


id: YPR170W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR170W-A"}


id: YPR170W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03962":null,"YPR170W-B":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR170W-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03962","reference_uniquename":"PMID:29761456"}],"product":"Putative, non-essential component vacuolar ATPase; conserved in fungi; SWAT-GFP fusion protein localizes to vacuole membrane; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR170W-B"}


id: YPR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSP1","product":"Actin filament binding protein; regulates actin filament capping by recruiting capping protein to endocytic sites and to the cytokinetic actin ring; interacts with the capping protein complex; adapter that links synaptojanins, Inp52p and Inp53p, to the cortical actin cytoskeleton; contains two WH2-like actin binding domains and a C-terminal capping protein interaction (CPI) motif","secondary_identifier":"SGD:S000006375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR171W"}


id: YPR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02770":null,"YPR172W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02770","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02770","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR172W"}


id: YPR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03892":null,"YPR173C":null},"has_protein_features":false,"name":"VPS4","ortholog_annotations":[{"gene_uniquename":"YPR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03892","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03892","reference_uniquename":"PMID:26896847"}],"product":"AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR173C"}


id: YPR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSA1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR174C"}


id: YPR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02667":null,"YPR175W":null},"has_protein_features":false,"name":"DPB2","ortholog_annotations":[{"gene_uniquename":"YPR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02667","reference_uniquename":"PMID:26896847"}],"product":"Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR175W"}


id: YPR176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04434":null,"YPR176C":null},"has_protein_features":false,"name":"BET2","ortholog_annotations":[{"gene_uniquename":"YPR176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04434","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04434","reference_uniquename":"PMID:26896847"}],"product":"Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR176C"}


id: YPR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex","secondary_identifier":"SGD:S000006381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR177C"}


id: YPR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00531":null,"YPR178W":null},"has_protein_features":false,"name":"PRP4","ortholog_annotations":[{"gene_uniquename":"YPR178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00531","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR178W"}


id: YPR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03685":null,"YPR179C":null},"has_protein_features":false,"name":"HDA3","ortholog_annotations":[{"gene_uniquename":"YPR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03685","reference_uniquename":"PMID:29761456"}],"product":"Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for activity of complex; relocalizes to cytosol in response to hypoxia; similar to Hda2p; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR179C"}


id: YPR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05032":null,"YPR180W":null},"has_protein_features":false,"name":"AOS1","ortholog_annotations":[{"gene_uniquename":"YPR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05032","reference_uniquename":"PMID:26896847"}],"product":"Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR180W"}


id: YPR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02539":null,"SJAG_03153":null,"YPR181C":null},"has_protein_features":false,"name":"SEC23","ortholog_annotations":[{"gene_uniquename":"YPR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02539","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03153","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR181C"}


id: YPR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02843":null,"YPR182W":null},"has_protein_features":false,"name":"SMX3","ortholog_annotations":[{"gene_uniquename":"YPR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02843","reference_uniquename":"PMID:26896847"}],"product":"Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR182W"}


id: YPR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02903":null,"YPR183W":null},"has_protein_features":false,"name":"DPM1","ortholog_annotations":[{"gene_uniquename":"YPR183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02903","reference_uniquename":"PMID:26896847"}],"product":"Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR183W"}


id: YPR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GDB1","product":"Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000006388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR184W"}


id: YPR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01274":null,"YPR185W":null},"has_protein_features":false,"name":"ATG13","ortholog_annotations":[{"gene_uniquename":"YPR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01274","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01274","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR185W"}


id: YPR186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00067":null,"YPR186C":null},"has_protein_features":false,"name":"PZF1","ortholog_annotations":[{"gene_uniquename":"YPR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00067","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR186C"}


id: YPR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04261":null,"YPR187W":null},"has_protein_features":false,"name":"RPO26","ortholog_annotations":[{"gene_uniquename":"YPR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04261","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04261","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR187W"}


id: YPR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01665":null,"YPR188C":null},"has_protein_features":false,"name":"MLC2","ortholog_annotations":[{"gene_uniquename":"YPR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01665","reference_uniquename":"PMID:29761456"}],"product":"Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR188C"}


id: YPR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03805":null,"YPR189W":null},"has_protein_features":false,"name":"SKI3","ortholog_annotations":[{"gene_uniquename":"YPR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03805","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03805","reference_uniquename":"PMID:26896847"}],"product":"Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR189W"}


id: YPR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00619":null,"YPR190C":null},"has_protein_features":false,"name":"RPC82","ortholog_annotations":[{"gene_uniquename":"YPR190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00619","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00619","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase III subunit C82","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR190C"}


id: YPR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00755":null,"YPR191W":null},"has_protein_features":false,"name":"QCR2","ortholog_annotations":[{"gene_uniquename":"YPR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00755","reference_uniquename":"PMID:26896847"}],"product":"Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR191W"}


id: YPR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AQY1","product":"Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance","secondary_identifier":"SGD:S000006396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR192W"}


id: YPR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03288":null,"YPR193C":null},"has_protein_features":false,"name":"HPA2","ortholog_annotations":[{"gene_uniquename":"YPR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03288","reference_uniquename":"PMID:29761456"}],"product":"Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR193C"}


id: YPR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00922":null,"SJAG_01660":null,"YPR194C":null},"has_protein_features":false,"name":"OPT2","ortholog_annotations":[{"gene_uniquename":"YPR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01660","reference_uniquename":"PMID:29761456"}],"product":"Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR194C"}


id: YPR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000006399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR195C"}


id: YPR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative maltose-responsive transcription factor","secondary_identifier":"SGD:S000006400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR196W"}


id: YPR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SGE1/YPR198W","secondary_identifier":"SGD:S000006401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR197C"}


id: YPR198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YPR198W":null},"has_protein_features":false,"name":"SGE1","ortholog_annotations":[{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR198W"}


id: YPR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARR1","product":"Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8","secondary_identifier":"SGD:S000006403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR199C"}


id: YPR200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04166":null,"YPR200C":null},"has_protein_features":false,"name":"ARR2","ortholog_annotations":[{"gene_uniquename":"YPR200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04166","reference_uniquename":"PMID:29761456"}],"product":"Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR200C"}


id: YPR201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARR3","product":"Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein displays 10 transmembrane segments with cytoplasmically oriented N- and C-terminal domains","secondary_identifier":"SGD:S000006405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR201W"}


id: YPR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo","secondary_identifier":"SGD:S000006406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR202W"}


id: YPR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000006407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR203W"}


id: YPR204C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR204C-A"}


id: YPR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"DNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1","secondary_identifier":"SGD:S000006408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR204W"}


