# genes

id: YGR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01358":null,"YGR218W":null},"has_protein_features":false,"name":"CRM1","ortholog_annotations":[{"gene_uniquename":"YGR218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01358","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01358","reference_uniquename":"PMID:26896847"}],"product":"Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR218W"}


id: YGR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C","secondary_identifier":"SGD:S000003451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR219W"}


id: YGR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01413":null,"YGR220C":null},"has_protein_features":false,"name":"MRPL9","ortholog_annotations":[{"gene_uniquename":"YGR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01413","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR220C"}


id: YGR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOS2","product":"Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR221C"}


id: YGR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET54","product":"Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p","secondary_identifier":"SGD:S000003454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR222W"}


id: YGR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00115":null,"YGR223C":null},"has_protein_features":false,"name":"HSV2","ortholog_annotations":[{"gene_uniquename":"YGR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00115","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide (PI) binding protein; involved in micronucleophagy; belongs to the PROPPIN family of proteins defined by a seven-bladed beta-propeller fold and FRRG motif required for PI binding; displays punctate cytoplasmic localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR223C"}


id: YGR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YGR224W":null},"has_protein_features":false,"name":"AZR1","ortholog_annotations":[{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR224W"}


id: YGR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03809":null,"SJAG_03858":null,"YGR225W":null},"has_protein_features":false,"name":"AMA1","ortholog_annotations":[{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03809","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03858","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03858","reference_uniquename":"PMID:26896847"}],"product":"Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR225W"}


id: YGR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W","secondary_identifier":"SGD:S000003458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR226C"}


id: YGR227C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OTO1","product":"Small toxic protein; overexpression inhibits ergosterol biosynthesis; not required for normal growth, not conserved in related yeast species including S. paradoxus","secondary_identifier":"SGD:S000303806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227C-A"}


id: YGR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03764":null,"YGR227W":null},"has_protein_features":false,"name":"DIE2","ortholog_annotations":[{"gene_uniquename":"YGR227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03764","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03764","reference_uniquename":"PMID:26896847"}],"product":"Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227W"}


id: YGR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C","secondary_identifier":"SGD:S000003460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR228W"}


id: YGR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03123":null,"YGR229C":null},"has_protein_features":false,"name":"SMI1","ortholog_annotations":[{"gene_uniquename":"YGR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03123","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03123","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR229C"}


id: YGR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01341":null,"YGR230W":null},"has_protein_features":false,"name":"BNS1","ortholog_annotations":[{"gene_uniquename":"YGR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01341","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; FEAR network component that partially overlaps the function of SPO12 in promoting Cdc14p release from the nucleolus during early mitotic anaphase and mitotic exit; overexpression partially suppresses the meiotic defect of spo12; BNS1 has a paralog, SPO12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR230W"}


id: YGR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01073":null,"YGR231C":null},"has_protein_features":false,"name":"PHB2","ortholog_annotations":[{"gene_uniquename":"YGR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01073","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01073","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR231C"}


id: YGR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00954":null,"YGR232W":null},"has_protein_features":false,"name":"NAS6","ortholog_annotations":[{"gene_uniquename":"YGR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00954","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00954","reference_uniquename":"PMID:26896847"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR232W"}


id: YGR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO81","product":"Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR233C"}


id: YGR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YHB1","product":"Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000003466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR234W"}


id: YGR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02501":null,"YGR235C":null},"has_protein_features":false,"name":"MIC26","ortholog_annotations":[{"gene_uniquename":"YGR235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02501","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex; orthologous to human APOO and APOOL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR235C"}


id: YGR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPG1","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR236C"}


id: YGR237C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR237C"}


id: YGR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01196":null,"SJAG_04322":null,"YGR238C":null},"has_protein_features":false,"name":"KEL2","ortholog_annotations":[{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01196","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04322","reference_uniquename":"PMID:29761456"}],"product":"Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR238C"}


id: YGR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX21","product":"Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress","secondary_identifier":"SGD:S000003471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR239C"}


id: YGR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00605":null,"YGR240C":null},"has_protein_features":false,"name":"PFK1","ortholog_annotations":[{"gene_uniquename":"YGR240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00605","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00605","reference_uniquename":"PMID:26896847"}],"product":"Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C"}


id: YGR240C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C-A"}


id: YGR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01748":null,"YGR241C":null},"has_protein_features":false,"name":"YAP1802","ortholog_annotations":[{"gene_uniquename":"YGR241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:26896847"}],"product":"Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR241C"}


id: YGR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C","secondary_identifier":"SGD:S000003474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR242W"}


id: YGR243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04593":null,"YGR243W":null},"has_protein_features":false,"name":"MPC3","ortholog_annotations":[{"gene_uniquename":"YGR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:26896847"}],"product":"Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR243W"}


id: YGR244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03813":null,"YGR244C":null},"has_protein_features":false,"name":"LSC2","ortholog_annotations":[{"gene_uniquename":"YGR244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03813","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR244C"}


id: YGR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04308":null,"YGR245C":null},"has_protein_features":false,"name":"SDA1","ortholog_annotations":[{"gene_uniquename":"YGR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04308","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04308","reference_uniquename":"PMID:26896847"}],"product":"Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR245C"}


id: YGR246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03120":null,"YGR246C":null},"has_protein_features":false,"name":"BRF1","ortholog_annotations":[{"gene_uniquename":"YGR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03120","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03120","reference_uniquename":"PMID:26896847"}],"product":"TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR246C"}


id: YGR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01428":null,"YGR247W":null},"has_protein_features":false,"name":"CPD1","ortholog_annotations":[{"gene_uniquename":"YGR247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01428","reference_uniquename":"PMID:29761456"}],"product":"Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR247W"}


id: YGR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YGR248W":null},"has_protein_features":false,"name":"SOL4","ortholog_annotations":[{"gene_uniquename":"YGR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:26896847"}],"product":"6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR248W"}


id: YGR249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MGA1","product":"Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants","secondary_identifier":"SGD:S000003481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR249W"}


id: YGR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIE1","product":"RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR250C"}


id: YGR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NOP19","product":"Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes","secondary_identifier":"SGD:S000003483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR251W"}


id: YGR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02773":null,"YGR252W":null},"has_protein_features":false,"name":"GCN5","ortholog_annotations":[{"gene_uniquename":"YGR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02773","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02773","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR252W"}


id: YGR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05316":null,"YGR253C":null},"has_protein_features":false,"name":"PUP2","ortholog_annotations":[{"gene_uniquename":"YGR253C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05316","reference_uniquename":"PMID:29761456"}],"product":"Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR253C"}


id: YGR254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YGR254W":null},"has_protein_features":false,"name":"ENO1","ortholog_annotations":[{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:26896847"}],"product":"Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR254W"}


id: YGR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04000":null,"YGR255C":null},"has_protein_features":false,"name":"COQ6","ortholog_annotations":[{"gene_uniquename":"YGR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04000","reference_uniquename":"PMID:26896847"}],"product":"Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR255C"}


id: YGR256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03852":null,"YGR256W":null},"has_protein_features":false,"name":"GND2","ortholog_annotations":[{"gene_uniquename":"YGR256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR256W"}


id: YGR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03577":null,"YGR257C":null},"has_protein_features":false,"name":"MTM1","ortholog_annotations":[{"gene_uniquename":"YGR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03577","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03577","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of the PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR257C"}


id: YGR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02031":null,"YGR258C":null},"has_protein_features":false,"name":"RAD2","ortholog_annotations":[{"gene_uniquename":"YGR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02031","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR258C"}


id: YGR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W","secondary_identifier":"SGD:S000003491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR259C"}


id: YGR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04706":null,"YGR260W":null},"has_protein_features":false,"name":"TNA1","ortholog_annotations":[{"gene_uniquename":"YGR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04706","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04706","reference_uniquename":"PMID:26896847"}],"product":"High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR260W"}


id: YGR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02453":null,"YGR261C":null},"has_protein_features":false,"name":"APL6","ortholog_annotations":[{"gene_uniquename":"YGR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:29761456"}],"product":"Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR261C"}


id: YGR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00378":null,"YGR262C":null},"has_protein_features":false,"name":"BUD32","ortholog_annotations":[{"gene_uniquename":"YGR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00378","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00378","reference_uniquename":"PMID:26896847"}],"product":"Component of KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; provides the ATPase and GTPase activities of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human ortholog TP53RK","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR262C"}


id: YGR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAY1","product":"Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER","secondary_identifier":"SGD:S000003495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR263C"}


id: YGR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01159":null,"YGR264C":null},"has_protein_features":false,"name":"MES1","ortholog_annotations":[{"gene_uniquename":"YGR264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01159","reference_uniquename":"PMID:29761456"}],"product":"Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR264C"}


id: YGR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase","secondary_identifier":"SGD:S000003497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR265W"}


id: YGR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR266W"}


id: YGR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03275":null,"YGR267C":null},"has_protein_features":false,"name":"FOL2","ortholog_annotations":[{"gene_uniquename":"YGR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03275","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03275","reference_uniquename":"PMID:26896847"}],"product":"GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR267C"}


id: YGR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03273":null,"YGR268C":null},"has_protein_features":false,"name":"HUA1","ortholog_annotations":[{"gene_uniquename":"YGR268C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03273","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR268C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03273","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR268C"}


id: YGR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C","secondary_identifier":"SGD:S000003501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR269W"}


id: YGR270C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W","secondary_identifier":"SGD:S000028641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270C-A"}


id: YGR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02906":null,"SJAG_04692":null,"YGR270W":null},"has_protein_features":false,"name":"YTA7","ortholog_annotations":[{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02906","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02906","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04692","reference_uniquename":"PMID:29761456"}],"product":"Chromatin segregase involved in DNA replication; ATPase activity, stimulated by S phase CDK-dependent phosphorylation, is coupled to nucleosome disassembly, promoting DNA replication; regulates cell-cycle-dependent histone gene expression; contains AAA+-ATPase domains and a non-canonical bromodomain; hexameric; relocalizes to the cytosol in response to hypoxia; human ortholog ATAD2 is a coregulator of oncogenic transcription factors and an oncogene overexpressed in cancers with poor prognosis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270W"}


id: YGR271C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00562":null,"YGR271C-A":null},"has_protein_features":false,"name":"EFG1","ortholog_annotations":[{"gene_uniquename":"YGR271C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00562","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR271C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00562","reference_uniquename":"PMID:26896847"}],"product":"Ribosome biogenesis factor required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271C-A"}


id: YGR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00898":null,"YGR271W":null},"has_protein_features":false,"name":"SLH1","ortholog_annotations":[{"gene_uniquename":"YGR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00898","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00898","reference_uniquename":"PMID:26896847"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; human homolog is ASCC3","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271W"}


id: YGR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein;YGR272C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGR271C-A","secondary_identifier":"SGD:S000003504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR272C"}


id: YGR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01255":null,"SJAG_04659":null,"YGR273C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01255","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04659","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog, YMR295C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR273C"}


id: YGR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03900":null,"YGR274C":null},"has_protein_features":false,"name":"TAF1","ortholog_annotations":[{"gene_uniquename":"YGR274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03900","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03900","reference_uniquename":"PMID:26896847"}],"product":"TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR274C"}


id: YGR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT102","product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR275W"}


id: YGR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02993":null,"YGR276C":null},"has_protein_features":false,"name":"RNH70","ortholog_annotations":[{"gene_uniquename":"YGR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02993","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR276C"}


id: YGR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05277":null,"YGR277C":null},"has_protein_features":false,"name":"CAB4","ortholog_annotations":[{"gene_uniquename":"YGR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05277","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05277","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR277C"}


id: YGR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16453":null,"YGR278W":null},"has_protein_features":false,"name":"CWC22","ortholog_annotations":[{"gene_uniquename":"YGR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16453","reference_uniquename":"PMID:29761456"}],"product":"Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR278W"}


id: YGR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SCW4","product":"Cell wall protein with similarity to glucanases; targeted to vacuole via AP-3 pathway; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR279C"}


id: YGR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02758":null,"YGR280C":null},"has_protein_features":false,"name":"PXR1","ortholog_annotations":[{"gene_uniquename":"YGR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02758","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02758","reference_uniquename":"PMID:26896847"}],"product":"Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR280C"}


id: YGR281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YGR281W":null},"has_protein_features":false,"name":"YOR1","ortholog_annotations":[{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR281W"}


id: YGR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02192":null,"YGR282C":null},"has_protein_features":false,"name":"BGL2","ortholog_annotations":[{"gene_uniquename":"YGR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02192","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02192","reference_uniquename":"PMID:26896847"}],"product":"Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR282C"}


id: YGR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03554":null,"YGR283C":null},"has_protein_features":false,"name":"UPA1","ortholog_annotations":[{"gene_uniquename":"YGR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03554","reference_uniquename":"PMID:29761456"}],"product":"Putative SPOUT methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; contributes to the methylation of Cse4-R37 in G2/M phase; overexpression leads to chromosomal instability; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR283C"}


id: YGR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02120":null,"YGR284C":null},"has_protein_features":false,"name":"ERV29","ortholog_annotations":[{"gene_uniquename":"YGR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02120","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02120","reference_uniquename":"PMID:26896847"}],"product":"Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR284C"}


id: YGR285C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03094":null,"YGR285C":null},"has_protein_features":false,"name":"ZUO1","ortholog_annotations":[{"gene_uniquename":"YGR285C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03094","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated co-chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains with Ssz1p and Ssb1/2p; subunit of the ribosome-associated complex (RAC) that stimulates Ssb1/2p ATPase activity to facilitate interaction with nascent polypeptide chains emerging from the ribosome exit tunnel; regulates translation upon inhibition of TORC1; contains a DnaJ domain; human gene DNAJC2 partially complements the yeast zuo1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR285C"}


id: YGR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01935":null,"YGR286C":null},"has_protein_features":false,"name":"BIO2","ortholog_annotations":[{"gene_uniquename":"YGR286C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01935","reference_uniquename":"PMID:29761456"}],"product":"Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR286C"}


id: YGR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA1","product":"Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family","secondary_identifier":"SGD:S000003519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR287C"}


id: YGR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL13","product":"MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000003520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR288W"}


id: YGR289C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YGR289C":null},"has_protein_features":false,"name":"MAL11","ortholog_annotations":[{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR289C"}


id: YGR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)","secondary_identifier":"SGD:S000003522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR290W"}


id: YGR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR291C"}


id: YGR292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL12","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000003524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR292W"}


id: YGR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W","secondary_identifier":"SGD:S000003525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR293C"}


id: YGR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU12","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticulum and vacuole","secondary_identifier":"SGD:S000003526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR294W"}


id: YGR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS6","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR295C"}


id: YGR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL07R","secondary_identifier":"SGD:S000028642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-A"}


id: YGR296C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; contained completely within TEL07R","secondary_identifier":"SGD:S000028643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-B"}


id: YGR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-3","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000003528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296W"}


id: YHL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01364":null,"SJAG_02890":null,"YHL001W":null},"has_protein_features":false,"name":"RPL14B","ortholog_annotations":[{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL001W"}


id: YHL002C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HSE1/YHL002W","secondary_identifier":"SGD:S000028770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002C-A"}


id: YHL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00821":null,"YHL002W":null},"has_protein_features":false,"name":"HSE1","ortholog_annotations":[{"gene_uniquename":"YHL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00821","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002W"}


id: YHL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02085":null,"SJAG_02842":null,"YHL003C":null},"has_protein_features":false,"name":"LAG1","ortholog_annotations":[{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02085","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:26896847"}],"product":"Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL003C"}


id: YHL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03584":null,"YHL004W":null},"has_protein_features":false,"name":"MRP4","ortholog_annotations":[{"gene_uniquename":"YHL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03584","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03584","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL004W"}


id: YHL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene","secondary_identifier":"SGD:S000000997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL005C"}


id: YHL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHU1","product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments","secondary_identifier":"SGD:S000000998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006C"}


id: YHL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF STE20/YHL007C","secondary_identifier":"SGD:S000028771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006W-A"}


id: YHL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00845":null,"SJAG_02878":null,"YHL007C":null},"has_protein_features":false,"name":"STE20","ortholog_annotations":[{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00845","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:26896847"}],"product":"Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL007C"}


id: YHL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL008C"}


id: YHL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP3","product":"Basic leucine zipper (bZIP) transcription factor","secondary_identifier":"SGD:S000001001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL009C"}


id: YHL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00509":null,"YHL010C":null},"has_protein_features":false,"name":"ETP1","ortholog_annotations":[{"gene_uniquename":"YHL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00509","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL010C"}


id: YHL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03811":null,"YHL011C":null},"has_protein_features":false,"name":"PRS3","ortholog_annotations":[{"gene_uniquename":"YHL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL011C"}


id: YHL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01089":null,"SJAG_02178":null,"YHL012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:26896847"}],"product":"Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL012W"}


id: YHL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02774":null,"YHL013C":null},"has_protein_features":false,"name":"OTU2","ortholog_annotations":[{"gene_uniquename":"YHL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02774","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02774","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL013C"}


id: YHL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04874":null,"YHL014C":null},"has_protein_features":false,"name":"YLF2","ortholog_annotations":[{"gene_uniquename":"YHL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04874","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL014C"}


id: YHL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04476":null,"YHL015W":null},"has_protein_features":false,"name":"RPS20","ortholog_annotations":[{"gene_uniquename":"YHL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04476","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W"}


id: YHL015W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W-A"}


id: YHL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02125":null,"YHL016C":null},"has_protein_features":false,"name":"DUR3","ortholog_annotations":[{"gene_uniquename":"YHL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02125","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02125","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL016C"}


id: YHL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02193":null,"SJAG_02823":null,"YHL017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02823","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL017W"}


id: YHL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCO14","product":"Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000001010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL018W"}


id: YHL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APM2","product":"Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport","secondary_identifier":"SGD:S000001011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019C"}


id: YHL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C","secondary_identifier":"SGD:S000028772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019W-A"}


id: YHL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI1","product":"Transcriptional regulator of a variety of genes; critical sensor of genotoxic stress; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid","secondary_identifier":"SGD:S000001012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL020C"}


id: YHL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM17","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL021C"}


id: YHL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05295":null,"YHL022C":null},"has_protein_features":false,"name":"SPO11","ortholog_annotations":[{"gene_uniquename":"YHL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05295","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05295","reference_uniquename":"PMID:26896847"}],"product":"Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL022C"}


id: YHL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01184":null,"YHL023C":null},"has_protein_features":false,"name":"NPR3","ortholog_annotations":[{"gene_uniquename":"YHL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01184","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL023C"}


id: YHL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01919":null,"YHL024W":null},"has_protein_features":false,"name":"RIM4","ortholog_annotations":[{"gene_uniquename":"YHL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01919","reference_uniquename":"PMID:26896847"}],"product":"Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL024W"}


id: YHL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SNF6","product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions","secondary_identifier":"SGD:S000001017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL025W"}


id: YHL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02612":null,"YHL026C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02612","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02612","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL026C"}


id: YHL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM101","product":"Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression; involved in cell wall assembly; plays role in lager yeast flocculation under brewing conditions; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC","secondary_identifier":"SGD:S000001019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL027W"}


id: YHL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YHL028W":null},"has_protein_features":false,"name":"WSC4","ortholog_annotations":[{"gene_uniquename":"YHL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL028W"}


id: YHL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OCA5","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000001021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL029C"}


id: YHL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00126":null,"YHL030W":null},"has_protein_features":false,"name":"ECM29","ortholog_annotations":[{"gene_uniquename":"YHL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00126","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00126","reference_uniquename":"PMID:26896847"}],"product":"Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W"}


id: YHL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C","secondary_identifier":"SGD:S000028773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W-A"}


id: YHL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04739":null,"YHL031C":null},"has_protein_features":false,"name":"GOS1","ortholog_annotations":[{"gene_uniquename":"YHL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04739","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL031C"}


id: YHL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GUT1","product":"Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p","secondary_identifier":"SGD:S000001024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL032C"}


id: YHL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00537":null,"YHL033C":null},"has_protein_features":false,"name":"RPL8A","ortholog_annotations":[{"gene_uniquename":"YHL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL033C"}


id: YHL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SBP1","product":"Protein involved in translation repression and P-body disassembly; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; binds eIF4G; HMT1-dependent arginine monomethylation important for stress granule localization during glucose starvation and for eIF4G binding; contains an RGG motif; found in cytoplasmic P bodies and stress granules; SBP1 has a paralog, RNP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034C"}


id: YHL034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C","secondary_identifier":"SGD:S000028774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034W-A"}


id: YHL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YHL035C":null},"has_protein_features":false,"name":"VMR1","ortholog_annotations":[{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL035C"}


id: YHL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MUP3","product":"Low affinity methionine permease; similar to Mup1p","secondary_identifier":"SGD:S000001028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL036W"}


id: YHL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL037C"}


id: YHL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBP2","product":"Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene","secondary_identifier":"SGD:S000001030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL038C"}


id: YHL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YHL039W":null},"has_protein_features":false,"name":"EFM1","ortholog_annotations":[{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:26896847"}],"product":"Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL039W"}


id: YHL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL040C":null},"has_protein_features":false,"name":"ARN1","ortholog_annotations":[{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL040C"}


id: YHL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL041W"}


id: YHL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER","secondary_identifier":"SGD:S000001034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL042W"}


id: YHL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM34","product":"Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL043W"}


id: YHL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DFP4","product":"Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern","secondary_identifier":"SGD:S000001036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL044W"}


id: YHL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PXP3","product":"Peroxisomal protein of unknown function; last 10 C-terminal amino acids contains a novel PTS1 motif, both necessary and sufficient for Pex5p-dependent peroxisomal targeting; also localizes to the nucleus; PXP3 is not an essential gene","secondary_identifier":"SGD:S000001037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL045W"}


id: YHL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU13","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000001038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046C"}


id: YHL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C","secondary_identifier":"SGD:S000028775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046W-A"}


id: YHL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL047C":null},"has_protein_features":false,"name":"ARN2","ortholog_annotations":[{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL047C"}


id: YHL048C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry; localizes to the peroxisome in a Pex5p-dependent manner in oleate","secondary_identifier":"SGD:S000028829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048C-A"}


id: YHL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS8","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048W"}


id: YHL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL049C"}


id: YHL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate","secondary_identifier":"SGD:S000001042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050C"}


id: YHL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050W-A"}


id: YHR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YHR001W":null},"has_protein_features":false,"name":"OSH7","ortholog_annotations":[{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W"}


id: YHR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07006":null,"YHR001W-A":null},"has_protein_features":false,"name":"QCR10","ortholog_annotations":[{"gene_uniquename":"YHR001W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07006","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W-A"}


id: YHR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03452":null,"YHR002W":null},"has_protein_features":false,"name":"LEU5","ortholog_annotations":[{"gene_uniquename":"YHR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03452","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03452","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR002W"}


id: YHR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02084":null,"YHR003C":null},"has_protein_features":false,"name":"TCD1","ortholog_annotations":[{"gene_uniquename":"YHR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:26896847"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR003C"}


id: YHR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01906":null,"YHR004C":null},"has_protein_features":false,"name":"NEM1","ortholog_annotations":[{"gene_uniquename":"YHR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01906","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01906","reference_uniquename":"PMID:26896847"}],"product":"Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology and sporulation; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; homolog of the human protein Dullard","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR004C"}


id: YHR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02233":null,"SJAG_02444":null,"YHR005C":null},"has_protein_features":false,"name":"GPA1","ortholog_annotations":[{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02233","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:26896847"}],"product":"Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C"}


id: YHR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00687":null,"YHR005C-A":null},"has_protein_features":false,"name":"TIM10","ortholog_annotations":[{"gene_uniquename":"YHR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C-A"}


id: YHR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STP2","product":"Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR006W"}


id: YHR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03750":null,"YHR007C":null},"has_protein_features":false,"name":"ERG11","ortholog_annotations":[{"gene_uniquename":"YHR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03750","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03750","reference_uniquename":"PMID:26896847"}],"product":"Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C"}


id: YHR007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000028830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C-A"}


id: YHR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03303":null,"YHR008C":null},"has_protein_features":false,"name":"SOD2","ortholog_annotations":[{"gene_uniquename":"YHR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03303","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR008C"}


id: YHR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00287":null,"SJAG_04359":null,"YHR009C":null},"has_protein_features":false,"name":"TDA3","ortholog_annotations":[{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00287","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04359","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04359","reference_uniquename":"PMID:26896847"}],"product":"Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR009C"}


id: YHR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01588":null,"SJAG_02802":null,"YHR010W":null},"has_protein_features":false,"name":"RPL27A","ortholog_annotations":[{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR010W"}


id: YHR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02977":null,"YHR011W":null},"has_protein_features":false,"name":"DIA4","ortholog_annotations":[{"gene_uniquename":"YHR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02977","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02977","reference_uniquename":"PMID:26896847"}],"product":"Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR011W"}


id: YHR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04629":null,"YHR012W":null},"has_protein_features":false,"name":"VPS29","ortholog_annotations":[{"gene_uniquename":"YHR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04629","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR012W"}


id: YHR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04631":null,"YHR013C":null},"has_protein_features":false,"name":"ARD1","ortholog_annotations":[{"gene_uniquename":"YHR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04631","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04631","reference_uniquename":"PMID:26896847"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR013C"}


id: YHR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO13","product":"Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; promotes phosphorylation of Cdc5p substrates in MI and impacts Hrr25p function in MII; substrate of the anaphase-promoting complex (APC) that is degraded during anaphase I; expressed solely in meiotic cells","secondary_identifier":"SGD:S000001056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR014W"}


id: YHR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIP6","product":"mRNA-binding protein; interacts with the UBA domain of mRNA export factor Mex67p; participates in the export of Msn2/4 stress-dependent mRNAs; partially redundant function with paralog PES4 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; redundant role with PES4 in sporulation; shuttles between the nucleus and cytoplasm, localizes to stress granules and the prospore membrane","secondary_identifier":"SGD:S000001057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR015W"}


id: YHR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00970":null,"YHR016C":null},"has_protein_features":false,"name":"YSC84","ortholog_annotations":[{"gene_uniquename":"YHR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:26896847"}],"product":"Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR016C"}


id: YHR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04124":null,"YHR017W":null},"has_protein_features":false,"name":"YSC83","ortholog_annotations":[{"gene_uniquename":"YHR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04124","reference_uniquename":"PMID:29761456"}],"product":"Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR017W"}


id: YHR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01461":null,"YHR018C":null},"has_protein_features":false,"name":"ARG4","ortholog_annotations":[{"gene_uniquename":"YHR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01461","reference_uniquename":"PMID:26896847"}],"product":"Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR018C"}


id: YHR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02517":null,"YHR019C":null},"has_protein_features":false,"name":"DED81","ortholog_annotations":[{"gene_uniquename":"YHR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02517","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02517","reference_uniquename":"PMID:26896847"}],"product":"Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR019C"}


id: YHR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01259":null,"YHR020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01259","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01259","reference_uniquename":"PMID:26896847"}],"product":"Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR020W"}


id: YHR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02340":null,"YHR021C":null},"has_protein_features":false,"name":"RPS27B","ortholog_annotations":[{"gene_uniquename":"YHR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021C"}


id: YHR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM12","product":"Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity","secondary_identifier":"SGD:S000003531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021W-A"}


id: YHR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YHR022C is not an essential gene","secondary_identifier":"SGD:S000001064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C"}


id: YHR022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C-A"}


id: YHR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02431":null,"SJAG_03703":null,"YHR023W":null},"has_protein_features":false,"name":"MYO1","ortholog_annotations":[{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02431","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03703","reference_uniquename":"PMID:29761456"}],"product":"Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR023W"}


id: YHR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04641":null,"YHR024C":null},"has_protein_features":false,"name":"MAS2","ortholog_annotations":[{"gene_uniquename":"YHR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04641","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04641","reference_uniquename":"PMID:26896847"}],"product":"Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR024C"}


id: YHR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03141":null,"YHR025W":null},"has_protein_features":false,"name":"THR1","ortholog_annotations":[{"gene_uniquename":"YHR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03141","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03141","reference_uniquename":"PMID:26896847"}],"product":"Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR025W"}


id: YHR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02023":null,"YHR026W":null},"has_protein_features":false,"name":"VMA16","ortholog_annotations":[{"gene_uniquename":"YHR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02023","reference_uniquename":"PMID:29761456"}],"product":"Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR026W"}


id: YHR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03638":null,"YHR027C":null},"has_protein_features":false,"name":"RPN1","ortholog_annotations":[{"gene_uniquename":"YHR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03638","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03638","reference_uniquename":"PMID:26896847"}],"product":"Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR027C"}


id: YHR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02565":null,"YHR028C":null},"has_protein_features":false,"name":"DAP2","ortholog_annotations":[{"gene_uniquename":"YHR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028C"}


id: YHR028W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C","secondary_identifier":"SGD:S000028776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028W-A"}


id: YHR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YHI9","product":"Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production","secondary_identifier":"SGD:S000001071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR029C"}


id: YHR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04551":null,"YHR030C":null},"has_protein_features":false,"name":"SLT2","ortholog_annotations":[{"gene_uniquename":"YHR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04551","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR030C"}


id: YHR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03780":null,"YHR031C":null},"has_protein_features":false,"name":"RRM3","ortholog_annotations":[{"gene_uniquename":"YHR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; deletion or inactivation of helicase function suppresses chromosome instability (CIN) associated with centromere or kinetochore defects; structurally and functionally related to Pif1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR031C"}


id: YHR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A","secondary_identifier":"SGD:S000028646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032C-A"}


id: YHR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YHR032W":null},"has_protein_features":false,"name":"ERC1","ortholog_annotations":[{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W"}


id: YHR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A","secondary_identifier":"SGD:S000028831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W-A"}


id: YHR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03457":null,"YHR033W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR033W"}


id: YHR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIH1","product":"Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II","secondary_identifier":"SGD:S000001076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR034C"}


id: YHR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NEL1","product":"Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene","secondary_identifier":"SGD:S000001077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR035W"}


id: YHR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01422":null,"YHR036W":null},"has_protein_features":false,"name":"BRL1","ortholog_annotations":[{"gene_uniquename":"YHR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:26896847"}],"product":"Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR036W"}


id: YHR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02235":null,"YHR037W":null},"has_protein_features":false,"name":"PUT2","ortholog_annotations":[{"gene_uniquename":"YHR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02235","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02235","reference_uniquename":"PMID:26896847"}],"product":"Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR037W"}


id: YHR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03232":null,"YHR038W":null},"has_protein_features":false,"name":"RRF1","ortholog_annotations":[{"gene_uniquename":"YHR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03232","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR038W"}


id: YHR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00482":null,"YHR039C":null},"has_protein_features":false,"name":"MSC7","ortholog_annotations":[{"gene_uniquename":"YHR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00482","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C"}


id: YHR039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01447":null,"YHR039C-A":null},"has_protein_features":false,"name":"VMA10","ortholog_annotations":[{"gene_uniquename":"YHR039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01447","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01447","reference_uniquename":"PMID:26896847"}],"product":"Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C-A"}


id: YHR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00752":null,"YHR040W":null},"has_protein_features":false,"name":"BCD1","ortholog_annotations":[{"gene_uniquename":"YHR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00752","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00752","reference_uniquename":"PMID:26896847"}],"product":"Essential protein required for the accumulation of box C/D snoRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR040W"}


id: YHR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04099":null,"YHR041C":null},"has_protein_features":false,"name":"SRB2","ortholog_annotations":[{"gene_uniquename":"YHR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04099","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR041C"}


id: YHR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04270":null,"YHR042W":null},"has_protein_features":false,"name":"NCP1","ortholog_annotations":[{"gene_uniquename":"YHR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04270","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04270","reference_uniquename":"PMID:26896847"}],"product":"NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR042W"}


id: YHR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DOG2","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR043C"}


id: YHR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DOG1","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR044C"}


id: YHR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDE1","product":"Protein involved in DNA damage response and ergosterol biosynthesis; acts in cooperation with Dap1p in regulating DNA damage response and ergosterol biosynthesis","secondary_identifier":"SGD:S000001087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR045W"}


id: YHR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INM1","product":"Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate","secondary_identifier":"SGD:S000001088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR046C"}


id: YHR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00181":null,"YHR047C":null},"has_protein_features":false,"name":"AAP1","ortholog_annotations":[{"gene_uniquename":"YHR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:26896847"}],"product":"Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR047C"}


id: YHR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02344":null,"YHR048W":null},"has_protein_features":false,"name":"YHK8","ortholog_annotations":[{"gene_uniquename":"YHR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:26896847"}],"product":"Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR048W"}


id: YHR049C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049C-A"}


id: YHR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03760":null,"YHR049W":null},"has_protein_features":false,"name":"FSH1","ortholog_annotations":[{"gene_uniquename":"YHR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049W"}


id: YHR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YHR050W":null},"has_protein_features":false,"name":"SMF2","ortholog_annotations":[{"gene_uniquename":"YHR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:26896847"}],"product":"Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W"}


id: YHR050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W-A"}


id: YHR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01355":null,"YHR051W":null},"has_protein_features":false,"name":"COX6","ortholog_annotations":[{"gene_uniquename":"YHR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01355","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01355","reference_uniquename":"PMID:26896847"}],"product":"Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR051W"}


id: YHR052C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052C-B"}


id: YHR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YHR052W":null},"has_protein_features":false,"name":"CIC1","ortholog_annotations":[{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W"}


id: YHR052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1","secondary_identifier":"SGD:S000028647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W-A"}


id: YHR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CUP1-1","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000001095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR053C"}


id: YHR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication","secondary_identifier":"SGD:S000001096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C"}


id: YHR054C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C-B"}


id: YHR054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2","secondary_identifier":"SGD:S000028648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054W-A"}


id: YHR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CUP1-2","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR055C"}


id: YHR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSC30","product":"Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056C"}


id: YHR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C","secondary_identifier":"SGD:S000028777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056W-A"}


id: YHR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02413":null,"YHR057C":null},"has_protein_features":false,"name":"CPR2","ortholog_annotations":[{"gene_uniquename":"YHR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR057C"}


id: YHR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04705":null,"YHR058C":null},"has_protein_features":false,"name":"MED6","ortholog_annotations":[{"gene_uniquename":"YHR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04705","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR058C"}


id: YHR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00060":null,"YHR059W":null},"has_protein_features":false,"name":"FYV4","ortholog_annotations":[{"gene_uniquename":"YHR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00060","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR059W"}


id: YHR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VMA22","product":"Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","secondary_identifier":"SGD:S000001102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR060W"}


id: YHR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIC1","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress","secondary_identifier":"SGD:S000001103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR061C"}


id: YHR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04916":null,"YHR062C":null},"has_protein_features":false,"name":"RPP1","ortholog_annotations":[{"gene_uniquename":"YHR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04916","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04916","reference_uniquename":"PMID:26896847"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR062C"}


id: YHR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAN5","product":"2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE","secondary_identifier":"SGD:S000001105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063C"}


id: YHR063W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C","secondary_identifier":"SGD:S000028778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063W-A"}


id: YHR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01510":null,"YHR064C":null},"has_protein_features":false,"name":"SSZ1","ortholog_annotations":[{"gene_uniquename":"YHR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01510","reference_uniquename":"PMID:26896847"}],"product":"Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR064C"}


id: YHR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04974":null,"YHR065C":null},"has_protein_features":false,"name":"RRP3","ortholog_annotations":[{"gene_uniquename":"YHR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04974","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04974","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR065C"}


id: YHR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02427":null,"YHR066W":null},"has_protein_features":false,"name":"SSF1","ortholog_annotations":[{"gene_uniquename":"YHR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:26896847"}],"product":"Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR066W"}


id: YHR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00305":null,"YHR067W":null},"has_protein_features":false,"name":"HTD2","ortholog_annotations":[{"gene_uniquename":"YHR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00305","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00305","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR067W"}


id: YHR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04130":null,"YHR068W":null},"has_protein_features":false,"name":"DYS1","ortholog_annotations":[{"gene_uniquename":"YHR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04130","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR068W"}


id: YHR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01521":null,"YHR069C":null},"has_protein_features":false,"name":"RRP4","ortholog_annotations":[{"gene_uniquename":"YHR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01521","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01521","reference_uniquename":"PMID:26896847"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C"}


id: YHR069C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W","secondary_identifier":"SGD:S000028779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C-A"}


id: YHR070C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W","secondary_identifier":"SGD:S000028780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070C-A"}


id: YHR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00255":null,"YHR070W":null},"has_protein_features":false,"name":"TRM5","ortholog_annotations":[{"gene_uniquename":"YHR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00255","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00255","reference_uniquename":"PMID:26896847"}],"product":"tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070W"}


id: YHR071C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W","secondary_identifier":"SGD:S000028781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071C-A"}


id: YHR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03591":null,"YHR071W":null},"has_protein_features":false,"name":"PCL5","ortholog_annotations":[{"gene_uniquename":"YHR071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03591","reference_uniquename":"PMID:29761456"}],"product":"Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071W"}


id: YHR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00624":null,"YHR072W":null},"has_protein_features":false,"name":"ERG7","ortholog_annotations":[{"gene_uniquename":"YHR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00624","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00624","reference_uniquename":"PMID:26896847"}],"product":"Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W"}


id: YHR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00566":null,"YHR072W-A":null},"has_protein_features":false,"name":"NOP10","ortholog_annotations":[{"gene_uniquename":"YHR072W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR072W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00566","reference_uniquename":"PMID:26896847"}],"product":"Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W-A"}


id: YHR073C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073C-B"}


id: YHR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00355":null,"YHR073W":null},"has_protein_features":false,"name":"OSH3","ortholog_annotations":[{"gene_uniquename":"YHR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00355","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00355","reference_uniquename":"PMID:26896847"}],"product":"Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W"}


id: YHR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W-A"}


id: YHR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02618":null,"YHR074W":null},"has_protein_features":false,"name":"QNS1","ortholog_annotations":[{"gene_uniquename":"YHR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02618","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02618","reference_uniquename":"PMID:26896847"}],"product":"Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR074W"}


id: YHR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01628":null,"YHR075C":null},"has_protein_features":false,"name":"PPE1","ortholog_annotations":[{"gene_uniquename":"YHR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01628","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01628","reference_uniquename":"PMID:26896847"}],"product":"Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR075C"}


id: YHR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01672":null,"YHR076W":null},"has_protein_features":false,"name":"PTC7","ortholog_annotations":[{"gene_uniquename":"YHR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01672","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01672","reference_uniquename":"PMID:26896847"}],"product":"Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR076W"}


id: YHR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05014":null,"YHR077C":null},"has_protein_features":false,"name":"NMD2","ortholog_annotations":[{"gene_uniquename":"YHR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05014","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05014","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; acts as a scaffold protein bridging Nam7p and Upf3p; involved in telomere maintenance; contains an acidic domain and three middle domains of eukaryotic initiation factor 4G (mIF4G) with aspartic 59 of mIF4G-1 important for NMD activity and translation termination accuracy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR077C"}


id: YHR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"High osmolarity-regulated gene of unknown function","secondary_identifier":"SGD:S000001120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR078W"}


id: YHR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04435":null,"YHR079C":null},"has_protein_features":false,"name":"IRE1","ortholog_annotations":[{"gene_uniquename":"YHR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04435","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04435","reference_uniquename":"PMID:26896847"}],"product":"Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C"}


id: YHR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03221":null,"YHR079C-A":null},"has_protein_features":false,"name":"SAE3","ortholog_annotations":[{"gene_uniquename":"YHR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03221","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C-A"}


id: YHR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YHR080C":null},"has_protein_features":false,"name":"LAM4","ortholog_annotations":[{"gene_uniquename":"YHR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR080C"}


id: YHR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01191":null,"YHR081W":null},"has_protein_features":false,"name":"LRP1","ortholog_annotations":[{"gene_uniquename":"YHR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01191","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR081W"}


id: YHR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03529":null,"YHR082C":null},"has_protein_features":false,"name":"KSP1","ortholog_annotations":[{"gene_uniquename":"YHR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR082C"}


id: YHR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01780":null,"YHR083W":null},"has_protein_features":false,"name":"SAM35","ortholog_annotations":[{"gene_uniquename":"YHR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01780","reference_uniquename":"PMID:29761456"}],"product":"Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR083W"}


id: YHR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STE12","product":"Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth","secondary_identifier":"SGD:S000001126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR084W"}


id: YHR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04252":null,"YHR085W":null},"has_protein_features":false,"name":"IPI1","ortholog_annotations":[{"gene_uniquename":"YHR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04252","reference_uniquename":"PMID:26896847"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR085W"}


id: YHR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YHR086W":null},"has_protein_features":false,"name":"NAM8","ortholog_annotations":[{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W"}


id: YHR086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000028552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W-A"}


id: YHR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00487":null,"YHR087W":null},"has_protein_features":false,"name":"RTC3","ortholog_annotations":[{"gene_uniquename":"YHR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00487","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR087W"}


id: YHR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04492":null,"YHR088W":null},"has_protein_features":false,"name":"RPF1","ortholog_annotations":[{"gene_uniquename":"YHR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04492","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04492","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR088W"}


id: YHR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01234":null,"YHR089C":null},"has_protein_features":false,"name":"GAR1","ortholog_annotations":[{"gene_uniquename":"YHR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01234","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01234","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR089C"}


id: YHR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YHR090C":null},"has_protein_features":false,"name":"YNG2","ortholog_annotations":[{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:26896847"}],"product":"Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR090C"}


id: YHR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00653":null,"YHR091C":null},"has_protein_features":false,"name":"MSR1","ortholog_annotations":[{"gene_uniquename":"YHR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR091C"}


id: YHR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR092C":null},"has_protein_features":false,"name":"HXT4","ortholog_annotations":[{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR092C"}


id: YHR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AHT1","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region","secondary_identifier":"SGD:S000001135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR093W"}


id: YHR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR094C":null},"has_protein_features":false,"name":"HXT1","ortholog_annotations":[{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR094C"}


id: YHR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR095W"}


id: YHR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR096C":null},"has_protein_features":false,"name":"HXT5","ortholog_annotations":[{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR096C"}


id: YHR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04050":null,"SJAG_05198":null,"YHR097C":null},"has_protein_features":false,"name":"PAL2","ortholog_annotations":[{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04050","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05198","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR097C"}


id: YHR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02349":null,"YHR098C":null},"has_protein_features":false,"name":"SFB3","ortholog_annotations":[{"gene_uniquename":"YHR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02349","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02349","reference_uniquename":"PMID:26896847"}],"product":"Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR098C"}


id: YHR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04613":null,"SJAG_05282":null,"YHR099W":null},"has_protein_features":false,"name":"TRA1","ortholog_annotations":[{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04613","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05282","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR099W"}


id: YHR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03700":null,"YHR100C":null},"has_protein_features":false,"name":"GEP4","ortholog_annotations":[{"gene_uniquename":"YHR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03700","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03700","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR100C"}


id: YHR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00771":null,"YHR101C":null},"has_protein_features":false,"name":"BIG1","ortholog_annotations":[{"gene_uniquename":"YHR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR101C"}


id: YHR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04461":null,"YHR102W":null},"has_protein_features":false,"name":"KIC1","ortholog_annotations":[{"gene_uniquename":"YHR102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04461","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR102W"}


id: YHR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SBE22","product":"Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR103W"}


id: YHR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GRE3","product":"Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR104W"}


id: YHR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPT35","product":"Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport","secondary_identifier":"SGD:S000001147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR105W"}


id: YHR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03653":null,"SJAG_04399":null,"YHR106W":null},"has_protein_features":false,"name":"TRR2","ortholog_annotations":[{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04399","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR106W"}


id: YHR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03374":null,"SJAG_03688":null,"YHR107C":null},"has_protein_features":false,"name":"CDC12","ortholog_annotations":[{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03374","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03688","reference_uniquename":"PMID:29761456"}],"product":"Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR107C"}


id: YHR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02912":null,"SJAG_03756":null,"YHR108W":null},"has_protein_features":false,"name":"GGA2","ortholog_annotations":[{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03756","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates Arf1p and Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; K63-specific Ub chain binding receptor with moderate selectivity; homologous to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR108W"}


id: YHR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTM1","product":"Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth","secondary_identifier":"SGD:S000001151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR109W"}


id: YHR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04598":null,"YHR110W":null},"has_protein_features":false,"name":"ERP5","ortholog_annotations":[{"gene_uniquename":"YHR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:26896847"}],"product":"Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR110W"}


id: YHR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03896":null,"YHR111W":null},"has_protein_features":false,"name":"UBA4","ortholog_annotations":[{"gene_uniquename":"YHR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03896","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03896","reference_uniquename":"PMID:26896847"}],"product":"E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR111W"}


id: YHR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02205":null,"YHR112C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02205","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02205","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR112C"}


id: YHR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03022":null,"YHR113W":null},"has_protein_features":false,"name":"APE4","ortholog_annotations":[{"gene_uniquename":"YHR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03022","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03022","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic aspartyl aminopeptidase with possible vacuole function; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms 12-subunit homo-oligomer; M18 metalloprotease family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR113W"}


id: YHR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04479":null,"YHR114W":null},"has_protein_features":false,"name":"BZZ1","ortholog_annotations":[{"gene_uniquename":"YHR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04479","reference_uniquename":"PMID:26896847"}],"product":"SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR114W"}


id: YHR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02169":null,"YHR115C":null},"has_protein_features":false,"name":"DMA1","ortholog_annotations":[{"gene_uniquename":"YHR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02169","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02169","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR115C"}


id: YHR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COX23","product":"Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs","secondary_identifier":"SGD:S000001158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR116W"}


id: YHR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04996":null,"YHR117W":null},"has_protein_features":false,"name":"TOM71","ortholog_annotations":[{"gene_uniquename":"YHR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04996","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR117W"}


id: YHR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01267":null,"YHR118C":null},"has_protein_features":false,"name":"ORC6","ortholog_annotations":[{"gene_uniquename":"YHR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01267","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR118C"}


id: YHR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00769":null,"YHR119W":null},"has_protein_features":false,"name":"SET1","ortholog_annotations":[{"gene_uniquename":"YHR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00769","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00769","reference_uniquename":"PMID:26896847"}],"product":"Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR119W"}


id: YHR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01807":null,"YHR120W":null},"has_protein_features":false,"name":"MSH1","ortholog_annotations":[{"gene_uniquename":"YHR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01807","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01807","reference_uniquename":"PMID:26896847"}],"product":"DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR120W"}


id: YHR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LSM12","product":"Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR121W"}


id: YHR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00040":null,"YHR122W":null},"has_protein_features":false,"name":"CIA2","ortholog_annotations":[{"gene_uniquename":"YHR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00040","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00040","reference_uniquename":"PMID:26896847"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR122W"}


id: YHR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04319":null,"YHR123W":null},"has_protein_features":false,"name":"EPT1","ortholog_annotations":[{"gene_uniquename":"YHR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04319","reference_uniquename":"PMID:26896847"}],"product":"sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR123W"}


id: YHR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NDT80","product":"Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)","secondary_identifier":"SGD:S000001166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR124W"}


id: YHR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR125W"}


id: YHR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ANS1","product":"Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p","secondary_identifier":"SGD:S000001168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR126C"}


id: YHR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis","secondary_identifier":"SGD:S000001169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR127W"}


id: YHR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04354":null,"SJAG_04709":null,"SJAG_04713":null,"YHR128W":null},"has_protein_features":false,"name":"FUR1","ortholog_annotations":[{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04354","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04354","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04709","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04713","reference_uniquename":"PMID:29761456"}],"product":"Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR128W"}


id: YHR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00397":null,"SJAG_01964":null,"YHR129C":null},"has_protein_features":false,"name":"ARP1","ortholog_annotations":[{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00397","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01964","reference_uniquename":"PMID:26896847"}],"product":"Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR129C"}


id: YHR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YHR130C is not an essential gene","secondary_identifier":"SGD:S000001172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR130C"}


id: YHR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR131C"}


id: YHR131W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YHR131C","secondary_identifier":"SGD:S000028782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR131W-A"}


id: YHR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00451":null,"YHR132C":null},"has_protein_features":false,"name":"ECM14","ortholog_annotations":[{"gene_uniquename":"YHR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00451","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00451","reference_uniquename":"PMID:26896847"}],"product":"Conserved fungal protein with similarity to zinc carboxypeptidases; in some strains required for normal cell wall assembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR132C"}


id: YHR132W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03309":null,"YHR132W-A":null},"has_protein_features":false,"name":"IGO2","ortholog_annotations":[{"gene_uniquename":"YHR132W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03309","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR132W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03309","reference_uniquename":"PMID:26896847"}],"product":"Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S64) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo1p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR132W-A"}


id: YHR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00770":null,"YHR133C":null},"has_protein_features":false,"name":"NSG1","ortholog_annotations":[{"gene_uniquename":"YHR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00770","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR133C"}


id: YHR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00406":null,"YHR134W":null},"has_protein_features":false,"name":"WSS1","ortholog_annotations":[{"gene_uniquename":"YHR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00406","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00406","reference_uniquename":"PMID:26896847"}],"product":"SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR134W"}


id: YHR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00402":null,"SJAG_01373":null,"SJAG_03987":null,"YHR135C":null},"has_protein_features":false,"name":"YCK1","ortholog_annotations":[{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:29761456"}],"product":"Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR135C"}


id: YHR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPL2","product":"Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR136C"}


id: YHR137C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR137C-A"}


id: YHR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03312":null,"YHR137W":null},"has_protein_features":false,"name":"ARO9","ortholog_annotations":[{"gene_uniquename":"YHR137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03312","reference_uniquename":"PMID:29761456"}],"product":"Aromatic aminotransferase II; involved in tyrosine, phenylalanine, and methionine metabolism; involved with Aro8p in production of kynurenic acid to detoxify excess tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR137W"}


id: YHR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR138C"}


id: YHR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPS100","product":"Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR139C"}


id: YHR139C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR139C-A"}


id: YHR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04570":null,"YHR140W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04570","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum protein; may contribute to maintenance of ER and nuclear morphology; null mutant shows discontinuity in nuclear envelope, clustering of nuclear pores, and lacks cortical ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR140W"}


id: YHR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04626":null,"YHR141C":null},"has_protein_features":false,"name":"RPL42B","ortholog_annotations":[{"gene_uniquename":"YHR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04626","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR141C"}


id: YHR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CHS7","product":"Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress","secondary_identifier":"SGD:S000001184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR142W"}


id: YHR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DSE2","product":"Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; localizes in birth scars; expression is repressed by cAMP","secondary_identifier":"SGD:S000001186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR143W"}


id: YHR143W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01313":null,"YHR143W-A":null},"has_protein_features":false,"name":"RPC10","ortholog_annotations":[{"gene_uniquename":"YHR143W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01313","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR143W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01313","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress; localizes to the peroxisome in a Pex5p-dependent manner","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR143W-A"}


id: YHR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03771":null,"YHR144C":null},"has_protein_features":false,"name":"DCD1","ortholog_annotations":[{"gene_uniquename":"YHR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03771","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03771","reference_uniquename":"PMID:26896847"}],"product":"Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR144C"}


id: YHR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR145C"}


id: YHR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CRP1","product":"Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR146W"}


id: YHR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01478":null,"YHR147C":null},"has_protein_features":false,"name":"MRPL6","ortholog_annotations":[{"gene_uniquename":"YHR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01478","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01478","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR147C"}


id: YHR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02372":null,"YHR148W":null},"has_protein_features":false,"name":"IMP3","ortholog_annotations":[{"gene_uniquename":"YHR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02372","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR148W"}


id: YHR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKG6","product":"Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog, TOS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR149C"}


id: YHR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03493":null,"YHR150W":null},"has_protein_features":false,"name":"PEX28","ortholog_annotations":[{"gene_uniquename":"YHR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03493","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR150W"}


id: YHR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC6","product":"ER-resident glycoprotein involved in high-pressure tolerance; proposed role promoting proper folding of nutrient permeases, such as Tat2p, in the ER during hydrostatic pressure stress and maintaining permease conformational stability; contains two transmembrane domains, a C-terminal cytoplasmic domain and a luminal region with 12 N-linked glycans; null is synthetically sick with cdc13-1; localizes to the ER membrane","secondary_identifier":"SGD:S000001194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR151C"}


id: YHR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01341":null,"YHR152W":null},"has_protein_features":false,"name":"SPO12","ortholog_annotations":[{"gene_uniquename":"YHR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01341","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR152W"}


id: YHR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO16","product":"Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation","secondary_identifier":"SGD:S000001196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR153C"}


id: YHR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02837":null,"SJAG_04142":null,"YHR154W":null},"has_protein_features":false,"name":"RTT107","ortholog_annotations":[{"gene_uniquename":"YHR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02837","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04142","reference_uniquename":"PMID:26896847"}],"product":"BRCA1 C-terminal domain protein needed for recovery from DNA damage; implicated in Mms22-dependent DNA repair during S phase; involved in recruiting SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR154W"}


id: YHR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03247":null,"YHR155W":null},"has_protein_features":false,"name":"LAM1","ortholog_annotations":[{"gene_uniquename":"YHR155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:26896847"}],"product":"Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR155W"}


id: YHR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00278":null,"YHR156C":null},"has_protein_features":false,"name":"LIN1","ortholog_annotations":[{"gene_uniquename":"YHR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00278","reference_uniquename":"PMID:29761456"}],"product":"Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR156C"}


id: YHR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"REC104","product":"Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination","secondary_identifier":"SGD:S000001200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR157W"}


id: YHR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01196":null,"SJAG_04322":null,"YHR158C":null},"has_protein_features":false,"name":"KEL1","ortholog_annotations":[{"gene_uniquename":"YHR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01196","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04322","reference_uniquename":"PMID:29761456"}],"product":"Protein required for proper cell fusion and cell morphology; acts as phosphorylation-regulated noise suppressor of pheromone signaling pathway; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR158C"}


id: YHR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TDA11","product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele","secondary_identifier":"SGD:S000001202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR159W"}


id: YHR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX18","product":"Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth","secondary_identifier":"SGD:S000001203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR160C"}


id: YHR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01748":null,"YHR161C":null},"has_protein_features":false,"name":"YAP1801","ortholog_annotations":[{"gene_uniquename":"YHR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:26896847"}],"product":"Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR161C"}


id: YHR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04593":null,"YHR162W":null},"has_protein_features":false,"name":"MPC2","ortholog_annotations":[{"gene_uniquename":"YHR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:26896847"}],"product":"Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR162W"}


id: YHR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YHR163W":null},"has_protein_features":false,"name":"SOL3","ortholog_annotations":[{"gene_uniquename":"YHR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:26896847"}],"product":"6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR163W"}


id: YHR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04183":null,"YHR164C":null},"has_protein_features":false,"name":"DNA2","ortholog_annotations":[{"gene_uniquename":"YHR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04183","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04183","reference_uniquename":"PMID:26896847"}],"product":"ATP-dependent 5'-flap endonuclease and DNA helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; cell cycle-dependent localization to telomeric chromatin and replicating chromosomes; required for telomerase-dependent telomere synthesis; stability, localization and nuclease activity regulated by sumoylation; forms nuclear foci upon replication stress; human homolog DNA2 complements yeast dna2 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR164C"}


id: YHR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04497":null,"YHR165C":null},"has_protein_features":false,"name":"PRP8","ortholog_annotations":[{"gene_uniquename":"YHR165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04497","reference_uniquename":"PMID:29761456"}],"product":"Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR165C"}


id: YHR165W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF PRP8/YHR165C","secondary_identifier":"SGD:S000028783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR165W-A"}


id: YHR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03351":null,"YHR166C":null},"has_protein_features":false,"name":"CDC23","ortholog_annotations":[{"gene_uniquename":"YHR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03351","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03351","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR166C"}


id: YHR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"THP2","product":"Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance","secondary_identifier":"SGD:S000001210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR167W"}


id: YHR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00231":null,"YHR168W":null},"has_protein_features":false,"name":"MTG2","ortholog_annotations":[{"gene_uniquename":"YHR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00231","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00231","reference_uniquename":"PMID:26896847"}],"product":"Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR168W"}


id: YHR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01182":null,"YHR169W":null},"has_protein_features":false,"name":"DBP8","ortholog_annotations":[{"gene_uniquename":"YHR169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01182","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01182","reference_uniquename":"PMID:26896847"}],"product":"ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR169W"}


id: YHR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03882":null,"YHR170W":null},"has_protein_features":false,"name":"NMD3","ortholog_annotations":[{"gene_uniquename":"YHR170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03882","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR170W"}


id: YHR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00645":null,"YHR171W":null},"has_protein_features":false,"name":"ATG7","ortholog_annotations":[{"gene_uniquename":"YHR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00645","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00645","reference_uniquename":"PMID:26896847"}],"product":"Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR171W"}


id: YHR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03835":null,"YHR172W":null},"has_protein_features":false,"name":"SPC97","ortholog_annotations":[{"gene_uniquename":"YHR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03835","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03835","reference_uniquename":"PMID:26896847"}],"product":"Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR172W"}


id: YHR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR173C"}


id: YHR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YHR174W":null},"has_protein_features":false,"name":"ENO2","ortholog_annotations":[{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:26896847"}],"product":"Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; mRNA is asymmetrically distributed to daughter cells in a Sir2p-dependent manner, and asymmetry is lost during replicative aging; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR174W"}


id: YHR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTR2","product":"Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway","secondary_identifier":"SGD:S000001218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W"}


id: YHR175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W-A"}


id: YHR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04608":null,"YHR176W":null},"has_protein_features":false,"name":"FMO1","ortholog_annotations":[{"gene_uniquename":"YHR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04608","reference_uniquename":"PMID:26896847"}],"product":"Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR176W"}


id: YHR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02921":null,"SJAG_04920":null,"YHR177W":null},"has_protein_features":false,"name":"ROF1","ortholog_annotations":[{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:26896847"}],"product":"Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR177W"}


id: YHR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB5","product":"Transcription factor; regulates multidrug resistance and the oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; negative regulator of autophagy, modulating the transcription of genes involved in NADPH production and the pentose phosphate pathway; Stb5p expression is reduced during nitrogen starvation and autophagy induction, while STB5 mRNA levels are significantly increased","secondary_identifier":"SGD:S000001221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR178W"}


id: YHR179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OYE2","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR179W"}


id: YHR180C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A","secondary_identifier":"SGD:S000028554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180C-B"}


id: YHR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W"}


id: YHR180W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3","secondary_identifier":"SGD:S000028555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W-A"}


id: YHR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00785":null,"YHR181W":null},"has_protein_features":false,"name":"SVP26","ortholog_annotations":[{"gene_uniquename":"YHR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00785","reference_uniquename":"PMID:26896847"}],"product":"ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR181W"}


id: YHR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF GND1/YHR183W","secondary_identifier":"SGD:S000028784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182C-A"}


id: YHR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGD3","product":"GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000001225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182W"}


id: YHR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03852":null,"YHR183W":null},"has_protein_features":false,"name":"GND1","ortholog_annotations":[{"gene_uniquename":"YHR183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR183W"}


id: YHR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSP1","product":"Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis","secondary_identifier":"SGD:S000001227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR184W"}


id: YHR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFS1","product":"Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation","secondary_identifier":"SGD:S000001228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR185C"}


id: YHR186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01509":null,"YHR186C":null},"has_protein_features":false,"name":"KOG1","ortholog_annotations":[{"gene_uniquename":"YHR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01509","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-binding protein; centrally regulates metabolic homeostasis and carbon utilization during nutrient limitation by managing Snf1p activity; subunit of TORC1 rapamycin-sensitive complex involved in growth control; central scaffold that holds the different components of TORC1 together; contains four HEAT repeats and seven WD-40 repeats","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR186C"}


id: YHR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04175":null,"YHR187W":null},"has_protein_features":false,"name":"IKI1","ortholog_annotations":[{"gene_uniquename":"YHR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04175","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04175","reference_uniquename":"PMID:26896847"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; localizes to cytosol, nucleus and peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR187W"}


id: YHR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00846":null,"YHR188C":null},"has_protein_features":false,"name":"GPI16","ortholog_annotations":[{"gene_uniquename":"YHR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00846","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00846","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR188C"}


id: YHR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00936":null,"YHR189W":null},"has_protein_features":false,"name":"PTH1","ortholog_annotations":[{"gene_uniquename":"YHR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00936","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00936","reference_uniquename":"PMID:26896847"}],"product":"One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR189W"}


id: YHR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02719":null,"YHR190W":null},"has_protein_features":false,"name":"ERG9","ortholog_annotations":[{"gene_uniquename":"YHR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02719","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02719","reference_uniquename":"PMID:26896847"}],"product":"Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR190W"}


id: YHR191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02373":null,"YHR191C":null},"has_protein_features":false,"name":"CTF8","ortholog_annotations":[{"gene_uniquename":"YHR191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR191C"}


id: YHR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03812":null,"YHR192W":null},"has_protein_features":false,"name":"LNP1","ortholog_annotations":[{"gene_uniquename":"YHR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03812","reference_uniquename":"PMID:29761456"}],"product":"Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR192W"}


id: YHR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01641":null,"YHR193C":null},"has_protein_features":false,"name":"EGD2","ortholog_annotations":[{"gene_uniquename":"YHR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01641","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01641","reference_uniquename":"PMID:26896847"}],"product":"Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C"}


id: YHR193C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W","secondary_identifier":"SGD:S000028785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C-A"}


id: YHR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03395":null,"YHR194W":null},"has_protein_features":false,"name":"MDM31","ortholog_annotations":[{"gene_uniquename":"YHR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR194W"}


id: YHR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NVJ1","product":"Nuclear envelope protein; anchored to nuclear inner membrane, interacts with vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN); targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000001238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR195W"}


id: YHR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02499":null,"SJAG_02702":null,"YHR196W":null},"has_protein_features":false,"name":"UTP9","ortholog_annotations":[{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02702","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR196W"}


id: YHR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01056":null,"YHR197W":null},"has_protein_features":false,"name":"RIX1","ortholog_annotations":[{"gene_uniquename":"YHR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01056","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR197W"}


id: YHR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM18","product":"Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity","secondary_identifier":"SGD:S000001241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR198C"}


id: YHR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM46","product":"Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity","secondary_identifier":"SGD:S000001242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C"}


id: YHR199C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00697":null,"YHR199C-A":null},"has_protein_features":false,"name":"NBL1","ortholog_annotations":[{"gene_uniquename":"YHR199C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00697","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C-A"}


id: YHR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02992":null,"YHR200W":null},"has_protein_features":false,"name":"RPN10","ortholog_annotations":[{"gene_uniquename":"YHR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02992","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02992","reference_uniquename":"PMID:26896847"}],"product":"Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR200W"}


id: YHR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03964":null,"YHR201C":null},"has_protein_features":false,"name":"PPX1","ortholog_annotations":[{"gene_uniquename":"YHR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03964","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03964","reference_uniquename":"PMID:26896847"}],"product":"Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR201C"}


id: YHR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02580":null,"SJAG_02582":null,"SJAG_02959":null,"YHR202W":null},"has_protein_features":false,"name":"SMN1","ortholog_annotations":[{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02959","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02959","reference_uniquename":"PMID:29761456"}],"product":"Putative AMP hydrolase; secreted protein proposed to function as an adenosine monophosphatase in NAD+ degradation, via nucleoside salvage pathway that converts NAD+ to AMP and adenosine; overexpression results in adenosine accumulation and reduced levels of NAD+, deletion results in increased NAD+ and NADH; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; similar to human NT5E/CD73 gene involved in cancer progression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR202W"}


id: YHR203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04324":null,"SJAG_04663":null,"YHR203C":null},"has_protein_features":false,"name":"RPS4B","ortholog_annotations":[{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR203C"}


id: YHR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01858":null,"YHR204W":null},"has_protein_features":false,"name":"MNL1","ortholog_annotations":[{"gene_uniquename":"YHR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01858","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01858","reference_uniquename":"PMID:26896847"}],"product":"Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR204W"}


id: YHR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02426":null,"SJAG_04394":null,"YHR205W":null},"has_protein_features":false,"name":"SCH9","ortholog_annotations":[{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02426","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02426","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04394","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04394","reference_uniquename":"PMID:26896847"}],"product":"AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR205W"}


id: YHR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YHR206W":null},"has_protein_features":false,"name":"SKN7","ortholog_annotations":[{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR206W"}


id: YHR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03630":null,"YHR207C":null},"has_protein_features":false,"name":"SET5","ortholog_annotations":[{"gene_uniquename":"YHR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03630","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR207C"}


id: YHR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04149":null,"YHR208W":null},"has_protein_features":false,"name":"BAT1","ortholog_annotations":[{"gene_uniquename":"YHR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04149","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR208W"}


id: YHR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02973":null,"YHR209W":null},"has_protein_features":false,"name":"CRG1","ortholog_annotations":[{"gene_uniquename":"YHR209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"}],"product":"S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR209W"}


id: YHR210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions","secondary_identifier":"SGD:S000001253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR210C"}


id: YHR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO5","product":"Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR211W"}


id: YHR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YHR212C has a paralog, YAR060C, that arose from a segmental duplication","secondary_identifier":"SGD:S000001255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212C"}


id: YHR212W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212W-A"}


id: YHR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W"}


id: YHR213W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-A"}


id: YHR213W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-B"}


id: YHR214C-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-D"}


id: YHR214C-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-E"}


id: YHR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W"}


id: YHR214W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog, YAR068W, that arose from a segmental duplication","secondary_identifier":"SGD:S000003535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W-A"}


id: YHR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YHR215W":null},"has_protein_features":false,"name":"PHO12","ortholog_annotations":[{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:26896847"}],"product":"One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR215W"}


id: YHR216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YHR216W":null},"has_protein_features":false,"name":"IMD2","ortholog_annotations":[{"gene_uniquename":"YHR216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR216W"}


id: YHR217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R","secondary_identifier":"SGD:S000001260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR217C"}


id: YHR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000001261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W"}


id: YHR218W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely within telomere TEL08L","secondary_identifier":"SGD:S000028786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W-A"}


id: YHR219C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219C-A"}


id: YHR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII","secondary_identifier":"SGD:S000001262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219W"}


id: YIL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02041":null,"YIL001W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02041","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02041","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL001W"}


id: YIL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04545":null,"YIL002C":null},"has_protein_features":false,"name":"INP51","ortholog_annotations":[{"gene_uniquename":"YIL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04545","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002C"}


id: YIL002W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CMI7","product":"Putative mitochondrial protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002W-A"}


id: YIL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02895":null,"YIL003W":null},"has_protein_features":false,"name":"CFD1","ortholog_annotations":[{"gene_uniquename":"YIL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:26896847"}],"product":"Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL003W"}


id: YIL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02103":null,"YIL004C":null},"has_protein_features":false,"name":"BET1","ortholog_annotations":[{"gene_uniquename":"YIL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02103","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02103","reference_uniquename":"PMID:26896847"}],"product":"Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL004C"}


id: YIL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00131":null,"SJAG_02301":null,"SJAG_04904":null,"YIL005W":null},"has_protein_features":false,"name":"EPS1","ortholog_annotations":[{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00131","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02301","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04904","reference_uniquename":"PMID:29761456"}],"product":"ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL005W"}


id: YIL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04328":null,"YIL006W":null},"has_protein_features":false,"name":"YIA6","ortholog_annotations":[{"gene_uniquename":"YIL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL006W"}


id: YIL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02570":null,"YIL007C":null},"has_protein_features":false,"name":"NAS2","ortholog_annotations":[{"gene_uniquename":"YIL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02570","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02570","reference_uniquename":"PMID:26896847"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL007C"}


id: YIL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03616":null,"YIL008W":null},"has_protein_features":false,"name":"URM1","ortholog_annotations":[{"gene_uniquename":"YIL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03616","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03616","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; functions as a protein tag involved in the urmylation of proteins involved in nutrient sensing and the oxidative stress response; regulates stress-dependent condensate formation, promoting phase separation of numerous proteins to promote stress resilience and survival; forms co-condensates with Uba4p resulting in increased target urmylation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL008W"}


id: YIL009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01378":null,"YIL009C-A":null},"has_protein_features":false,"name":"EST3","ortholog_annotations":[{"gene_uniquename":"YIL009C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01378","reference_uniquename":"PMID:29761456"}],"product":"Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009C-A"}


id: YIL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YIL009W":null},"has_protein_features":false,"name":"FAA3","ortholog_annotations":[{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:26896847"}],"product":"Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009W"}


id: YIL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02515":null,"YIL010W":null},"has_protein_features":false,"name":"DOT5","ortholog_annotations":[{"gene_uniquename":"YIL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02515","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02515","reference_uniquename":"PMID:26896847"}],"product":"Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL010W"}


id: YIL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR3","product":"Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL011W"}


id: YIL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL012W"}


id: YIL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YIL013C":null},"has_protein_features":false,"name":"PDR11","ortholog_annotations":[{"gene_uniquename":"YIL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:26896847"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL013C"}


id: YIL014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon","secondary_identifier":"SGD:S000003536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014C-A"}


id: YIL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNT3","product":"Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation","secondary_identifier":"SGD:S000001276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014W"}


id: YIL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BAR1","product":"Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest","secondary_identifier":"SGD:S000001277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL015W"}


id: YIL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01737":null,"SJAG_04817":null,"YIL016W":null},"has_protein_features":false,"name":"SNL1","ortholog_annotations":[{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01737","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04817","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; proposed to act in protein synthesis, nuclear pore complex biogenesis and maintenance as well as protein folding and prion maintenance; ; has similarity to the mammalian BAG-1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL016W"}


id: YIL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02197":null,"YIL017C":null},"has_protein_features":false,"name":"VID28","ortholog_annotations":[{"gene_uniquename":"YIL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02197","reference_uniquename":"PMID:29761456"}],"product":"GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL017C"}


id: YIL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YIL018W":null},"has_protein_features":false,"name":"RPL2B","ortholog_annotations":[{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL018W"}


id: YIL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01347":null,"YIL019W":null},"has_protein_features":false,"name":"FAF1","ortholog_annotations":[{"gene_uniquename":"YIL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01347","reference_uniquename":"PMID:29761456"}],"product":"Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL019W"}


id: YIL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01346":null,"YIL020C":null},"has_protein_features":false,"name":"HIS6","ortholog_annotations":[{"gene_uniquename":"YIL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01346","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01346","reference_uniquename":"PMID:26896847"}],"product":"Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C"}


id: YIL020C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918, partially overlaps ORF RPB3/YIL021W","secondary_identifier":"SGD:S000028787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C-A"}


id: YIL021C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021C-A"}


id: YIL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02506":null,"YIL021W":null},"has_protein_features":false,"name":"RPB3","ortholog_annotations":[{"gene_uniquename":"YIL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02506","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02506","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021W"}


id: YIL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02077":null,"YIL022W":null},"has_protein_features":false,"name":"TIM44","ortholog_annotations":[{"gene_uniquename":"YIL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02077","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02077","reference_uniquename":"PMID:26896847"}],"product":"Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL022W"}


id: YIL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00222":null,"YIL023C":null},"has_protein_features":false,"name":"YKE4","ortholog_annotations":[{"gene_uniquename":"YIL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00222","reference_uniquename":"PMID:26896847"}],"product":"Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL023C"}


id: YIL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG45","product":"Autophagy receptor for glycogen; cytosolic receptor for glycogen that mediates glycophagy, the autophagy of glycogen; induced during prolonged nitrogen starvation and highly expressed during sporulation, both glycophagy-inducing conditions; expression directly regulated by Ume6p, a metabolic and meiotic transcriptional regulator; contains a glycogen-binding domain (GBD) and an Atg8 family-interacting motif (AIM) proposed to facilitate sequestration of glycogen by autophagic isolation membranes","secondary_identifier":"SGD:S000001286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL024C"}


id: YIL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL025C"}


id: YIL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03418":null,"SJAG_03698":null,"YIL026C":null},"has_protein_features":false,"name":"IRR1","ortholog_annotations":[{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03418","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03698","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03698","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL026C"}


id: YIL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01223":null,"YIL027C":null},"has_protein_features":false,"name":"EMC5","ortholog_annotations":[{"gene_uniquename":"YIL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01223","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL027C"}


id: YIL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL028W"}


id: YIL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EMA17","product":"Protein involved in targeting mitochondrial membrane protein precursors to mitochondrial translocation system; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, that arose from a single-locus duplication","secondary_identifier":"SGD:S000001291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029C"}


id: YIL029W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSM4/YIL030C","secondary_identifier":"SGD:S000028788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029W-A"}


id: YIL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03657":null,"YIL030C":null},"has_protein_features":false,"name":"SSM4","ortholog_annotations":[{"gene_uniquename":"YIL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03657","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03657","reference_uniquename":"PMID:26896847"}],"product":"Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030C"}


id: YIL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF ULP2/YIL031W","secondary_identifier":"SGD:S000028789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030W-A"}


id: YIL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16454":null,"YIL031W":null},"has_protein_features":false,"name":"ULP2","ortholog_annotations":[{"gene_uniquename":"YIL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16454","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16454","reference_uniquename":"PMID:26896847"}],"product":"Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL031W"}


id: YIL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL032C"}


id: YIL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01245":null,"YIL033C":null},"has_protein_features":false,"name":"BCY1","ortholog_annotations":[{"gene_uniquename":"YIL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01245","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01245","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; regulator of meiotic commitment","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL033C"}


id: YIL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02700":null,"YIL034C":null},"has_protein_features":false,"name":"CAP2","ortholog_annotations":[{"gene_uniquename":"YIL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02700","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02700","reference_uniquename":"PMID:26896847"}],"product":"Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches and the cytokinetic contractile ring; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL034C"}


id: YIL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01799":null,"YIL035C":null},"has_protein_features":false,"name":"CKA1","ortholog_annotations":[{"gene_uniquename":"YIL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:26896847"}],"product":"Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL035C"}


id: YIL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CST6","product":"Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL036W"}


id: YIL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM2","product":"Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion","secondary_identifier":"SGD:S000001299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL037C"}


id: YIL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04350":null,"YIL038C":null},"has_protein_features":false,"name":"NOT3","ortholog_annotations":[{"gene_uniquename":"YIL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04350","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL038C"}


id: YIL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01860":null,"YIL039W":null},"has_protein_features":false,"name":"TED1","ortholog_annotations":[{"gene_uniquename":"YIL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01860","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01860","reference_uniquename":"PMID:26896847"}],"product":"GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL039W"}


id: YIL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04578":null,"YIL040W":null},"has_protein_features":false,"name":"APQ12","ortholog_annotations":[{"gene_uniquename":"YIL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04578","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL040W"}


id: YIL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GVP36","product":"BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis","secondary_identifier":"SGD:S000001303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL041W"}


id: YIL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01402":null,"YIL042C":null},"has_protein_features":false,"name":"PKP1","ortholog_annotations":[{"gene_uniquename":"YIL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL042C"}


id: YIL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00235":null,"YIL043C":null},"has_protein_features":false,"name":"CBR1","ortholog_annotations":[{"gene_uniquename":"YIL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00235","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL043C"}


id: YIL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01600":null,"SJAG_04724":null,"YIL044C":null},"has_protein_features":false,"name":"AGE2","ortholog_annotations":[{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04724","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL044C"}


id: YIL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIG2","product":"Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL045W"}


id: YIL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00192":null,"YIL046W":null},"has_protein_features":false,"name":"MET30","ortholog_annotations":[{"gene_uniquename":"YIL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00192","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00192","reference_uniquename":"PMID:26896847"}],"product":"F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W"}


id: YIL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W-A"}


id: YIL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00233":null,"YIL047C":null},"has_protein_features":false,"name":"SYG1","ortholog_annotations":[{"gene_uniquename":"YIL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00233","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of unknown function; targeted to vacuole via AP-3 pathway; truncation and overexpression suppresses lethality of G-alpha protein deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C"}


id: YIL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SYG1/YIL047C","secondary_identifier":"SGD:S000028790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C-A"}


id: YIL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05209":null,"YIL048W":null},"has_protein_features":false,"name":"NEO1","ortholog_annotations":[{"gene_uniquename":"YIL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05209","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and Golgi apparatus; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL048W"}


id: YIL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04954":null,"YIL049W":null},"has_protein_features":false,"name":"DFG10","ortholog_annotations":[{"gene_uniquename":"YIL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04954","reference_uniquename":"PMID:29761456"}],"product":"Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL049W"}


id: YIL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05978":null,"YIL050W":null},"has_protein_features":false,"name":"PCL7","ortholog_annotations":[{"gene_uniquename":"YIL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL050W"}


id: YIL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00107":null,"YIL051C":null},"has_protein_features":false,"name":"MMF1","ortholog_annotations":[{"gene_uniquename":"YIL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL051C"}


id: YIL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YIL052C":null},"has_protein_features":false,"name":"RPL34B","ortholog_annotations":[{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL052C"}


id: YIL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPP1","product":"Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL053W"}


id: YIL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000001316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL054W"}


id: YIL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL055C"}


id: YIL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHR1","product":"Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL056W"}


id: YIL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGI2","product":"Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog, RGI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL057C"}


id: YIL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL058W"}


id: YIL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; has predicted signal peptide cleavage site in  non-enzymatic end; located adjacent and on opposite strand to a Ty2 LTR, suggesting horizontal transfer; partially overlaps uncharacterized ORF YIL060W","secondary_identifier":"SGD:S000001321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL059C"}


