# genes

id: YER012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04888":null,"YER012W":null},"has_protein_features":false,"name":"PRE1","ortholog_annotations":[{"gene_uniquename":"YER012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04888","reference_uniquename":"PMID:29761456"}],"product":"Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000814","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER012W"}


id: YER013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05025":null,"YER013W":null},"has_protein_features":false,"name":"PRP22","ortholog_annotations":[{"gene_uniquename":"YER013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05025","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000815","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER013W"}


id: YER014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD25","product":"Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern","secondary_identifier":"SGD:S000007590","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014C-A"}


id: YER014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02876":null,"YER014W":null},"has_protein_features":false,"name":"HEM14","ortholog_annotations":[{"gene_uniquename":"YER014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02876","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02876","reference_uniquename":"PMID:26896847"}],"product":"Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000816","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014W"}


id: YER015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAA2","product":"Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon","secondary_identifier":"SGD:S000000817","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER015W"}


id: YER016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02045":null,"YER016W":null},"has_protein_features":false,"name":"BIM1","ortholog_annotations":[{"gene_uniquename":"YER016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02045","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02045","reference_uniquename":"PMID:26896847"}],"product":"Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000818","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER016W"}


id: YER017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01179":null,"YER017C":null},"has_protein_features":false,"name":"AFG3","ortholog_annotations":[{"gene_uniquename":"YER017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000819","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER017C"}


id: YER018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03683":null,"YER018C":null},"has_protein_features":false,"name":"SPC25","ortholog_annotations":[{"gene_uniquename":"YER018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03683","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000820","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER018C"}


id: YER019C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00064":null,"YER019C-A":null},"has_protein_features":false,"name":"SBH2","ortholog_annotations":[{"gene_uniquename":"YER019C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER019C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:26896847"}],"product":"Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002127","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019C-A"}


id: YER019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01219":null,"YER019W":null},"has_protein_features":false,"name":"ISC1","ortholog_annotations":[{"gene_uniquename":"YER019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01219","reference_uniquename":"PMID:26896847"}],"product":"Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000821","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019W"}


id: YER020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02444":null,"YER020W":null},"has_protein_features":false,"name":"GPA2","ortholog_annotations":[{"gene_uniquename":"YER020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000822","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER020W"}


id: YER021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04572":null,"YER021W":null},"has_protein_features":false,"name":"RPN3","ortholog_annotations":[{"gene_uniquename":"YER021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04572","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000823","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER021W"}


id: YER022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00904":null,"YER022W":null},"has_protein_features":false,"name":"SRB4","ortholog_annotations":[{"gene_uniquename":"YER022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00904","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00904","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000824","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER022W"}


id: YER023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028622","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023C-A"}


id: YER023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00120":null,"YER023W":null},"has_protein_features":false,"name":"PRO3","ortholog_annotations":[{"gene_uniquename":"YER023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00120","reference_uniquename":"PMID:29761456"}],"product":"Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000825","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023W"}


id: YER024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAT2","product":"Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane","secondary_identifier":"SGD:S000000826","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER024W"}


id: YER025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00466":null,"YER025W":null},"has_protein_features":false,"name":"GCD11","ortholog_annotations":[{"gene_uniquename":"YER025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00466","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000827","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER025W"}


id: YER026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01233":null,"YER026C":null},"has_protein_features":false,"name":"CHO1","ortholog_annotations":[{"gene_uniquename":"YER026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01233","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000828","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER026C"}


id: YER027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03802":null,"YER027C":null},"has_protein_features":false,"name":"GAL83","ortholog_annotations":[{"gene_uniquename":"YER027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03802","reference_uniquename":"PMID:26896847"}],"product":"One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000829","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER027C"}


id: YER028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YER028C":null},"has_protein_features":false,"name":"MIG3","ortholog_annotations":[{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000830","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER028C"}


id: YER029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02279":null,"YER029C":null},"has_protein_features":false,"name":"SMB1","ortholog_annotations":[{"gene_uniquename":"YER029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02279","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02279","reference_uniquename":"PMID:26896847"}],"product":"Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000831","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER029C"}


id: YER030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02035":null,"YER030W":null},"has_protein_features":false,"name":"CHZ1","ortholog_annotations":[{"gene_uniquename":"YER030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02035","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000832","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER030W"}


id: YER031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03915":null,"YER031C":null},"has_protein_features":false,"name":"YPT31","ortholog_annotations":[{"gene_uniquename":"YER031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03915","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03915","reference_uniquename":"PMID:26896847"}],"product":"Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000833","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER031C"}


id: YER032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIR1","product":"Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate","secondary_identifier":"SGD:S000000834","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER032W"}


id: YER033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZRG8","product":"Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000000835","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER033C"}


id: YER034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000836","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER034W"}


id: YER035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01746":null,"YER035W":null},"has_protein_features":false,"name":"EDC2","ortholog_annotations":[{"gene_uniquename":"YER035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01746","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000837","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER035W"}


id: YER036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00599":null,"YER036C":null},"has_protein_features":false,"name":"ARB1","ortholog_annotations":[{"gene_uniquename":"YER036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00599","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000838","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER036C"}


id: YER037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02593":null,"YER037W":null},"has_protein_features":false,"name":"PHM8","ortholog_annotations":[{"gene_uniquename":"YER037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:26896847"}],"product":"Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000839","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER037W"}


id: YER038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00213":null,"YER038C":null},"has_protein_features":false,"name":"KRE29","ortholog_annotations":[{"gene_uniquename":"YER038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00213","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000840","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038C"}


id: YER038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP49","product":"Mitochondrial protein of unknown function; almost completely overlaps ORF HVG1/YER039C","secondary_identifier":"SGD:S000028746","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038W-A"}


id: YER039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00339":null,"YER039C":null},"has_protein_features":false,"name":"HVG1","ortholog_annotations":[{"gene_uniquename":"YER039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000841","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C"}


id: YER039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00339":null,"YER039C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; YER039C-A is not an essential gene","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000007226","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C-A"}


id: YER040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02730":null,"YER040W":null},"has_protein_features":false,"name":"GLN3","ortholog_annotations":[{"gene_uniquename":"YER040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02730","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional activator in nitrogen catabolite repression system; localization and activity regulated by quality of nitrogen source and Ure2p; full-length protein forms prion-like aggregates when overproduced","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000842","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER040W"}


id: YER041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEN1","product":"Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p","secondary_identifier":"SGD:S000000843","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER041W"}


id: YER042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00419":null,"YER042W":null},"has_protein_features":false,"name":"MXR1","ortholog_annotations":[{"gene_uniquename":"YER042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00419","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00419","reference_uniquename":"PMID:26896847"}],"product":"Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000844","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER042W"}


id: YER043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03556":null,"YER043C":null},"has_protein_features":false,"name":"SAH1","ortholog_annotations":[{"gene_uniquename":"YER043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03556","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03556","reference_uniquename":"PMID:26896847"}],"product":"S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000845","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER043C"}


id: YER044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00453":null,"YER044C":null},"has_protein_features":false,"name":"ERG28","ortholog_annotations":[{"gene_uniquename":"YER044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00453","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000846","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C"}


id: YER044C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02490":null,"YER044C-A":null},"has_protein_features":false,"name":"MEI4","ortholog_annotations":[{"gene_uniquename":"YER044C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02490","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001954","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C-A"}


id: YER045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ACA1","product":"ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000847","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER045C"}


id: YER046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00974":null,"YER046W":null},"has_protein_features":false,"name":"SPO73","ortholog_annotations":[{"gene_uniquename":"YER046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00974","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000848","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W"}


id: YER046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C","secondary_identifier":"SGD:S000028747","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W-A"}


id: YER047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YER047C":null},"has_protein_features":false,"name":"SAP1","ortholog_annotations":[{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:26896847"}],"product":"Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000849","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER047C"}


id: YER048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YER048C":null},"has_protein_features":false,"name":"CAJ1","ortholog_annotations":[{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:26896847"}],"product":"Nuclear type II J heat shock protein of the E. coli dnaJ family; overexpression stabilizes amino acid permeases; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000850","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048C"}


id: YER048W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00894":null,"YER048W-A":null},"has_protein_features":false,"name":"ISD11","ortholog_annotations":[{"gene_uniquename":"YER048W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00894","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER048W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00894","reference_uniquename":"PMID:26896847"}],"product":"Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007237","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048W-A"}


id: YER049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00642":null,"YER049W":null},"has_protein_features":false,"name":"TPA1","ortholog_annotations":[{"gene_uniquename":"YER049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00642","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00642","reference_uniquename":"PMID:26896847"}],"product":"Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000851","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER049W"}


id: YER050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04281":null,"YER050C":null},"has_protein_features":false,"name":"RSM18","ortholog_annotations":[{"gene_uniquename":"YER050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04281","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04281","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000852","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER050C"}


id: YER051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03664":null,"YER051W":null},"has_protein_features":false,"name":"JHD1","ortholog_annotations":[{"gene_uniquename":"YER051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03664","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03664","reference_uniquename":"PMID:26896847"}],"product":"JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000853","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER051W"}


id: YER052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00881":null,"YER052C":null},"has_protein_features":false,"name":"HOM3","ortholog_annotations":[{"gene_uniquename":"YER052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00881","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00881","reference_uniquename":"PMID:26896847"}],"product":"Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; subject to allosteric feedback inhibition by threonine; expression regulated by Gcn4p and the general control of amino acid synthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000854","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER052C"}


id: YER053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00547":null,"YER053C":null},"has_protein_features":false,"name":"PIC2","ortholog_annotations":[{"gene_uniquename":"YER053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00547","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000855","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C"}


id: YER053C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007523","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C-A"}


id: YER054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIP2","product":"Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000856","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER054C"}


id: YER055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04747":null,"YER055C":null},"has_protein_features":false,"name":"HIS1","ortholog_annotations":[{"gene_uniquename":"YER055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04747","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04747","reference_uniquename":"PMID:26896847"}],"product":"ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000857","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER055C"}


id: YER056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY2","product":"Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress","secondary_identifier":"SGD:S000000858","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C"}


id: YER056C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YER056C-A":null},"has_protein_features":false,"name":"RPL34A","ortholog_annotations":[{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002135","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C-A"}


id: YER057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00107":null,"YER057C":null},"has_protein_features":false,"name":"HMF1","ortholog_annotations":[{"gene_uniquename":"YER057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:26896847"}],"product":"Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000859","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER057C"}


id: YER058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00852":null,"YER058W":null},"has_protein_features":false,"name":"PET117","ortholog_annotations":[{"gene_uniquename":"YER058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00852","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000860","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER058W"}


id: YER059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05978":null,"YER059W":null},"has_protein_features":false,"name":"PCL6","ortholog_annotations":[{"gene_uniquename":"YER059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000861","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER059W"}


id: YER060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY21","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000000862","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W"}


id: YER060W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY22","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000002958","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W-A"}


id: YER061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01946":null,"YER061C":null},"has_protein_features":false,"name":"CEM1","ortholog_annotations":[{"gene_uniquename":"YER061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01946","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000863","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER061C"}


id: YER062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPP2","product":"DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000864","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER062C"}


id: YER063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02534":null,"YER063W":null},"has_protein_features":false,"name":"THO1","ortholog_annotations":[{"gene_uniquename":"YER063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02534","reference_uniquename":"PMID:29761456"}],"product":"Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000865","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER063W"}


id: YER064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHR2","product":"Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000000866","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER064C"}


id: YER065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICL1","product":"Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose","secondary_identifier":"SGD:S000000867","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER065C"}


id: YER066C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W","secondary_identifier":"SGD:S000002959","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066C-A"}


id: YER066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT13","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000000868","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066W"}


id: YER067C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF RGI1/YER067W","secondary_identifier":"SGD:S000028748","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER067C-A"}


id: YER067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGI1","product":"Protein involved in energy metabolism under respiratory conditions; abundance is increased upon intracellular iron depletion or in response to DNA replication stress; suppresses pro-apoptotic effect of expressing human BAX in yeast cells; RGI1 has a paralog, RGI2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000869","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER067W"}


id: YER068C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARG5,6/YER069W","secondary_identifier":"SGD:S000028749","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER068C-A"}


id: YER068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03883":null,"YER068W":null},"has_protein_features":false,"name":"MOT2","ortholog_annotations":[{"gene_uniquename":"YER068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03883","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03883","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000870","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER068W"}


id: YER069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00636":null,"YER069W":null},"has_protein_features":false,"name":"ARG56","ortholog_annotations":[{"gene_uniquename":"YER069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00636","reference_uniquename":"PMID:26896847"}],"product":"Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000871","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER069W"}


id: YER070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04665":null,"YER070W":null},"has_protein_features":false,"name":"RNR1","ortholog_annotations":[{"gene_uniquename":"YER070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04665","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04665","reference_uniquename":"PMID:26896847"}],"product":"Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000872","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER070W"}


id: YER071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01370":null,"YER071C":null},"has_protein_features":false,"name":"TDA2","ortholog_annotations":[{"gene_uniquename":"YER071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01370","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000873","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER071C"}


id: YER072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01319":null,"YER072W":null},"has_protein_features":false,"name":"VTC1","ortholog_annotations":[{"gene_uniquename":"YER072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01319","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000874","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER072W"}


id: YER073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03786":null,"YER073W":null},"has_protein_features":false,"name":"ALD5","ortholog_annotations":[{"gene_uniquename":"YER073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000875","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER073W"}


id: YER074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00468":null,"SJAG_02585":null,"YER074W":null},"has_protein_features":false,"name":"RPS24A","ortholog_annotations":[{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02585","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02585","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000876","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER074W"}


id: YER074W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05013":null,"YER074W-A":null},"has_protein_features":false,"name":"YOS1","ortholog_annotations":[{"gene_uniquename":"YER074W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05013","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER074W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05013","reference_uniquename":"PMID:26896847"}],"product":"Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000007651","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER074W-A"}


id: YER075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02000":null,"SJAG_02013":null,"YER075C":null},"has_protein_features":false,"name":"PTP3","ortholog_annotations":[{"gene_uniquename":"YER075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02013","reference_uniquename":"PMID:29761456"}],"product":"Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000877","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER075C"}


id: YER076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization","secondary_identifier":"SGD:S000000878","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER076C"}


id: YER076W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C","secondary_identifier":"SGD:S000028750","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER076W-A"}


id: YER077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX1","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport","secondary_identifier":"SGD:S000000879","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER077C"}


id: YER078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01896":null,"YER078C":null},"has_protein_features":false,"name":"ICP55","ortholog_annotations":[{"gene_uniquename":"YER078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01896","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aminopeptidase; cleaves N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of aminopeptidase P family; exists in rapid equilibrium between monomer and dimer, with dimer being active species; ortholog of human gene XPNPEP3, which is mutated in rare hereditary kidney disease similar to nephronophthisis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000880","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER078C"}


id: YER078W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028546","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER078W-A"}


id: YER079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF AIM9/YER080W","secondary_identifier":"SGD:S000028751","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER079C-A"}


id: YER079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000881","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER079W"}


id: YER080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM9","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000000882","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER080W"}


id: YER081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02313":null,"YER081W":null},"has_protein_features":false,"name":"SER3","ortholog_annotations":[{"gene_uniquename":"YER081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02313","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02313","reference_uniquename":"PMID:26896847"}],"product":"3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); directly phosphorylated by TORC1 in a Pib2-dependent manner; localizes to the cytoplasm; ER3 has a paralog, SER33, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000883","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER081W"}


id: YER082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04908":null,"YER082C":null},"has_protein_features":false,"name":"UTP7","ortholog_annotations":[{"gene_uniquename":"YER082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04908","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000884","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER082C"}


id: YER083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01940":null,"YER083C":null},"has_protein_features":false,"name":"GET2","ortholog_annotations":[{"gene_uniquename":"YER083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01940","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GET complex; involved in insertion of  tail-anchored proteins proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000885","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER083C"}


id: YER084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000000886","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER084W"}


id: YER084W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps uncharacterized ORF YER085C","secondary_identifier":"SGD:S000028752","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER084W-A"}


id: YER085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000887","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER085C"}


id: YER086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00830":null,"YER086W":null},"has_protein_features":false,"name":"ILV1","ortholog_annotations":[{"gene_uniquename":"YER086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00830","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00830","reference_uniquename":"PMID:26896847"}],"product":"Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000888","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER086W"}


id: YER087C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF AIM10/YER087W","secondary_identifier":"SGD:S000028753","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087C-A"}


id: YER087C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00064":null,"YER087C-B":null},"has_protein_features":false,"name":"SBH1","ortholog_annotations":[{"gene_uniquename":"YER087C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER087C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:26896847"}],"product":"Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002128","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087C-B"}


id: YER087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02236":null,"YER087W":null},"has_protein_features":false,"name":"AIM10","ortholog_annotations":[{"gene_uniquename":"YER087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02236","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02236","reference_uniquename":"PMID:26896847"}],"product":"Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000889","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087W"}


id: YER088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DOT6","product":"Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000000890","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088C"}


id: YER088C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs PTC2/YER089C and YER088W-B","secondary_identifier":"SGD:S000028754","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088C-A"}


id: YER088W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching","secondary_identifier":"SGD:S000028623","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088W-B"}


id: YER089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03482":null,"SJAG_03893":null,"YER089C":null},"has_protein_features":false,"name":"PTC2","ortholog_annotations":[{"gene_uniquename":"YER089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03893","reference_uniquename":"PMID:29761456"}],"product":"Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000891","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER089C"}


id: YER090C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000029725","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER090C-A"}


id: YER090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02505":null,"YER090W":null},"has_protein_features":false,"name":"TRP2","ortholog_annotations":[{"gene_uniquename":"YER090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02505","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02505","reference_uniquename":"PMID:26896847"}],"product":"Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000892","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER090W"}


id: YER091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02290":null,"YER091C":null},"has_protein_features":false,"name":"MET6","ortholog_annotations":[{"gene_uniquename":"YER091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02290","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02290","reference_uniquename":"PMID:26896847"}],"product":"Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000893","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER091C"}


id: YER091C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007238","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER091C-A"}


id: YER092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES5","product":"Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination","secondary_identifier":"SGD:S000000894","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER092W"}


id: YER093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04460":null,"YER093C":null},"has_protein_features":false,"name":"TSC11","ortholog_annotations":[{"gene_uniquename":"YER093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04460","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04460","reference_uniquename":"PMID:26896847"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000895","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER093C"}


id: YER093C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04460":null,"YER093C-A":null},"has_protein_features":false,"name":"AIM11","ortholog_annotations":[{"gene_uniquename":"YER093C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04460","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; localizes to the peroxisome in glucose; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002960","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER093C-A"}


id: YER094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04229":null,"YER094C":null},"has_protein_features":false,"name":"PUP3","ortholog_annotations":[{"gene_uniquename":"YER094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04229","reference_uniquename":"PMID:29761456"}],"product":"Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000896","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER094C"}


id: YER095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01410":null,"YER095W":null},"has_protein_features":false,"name":"RAD51","ortholog_annotations":[{"gene_uniquename":"YER095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01410","reference_uniquename":"PMID:29761456"}],"product":"Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000897","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER095W"}


id: YER096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02733":null,"SJAG_04595":null,"YER096W":null},"has_protein_features":false,"name":"SHC1","ortholog_annotations":[{"gene_uniquename":"YER096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04595","reference_uniquename":"PMID:29761456"}],"product":"Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000898","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER096W"}


id: YER097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000899","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER097W"}


id: YER098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00546":null,"YER098W":null},"has_protein_features":false,"name":"UBP9","ortholog_annotations":[{"gene_uniquename":"YER098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00546","reference_uniquename":"PMID:29761456"}],"product":"Putative ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000900","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER098W"}


id: YER099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03811":null,"YER099C":null},"has_protein_features":false,"name":"PRS2","ortholog_annotations":[{"gene_uniquename":"YER099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000901","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER099C"}


id: YER100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05022":null,"YER100W":null},"has_protein_features":false,"name":"UBC6","ortholog_annotations":[{"gene_uniquename":"YER100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05022","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05022","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000902","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER100W"}


id: YER101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AST2","product":"Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000903","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER101C"}


id: YER102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02020":null,"SJAG_04029":null,"YER102W":null},"has_protein_features":false,"name":"RPS8B","ortholog_annotations":[{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02020","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04029","reference_uniquename":"PMID:26896847"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000904","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER102W"}


id: YER103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YER103W":null},"has_protein_features":false,"name":"SSA4","ortholog_annotations":[{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000905","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER103W"}


id: YER104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT105","product":"Chaperone for Replication Protein A complex (RPA); involved in nuclear import of RPA and its binding to ssDNA at replication forks; has a role in regulation of Ty1 transposition","secondary_identifier":"SGD:S000000906","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER104W"}


id: YER105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02757":null,"YER105C":null},"has_protein_features":false,"name":"NUP157","ortholog_annotations":[{"gene_uniquename":"YER105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02757","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02757","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000907","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER105C"}


id: YER106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAM1","product":"Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division","secondary_identifier":"SGD:S000000908","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER106W"}


id: YER107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04379":null,"YER107C":null},"has_protein_features":false,"name":"GLE2","ortholog_annotations":[{"gene_uniquename":"YER107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04379","reference_uniquename":"PMID:29761456"}],"product":"RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000909","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER107C"}


id: YER107W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF GLE2/YER107C","secondary_identifier":"SGD:S000028755","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER107W-A"}


id: YER108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged ORF; YER108C has been merged into YER109C because it has been demonstrated that they correspond to a mutated FLO8 gene with an A to G transition at position 431 in strain S288C, changing amino acid 144 from a Trp to a stop","secondary_identifier":"SGD:S000117700","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER108C"}


id: YER109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01441":null,"SJAG_04421":null,"YER109C":null},"has_protein_features":false,"name":"FLO8","ortholog_annotations":[{"gene_uniquename":"YER109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01441","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04421","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; required for flocculation, diploid filamentous growth, and haploid invasive growth; forms a heterodimer with Mss11p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1; S. cerevisiae genome reference strain S288C contains an internal in-frame stop at codon 142, which in other strains encodes tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000911","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER109C"}


id: YER110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03662":null,"YER110C":null},"has_protein_features":false,"name":"KAP123","ortholog_annotations":[{"gene_uniquename":"YER110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03662","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03662","reference_uniquename":"PMID:26896847"}],"product":"Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000912","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER110C"}


id: YER111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00693":null,"YER111C":null},"has_protein_features":false,"name":"SWI4","ortholog_annotations":[{"gene_uniquename":"YER111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00693","reference_uniquename":"PMID:29761456"}],"product":"DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000913","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER111C"}


id: YER112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03070":null,"YER112W":null},"has_protein_features":false,"name":"LSM4","ortholog_annotations":[{"gene_uniquename":"YER112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03070","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03070","reference_uniquename":"PMID:26896847"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000914","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER112W"}


id: YER113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMN3","product":"Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation","secondary_identifier":"SGD:S000000915","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER113C"}


id: YER114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01448":null,"YER114C":null},"has_protein_features":false,"name":"BOI2","ortholog_annotations":[{"gene_uniquename":"YER114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01448","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01448","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000916","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER114C"}


id: YER115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPR6","product":"Protein of unknown function; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation","secondary_identifier":"SGD:S000000917","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER115C"}


id: YER116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02299":null,"YER116C":null},"has_protein_features":false,"name":"SLX8","ortholog_annotations":[{"gene_uniquename":"YER116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02299","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000918","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER116C"}


id: YER117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01087":null,"SJAG_03197":null,"YER117W":null},"has_protein_features":false,"name":"RPL23B","ortholog_annotations":[{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03197","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03197","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000919","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER117W"}


id: YER118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHO1","product":"Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p","secondary_identifier":"SGD:S000000920","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER118C"}


id: YER119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03256":null,"YER119C":null},"has_protein_features":false,"name":"AVT6","ortholog_annotations":[{"gene_uniquename":"YER119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03256","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000921","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER119C"}


id: YER119C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2","secondary_identifier":"SGD:S000002961","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER119C-A"}


id: YER120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00053":null,"SJAG_03170":null,"YER120W":null},"has_protein_features":false,"name":"SCS2","ortholog_annotations":[{"gene_uniquename":"YER120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00053","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03170","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03170","reference_uniquename":"PMID:26896847"}],"product":"Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000922","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER120W"}


id: YER121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy","secondary_identifier":"SGD:S000000923","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER121W"}


id: YER122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04391":null,"YER122C":null},"has_protein_features":false,"name":"GLO3","ortholog_annotations":[{"gene_uniquename":"YER122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04391","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000924","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER122C"}


id: YER123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00402":null,"SJAG_01373":null,"SJAG_03987":null,"YER123W":null},"has_protein_features":false,"name":"YCK3","ortholog_annotations":[{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:26896847"}],"product":"Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; targeted to vacuole via AP-3 pathway; regulates vesicle fusion in AP-3 pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000925","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER123W"}


id: YER124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DSE1","product":"Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000000926","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER124C"}


id: YER125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01360":null,"SJAG_03970":null,"SJAG_04600":null,"YER125W":null},"has_protein_features":false,"name":"RSP5","ortholog_annotations":[{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01360","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04600","reference_uniquename":"PMID:29761456"}],"product":"NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000927","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER125W"}


id: YER126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01811":null,"YER126C":null},"has_protein_features":false,"name":"NSA2","ortholog_annotations":[{"gene_uniquename":"YER126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01811","reference_uniquename":"PMID:29761456"}],"product":"Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000928","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER126C"}


id: YER127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00294":null,"YER127W":null},"has_protein_features":false,"name":"LCP5","ortholog_annotations":[{"gene_uniquename":"YER127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00294","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00294","reference_uniquename":"PMID:26896847"}],"product":"Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000929","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER127W"}


id: YER128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00777":null,"YER128W":null},"has_protein_features":false,"name":"VFA1","ortholog_annotations":[{"gene_uniquename":"YER128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00777","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000930","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER128W"}


id: YER129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03486":null,"YER129W":null},"has_protein_features":false,"name":"SAK1","ortholog_annotations":[{"gene_uniquename":"YER129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03486","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03486","reference_uniquename":"PMID:26896847"}],"product":"Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000931","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER129W"}


id: YER130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03388":null,"YER130C":null},"has_protein_features":false,"name":"COM2","ortholog_annotations":[{"gene_uniquename":"YER130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000932","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER130C"}


id: YER131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01366":null,"SJAG_02894":null,"YER131W":null},"has_protein_features":false,"name":"RPS26B","ortholog_annotations":[{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01366","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01366","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02894","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02894","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000933","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER131W"}


id: YER132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PMD1","product":"Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000934","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER132C"}


id: YER133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02536":null,"SJAG_03126":null,"YER133W":null},"has_protein_features":false,"name":"GLC7","ortholog_annotations":[{"gene_uniquename":"YER133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02536","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03126","reference_uniquename":"PMID:29761456"}],"product":"Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple regulatory subunits; regulates actomyosin ring formation; subunit of CPF; recruited to mating projections by Afr1p interaction; regulates nucleocytoplasmic shuttling of Hxk2p; import into the nucleus is inhibited during spindle assembly checkpoint arrest; involved in dephosphorylating Rps6a/b and Bnr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000935","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER133W"}


id: YER133W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF YER134C","secondary_identifier":"SGD:S000028756","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER133W-A"}


id: YER134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02405":null,"YER134C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02405","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02405","reference_uniquename":"PMID:26896847"}],"product":"Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000936","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER134C"}


id: YER135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YER135C is not an essential gene","secondary_identifier":"SGD:S000000937","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER135C"}


id: YER136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02422":null,"YER136W":null},"has_protein_features":false,"name":"GDI1","ortholog_annotations":[{"gene_uniquename":"YER136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02422","reference_uniquename":"PMID:29761456"}],"product":"GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000938","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER136W"}


id: YER137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function","secondary_identifier":"SGD:S000000939","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER137C"}


id: YER137W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER137C","secondary_identifier":"SGD:S000028757","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER137W-A"}


id: YER138W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication","secondary_identifier":"SGD:S000007239","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER138W-A"}


id: YER139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02203":null,"YER139C":null},"has_protein_features":false,"name":"RTR1","ortholog_annotations":[{"gene_uniquename":"YER139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02203","reference_uniquename":"PMID:29761456"}],"product":"Dual specificity protein phosphatase; dephosphorylates T1 and S5 in  C-terminal domain (CTD) of RNA polymerase II largest subunit, Rpo21p; autoregulates turnover of its mRNA; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000941","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER139C"}


id: YER140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00893":null,"YER140W":null},"has_protein_features":false,"name":"EMP65","ortholog_annotations":[{"gene_uniquename":"YER140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00893","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00893","reference_uniquename":"PMID:26896847"}],"product":"Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000942","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER140W"}


id: YER141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04397":null,"YER141W":null},"has_protein_features":false,"name":"COX15","ortholog_annotations":[{"gene_uniquename":"YER141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04397","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04397","reference_uniquename":"PMID:26896847"}],"product":"Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000943","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER141W"}


id: YER142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01971":null,"SJAG_05257":null,"YER142C":null},"has_protein_features":false,"name":"MAG1","ortholog_annotations":[{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01971","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01971","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05257","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05257","reference_uniquename":"PMID:26896847"}],"product":"3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000944","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER142C"}


id: YER143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03763":null,"YER143W":null},"has_protein_features":false,"name":"DDI1","ortholog_annotations":[{"gene_uniquename":"YER143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03763","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03763","reference_uniquename":"PMID:26896847"}],"product":"Aspartic-type endopeptidase; involved in the cleavage of long-chain polyubiquitinated substrates; role in proteasome-independent, ubiquitin (Ub)-dependent proteolysis and DNA-protein crosslink repair; Ub-shuttle receptor for HO and Ufo1p; DNA damage-inducible v-SNARE binding protein and negative regulator of constitutive exocytosis; possible role in the S-phase checkpoint; UBL-UBA family member containing Ub-like (UBL), helical, Ub-associated (UBA) and retroviral-like proteinase (RVP) domains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000945","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER143W"}


id: YER144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03429":null,"YER144C":null},"has_protein_features":false,"name":"UBP5","ortholog_annotations":[{"gene_uniquename":"YER144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03429","reference_uniquename":"PMID:29761456"}],"product":"Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000946","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER144C"}


id: YER145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04675":null,"YER145C":null},"has_protein_features":false,"name":"FTR1","ortholog_annotations":[{"gene_uniquename":"YER145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04675","reference_uniquename":"PMID:29761456"}],"product":"High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000947","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER145C"}


id: YER145C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps verified ORF LSM5/YER146W","secondary_identifier":"SGD:S000028758","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER145C-A"}


id: YER146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01327":null,"YER146W":null},"has_protein_features":false,"name":"LSM5","ortholog_annotations":[{"gene_uniquename":"YER146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01327","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01327","reference_uniquename":"PMID:26896847"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000948","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER146W"}


id: YER147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00682":null,"YER147C":null},"has_protein_features":false,"name":"SCC4","ortholog_annotations":[{"gene_uniquename":"YER147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00682","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000949","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER147C"}


id: YER147C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SPT15/YER148W","secondary_identifier":"SGD:S000028759","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER147C-A"}


id: YER148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00421":null,"YER148W":null},"has_protein_features":false,"name":"SPT15","ortholog_annotations":[{"gene_uniquename":"YER148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00421","reference_uniquename":"PMID:26896847"}],"product":"TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000950","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER148W"}


id: YER148W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PEA2/YER149C","secondary_identifier":"SGD:S000028760","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER148W-A"}


id: YER149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEA2","product":"Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion","secondary_identifier":"SGD:S000000951","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER149C"}


id: YER150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPI1","product":"GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000952","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER150W"}


id: YER151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02419":null,"YER151C":null},"has_protein_features":false,"name":"UBP3","ortholog_annotations":[{"gene_uniquename":"YER151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02419","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02419","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-specific protease that cleaves Ub-protein fusions; interacts with cofactor Bre5p to regulate transport between ER and Golgi, deubiquitinating COPII and COPI proteins, Sec23p and Sec27p; mediates steady-state retention of Golgi membrane proteins with Bre5p; phosphorylation (S695) by Hog1p regulates transcriptional activation by osmostress; inhibits Ras/PKA signaling through Ira2p; inhibits silencing; role in ribophagy; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000953","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER151C"}


id: YER152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04678":null,"YER152C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER152C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04678","reference_uniquename":"PMID:26896847"}],"product":"Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000954","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER152C"}


id: YER152W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER152C","secondary_identifier":"SGD:S000028761","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER152W-A"}


id: YER153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET122","product":"Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000000955","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER153C"}


id: YER154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03633":null,"SJAG_05300":null,"YER154W":null},"has_protein_features":false,"name":"OXA1","ortholog_annotations":[{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03633","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03633","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05300","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05300","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000956","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER154W"}


id: YER155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BEM2","product":"Rho GTPase activating protein (RhoGAP); contains RhoGAP activity specific for both Rho1p and Cdc42p, and potentially Rho4p; acts with the RhoGAP Bem3p to negatively regulate Cdc42p-dependent signal transduction; involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence and for the morphogenesis checkpoint in response to actin depolymerization; localizes to sites of polarized growth and the plasma membrane","secondary_identifier":"SGD:S000000957","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER155C"}


id: YER156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01501":null,"YER156C":null},"has_protein_features":false,"name":"MYG1","ortholog_annotations":[{"gene_uniquename":"YER156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01501","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01501","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in mitochondrial function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; role in preventing L-A mycovirus pathogenesis; human homolog MYG1 is linked to developmental processes and dermatological diseases, complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000958","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER156C"}


id: YER157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01459":null,"YER157W":null},"has_protein_features":false,"name":"COG3","ortholog_annotations":[{"gene_uniquename":"YER157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01459","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000959","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER157W"}


id: YER158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000960","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER158C"}


id: YER158W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028624","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER158W-A"}


id: YER159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00958":null,"YER159C":null},"has_protein_features":false,"name":"BUR6","ortholog_annotations":[{"gene_uniquename":"YER159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00958","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000961","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER159C"}


id: YER161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04257":null,"YER161C":null},"has_protein_features":false,"name":"SPT2","ortholog_annotations":[{"gene_uniquename":"YER161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04257","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000963","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER161C"}


id: YER162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01049":null,"SJAG_01887":null,"YER162C":null},"has_protein_features":false,"name":"RAD4","ortholog_annotations":[{"gene_uniquename":"YER162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01887","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01887","reference_uniquename":"PMID:26896847"}],"product":"Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000964","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER162C"}


id: YER163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00903":null,"YER163C":null},"has_protein_features":false,"name":"GCG1","ortholog_annotations":[{"gene_uniquename":"YER163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00903","reference_uniquename":"PMID:26896847"}],"product":"Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000965","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER163C"}


id: YER164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01653":null,"SJAG_04038":null,"YER164W":null},"has_protein_features":false,"name":"CHD1","ortholog_annotations":[{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01653","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04038","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04038","reference_uniquename":"PMID:26896847"}],"product":"Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains chromo domain, helicase domain and DNA-binding domain; component of both SAGA and SLIK complexes; in human, deletion of CHD1 is a frequent event in prostate cancer","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000966","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER164W"}


id: YER165C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W","secondary_identifier":"SGD:S000028762","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER165C-A"}


id: YER165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04427":null,"YER165W":null},"has_protein_features":false,"name":"PAB1","ortholog_annotations":[{"gene_uniquename":"YER165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04427","reference_uniquename":"PMID:29761456"}],"product":"Poly(A) binding protein; interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex; role in preventing L-A mycovirus pathogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000967","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER165W"}


id: YER166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01731":null,"SJAG_02897":null,"YER166W":null},"has_protein_features":false,"name":"DNF1","ortholog_annotations":[{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:26896847"}],"product":"Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000968","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER166W"}


id: YER167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BCK2","product":"Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations","secondary_identifier":"SGD:S000000969","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER167W"}


id: YER168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01704":null,"SJAG_02288":null,"YER168C":null},"has_protein_features":false,"name":"CCA1","ortholog_annotations":[{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01704","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01704","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02288","reference_uniquename":"PMID:26896847"}],"product":"ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000970","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER168C"}


id: YER169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03041":null,"YER169W":null},"has_protein_features":false,"name":"RPH1","ortholog_annotations":[{"gene_uniquename":"YER169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03041","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000971","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER169W"}


id: YER170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02038":null,"YER170W":null},"has_protein_features":false,"name":"ADK2","ortholog_annotations":[{"gene_uniquename":"YER170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02038","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000972","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER170W"}


id: YER171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00995":null,"YER171W":null},"has_protein_features":false,"name":"RAD3","ortholog_annotations":[{"gene_uniquename":"YER171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00995","reference_uniquename":"PMID:29761456"}],"product":"5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000973","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER171W"}


id: YER172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02295":null,"YER172C":null},"has_protein_features":false,"name":"BRR2","ortholog_annotations":[{"gene_uniquename":"YER172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02295","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02295","reference_uniquename":"PMID:26896847"}],"product":"RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000974","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER172C"}


id: YER172C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAD24/YER173W","secondary_identifier":"SGD:S000028763","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER172C-A"}


id: YER173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02563":null,"YER173W":null},"has_protein_features":false,"name":"RAD24","ortholog_annotations":[{"gene_uniquename":"YER173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02563","reference_uniquename":"PMID:26896847"}],"product":"Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000975","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER173W"}


id: YER174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00822":null,"YER174C":null},"has_protein_features":false,"name":"GRX4","ortholog_annotations":[{"gene_uniquename":"YER174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:26896847"}],"product":"Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000976","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER174C"}


id: YER175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02973":null,"YER175C":null},"has_protein_features":false,"name":"TMT1","ortholog_annotations":[{"gene_uniquename":"YER175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"}],"product":"Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000977","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER175C"}


id: YER175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028625","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER175W-A"}


id: YER176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM32","product":"DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes","secondary_identifier":"SGD:S000000978","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER176W"}


id: YER177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02266":null,"SJAG_02576":null,"YER177W":null},"has_protein_features":false,"name":"BMH1","ortholog_annotations":[{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:26896847"}],"product":"14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000979","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER177W"}


id: YER178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02006":null,"YER178W":null},"has_protein_features":false,"name":"PDA1","ortholog_annotations":[{"gene_uniquename":"YER178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02006","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02006","reference_uniquename":"PMID:26896847"}],"product":"E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000980","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER178W"}


id: YER179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02267":null,"YER179W":null},"has_protein_features":false,"name":"DMC1","ortholog_annotations":[{"gene_uniquename":"YER179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02267","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02267","reference_uniquename":"PMID:26896847"}],"product":"Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes and for the normal morphogenesis of synaptonemal complex; binds ssDNA and dsDNA, forms helical filaments; potent inhibitor of the ATPase activity of  Srs2p helicase, blocking its ssDNA translocating motor activity and inhibiting its antirecombinase activity; stimulated by Rdh54p; homolog of Rad51p and the bacterial RecA protein","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000981","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER179W"}


id: YER180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISC10","product":"Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II","secondary_identifier":"SGD:S000000982","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER180C"}


id: YER180C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03365":null,"YER180C-A":null},"has_protein_features":false,"name":"SLO1","ortholog_annotations":[{"gene_uniquename":"YER180C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03365","reference_uniquename":"PMID:29761456"}],"product":"Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028437","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER180C-A"}


id: YER181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Mitochondrial protein of unknown function; conserved among S. cerevisiae strains; extensively overlaps a Ty1 LTR; YER181C is not an essential gene","secondary_identifier":"SGD:S000000983","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER181C"}


id: YER182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04007":null,"SJAG_04895":null,"YER182W":null},"has_protein_features":false,"name":"FMP10","ortholog_annotations":[{"gene_uniquename":"YER182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04007","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04895","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000984","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER182W"}


id: YER183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01616":null,"YER183C":null},"has_protein_features":false,"name":"FAU1","ortholog_annotations":[{"gene_uniquename":"YER183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01616","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01616","reference_uniquename":"PMID:26896847"}],"product":"5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000985","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER183C"}


id: YER184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOG1","product":"Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source","secondary_identifier":"SGD:S000000986","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER184C"}


id: YER185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YER185W":null},"has_protein_features":false,"name":"PUG1","ortholog_annotations":[{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000987","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER185W"}


id: YER186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000988","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER186C"}


id: YER186W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; the YER186W-A was removed because it does not begin with a start codon or end with a stop codon, and has an in-frame internal stop codon (see the Locus History for more details)","secondary_identifier":"SGD:S000007427","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER186W-A"}


id: YER187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; induced in respiratory-deficient cells","secondary_identifier":"SGD:S000000989","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER187W"}


id: YER188C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028764","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER188C-A"}


id: YER188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p","secondary_identifier":"SGD:S000000990","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER188W"}


id: YER189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000991","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER189W"}


id: YER190C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology","secondary_identifier":"SGD:S000028626","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190C-A"}


id: YER190C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028627","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190C-B"}


id: YER190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-2","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000000992","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190W"}


id: YFL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02978":null,"YFL001W":null},"has_protein_features":false,"name":"DEG1","ortholog_annotations":[{"gene_uniquename":"YFL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02978","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02978","reference_uniquename":"PMID:26896847"}],"product":"tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001895","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL001W"}


id: YFL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00616":null,"YFL002C":null},"has_protein_features":false,"name":"SPB4","ortholog_annotations":[{"gene_uniquename":"YFL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00616","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001894","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL002C"}


id: YFL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSH4","product":"Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein","secondary_identifier":"SGD:S000001891","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL003C"}


id: YFL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03442":null,"YFL004W":null},"has_protein_features":false,"name":"VTC2","ortholog_annotations":[{"gene_uniquename":"YFL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03442","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03442","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC2 has a paralog, VTC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001890","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL004W"}


id: YFL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00430":null,"SJAG_02640":null,"YFL005W":null},"has_protein_features":false,"name":"SEC4","ortholog_annotations":[{"gene_uniquename":"YFL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00430","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02640","reference_uniquename":"PMID:26896847"}],"product":"Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; exocyst association is negatively regulated via phosphorylation by Cdc5p during cytokinesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001889","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL005W"}


id: YFL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YFL006W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YFL007W","secondary_identifier":"SGD:S000001888","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL006W"}


id: YFL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00591":null,"SJAG_00837":null,"SJAG_02625":null,"SJAG_05252":null,"YFL007W":null},"has_protein_features":false,"name":"BLM10","ortholog_annotations":[{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00591","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00837","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02625","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05252","reference_uniquename":"PMID:26896847"}],"product":"Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001887","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL007W"}


id: YFL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01831":null,"YFL008W":null},"has_protein_features":false,"name":"SMC1","ortholog_annotations":[{"gene_uniquename":"YFL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01831","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01831","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001886","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL008W"}


id: YFL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02162":null,"SJAG_02651":null,"YFL009W":null},"has_protein_features":false,"name":"CDC4","ortholog_annotations":[{"gene_uniquename":"YFL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02162","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02651","reference_uniquename":"PMID:29761456"}],"product":"F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001885","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL009W"}


id: YFL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03049":null,"YFL010C":null},"has_protein_features":false,"name":"WWM1","ortholog_annotations":[{"gene_uniquename":"YFL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03049","reference_uniquename":"PMID:29761456"}],"product":"WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001884","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL010C"}


id: YFL010W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AUA1","product":"Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease","secondary_identifier":"SGD:S000001955","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL010W-A"}


id: YFL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YFL011W":null},"has_protein_features":false,"name":"HXT10","ortholog_annotations":[{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Hexose transporter; expressed at low levels and expression is repressed by glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001883","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL011W"}


id: YFL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin","secondary_identifier":"SGD:S000001882","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL012W"}


id: YFL012W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C","secondary_identifier":"SGD:S000002964","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL012W-A"}


id: YFL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES1","product":"Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000001881","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL013C"}


id: YFL013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028628","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL013W-A"}


id: YFL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00223":null,"YFL014W":null},"has_protein_features":false,"name":"HSP12","ortholog_annotations":[{"gene_uniquename":"YFL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00223","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00223","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001880","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL014W"}


id: YFL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene","secondary_identifier":"SGD:S000001879","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL015C"}


id: YFL015W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YFL015C","secondary_identifier":"SGD:S000028765","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL015W-A"}


id: YFL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01052":null,"YFL016C":null},"has_protein_features":false,"name":"MDJ1","ortholog_annotations":[{"gene_uniquename":"YFL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01052","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001878","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL016C"}


id: YFL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GNA1","product":"Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA","secondary_identifier":"SGD:S000001877","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL017C"}


id: YFL017W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01870":null,"YFL017W-A":null},"has_protein_features":false,"name":"SMX2","ortholog_annotations":[{"gene_uniquename":"YFL017W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL017W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01870","reference_uniquename":"PMID:26896847"}],"product":"Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002965","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL017W-A"}


id: YFL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03290":null,"YFL018C":null},"has_protein_features":false,"name":"LPD1","ortholog_annotations":[{"gene_uniquename":"YFL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03290","reference_uniquename":"PMID:29761456"}],"product":"Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001876","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL018C"}


id: YFL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YFL019C is not an essential gene","secondary_identifier":"SGD:S000001875","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL019C"}


id: YFL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU5","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme","secondary_identifier":"SGD:S000001874","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL020C"}


id: YFL021C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF GAT1/YFL021W","secondary_identifier":"SGD:S000028766","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL021C-A"}


id: YFL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02730":null,"YFL021W":null},"has_protein_features":false,"name":"GAT1","ortholog_annotations":[{"gene_uniquename":"YFL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02730","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001873","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL021W"}


id: YFL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03626":null,"YFL022C":null},"has_protein_features":false,"name":"FRS2","ortholog_annotations":[{"gene_uniquename":"YFL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03626","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001872","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL022C"}


id: YFL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04093":null,"YFL023W":null},"has_protein_features":false,"name":"BUD27","ortholog_annotations":[{"gene_uniquename":"YFL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04093","reference_uniquename":"PMID:29761456"}],"product":"Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I, II, and III in an Rpb5p-dependent manner; shuttles between nucleus and cytoplasm; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; mutations affect TOR signaling; ortholog of human URI/RMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001871","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL023W"}


id: YFL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03792":null,"YFL024C":null},"has_protein_features":false,"name":"EPL1","ortholog_annotations":[{"gene_uniquename":"YFL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03792","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03792","reference_uniquename":"PMID:26896847"}],"product":"Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001870","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL024C"}


id: YFL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01570":null,"YFL025C":null},"has_protein_features":false,"name":"BST1","ortholog_annotations":[{"gene_uniquename":"YFL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01570","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01570","reference_uniquename":"PMID:26896847"}],"product":"GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001869","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL025C"}


id: YFL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01978":null,"YFL026W":null},"has_protein_features":false,"name":"STE2","ortholog_annotations":[{"gene_uniquename":"YFL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01978","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01978","reference_uniquename":"PMID:26896847"}],"product":"Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001868","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL026W"}


id: YFL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04938":null,"YFL027C":null},"has_protein_features":false,"name":"GYP8","ortholog_annotations":[{"gene_uniquename":"YFL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04938","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04938","reference_uniquename":"PMID:26896847"}],"product":"GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; localizes to the ER and peroxisomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001867","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL027C"}


id: YFL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01944":null,"YFL028C":null},"has_protein_features":false,"name":"CAF16","ortholog_annotations":[{"gene_uniquename":"YFL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01944","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01944","reference_uniquename":"PMID:26896847"}],"product":"Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001866","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL028C"}


id: YFL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01000":null,"YFL029C":null},"has_protein_features":false,"name":"CAK1","ortholog_annotations":[{"gene_uniquename":"YFL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01000","reference_uniquename":"PMID:26896847"}],"product":"Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; required for premeiotic DNA synthesis, expression of early and middle sporulation specific genes and direct phosphorylation of the Smk1p MAPK to regulate spore morphogenesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001865","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL029C"}


id: YFL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGX1","product":"Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant","secondary_identifier":"SGD:S000001864","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL030W"}


id: YFL031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028629","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL031C-A"}


id: YFL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAC1","product":"Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates unfolded protein response via UPRE binding and membrane biogenesis; translation initiation repressed under non-stress conditions by un-spliced intron that interacts with 5'-UTR; under ER stress Ire1p nuclease cleaves out inhibitory intron and triggers efficient Hac1p translation; two functional forms of Hac1p are produced; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001863","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL031W"}


id: YFL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene","secondary_identifier":"SGD:S000001862","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL032W"}


id: YFL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00256":null,"SJAG_00704":null,"SJAG_02498":null,"YFL033C":null},"has_protein_features":false,"name":"RIM15","ortholog_annotations":[{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00256","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00704","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02498","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02498","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001861","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL033C"}


id: YFL034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00220":null,"YFL034C-A":null},"has_protein_features":false,"name":"RPL22B","ortholog_annotations":[{"gene_uniquename":"YFL034C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00220","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; autoregulates splicing of its pre-m-RNA; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006436","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034C-A"}


id: YFL034C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00236":null,"YFL034C-B":null},"has_protein_features":false,"name":"MOB2","ortholog_annotations":[{"gene_uniquename":"YFL034C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00236","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL034C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00236","reference_uniquename":"PMID:26896847"}],"product":"Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001859","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034C-B"}


id: YFL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01381":null,"SJAG_02715":null,"YFL034W":null},"has_protein_features":false,"name":"MIL1","ortholog_annotations":[{"gene_uniquename":"YFL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01381","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01381","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02715","reference_uniquename":"PMID:29761456"}],"product":"Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001860","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034W"}


id: YFL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03014":null,"YFL036W":null},"has_protein_features":false,"name":"RPO41","ortholog_annotations":[{"gene_uniquename":"YFL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03014","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03014","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001858","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL036W"}


id: YFL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04003":null,"YFL037W":null},"has_protein_features":false,"name":"TUB2","ortholog_annotations":[{"gene_uniquename":"YFL037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04003","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04003","reference_uniquename":"PMID:26896847"}],"product":"Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001857","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL037W"}


id: YFL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02640":null,"YFL038C":null},"has_protein_features":false,"name":"YPT1","ortholog_annotations":[{"gene_uniquename":"YFL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02640","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02640","reference_uniquename":"PMID:26896847"}],"product":"Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001856","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL038C"}


id: YFL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03145":null,"YFL039C":null},"has_protein_features":false,"name":"ACT1","ortholog_annotations":[{"gene_uniquename":"YFL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03145","reference_uniquename":"PMID:29761456"}],"product":"Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001855","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL039C"}


id: YFL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport","secondary_identifier":"SGD:S000001854","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL040W"}


id: YFL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04677":null,"YFL041W":null},"has_protein_features":false,"name":"FET5","ortholog_annotations":[{"gene_uniquename":"YFL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04677","reference_uniquename":"PMID:29761456"}],"product":"Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001853","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL041W"}


id: YFL041W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028547","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL041W-A"}


id: YFL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YFL042C":null},"has_protein_features":false,"name":"LAM5","ortholog_annotations":[{"gene_uniquename":"YFL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; localizes to membrane contact sites throughout the cell, including nucleus-vacuole junctions and ER-mitochondrial contact sites","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001852","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL042C"}


id: YFL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YFL043C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YFL042C","secondary_identifier":"SGD:S000001851","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL043C"}


id: YFL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01768":null,"YFL044C":null},"has_protein_features":false,"name":"OTU1","ortholog_annotations":[{"gene_uniquename":"YFL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01768","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01768","reference_uniquename":"PMID:26896847"}],"product":"Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001850","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL044C"}


id: YFL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02783":null,"YFL045C":null},"has_protein_features":false,"name":"SEC53","ortholog_annotations":[{"gene_uniquename":"YFL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02783","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02783","reference_uniquename":"PMID:26896847"}],"product":"Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; human homolog PMM2 complements yeast mutants","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001849","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL045C"}


id: YFL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03399":null,"SJAG_03873":null,"YFL046W":null},"has_protein_features":false,"name":"FMP32","ortholog_annotations":[{"gene_uniquename":"YFL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03399","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03873","reference_uniquename":"PMID:29761456"}],"product":"Regulator of mitochondrial proline metabolism; tethered with Put7p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001848","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL046W"}


id: YFL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03748":null,"YFL047W":null},"has_protein_features":false,"name":"RGD2","ortholog_annotations":[{"gene_uniquename":"YFL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03748","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03748","reference_uniquename":"PMID:26896847"}],"product":"GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001847","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL047W"}


id: YFL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02839":null,"YFL048C":null},"has_protein_features":false,"name":"EMP47","ortholog_annotations":[{"gene_uniquename":"YFL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02839","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; forms a complex with Ssp120p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; EMP47 has a paralog, EMP46, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001846","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL048C"}


id: YFL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04005":null,"YFL049W":null},"has_protein_features":false,"name":"SWP82","ortholog_annotations":[{"gene_uniquename":"YFL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04005","reference_uniquename":"PMID:26896847"}],"product":"Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001845","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL049W"}


id: YFL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03516":null,"YFL050C":null},"has_protein_features":false,"name":"ALR2","ortholog_annotations":[{"gene_uniquename":"YFL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:26896847"}],"product":"Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001844","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL050C"}


id: YFL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the cell periphery while mCherry fusion protein localizes to both the cell periphery and vacuole; YFL051C is not an essential gene","secondary_identifier":"SGD:S000001843","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL051C"}


id: YFL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZNF1","product":"Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon source utilization and adaptation to pH, osmotic and ethanol stress especially during non-fermentative metabolism","secondary_identifier":"SGD:S000001842","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL052W"}


id: YFL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04320":null,"YFL053W":null},"has_protein_features":false,"name":"DAK2","ortholog_annotations":[{"gene_uniquename":"YFL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04320","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001841","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL053W"}


id: YFL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AQY3","product":"Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol","secondary_identifier":"SGD:S000001840","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL054C"}


id: YFL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGP3","product":"Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition","secondary_identifier":"SGD:S000001839","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL055W"}


id: YFL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD16","product":"Putative aryl alcohol dehydrogenase; similar to Phanerochaete chrysosporium aryl alcohol dehydrogenase; ORFs AAD6/YFL056C and AAD16/YFL057C are displaced from one another by -1 frameshift; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000001837","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL057C"}


id: YFL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YFL058W":null},"has_protein_features":false,"name":"THI5","ortholog_annotations":[{"gene_uniquename":"YFL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001836","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL058W"}


id: YFL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YFL059W":null},"has_protein_features":false,"name":"SNZ3","ortholog_annotations":[{"gene_uniquename":"YFL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:26896847"}],"product":"Pyridoxal-5'-phosphate synthase; involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamine in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO3; paralog of SNZ1 and SNZ2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001835","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL059W"}


id: YFL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YFL060C":null},"has_protein_features":false,"name":"SNO3","ortholog_annotations":[{"gene_uniquename":"YFL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001834","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL060C"}


id: YFL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDI3","product":"Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p","secondary_identifier":"SGD:S000001833","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL061W"}


id: YFL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS4","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001832","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL062W"}


id: YFL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001831","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL063W"}


id: YFL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001830","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL064C"}


id: YFL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000001829","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL065C"}


id: YFL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation; SWAT-GFP and mCherry fusion proteins localize to the nucleus","secondary_identifier":"SGD:S000001828","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL066C"}


id: YFL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001827","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL067W"}


id: YFL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001826","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL068W"}


id: YFR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04919":null,"YFR001W":null},"has_protein_features":false,"name":"LOC1","ortholog_annotations":[{"gene_uniquename":"YFR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04919","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in the asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'-UTR of the mRNA; constituent of 66S pre-ribosomal particles involved in pre-rRNA processing and nuclear export of the 60S subunit; may facilitate Rpl43p loading; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001897","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR001W"}


id: YFR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00093":null,"SJAG_01185":null,"YFR002W":null},"has_protein_features":false,"name":"NIC96","ortholog_annotations":[{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00093","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01185","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01185","reference_uniquename":"PMID:26896847"}],"product":"Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001898","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR002W"}


id: YFR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04999":null,"YFR003C":null},"has_protein_features":false,"name":"YPI1","ortholog_annotations":[{"gene_uniquename":"YFR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04999","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04999","reference_uniquename":"PMID:26896847"}],"product":"Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001899","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR003C"}


id: YFR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02900":null,"YFR004W":null},"has_protein_features":false,"name":"RPN11","ortholog_annotations":[{"gene_uniquename":"YFR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02900","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02900","reference_uniquename":"PMID:26896847"}],"product":"Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001900","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR004W"}


id: YFR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04538":null,"YFR005C":null},"has_protein_features":false,"name":"SAD1","ortholog_annotations":[{"gene_uniquename":"YFR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04538","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04538","reference_uniquename":"PMID:26896847"}],"product":"Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001901","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR005C"}


id: YFR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene","secondary_identifier":"SGD:S000001902","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR006W"}


id: YFR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00533":null,"YFR007W":null},"has_protein_features":false,"name":"YFH7","ortholog_annotations":[{"gene_uniquename":"YFR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00533","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00533","reference_uniquename":"PMID:26896847"}],"product":"Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001903","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR007W"}


id: YFR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR7","product":"Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001904","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR008W"}


id: YFR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00541":null,"YFR009W":null},"has_protein_features":false,"name":"GCN20","ortholog_annotations":[{"gene_uniquename":"YFR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00541","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00541","reference_uniquename":"PMID:26896847"}],"product":"Positive regulator of the Gcn2p kinase activity; important for disaggregation of ordered and disordered protein aggregates; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001905","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR009W"}


id: YFR009W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028823","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR009W-A"}


id: YFR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02244":null,"YFR010W":null},"has_protein_features":false,"name":"UBP6","ortholog_annotations":[{"gene_uniquename":"YFR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02244","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02244","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001906","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR010W"}


id: YFR010W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028824","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR010W-A"}


id: YFR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05241":null,"YFR011C":null},"has_protein_features":false,"name":"MIC19","ortholog_annotations":[{"gene_uniquename":"YFR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05241","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001907","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR011C"}


id: YFR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YFR012W":null},"has_protein_features":false,"name":"DCV1","ortholog_annotations":[{"gene_uniquename":"YFR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001908","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR012W"}


id: YFR012W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by homology","secondary_identifier":"SGD:S000007606","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR012W-A"}


id: YFR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC3","product":"Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001909","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR013W"}


id: YFR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02858":null,"YFR014C":null},"has_protein_features":false,"name":"CMK1","ortholog_annotations":[{"gene_uniquename":"YFR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02858","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001910","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR014C"}


id: YFR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSY1","product":"Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000001911","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR015C"}


id: YFR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIP5","product":"Protein that positively regulates actin assembly; forms a homodimer and interacts with G-actin; localization to the bud neck and bud tip requires Spa2p; YFR016C is not an essential gene","secondary_identifier":"SGD:S000001912","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR016C"}


id: YFR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IGD1","product":"Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001913","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR017C"}


id: YFR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001914","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR018C"}


id: YFR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00638":null,"YFR019W":null},"has_protein_features":false,"name":"FAB1","ortholog_annotations":[{"gene_uniquename":"YFR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00638","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00638","reference_uniquename":"PMID:26896847"}],"product":"1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001915","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR019W"}


id: YFR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS2","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) and extracellular region, while mCherry fusion protein localizes to the ER and vacuole; mRNA identified as translated by ribosome profiling data; CSS2 is a non-essential gene","secondary_identifier":"SGD:S000001916","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR020W"}


id: YFR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01783":null,"SJAG_04963":null,"YFR021W":null},"has_protein_features":false,"name":"ATG18","ortholog_annotations":[{"gene_uniquename":"YFR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01783","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04963","reference_uniquename":"PMID:26896847"}],"product":"Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat-containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon replication stress; forms higher order helical assemblies; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WDR45; human WDR45 mutations cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001917","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR021W"}


id: YFR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YFR022W":null},"has_protein_features":false,"name":"ROG3","ortholog_annotations":[{"gene_uniquename":"YFR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001918","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR022W"}


id: YFR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PES4","product":"Putative RNA binding protein; partially redundant function with paralog MIP6 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; regulator of meiotic commitment; redundant function with MIP6 in sporulation; localizes to puncta near the openings of the prospore membrane; suppressor of a DNA polymerase epsilon mutation; induced by NDT80","secondary_identifier":"SGD:S000001919","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR023W"}


id: YFR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a discrete protein; YFR024C was originally annotated as a separate ORF, but was later removed because it was demonstrated to be theC-terminus of LSB3/YFR024C-A","secondary_identifier":"SGD:S000001920","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C"}


id: YFR024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00970":null,"YFR024C-A":null},"has_protein_features":false,"name":"LSB3","ortholog_annotations":[{"gene_uniquename":"YFR024C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR024C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:26896847"}],"product":"Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002968","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C-A"}


id: YFR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00248":null,"YFR025C":null},"has_protein_features":false,"name":"HIS2","ortholog_annotations":[{"gene_uniquename":"YFR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00248","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00248","reference_uniquename":"PMID:26896847"}],"product":"Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001921","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR025C"}


id: YFR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ULI1","product":"Protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000001922","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR026C"}


id: YFR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04791":null,"YFR027W":null},"has_protein_features":false,"name":"ECO1","ortholog_annotations":[{"gene_uniquename":"YFR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04791","reference_uniquename":"PMID:29761456"}],"product":"Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001923","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR027W"}


id: YFR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00082":null,"YFR028C":null},"has_protein_features":false,"name":"CDC14","ortholog_annotations":[{"gene_uniquename":"YFR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00082","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00082","reference_uniquename":"PMID:26896847"}],"product":"Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001924","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR028C"}


id: YFR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PTR3","product":"Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p","secondary_identifier":"SGD:S000001925","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR029W"}


id: YFR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01693":null,"YFR030W":null},"has_protein_features":false,"name":"MET10","ortholog_annotations":[{"gene_uniquename":"YFR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01693","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01693","reference_uniquename":"PMID:26896847"}],"product":"Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001926","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR030W"}


id: YFR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03832":null,"YFR031C":null},"has_protein_features":false,"name":"SMC2","ortholog_annotations":[{"gene_uniquename":"YFR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03832","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03832","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001927","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C"}


id: YFR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YFR031C-A":null},"has_protein_features":false,"name":"RPL2A","ortholog_annotations":[{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002104","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C-A"}


id: YFR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT5","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation","secondary_identifier":"SGD:S000001928","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C"}


id: YFR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03127":null,"YFR032C-A":null},"has_protein_features":false,"name":"RPL29","ortholog_annotations":[{"gene_uniquename":"YFR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03127","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03127","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006437","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-A"}


id: YFR032C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN10","product":"Mitochondrial protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028630","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-B"}


id: YFR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01490":null,"YFR033C":null},"has_protein_features":false,"name":"QCR6","ortholog_annotations":[{"gene_uniquename":"YFR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01490","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01490","reference_uniquename":"PMID:26896847"}],"product":"Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001929","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR033C"}


id: YFR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO4","product":"Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability","secondary_identifier":"SGD:S000001930","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034C"}


id: YFR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028631","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034W-A"}


id: YFR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000001931","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035C"}


id: YFR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; added to genome annotation based on evolutionary, translation, and proteomics evidence","secondary_identifier":"SGD:S000350095","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035W-A"}


id: YFR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01801":null,"YFR036W":null},"has_protein_features":false,"name":"CDC26","ortholog_annotations":[{"gene_uniquename":"YFR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01801","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001932","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W"}


id: YFR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF RSC8/YFR037C","secondary_identifier":"SGD:S000028767","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W-A"}


id: YFR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02589":null,"YFR037C":null},"has_protein_features":false,"name":"RSC8","ortholog_annotations":[{"gene_uniquename":"YFR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:26896847"}],"product":"Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001933","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR037C"}


id: YFR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC5","product":"Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus","secondary_identifier":"SGD:S000001934","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR038W"}


id: YFR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSW7","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog, SHE10, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly","secondary_identifier":"SGD:S000001935","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR039C"}


id: YFR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YFR040W":null},"has_protein_features":false,"name":"SAP155","ortholog_annotations":[{"gene_uniquename":"YFR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:26896847"}],"product":"Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001936","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR040W"}


id: YFR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03030":null,"YFR041C":null},"has_protein_features":false,"name":"ERJ5","ortholog_annotations":[{"gene_uniquename":"YFR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03030","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03030","reference_uniquename":"PMID:26896847"}],"product":"Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001937","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR041C"}


id: YFR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KEG1","product":"Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability","secondary_identifier":"SGD:S000001938","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR042W"}


id: YFR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05011":null,"YFR043C":null},"has_protein_features":false,"name":"IRC6","ortholog_annotations":[{"gene_uniquename":"YFR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05011","reference_uniquename":"PMID:29761456"}],"product":"Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001939","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR043C"}


id: YFR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04858":null,"YFR044C":null},"has_protein_features":false,"name":"DUG1","ortholog_annotations":[{"gene_uniquename":"YFR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04858","reference_uniquename":"PMID:29761456"}],"product":"Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001940","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR044C"}


id: YFR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX20","product":"Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white","secondary_identifier":"SGD:S000001941","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR045W"}


id: YFR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02513":null,"YFR046C":null},"has_protein_features":false,"name":"CNN1","ortholog_annotations":[{"gene_uniquename":"YFR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02513","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001942","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR046C"}


id: YFR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA6","product":"Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000001943","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR047C"}


id: YFR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YFR048W":null},"has_protein_features":false,"name":"RMD8","ortholog_annotations":[{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic protein required for sporulation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001944","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR048W"}


id: YFR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06382":null,"YFR049W":null},"has_protein_features":false,"name":"KGD4","ortholog_annotations":[{"gene_uniquename":"YFR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06382","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial α-KGDH complexes; homolog of human KGD4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001945","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR049W"}


id: YFR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04541":null,"YFR050C":null},"has_protein_features":false,"name":"PRE4","ortholog_annotations":[{"gene_uniquename":"YFR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04541","reference_uniquename":"PMID:29761456"}],"product":"Beta 7 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001946","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR050C"}


id: YFR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02482":null,"YFR051C":null},"has_protein_features":false,"name":"RET2","ortholog_annotations":[{"gene_uniquename":"YFR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02482","reference_uniquename":"PMID:26896847"}],"product":"Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001947","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR051C"}


id: YFR052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HXK1/YFR053C","secondary_identifier":"SGD:S000028768","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052C-A"}


id: YFR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01203":null,"YFR052W":null},"has_protein_features":false,"name":"RPN12","ortholog_annotations":[{"gene_uniquename":"YFR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01203","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01203","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001948","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052W"}


id: YFR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04334":null,"YFR053C":null},"has_protein_features":false,"name":"HXK1","ortholog_annotations":[{"gene_uniquename":"YFR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04334","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001949","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR053C"}


id: YFR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001950","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR054C"}


id: YFR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC7","product":"Cysteine desulphydrase, enables growth on cysteine as nitrogen source; involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner","secondary_identifier":"SGD:S000001952","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR055W"}


id: YFR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W","secondary_identifier":"SGD:S000001951","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR056C"}


id: YFR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Telomere-linked gene, silencing of which is strictly Sir2-dependent","secondary_identifier":"SGD:S000001953","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR057W"}


id: YGL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02855":null,"YGL001C":null},"has_protein_features":false,"name":"ERG26","ortholog_annotations":[{"gene_uniquename":"YGL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02855","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02855","reference_uniquename":"PMID:26896847"}],"product":"C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002969","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL001C"}


id: YGL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04598":null,"YGL002W":null},"has_protein_features":false,"name":"ERP6","ortholog_annotations":[{"gene_uniquename":"YGL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:26896847"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002970","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL002W"}


id: YGL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00071":null,"SJAG_04853":null,"YGL003C":null},"has_protein_features":false,"name":"CDH1","ortholog_annotations":[{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00071","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00071","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04853","reference_uniquename":"PMID:26896847"}],"product":"Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002971","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL003C"}


id: YGL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPN14","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p","secondary_identifier":"SGD:S000002972","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL004C"}


id: YGL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COG7","product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","secondary_identifier":"SGD:S000002973","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL005C"}


id: YGL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01400":null,"YGL006W":null},"has_protein_features":false,"name":"PMC1","ortholog_annotations":[{"gene_uniquename":"YGL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01400","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01400","reference_uniquename":"PMID:26896847"}],"product":"Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002974","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W"}


id: YGL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028769","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W-A"}


id: YGL007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding","secondary_identifier":"SGD:S000028632","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007C-A"}


id: YGL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BRP1","product":"Putative protein of unknown function; located in the upstream region of PMA1; conserved among S. cerevisiae strains; mediates the cycloheximide-induced degradation of ubiquitinated Agp2p, a regulator of high affinity polyamine and carnitine transport; null mutant is polyamine resistant due to downregulation of PMA1","secondary_identifier":"SGD:S000002975","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007W"}


id: YGL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01129":null,"SJAG_01669":null,"SJAG_04258":null,"YGL008C":null},"has_protein_features":false,"name":"PMA1","ortholog_annotations":[{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04258","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002976","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL008C"}


id: YGL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03243":null,"YGL009C":null},"has_protein_features":false,"name":"LEU1","ortholog_annotations":[{"gene_uniquename":"YGL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03243","reference_uniquename":"PMID:26896847"}],"product":"Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002977","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL009C"}


id: YGL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00519":null,"YGL010W":null},"has_protein_features":false,"name":"MPO1","ortholog_annotations":[{"gene_uniquename":"YGL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00519","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00519","reference_uniquename":"PMID:26896847"}],"product":"Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002978","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL010W"}


id: YGL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02562":null,"YGL011C":null},"has_protein_features":false,"name":"SCL1","ortholog_annotations":[{"gene_uniquename":"YGL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02562","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02562","reference_uniquename":"PMID:26896847"}],"product":"Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002979","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL011C"}


id: YGL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03024":null,"YGL012W":null},"has_protein_features":false,"name":"ERG4","ortholog_annotations":[{"gene_uniquename":"YGL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03024","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03024","reference_uniquename":"PMID:26896847"}],"product":"C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002980","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL012W"}


id: YGL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR1","product":"Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002981","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL013C"}


id: YGL014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028825","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL014C-A"}


id: YGL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02239":null,"SJAG_05322":null,"YGL014W":null},"has_protein_features":false,"name":"PUF4","ortholog_annotations":[{"gene_uniquename":"YGL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02239","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05322","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05322","reference_uniquename":"PMID:26896847"}],"product":"Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002982","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL014W"}


id: YGL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BIL2","product":"Formin inhibitor; inhibits Bnr1p-mediated actin filament nucleation but not elongation during vegetative growth; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth","secondary_identifier":"SGD:S000002983","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL015C"}


id: YGL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00968":null,"YGL016W":null},"has_protein_features":false,"name":"KAP122","ortholog_annotations":[{"gene_uniquename":"YGL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00968","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin beta; bidirectional nuclear transport receptor (biportin) that shuttles distinct sets of cargoes in opposite directions; responsible for import of Toa1p-Toa2p complex into nucleus; depletes eIF5A and eEF2 from cell nuclei; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002984","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL016W"}


id: YGL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02705":null,"YGL017W":null},"has_protein_features":false,"name":"ATE1","ortholog_annotations":[{"gene_uniquename":"YGL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02705","reference_uniquename":"PMID:26896847"}],"product":"Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; may have a role in regulating stress response","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002985","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL017W"}


id: YGL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00066":null,"YGL018C":null},"has_protein_features":false,"name":"JAC1","ortholog_annotations":[{"gene_uniquename":"YGL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00066","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00066","reference_uniquename":"PMID:26896847"}],"product":"Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002986","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL018C"}


id: YGL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00142":null,"SJAG_03931":null,"YGL019W":null},"has_protein_features":false,"name":"CKB1","ortholog_annotations":[{"gene_uniquename":"YGL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03931","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03931","reference_uniquename":"PMID:26896847"}],"product":"Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002987","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL019W"}


id: YGL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01178":null,"YGL020C":null},"has_protein_features":false,"name":"GET1","ortholog_annotations":[{"gene_uniquename":"YGL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01178","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GET complex; involved in insertion of tail-anchored proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002988","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL020C"}


id: YGL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00678":null,"YGL021W":null},"has_protein_features":false,"name":"ALK1","ortholog_annotations":[{"gene_uniquename":"YGL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00678","reference_uniquename":"PMID:29761456"}],"product":"Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002989","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL021W"}


id: YGL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04127":null,"YGL022W":null},"has_protein_features":false,"name":"STT3","ortholog_annotations":[{"gene_uniquename":"YGL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04127","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04127","reference_uniquename":"PMID:26896847"}],"product":"Catalytic subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER lumen; involved in recognition of N-acetylglucosamine; forms a subcomplex with Ost3p and Ost4p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002990","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL022W"}


id: YGL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03405":null,"YGL023C":null},"has_protein_features":false,"name":"PIB2","ortholog_annotations":[{"gene_uniquename":"YGL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03405","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03405","reference_uniquename":"PMID:26896847"}],"product":"Phosphatidylinositol 3-phosphate binding protein; forms a distinct complex with TORC1, induced by glutamine in a dose-dependent manner, resulting in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; functions as a cysteine sensor involved in TORC1 activation; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1; contains a PI3P binding FYVE domain; similar to Fab1p and Vps27p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002991","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL023C"}


id: YGL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C","secondary_identifier":"SGD:S000002992","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL024W"}


id: YGL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PGD1","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor","secondary_identifier":"SGD:S000002993","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL025C"}


id: YGL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05007":null,"YGL026C":null},"has_protein_features":false,"name":"TRP5","ortholog_annotations":[{"gene_uniquename":"YGL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05007","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05007","reference_uniquename":"PMID:26896847"}],"product":"Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002994","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL026C"}


id: YGL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04363":null,"YGL027C":null},"has_protein_features":false,"name":"CWH41","ortholog_annotations":[{"gene_uniquename":"YGL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04363","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04363","reference_uniquename":"PMID:26896847"}],"product":"Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002995","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL027C"}


id: YGL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SCW11","product":"Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p","secondary_identifier":"SGD:S000002996","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL028C"}


id: YGL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01674":null,"YGL029W":null},"has_protein_features":false,"name":"CGR1","ortholog_annotations":[{"gene_uniquename":"YGL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01674","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01674","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002997","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL029W"}


id: YGL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03383":null,"YGL030W":null},"has_protein_features":false,"name":"RPL30","ortholog_annotations":[{"gene_uniquename":"YGL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03383","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03383","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002998","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL030W"}


id: YGL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02243":null,"SJAG_03922":null,"YGL031C":null},"has_protein_features":false,"name":"RPL24A","ortholog_annotations":[{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L24A; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002999","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL031C"}


id: YGL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGA2","product":"Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds","secondary_identifier":"SGD:S000003000","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL032C"}


id: YGL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04950":null,"YGL033W":null},"has_protein_features":false,"name":"HOP2","ortholog_annotations":[{"gene_uniquename":"YGL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04950","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003001","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL033W"}


id: YGL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGL034C is not an essential gene","secondary_identifier":"SGD:S000003002","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL034C"}


id: YGL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YGL035C":null},"has_protein_features":false,"name":"MIG1","ortholog_annotations":[{"gene_uniquename":"YGL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003003","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL035C"}


id: YGL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VIR1","product":"Protein required for mRNA m6A methylation and meiosis; subunit of the m6A methyltransferase (MIS) complex; required for the stability of MIS complex subunits and consistent with a scaffolding function; non-essential gene required for pre-meiotic S-phase; may be required to initiate the meiotic program, for progression through meiotic divisions and for spore formation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of VIRMA/virilizer/VIR","secondary_identifier":"SGD:S000003004","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL036W"}


id: YGL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04467":null,"YGL037C":null},"has_protein_features":false,"name":"PNC1","ortholog_annotations":[{"gene_uniquename":"YGL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04467","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04467","reference_uniquename":"PMID:26896847"}],"product":"Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003005","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL037C"}


id: YGL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04770":null,"YGL038C":null},"has_protein_features":false,"name":"OCH1","ortholog_annotations":[{"gene_uniquename":"YGL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04770","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04770","reference_uniquename":"PMID:26896847"}],"product":"Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003006","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL038C"}


id: YGL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YGL039W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003007","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL039W"}


id: YGL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01372":null,"YGL040C":null},"has_protein_features":false,"name":"HEM2","ortholog_annotations":[{"gene_uniquename":"YGL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01372","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01372","reference_uniquename":"PMID:26896847"}],"product":"Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003008","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL040C"}


id: YGL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003009","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041C"}


id: YGL041C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000028548","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041C-B"}


id: YGL041W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04722":null,"YGL041W-A":null},"has_protein_features":false,"name":"DPC13","ortholog_annotations":[{"gene_uniquename":"YGL041W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04722","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; conserved in fungi; identified by expression profiling and mass spectrometry","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028826","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041W-A"}


id: YGL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1","secondary_identifier":"SGD:S000003010","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL042C"}


id: YGL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02691":null,"YGL043W":null},"has_protein_features":false,"name":"DST1","ortholog_annotations":[{"gene_uniquename":"YGL043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02691","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02691","reference_uniquename":"PMID:26896847"}],"product":"General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003011","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL043W"}


id: YGL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01412":null,"SJAG_04022":null,"YGL044C":null},"has_protein_features":false,"name":"RNA15","ortholog_annotations":[{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01412","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01412","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04022","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04022","reference_uniquename":"PMID:26896847"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003012","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL044C"}


id: YGL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM8","product":"Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family","secondary_identifier":"SGD:S000003013","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL045W"}


id: YGL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YGL046W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGL045W","secondary_identifier":"SGD:S000003014","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL046W"}


id: YGL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03311":null,"YGL047W":null},"has_protein_features":false,"name":"ALG13","ortholog_annotations":[{"gene_uniquename":"YGL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03311","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03311","reference_uniquename":"PMID:26896847"}],"product":"Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003015","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL047W"}


id: YGL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01131":null,"YGL048C":null},"has_protein_features":false,"name":"RPT6","ortholog_annotations":[{"gene_uniquename":"YGL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01131","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01131","reference_uniquename":"PMID:26896847"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003016","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL048C"}


id: YGL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01954":null,"YGL049C":null},"has_protein_features":false,"name":"TIF4632","ortholog_annotations":[{"gene_uniquename":"YGL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01954","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); proposed to stimulate the ATPase and helicase activities of eIF4A synergistically with eIF4G based on sequence similarity with Tif4631p; proposed to be required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; associated with Pab1p-mediated poly(A)-tail stimulated, translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003017","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL049C"}


id: YGL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05334":null,"YGL050W":null},"has_protein_features":false,"name":"TYW3","ortholog_annotations":[{"gene_uniquename":"YGL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05334","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05334","reference_uniquename":"PMID:26896847"}],"product":"tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003018","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL050W"}


id: YGL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MST27","product":"Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog, MST28, that arose from a segmental duplication","secondary_identifier":"SGD:S000003019","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL051W"}


id: YGL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27","secondary_identifier":"SGD:S000003020","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL052W"}


id: YGL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM8","product":"Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication","secondary_identifier":"SGD:S000003021","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL053W"}


id: YGL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02264":null,"SJAG_04740":null,"YGL054C":null},"has_protein_features":false,"name":"ERV14","ortholog_annotations":[{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:26896847"}],"product":"COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003022","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL054C"}


id: YGL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03943":null,"YGL055W":null},"has_protein_features":false,"name":"OLE1","ortholog_annotations":[{"gene_uniquename":"YGL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03943","reference_uniquename":"PMID:26896847"}],"product":"Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003023","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL055W"}


id: YGL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02380":null,"YGL056C":null},"has_protein_features":false,"name":"SDS23","ortholog_annotations":[{"gene_uniquename":"YGL056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:26896847"}],"product":"Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has a paralog, SDS24, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003024","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL056C"}


id: YGL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GEP7","product":"Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003025","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL057C"}


id: YGL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00293":null,"YGL058W":null},"has_protein_features":false,"name":"RAD6","ortholog_annotations":[{"gene_uniquename":"YGL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00293","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00293","reference_uniquename":"PMID:26896847"}],"product":"Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003026","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL058W"}


id: YGL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01402":null,"YGL059W":null},"has_protein_features":false,"name":"PKP2","ortholog_annotations":[{"gene_uniquename":"YGL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003027","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL059W"}


id: YGL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02485":null,"YGL060W":null},"has_protein_features":false,"name":"YBP2","ortholog_annotations":[{"gene_uniquename":"YGL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02485","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003028","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL060W"}


id: YGL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01211":null,"YGL061C":null},"has_protein_features":false,"name":"DUO1","ortholog_annotations":[{"gene_uniquename":"YGL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01211","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003029","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL061C"}


id: YGL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00464":null,"YGL062W":null},"has_protein_features":false,"name":"PYC1","ortholog_annotations":[{"gene_uniquename":"YGL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:26896847"}],"product":"Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003030","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL062W"}


id: YGL063C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028633","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL063C-A"}


id: YGL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00088":null,"SJAG_00319":null,"YGL063W":null},"has_protein_features":false,"name":"PUS2","ortholog_annotations":[{"gene_uniquename":"YGL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00088","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003031","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL063W"}


id: YGL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRH4","product":"Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes","secondary_identifier":"SGD:S000003032","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL064C"}


id: YGL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03056":null,"YGL065C":null},"has_protein_features":false,"name":"ALG2","ortholog_annotations":[{"gene_uniquename":"YGL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03056","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03056","reference_uniquename":"PMID:26896847"}],"product":"Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003033","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL065C"}


id: YGL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00087":null,"YGL066W":null},"has_protein_features":false,"name":"SGF73","ortholog_annotations":[{"gene_uniquename":"YGL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00087","reference_uniquename":"PMID:26896847"}],"product":"Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003034","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL066W"}


id: YGL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03091":null,"YGL067W":null},"has_protein_features":false,"name":"NPY1","ortholog_annotations":[{"gene_uniquename":"YGL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03091","reference_uniquename":"PMID:26896847"}],"product":"NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; enzymatic component of one of several partly redundant surveillance pathways involved in decapping of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); also possesses deCoAping activity involved in the decapping of non-canonical dephospho-CoA capped RNA (dpCoA-RNA); nudix hydrolase family member","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003035","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL067W"}


id: YGL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05218":null,"YGL068W":null},"has_protein_features":false,"name":"MNP1","ortholog_annotations":[{"gene_uniquename":"YGL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05218","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05218","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003036","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL068W"}


id: YGL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000003037","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL069C"}


id: YGL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00119":null,"YGL070C":null},"has_protein_features":false,"name":"RPB9","ortholog_annotations":[{"gene_uniquename":"YGL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00119","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00119","reference_uniquename":"PMID:26896847"}],"product":"RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription; positively regulates ATG1 transcription as a key regulator of autophagy","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003038","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL070C"}


id: YGL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFT1","product":"Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003039","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL071W"}


id: YGL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000003040","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL072C"}


id: YGL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YGL073W":null},"has_protein_features":false,"name":"HSF1","ortholog_annotations":[{"gene_uniquename":"YGL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:26896847"}],"product":"Trimeric heat shock transcription factor; forms condensate with Mediator and RNA Pol II upon heat shock; activates multiple genes in response to diverse stresses and transient intracellular acidification; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status through RQC (Ribosomal Quality Control)-mediated translation-stress signal; human homolog HSF1 with linker region mutations can complement yeast hsf1 mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003041","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL073W"}


id: YGL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor","secondary_identifier":"SGD:S000003042","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL074C"}


id: YGL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPS2","product":"Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003043","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL075C"}


id: YGL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01551":null,"SJAG_03425":null,"YGL076C":null},"has_protein_features":false,"name":"RPL7A","ortholog_annotations":[{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:26896847"}],"product":"Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003044","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL076C"}


id: YGL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YGL077C":null},"has_protein_features":false,"name":"HNM1","ortholog_annotations":[{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; human FLVCR2 (MFSD7c), a choline transporter involved in Fowler syndrome, can complement the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003045","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL077C"}


id: YGL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04081":null,"YGL078C":null},"has_protein_features":false,"name":"DBP3","ortholog_annotations":[{"gene_uniquename":"YGL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04081","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04081","reference_uniquename":"PMID:26896847"}],"product":"RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003046","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL078C"}


id: YGL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KXD1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome","secondary_identifier":"SGD:S000003047","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL079W"}


id: YGL080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01924":null,"YGL080W":null},"has_protein_features":false,"name":"MPC1","ortholog_annotations":[{"gene_uniquename":"YGL080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01924","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01924","reference_uniquename":"PMID:26896847"}],"product":"Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003048","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL080W"}


id: YGL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis","secondary_identifier":"SGD:S000003049","split_by_parent_groups":{},"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL081W"}


