Changes between Version 112 and Version 113 of ChromosomeSegregation


Ignore:
Timestamp:
Jan 22, 2015, 6:08:25 PM (6 years ago)
Author:
vw253
Comment:

--

Legend:

Unmodified
Added
Removed
Modified
  • ChromosomeSegregation

    v112 v113  
    1919||cdc2|| PMID: 8557037|| mcs6 substrate cdc2 ||
    2020||Clp1|| PMID: 18378776 ||Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly||
    21 
    22  *  Indeed, Sid2 phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention (Chen et al. 2008) cytoplasmic retention
    23  *  mid1 is a plo1 substrate
     21||plo1|| ??|| mid is a substrate||
     22|| Sid2|| Chen et al. 2008||  phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention||
     23 
    2424 * from 21008122 In humans and both yeasts, DSBs are initially detected and processed by the Mre11-Rad50-Nbs1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729
    2525 * HIGH PRIORITY from 21098122 :The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with Mre11-Rad50- Nbs1Xrs2 (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex