Changes between Version 118 and Version 119 of ChromosomeSegregation


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Timestamp:
Jan 22, 2015, 6:19:10 PM (6 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v118 v119  
    2020||Sid2||Chen et al. 2008||phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention||
    2121||Mre11-Rad50-Nbs||PMID:21008122 and papers reffed within|| In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with  (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex ||
     22|| crb2||  PMID: 14739927 || Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate) ||
     23|| crb2||  PMID:21098122 || There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A ||
     24|| Tel1 || PMID:21098122 || Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)||
     25|| crb2 ||????|| find physical interaction with Rad9||
     26||All histones|| ????||. these are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'||
    2227
    23 
    24  * PMID: 14739927 Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate)
    25  * HIGH PRIORITY from 21098122 There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A
    26  * HIGH PRIORITY from 21098122 Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)
    27  * find physical interaction between rad9 and crb2
    28  * HIGH PRIORITY All histones..... these are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'
    2928 * cdc2 PMID: 6526270 uniprot has this paper for allele cdc2-4w C67F (we have 'unspecified')
    3029 * cdc2  Millar JB et al. (1991) Moreno S et al. (1989) Moreno S et al. (1989) Simanis V et al. (1986) Booher RN et al. (1989) Noguchi E et al. (2002)
     
    9190|| hos2 || 17352737 plus|| -||
    9291||pcs1|| PMID:20935472 plus... ||-||
    93 ||ams12| chen et al, cenp-a loading ||-|||
     92||ams12|| chen et al, cenp-a loading ||-|||
    9493
    9594|| dis2 phosphatase  || PMID:3409871 PMID: 2544292 PMID: 2544298 PMID:2245912 PMID:2170029 PMID:1846086 PMID:1944266 PMID:1314161 PMID:8387356 PMID:8389306 PMID:8305731 PMID:7983142 PMID:7957097 PMID:9264466 PMID:9790575 PMID:10668632 PMID:11085271 PMID:16411888 PMID:17895368 PMID:19592249 PMID:21664573 PMID:21703453 PMID:21965289 PMID:23333317 PMID:24554432 PMID:24945319 PMID:25487150 || -||