Changes between Version 119 and Version 120 of ChromosomeSegregation


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Timestamp:
Jan 22, 2015, 6:20:30 PM (7 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v119 v120  
    1212  * kinases, phosphatases, GTPAses, ubiquitin ligases, protein methylases (anything with direct substrate to improve networks)
    1313
    14  ==  HIGHEST priority papers ==
     14 ==  HIGHEST priority genes/complexes/papers ==
    1515
    16 || mus81 || PMID:15805465 || Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest ||
     16|| mus81 || PMID:15805465 ||Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest ||
    1717||cdc2|| PMID:8557037|| mcs6 substrate cdc2 ||
    1818||Clp1|| PMID:18378776 ||Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly||
    1919||plo1|| ??||mid is a substrate||
    2020||Sid2||Chen et al. 2008||phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention||
    21 ||Mre11-Rad50-Nbs||PMID:21008122 and papers reffed within|| In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with  (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex ||
    22 || crb2||  PMID: 14739927 || Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate) ||
    23 || crb2||  PMID:21098122 || There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A ||
    24 || Tel1 || PMID:21098122 || Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)||
     21||Mre1 complex||PMID:21008122 and papers cited within|| In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with  (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex ||
     22|| crb2||PMID:14739927 || Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate) ||
     23|| crb2||PMID:21098122 || There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A ||
     24|| Tel1 ||PMID:21098122 || Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)||
    2525|| crb2 ||????|| find physical interaction with Rad9||
    2626||All histones|| ????||. these are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'||