Changes between Version 123 and Version 124 of ChromosomeSegregation


Ignore:
Timestamp:
Jan 22, 2015, 6:24:05 PM (6 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v123 v124  
    1515
    1616|| mus81 || PMID:15805465 ||Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest ||
    17 ||cdc2|| PMID:8557037|| mcs6 substrate cdc2 ||
     17||cdc2|| PMID:8557037||mcs6 substrate cdc2 ||
    1818||cdc2||PMID:6526270||uniprot has this paper for allele cdc2-4w C67F (we have 'unspecified')||
    19 ||Clp1|| PMID:18378776 ||Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly||
    20 ||plo1|| ??||mid is a substrate||
     19||Clp1||PMID:18378776 ||Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly||
     20||plo1||?????||mid is a substrate||
    2121||Sid2||Chen et al. 2008||phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention||
    2222||Mre1 complex||PMID:21008122 and papers cited within|| In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with  (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex ||