Changes between Version 139 and Version 140 of ChromosomeSegregation


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Timestamp:
Jan 29, 2015, 12:06:06 AM (7 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v139 v140  
    9393|| hos2 || 17352737 plus|| -||
    9494||pcs1|| PMID:20935472 plus... ||-||
    95 ||ams12|| chen et al, cenp-a loading ||-|||
    96 ||nsk1|| abnormal clustering of kinetochores to spindle pole bodies||-||-||
     95||ams12|| chen et al, cenp-a loading ||-||
     96||nsk1|| abnormal clustering of kinetochores to spindle pole bodies||-||
     97
     98== other chromosome segregation==
    9799
    98100|| dis2 phosphatase  ||  (PMID:14765108 - describes checkpoint termination Dis2 abrogates Chk1 phosphorylation and activation in vivo, ) PMID:2245912   PMID:8389306 PMID:8305731 PMID:7983142 PMID:7957097 PMID:9264466 PMID:9790575 PMID:10668632 PMID:11085271 PMID:16411888 PMID:17895368 PMID:19592249 PMID:21664573 (Out for CC PMID:21703453 PMID:21965289 PMID:23333317)  (Iain Hagan  PMID:25487150) || -||
     101||dis1 || XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase
     102and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||
    99103
    100104 === Notes and annotation questions on chromosome segregation ===