Changes between Version 185 and Version 186 of ChromosomeSegregation


Ignore:
Timestamp:
Apr 27, 2015, 9:36:13 PM (6 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v185 v186  
    1414 ==  HIGHEST priority genes/complexes/papers ==
    1515
    16 || mus81 || PMID:15805465 ||Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest ||
     16||mus81 || PMID:15805465 ||Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest ||
    1717||cdc2||PMID:8557037||mcs6 substrate cdc2 ||
    1818||cdc2||PMID:6526270||uniprot has this paper for allele cdc2-4w C67F (we have 'unspecified')||
    1919||Clp1||PMID:18378776 ||Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly||
    20 ||plo1||?????||mid is a substrate||
     20||plo1||?????||mid1? is a substrate||
    2121||Sid2||Chen et al. 2008||phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention||
    2222||Mre1 complex||PMID:21008122 and papers cited within|| In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with  (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex ||
     
    2626|| crb2 ||????||Find physical interaction with Rad9||
    2727||All histones||????||These are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'||
    28 ||srw ||PMID:9571240, PMID:9736616 PMID:10921878 ||has no mitotic cell cycle regulation annotation||
     28||srw1||PMID:9571240, PMID:9736616 PMID:10921878 ||has no mitotic cell cycle regulation annotation||
    2929|| fnx1 & 2||PMID: 18503766 || This wouldn't normally be a priority, but I'm putting it in becasue the exisitng transport GO annotations look a bit of a mess (stretch) ... need to get detailed phenotypes and then decide what it is possible to infer sensibly||
    3030||Scf complex||?????||-||
     
    3939||phosphatase||||||||1703321,||
    4040
    41 
    42  *
    4341
    4442 == Process priorities ==