Changes between Version 233 and Version 234 of ChromosomeSegregation


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Timestamp:
Oct 23, 2015, 8:50:43 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v233 v234  
    1414 ==  HIGHEST priority genes/complexes/papers ==
    1515
    16 ||crb2||PMID:14739927 ||Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate) ||
    17 
    1816||Tel1 ||PMID:21098122 ||Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)||
    1917||All histones||????||These are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'||
    20 
    21 
    2218|| fnx1 & 2||PMID: 18503766 || This wouldn't normally be a priority, but I'm putting it in becasue the exisitng transport GO annotations look a bit of a mess (stretch) ... need to get detailed phenotypes and then decide what it is possible to infer sensibly||
    2319||Scf complex||?????||-||
    2420||scp1||???||Skp1 doesn't have ubiquitin ligase activity so these MF annotations should probably be on BP ||
    2521||dsc2||???||activation of sre2 TF? positive regulation of SREBP signaling pathway by transcription factor cleavage? for the Dsc subunits? may be in one of the other dsc papers.... chung paper?||
    26 
    2722||pck1||?????||phosphorylates  mcm2,4,6, caf1, swi6,rad9, swi3, mrc1 crm1 and other importins||
    2823||Pad1/Rpn11 and Mts3/Rpn12 are subunits of the lid subcomplex||?????|| in PMID: 16149916 Mutations in the genes encoding these two subunits were isolated in a screen for mutants that were both esistant to methyl 2-benzimidazolecarbamate, a microtubule in- hibitor, and Ts for cell-cycle progression [19,20]. Ts mutations in both genes cause arrest of the cells in mitosis, probably because of a failure to degrade cyclin B/Cdc13 and securin/Cut2. ||