Changes between Version 235 and Version 236 of ChromosomeSegregation


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Timestamp:
Oct 23, 2015, 8:55:25 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v235 v236  
    2121||pck1||?????||phosphorylates  mcm2,4,6, caf1, swi6,rad9, swi3, mrc1 crm1 and other importins||
    2222||Pad1/Rpn11 and Mts3/Rpn12 are subunits of the lid subcomplex||?????|| in PMID: 16149916 Mutations in the genes encoding these two subunits were isolated in a screen for mutants that were both esistant to methyl 2-benzimidazolecarbamate, a microtubule in- hibitor, and Ts for cell-cycle progression [19,20]. Ts mutations in both genes cause arrest of the cells in mitosis, probably because of a failure to degrade cyclin B/Cdc13 and securin/Cut2. ||
    23 || mde4 ||?????|| Previous results showed that in interphase, when Mde4 is dephosphorylated, the Mde4-Pcs1 complex localizes to the nucleolus and to the kinetochores, which cluster at the nuclear periphery next to the spindle pole bodies (SPBs) [6,8]. As cells enter mitosis and Mde4 becomes phosphorylated, Mde4- Pcs1 leave the nucleolus but remain at the kinetochores [6,8]. PubMed: 17627824/12689592]||
    2423||cdc20|| ?????|| When Cdc20 is overexpressed, securin can be degraded during interphase, whereas other destruction box proteins will remain stable. In cells lacking Cdc20, securin remains stable, and sister chromatids will not separate (Visintin et al., 1997).||
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