Changes between Version 241 and Version 242 of ChromosomeSegregation


Ignore:
Timestamp:
Oct 23, 2015, 9:10:49 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v241 v242  
    1818
    1919||Pad1/Rpn11 and Mts3/Rpn12 are subunits of the lid subcomplex||?????|| in PMID: 16149916 Mutations in the genes encoding these two subunits were isolated in a screen for mutants that were both esistant to methyl 2-benzimidazolecarbamate, a microtubule in- hibitor, and Ts for cell-cycle progression [19,20]. Ts mutations in both genes cause arrest of the cells in mitosis, probably because of a failure to degrade cyclin B/Cdc13 and securin/Cut2. ||
    20 ||cdc20|| ?????|| When Cdc20 is overexpressed, securin can be degraded during interphase, whereas other destruction box proteins will remain stable. In cells lacking Cdc20, securin remains stable, and sister chromatids will not separate (Visintin et al., 1997).||
    2120||plo1||??? ||priority papers for G2/M network, need to annotate papers which capture plo1 role in mitotic G2/M transition AND cdc25 target, and plo1 as a target of MAPK signalling||
    2221
     
    9190||mzt1 mitotic spindle organizing protein Mzt1 ||annotation complete||23/4/2015||
    9291||mad2 & SCC ||mad2 targets slp1 acting as a mitotic anaphase-promoting complex inhibitor activity||---||
     92||cdc20|| Cdc20 OX > securin can be degraded during interphase, whereas other destruction box proteins will remain stable. In cells lacking Cdc20, securin remains stable, and sister chromatids will not separate (Visintin et al., 1997).||
    9393
    9494===