Changes between Version 249 and Version 250 of ChromosomeSegregation


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Timestamp:
Oct 23, 2015, 9:25:34 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v249 v250  
    55 
    66  * 1. Issues  on the curation tracker
    7   * anything which will improve networks inferred from GO
     7  * 2. anything which will improve networks inferred from GO
    88    * i) substrates
    9     * physical interactions
    10    * complexes
    11   * 2. Anything related to cell cycle regulation
     9    * ii) physical interactions
     10    * iii) complexes
     11  * 3. Anything related to cell cycle regulation
     12  * 4. Process targets (see below...things mature enough to build pathways)
     13  * 5. New gene characterizations -These should be sent out for community curation, but followed up
     14
     15
    1216  * Have large percentage of functionally characterised genes (for example mitochondrion organization has 40 published genes/294, so is low priority compared to cytokinesis 136/139)
    13   * Are mature enough to be able to construct pathways/networks
    14   * New gene characterizations -These should be sent out for community curation, but followed up
     17 
     18 
    1519  * phenotype screens see [http://curation.pombase.org/pombe/view/list/triage_phenotype_screen_publications?model=track canto]
    1620  * Process priorities : chromosome segregation, DNA metabolism, cytokinesis, regulation of mitotic cell cycle, any signaling pathway,  chromatin organization, , cytokinesis, establishment or maintenance of cell polarity, protein modification by small protein conjugation or removal
     
    9397||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||
    9498|| dis2 phosphatase  ||  (PMID:14765108 - describes checkpoint termination Dis2 abrogates Chk1 phosphorylation and activation in vivo, ) PMID:2245912   PMID:8389306 PMID:8305731 PMID:7983142 PMID:7957097 PMID:9264466 PMID:9790575 PMID:10668632 PMID:11085271 PMID:16411888 PMID:17895368 PMID:19592249 PMID:21664573 (Out for CC PMID:21703453 PMID:21965289 PMID:23333317)  (Iain Hagan  PMID:25487150) || -||
    95 ||cut7|||?????|| In the temperature-sensitive cut7 mutant, spindle formation is blocked shortly after duplication of the SPB. The mitotic spindle radiating from the opposite poles cannot interdigitate and thus remains as a V shape (Hagan and Yanagida, 1992). The cut7- specific defect generates a condition whereby the bipolar attachment of the spindle to kinetochores is not achieved. Previously, we demonstrated that this defect causes an arrest in a mad2+-dependent manner (Kim et al., 1998). At the restrictive temperature the majority of Mad2-GFP was found on condensed chromosomes as one or more speckles (Fig. 4).||
     99||cut7||?????|| In the temperature-sensitive cut7 mutant, spindle formation is blocked shortly after duplication of the SPB. The mitotic spindle radiating from the opposite poles cannot interdigitate and thus remains as a V shape (Hagan and Yanagida, 1992). The cut7- specific defect generates a condition whereby the bipolar attachment of the spindle to kinetochores is not achieved. Previously, we demonstrated that this defect causes an arrest in a mad2+-dependent manner (Kim et al., 1998). At the restrictive temperature the majority of Mad2-GFP was found on condensed chromosomes as one or more speckles (Fig. 4).||
    96100
    97101 === Notes and annotation questions on chromosome segregation ===