Changes between Version 268 and Version 269 of ChromosomeSegregation


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Timestamp:
Nov 18, 2015, 3:21:43 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v268 v269  
    9191||mad2 & SCC ||mad2 targets slp1 acting as a mitotic anaphase-promoting complex inhibitor activity||---||
    9292||cdc20||Cdc20 OX > securin can be degraded during interphase, whereas other destruction box proteins will remain stable. In cells lacking Cdc20, securin remains stable, and sister chromatids will not separate (Visintin et al., 1997).||-||
    93 ||ubc11 ubiquitin conjugating enzyme E2- ||  PMID: 11279037 ||-||
     93||ubc11 ubiquitin conjugating enzyme E2- ||  ||18/11/2015||
    9494===
    9595||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||