Changes between Version 279 and Version 280 of ChromosomeSegregation


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Timestamp:
Feb 9, 2016, 8:01:33 AM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v279 v280  
    9797||ubc11 ubiquitin conjugating enzyme E2- ||annotation complete ||18/11/2015||
    9898||cut8 tethering factor for nuclear proteasome ||PMID: 8065367  PMID: 10582241  PMID: 12653962  PMID: 16922381   PMID: 17178839  PMID: 19349280  PMID: 2109137   PMID: 21976488   PMID: 24710126|| -||
     99||pop1|| PMID:14970237||-||
     100||pop2|| PMID:14970237||-||
    99101===
    100102||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||