Changes between Version 358 and Version 359 of ChromosomeSegregation


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Timestamp:
Apr 10, 2016, 10:28:49 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v358 v359  
    201201||pcs1||PMID:20935472 plus... ||-||
    202202||ams2||PMID:12535531  cenp-a loading PMID:20604974 CC PMID:23195958 PMID:23267073 ||-||
    203 
    204 
     203||orc5  origin recognition complex subunit Orc5  ||-||
     204||cdc31 centrin  ||-||
     205||nud3 nuclear distribution protein NUDC homolog  ||-||
     206||ams2 cell cycle regulated GATA-type transcription factor Ams2 ||-||
     207||dcc1 Ctf18 RFC-like complex subunit Dcc1 ||-||
     208||sfc3 transcription factor TFIIIC complex B box binding subunit Sfc3  ||-||
     209||top1 DNA topoisomerase I  ||-||
     210||ctf8 DNA replication factor C complex subunit Ctf8 ||-||
     211||gpn2 conserved ATP binding protein  ||-||
     212||rna1 Ran GAP Rna1  ||-||
     213||top3 DNA topoisomerase III ||-||
    205214===
    206215||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||