Changes between Version 364 and Version 365 of ChromosomeSegregation


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Timestamp:
Apr 18, 2016, 8:06:15 PM (5 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v364 v365  
    208208||rna1 Ran GAP Rna1  ||-||
    209209||top3 DNA topoisomerase III ||-||
     210||sfi1|| -||-||
    210211===
    211212||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to ex- perience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||