Changes between Version 458 and Version 459 of ChromosomeSegregation


Ignore:
Timestamp:
Oct 17, 2016, 1:56:43 PM (4 years ago)
Author:
vw253
Comment:

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Legend:

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  • ChromosomeSegregation

    v458 v459  
    144144||sds23 PP2A-type phosphatase inhibitor||-||-||
    145145||cdc13 G2/M B-type cyclin Cdc13||-||-||
    146 ||dis2 serine/threonine protein phosphatase PP1||PMID:2561424  PMID:2245912 review-PMID:1668885  useful_review-PMID:1336448 PMID:19592249 PMID:10668632  PMID:14765108  PMID:15020842  PMID:19592249  PMID:21664573 CC-PMID:21703453  PMID: 21965289   PMID: 23333317  PMID: 24554432 PMID: 24945319||-||
     146||dis2 serine/threonine protein phosphatase PP1||PMID:2561424  PMID:2245912 review-PMID:1668885  useful_review-PMID:1336448 PMID:19592249 PMID:10668632  PMID:14765108  PMID:15020842 PMID:8305731 PMID:21664573 CC-PMID:21703453  PMID: 21965289   PMID: 23333317  PMID: 24554432 PMID: 24945319    CC-PMID:23333317||-||
    147147||cdc2 cyclin-dependent protein kinase Cdk1/Cdc2||-||-||
    148148||fin1 serine/threonine protein kinase||- ||-||
     
    202202===
    203203||dis1 ||PMID:16920624 plus…XMAP215/ TOG/Stu2-family homolog, binds microtubules and localizes to kinetochores (Nakaseko et al., 2001). Mutants in dis1 lack the chromosome alignment phase in metaphase and arrest with elongated spindles and segregated but unseparated chromosome pairs (Nabe- shima et al., 1998; Ohkura et al., 1988).dis1 mutants arrest with an activated spindle checkpoint and appear to experience an increase in sister chromatid cosegregation (70%) at full restrictive temperature. Such cosegregation results when mono-oriented attachment of sister kineto- chores to microtubules from the same SPB is not corrected. Since dis1 mutants lack the phase of constant spindle length when chromosomes are properly aligned ||-||
    204 || dis2 phosphatase  ||  (PMID:14765108 - describes checkpoint termination Dis2 abrogates Chk1 phosphorylation and activation in vivo, ) PMID:2245912   PMID:8389306 PMID:8305731 PMID:7983142 PMID:7957097 PMID:9264466 PMID:9790575 PMID:10668632 PMID:11085271 PMID:16411888 PMID:17895368 PMID:19592249 PMID:21664573 (Out for CC PMID:21703453 PMID:21965289 PMID:23333317)  (Iain Hagan  PMID:25487150) || -||
     204|| dis2 phosphatase  ||PMID:21664573 PMID:21965289|| -||
    205205||cut7||In the temperature-sensitive cut7 mutant, spindle formation is blocked shortly after duplication of the SPB. The mitotic spindle radiating from the opposite poles cannot interdigitate and thus remains as a V shape (Hagan and Yanagida, 1992). The cut7- specific defect generates a condition whereby the bipolar attachment of the spindle to kinetochores is not achieved. Previously, we demonstrated that this defect causes an arrest in a mad2+-dependent manner (Kim et al., 1998). At the restrictive temperature the majority of Mad2-GFP was found on condensed chromosomes as one or more speckles (Fig. 4).||
    206206||skp1||PMID:15147872||-||