Changes between Version 467 and Version 468 of ChromosomeSegregation


Ignore:
Timestamp:
Oct 17, 2016, 2:17:34 PM (4 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v467 v468  
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    203203
    204  === Notes and annotation questions on chromosome segregation ===
    205 
    206  * read review PMID: 23512483
    207  * is CENP-A containing nucleosome assembly part of kinetochore assembly? Although the outer repeats play an important role in sister centromere cohesion and possibly help to properly orient the multiple kinetochore microtubule attachment sites (Pidoux and Allshire, 2004 
    208  * Centromeres: getting a grip of chromosomes. Curr. Opin. Cell Biol. 12, 308–319., the central region is needed for the assembly of the kinetochore per se and the interaction with the mitotic spindle fibers
    209  * what is the relationship between kinetochoe assembly, spindle elongation and chromosome segregation (currently disjoint)
    210  * reannotate ndc80 and MIND subcomplexes annotate PAS complex
    211  * ask expert to look at CENP_A assembly vs CENP-A assembly phenotype
    212 * no substrates currently annotated for APC, look for motifs ABBA, KENm D-Box, C-BOX, F-box, 2BR, LRRL
    213  * I think from humanUbc11 is the APC E2, has some substrates assigned (cdc13 direct, slp1 indirect), but sc imlies ubc4 and ubc1 (amybe all)
    214 * possible substrates to annotate mitotic securin and cylin; late mitosis cdh1 , cytokinesis  aurora, cyclins, cdc29; G1 geminin, cdc6, skp2,ubcH10(ubc11)
    215 * check all know APC targets annotated
    216 
    217  == Cytokinesis but feel free to do any genes or complexes that I haven't started ==
     204 == Cytokinesis ==
    218205
    219206||process cytokinesis: 139 of which 136 published  [http://www.esyn.org/builder.php?type=Graph&term=GO:0000910&interactionType=physical&source=pombase&includeInteractors=false esyN] ||