Changes between Version 58 and Version 59 of ChromosomeSegregation


Ignore:
Timestamp:
Jan 7, 2015, 12:57:55 PM (6 years ago)
Author:
vw253
Comment:

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  • ChromosomeSegregation

    v58 v59  
    2929 * from 21008122 In humans and both yeasts, DSBs are initially detected and processed by the Mre11-Rad50-Nbs1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729
    3030 * HIGH PRIORITY from 21098122 :The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with Mre11-Rad50- Nbs1Xrs2 (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52).  use these papers to annotate the missing connection between tel1 and the mre11 complex
     31 * PMID: 14739927 Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate)
    3132
    3233 == anything which pins down the cell cycle annotations to the specific phase/transition they regulate ==