| mus81 | PMID:15805465 | Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest
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| cdc2 | PMID:8557037 | mcs6 substrate cdc2
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| cdc2 | PMID:6526270 | uniprot has this paper for allele cdc2-4w C67F (we have 'unspecified')
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| Clp1 | PMID:18378776 | Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly
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| plo1 | ????? | mid is a substrate
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| Sid2 | Chen et al. 2008 | phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention
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| Mre1 complex | PMID:21008122 and papers cited within | In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52). use these papers to annotate the missing connection between tel1 and the mre11 complex
|
| crb2 | PMID:14739927 | Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate)
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| crb2 | PMID:21098122 | There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A
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| Tel1 | PMID:21098122 | Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)
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| crb2 | ???? | Find physical interaction with Rad9
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| All histones | ???? | These are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'
|
| srw | PMID:9571240, PMID:9736616 PMID:10921878 | has no mitotic cell cycle regulation annotation
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| fnx1 & 2 | PMID: 18503766 | This wouldn't normally be a priority, but I'm putting it in becasue the exisitng transport GO annotations look a bit of a mess (stretch) ... need to get detailed phenotypes and then decide what it is possible to infer sensibly
|
| process chromosome segregation: genes 207 of which 183 published esyN
|
| gene/complex | status | date
|
| fta1 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta2 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta3 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta4 Mis6-Sim4 complex | annotation complete | 15/1/2015
|
| fta6 Mis6-Sim4 complex | annotation complete | 15/1/2015
|
| fta7 Mis6-Sim4 complex | annotation complete except CC PMID: 24789708 | 20/1/2015
|
| mis6 Mis6-Sim4 complex | annotation complete except CC PMID:24789708 PMID25375240 | 20/1/2015
|
| mis15 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| mal2 Mis6-Sim4 complex | PMID: 12242294 + others | -
|
| sim4 Mis6-Sim4 complex | annotation complete | 20/1/2015
|
| sos7 NMS complex | annotation complete | 6/1/2014
|
| spc25 NMS complex/ Ndc80 complex | annotation complete | 20/1/2015
|
| spc7 NMS complex | in progress IS THIS TURNING SAC SIGNALLING OFF? PMID: 17035632 | -
|
| ndc80 NMS complex/Ndc80 | annotation complete except CC PMID:21256022 | -
|
| mis12 NMS complex | to do PMID:15930132 check biorientation ann | -
|
| mis13 NMS complex | annotation complete | 20/1/2015
|
| mis14 NMS complex | annotation complete | 6/1/2014
|
| nnf1 NMS complex | to do PMID:17035632 | -
|
| mis16 CENP-A recruiting complex | complete except PMID:22771823 (out for CC) and scm3 papers | -
|
| mis18 CENP-A recruiting complex | complete except PMID:24789708 (out for CC) | -
|
| mis19 CENP-A recruiting complex | complete except PMID:25375240 (out for CC) | -
|
| mis20 CENP-A recruiting complex | annotation complete | 20/1/2015
|
| nuf2 Ndc80 complex | 2 plus PMID:23770679 (out for CC) | -
|
| spc24 Ndc80 complex | annotation complete | 20/1/2015
|
| dad1 DASH complex | to do PMID:16079914 PMID:16079915 | -
|
| csm1 monopolin complex | in progress PMID: 20935472 plus… | -
|
| mde4 monopolin complex | in progress | -
|
| hhp1 monopolin complex | in progress | -
|
| hhp2 monopolin complex | in progress | -
|
| mis17 | annotation complete | 6/1/2015
|
| cnp20 | annotation complete | 6/1/2015
|
| dis1 | PMID:16920624 plus… | -
|
| ppe1 | to do PMID: 12773390 | -|
|
| scm3 | to do PMID: 19217403 PMID: 19217404 (also mis16) | -
|
| cnp1 | in progress | -
|
| mal3 | in progress | -
|
| dad1 | PMID: 17352737 | -
|
| cnp3 | PMID: 15791413 PMID: 24449889 autonomous | -
|
| sds22 phoshatase | PMID: 1846086 PMID: 15335873 PMID: 8374168 | -
|
| cnd1 condensin complex non-SMC subunit | PMID: 18362178 | -
|
| cnd2 condensin complex non-SMC subunit | - | -
|
| cnd3 condensin complex non-SMC subunit | - | -
|
| hos2 | 17352737 plus | -
|
| pcs1 | PMID:20935472 plus... | -
|
| ams12 | chen et al, cenp-a loading | - | |
|
