| mus81 | PMID:15805465 | Mus81-T239A disrupts the ability of Cds1 to bind and phosphorylate Mus81 and causes hyper-recombination upon hydroxyurea-induced replication arrest
|
| cdc2 | PMID:8557037 | mcs6 substrate cdc2
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| cdc2 | PMID:6526270 | uniprot has this paper for allele cdc2-4w C67F (we have 'unspecified')
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| Clp1 | PMID:18378776 | Clp1 in turn dephosphorylates the essential F-BAR scaffold protein Cdc15, CR assembly
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| plo1 | ????? | mid1? is a substrate
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| Sid2 | Chen et al. 2008 | phosphorylates the nonessential Cdc14 phosphatase Clp1 to foster Clp1’s cytoplasmic retention
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| Mre1 complex | PMID:21008122 and papers cited within | In humans and both yeasts, DSBs are initially detected and processed by the 1Xrs2 (MRN) nucleolytic protein complex in association with the Tel1ATM checkpoint kinase and the Ctp1CtIP/Sae2 DNA-end processing factor;...implies tel1 /rad50/nbs1 should be annotated to GO:0000729 The functions of ATM and ATR orthologs are intimately tied to the detection and nucleolytic processing of DSBs. ATMTel1 localizes at DSBs by interacting with (MRN) protein complex, which directly binds DNA ends (12, 20, 24, 50, 52). use these papers to annotate the missing connection between tel1 and the mre11 complex
|
| crb2 | PMID:14739927 | Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity (direct enzyme regulator substrate)
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| crb2 | PMID:21098122 | There are two pathways that lead to Crb2 localization at sites of DNA damage (10). One pathway requires two inde- pendent histone modifications: (i) phosphorylation of the C- terminal tail of histone H2A
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| Tel1 | PMID:21098122 | Tel1 phosphorylation of histone H2A at DSBs depends on its interaction with the Nbs1 subunit of MRN complex (52). (add tel1 targets as histones)
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| crb2 | ???? | Find physical interaction with Rad9
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| All histones | ???? | These are often not annotated with their roles in cell cycle regulation and repair, and so they are excluded from the graphs (also need to have specific nucleosome terms, 'what do you call a normal nucleosome?l' and 'centromere specific'
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| srw1 | PMID:9571240, PMID:9736616 PMID:10921878 | has no mitotic cell cycle regulation annotation
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| fnx1 & 2 | PMID: 18503766 | This wouldn't normally be a priority, but I'm putting it in becasue the exisitng transport GO annotations look a bit of a mess (stretch) ... need to get detailed phenotypes and then decide what it is possible to infer sensibly
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| Scf complex | ????? | -
|
| scp1 | ??? | Skp1 doesn't have ubiquitin ligase activity so these MF annotations should probably be on BP
|
| dsc2 | ??? | activation of sre2 TF? positive regulation of SREBP signaling pathway by transcription factor cleavage? for the Dsc subunits?(may be in one of the other dsc papers though....) chung paper?
|
| cul1 | ????? | -
|
| ppa1 | ????? | targets ppe1?
|
| ppe1 | ????? | targets pim1?
|
| pck1 | ????? | targets ppe1?
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| pck1 | ????? | phosphorylates mcm2,4,6, caf1, swi6,rad9, swi3, mrc1 crm1 and other importins
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| Pad1/Rpn11 and Mts3/Rpn12 are subunits of the lid subcomplex | ????? | in PMID: 16149916 Mutations in the genes encoding these two subunits were isolated in a screen for mutants that were both esistant to methyl 2-benzimidazolecarbamate, a microtubule in- hibitor, and Ts for cell-cycle progression [19,20]. Ts mutations in both genes cause arrest of the cells in mitosis, probably because of a failure to degrade cyclin B/Cdc13 and securin/Cut2.
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| mde4 | | ?????| Previous results showed that in interphase, when Mde4 is dephosphorylated, the Mde4-Pcs1 complex localizes to the nucleolus and to the kinetochores, which cluster at the nuclear periphery next to the spindle pole bodies (SPBs) [6,8]. As cells enter mitosis and Mde4 becomes phosphorylated, Mde4- Pcs1 leave the nucleolus but remain at the kinetochores [6,8]. [6. PubMed?: 17627824] [8. PubMed?: 12689592]
|
| process chromosome segregation: genes 207 of which 183 published esyN
|
| gene/complex | status | date
|
| fta1 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta2 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta3 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| fta4 Mis6-Sim4 complex | annotation complete | 15/1/2015
|
| fta6 Mis6-Sim4 complex | annotation complete | 15/1/2015
|
| fta7 Mis6-Sim4 complex | annotation complete except CC PMID: 24789708 | 20/1/2015
|
| mis6 Mis6-Sim4 complex | annotation complete except CC PMID:24789708 PMID25375240 | 20/1/2015
|
| mis15 Mis6-Sim4 complex | annotation complete | 6/1/2015
|
| mal2 Mis6-Sim4 complex | PMID: 12242294 + others | -
|
| sim4 Mis6-Sim4 complex | annotation complete | 20/1/2015
|
| sos7 NMS complex | annotation complete | 6/1/2014
|
| spc25 NMS complex/ Ndc80 complex | annotation complete needs annotation to ndc80 complex | 20/1/2015
|
| spc7 NMS complex | in progress IS THIS TURNING SAC SIGNALLING OFF? PMID: 17035632 | -
|
| ndc80 NMS complex/Ndc80 | annotation complete needs annotation to ndc80 complex | -
|
| mis12 NMS complex | to do PMID:15930132 check biorientation ann | -
|
| mis13 NMS complex | annotation complete | 20/1/2015
|
| mis14 NMS complex | annotation complete | 6/1/2014
|
| nnf1 NMS complex | to do PMID:17035632 | -
|
| mis16 CENP-A recruiting complex | complete except PMID:22771823 (out for CC) and scm3 papers | -
|
| mis18 CENP-A recruiting complex | complete except PMID:24789708 (out for CC) | -
|
| mis19 CENP-A recruiting complex | complete except PMID:25375240 (out for CC) | -
|
| mis20 CENP-A recruiting complex | annotation complete | 20/1/2015
|
| nuf2 Ndc80 complex | 2 plus PMID:23770679 (out for CC) needs annotation to ndc80 complex | -
|
| spc24 Ndc80 complex | annotation complete needs annotation to ndc80 complex | 20/1/2015
|
| dad1 DASH complex | to do PMID:16079914 PMID:16079915 | -
|
| csm1 monopolin complex | in progress PMID: 20935472 PMID:12689592 plus… | -
|
| mde4 monopolin complex | TODO ONLY PMID:19523829 PMID:20723757 PMID: 22264609 | -
|
| mis17 | annotation complete | 6/1/2015
|
| cnp20 | annotation complete | 6/1/2015
|
| dis1 | PMID:16920624 plus… | -
|
| ppe1 | to do PMID: 12773390 | -|
|
| scm3 | to do PMID: 19217403 PMID: 19217404 (also mis16) | -
|
| cnp1 | in progress | -
|
| mal3 | in progress | -
|
| dad1 | PMID:17352737 | -
|
| cnp3 | PMID:15791413 PMID: 24449889 autonomous | -
|
| sds22 phoshatase | PMID: 1846086 PMID: 15335873 PMID: 8374168 | -
|
| cnd1 condensin complex non-SMC subunit | PMID: 18362178 | -
|
| cnd2 condensin complex non-SMC subunit | PMID:21633354 | -
|
| cnd3 condensin complex non-SMC subunit | - | -
|
| hos2 | PMID:17352737 plus | -
|
| pcs1 | PMID:20935472 plus... | -
|
| ams12 | chen et al, cenp-a loading | -
|
| nsk1 | abnormal clustering of kinetochores to spindle pole bodies | -
|
| cut4/apc1 anaphase-promoting complex subunit, platform subcomplex | ??? | -
|
| apc4/cut5 anaphase-promoting complex subunit, platform subcomplex | ??? | -
|
| apc5/cut5 anaphase-promoting complex subunit, platform subcomplex TPR | ??? | -
|
| apc15 anaphase-promoting complex subunit, platform subcomplex | ??? | -
|
| apc8 anaphase-promoting complex TPR lobe subcomplex | ??? | -
|
| cut9/apc6 anaphase-promoting complex TPR lobe subcomplex | ??? | -
|
| apc3 anaphase-promoting complex TPR lobe subcomplex | ??? | -
|
| apc12 anaphase-promoting complex subunit TPR lobe accessory factor Hcn1 | ??? | -
|
| apc13 anaphase-promoting complex subunit TPR lobe accessory factor | ??? | -
|
| apc10 anaphase-promoting complex substrate recognition subunit Apc10 | ??? | -
|
| apc2 anaphase-promoting complex cullin family subunit | ??? | -
|
| apc11 anaphase-promoting complex ubiquitin protein-ligase E3 subunit | ??? | -
|
| apc14 anaphase-promoting complex (might be apc16 ortholog) | ??? | -
|
| alp4 gamma tubulin complex Spc97/GCP2 subunit Alp4 | do PMID:16611238 PMID:18418055 PMID:16611237 PMID:15772152 CC-PMID: 24704079 PMID: 23886939 | -
|
| alp6 gamma tubulin complex Alp6 | ??? | -
|
| alp16 gamma tubulin complex Alp16 | annotation complete | 23/4/2015
|
| gfh1 gamma tubulin complex Gfh1 | ??? | -
|
| gtb1 gamma tubulin Gtb1 | ??? | -
|
| mod21 gamma tubulin complex Mod21 | ??? | -
|
| mzt1 mitotic spindle organizing protein Mzt1 | annotation complete | 23/4/2015
|
