| 63 | | * GO or phenotype (update) |
| 64 | | |
| 65 | | === Making GO process annotations from IMP === |
| 66 | | |
| 67 | | We use GO annotations to describe direct involvement in a process, or its regulation (see below for more detail on regulation). We don't annotate indirect upstream effects. Caution must therefore be used when using IMP to make process annotation, as it often isn't clear whether the effect is directly involved, regulation, or only affecting a process indirectly. |
| | 63 | * GO or phenotype ? |
| | 64 | * We use GO annotations to describe direct involvement in a process, or its regulation (see below for more detail on regulation). We don't annotate indirect upstream effects. Caution must therefore be used when using IMP to make process annotation, as it often isn't clear whether the effect is directly involved, regulation, or only affecting a process indirectly. |
| 71 | | Example 1 |
| 72 | | dil1 in /curs/c7fac5251ee4f493/ro/ where annotation to dynein-driven meiotic oscillatory nuclear movement with IMP is based on a combination of phenotypes : |
| 73 | | * decreased meiotic recombination |
| 74 | | * horsetail movement abolished |
| 75 | | * unequal meiotic chromosome segregation |
| 76 | | * decreased protein localization to microtubule cytoskeleton |
| | 68 | * Example 1 dil1 in /curs/c7fac5251ee4f493/ro/ where annotation to dynein-driven meiotic oscillatory nuclear movement with IMP is based on a combination of phenotypes : |
| | 69 | * decreased meiotic recombination |
| | 70 | * horsetail movement abolished |
| | 71 | * unequal meiotic chromosome segregation |
| | 72 | * decreased protein localization to microtubule cytoskeleton |
| 78 | | Example 2 |
| 79 | | nda3 and mug164 annotations to intracellular distribution of mitochondria with IMP is based on |
| 80 | | * abolished mitochondrion inheritance |
| 81 | | * mitochondrial aggregation at cell tip |
| 82 | | * normal mitochondrial fission |
| 83 | | * normal mitochondrial fusion |
| | 74 | * Example 2 nda3 and mug164 annotations to intracellular distribution of mitochondria with IMP is based on |
| | 75 | * abolished mitochondrion inheritance |
| | 76 | * mitochondrial aggregation at cell tip |
| | 77 | * normal mitochondrial fission |
| | 78 | * normal mitochondrial fusion |
