Changes between Initial Version and Version 1 of GeneticAndPhysical


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Timestamp:
Jan 27, 2015, 4:40:44 PM (6 years ago)
Author:
vw253
Comment:

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  • GeneticAndPhysical

    v1 v1  
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     3== Genetic and Physical interactions ==
     4 * [http://wiki.thebiogrid.org/doku.php/experimental_systems Biogrid evidence code definitions]
     5 * [wiki:BiogridSymmetry List of which IGI & IPI are reciprocal]
     6 * Directionality of annotation
     7  * Interactor A (BioGRID) = subject (chado) = bait
     8  * Interactor B = object = hit/prey
     9  * [http://www.yeastgenome.org/help/function-help/interactions SGD Curator help] - has a section on the direction of the interactions (bait/hit).  In general, the rescued gene is the bait and the rescuer is the hit.  Similarly, the enhanced gene is the bait and the enhancer is the hit. 
     10  * NEW epistasis (same pathway/ no additive effect) BioGRID are going to add this calling it  "asynthetic" (wt<a=b=ab).
     11   * Document these on the wiki for now. Later need to migrate my legacy annotations which are done with GO process/IGI? and qualifier "same pathway" (we do not require this is duplicated as a GO annotation because it should already be captured by the IMP for the single mutant)
     12  * also see BioGridBaitHitNotationMapping