Genetic and Physical interactions

• ​Biogrid evidence code definitions
• List of which IGI & IPI are reciprocal
• Directionality of annotation
  • Interactor A (BioGRID) = subject (chado) = bait
  • Interactor B = object = hit/prey
  • ​SGD Curator help - has a section on the direction of the interactions (bait/hit). In general, the rescued gene is the bait and the rescuer is the hit. Similarly, the enhanced gene is the bait and the enhancer is the hit.
  • NEW epistasis (same pathway/ no additive effect) BioGRID are going to add this calling it "asynthetic" (wt<a=b=ab).
    • Document these on the wiki for now. Later need to migrate my legacy annotations which are done with GO process/IGI? and qualifier "same pathway" (we do not require this is duplicated as a GO annotation because it should already be captured by the IMP for the single mutant)
  • also see BioGridBaitHitNotationMapping