Changes between Version 100 and Version 101 of MatrixProject


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Timestamp:
Nov 7, 2012, 10:20:02 AM (9 years ago)
Author:
val_wood
Comment:

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  • MatrixProject

    v100 v101  
    11
     2= QC of GO annotation using annotation overlaps =
     3
     4This project leverages the  existing annotation,  to identify annotations which conflict with current biological knowledge.
     5Using  process GO slim terms, each term is assessed for overlaps with other slim terms. If no known overlaps exist this is scored as "NO OVERLAP" and any annotations which are made to this intersection will be queried for validity.
     6The template rules are defined after assessing the current annotation set for fission yeast, budding yeast and mouse.
     7More specific rules are created by identifying specific processes, complexes or functions which *are* allowed in intersections, and  can be extended over time to take account of new biology, or existing annotations in other organisms.
     8
     9Querying annotation overlaps is a powerful method to:
     10 * Identify annotation errors (curated and automated)
     11 * Identify problems in the gene ontology
     12 * Distinguish between  direct and indirect effects and refine existing annotation
     13 * etc
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     17|| term ID 1 || term ID 2|| term name 2|| exceptions (everything in this column which is NOT a GO ID or "OR/AND" needs to be in brackets|| comments/checked in species ||
    218
    319Matrix tool: