• Examples of "distant" orthologs?

Examples of distant orthologs not picked up by most ortholog predictors

• Sfr1 / MEI5 ​http://pfam.sanger.ac.uk/family/PF10376 (conserved to human)
• Rum1 / SIC1
• ipk1 / IPK1 (orthoMcl only)
• orc6 / ORC6 pfam.sanger.ac.uk/family/PF05460
• APC13 / YDR260C ​http://pfam.sanger.ac.uk/protein/O74358
• SPCC622.10c -> A. gossypii AGL158C (fasta) which is is syntentic ortholog of S. cerevisiae YDR166C
• rrn10/ RRN10 (small) (fungal only) ​http://pfam.sanger.ac.uk/family/PF05234
• SPCC553.01c/ YGR042W (to human) ​http://pfam.sanger.ac.uk/family/PF10382
• Sds3 /YIL084C (KOGS only) ​http://pfam.sanger.ac.uk/family/PF08598
• Swi5/SAE3 ​http://pfam.sanger.ac.uk/family/PF07061
• Sus1/SUS1 (OrthoMcl? only) ​http://pfam.sanger.ac.uk/family/PF10163
• Mediator complex subunits (add details)
• APC complex subunits (add details)
• Atp15/ATP15 (KOGS only) ​http://pfam.sanger.ac.uk/family/PF04627
• SPCC297.06c / YKL142W ​http://pfam.sanger.ac.uk/family/PF07957
• vps51 OrthoMCL builds to human but not cerevisiae, others miss most
• scm3 human HJURP PMID:19563746 ​http://pfam.xfam.org/family/PF10384
• mzt1 human MZT1 ​http://pfam.xfam.org/family/PF12554
• vph2 sequence orphan-> fungal specific-> vertebrate ​http://pfam.xfam.org/family/PF11712
• cwf20 ​http://pfam.xfam.org/family/PF10253
• sfc3 ​http://pfam.xfam.org/family/PF04182
• nrm1 ​http://pfam.xfam.org/family/PF08528
• SPAC3A12.19 mrpl27 ​http://pfam.xfam.org/family/PF09809
• Vta1 family ​http://pfam.xfam.org/family/PF04652
• hop1 YIL072W PMID:15226405;
• SPAC3A12.08
• Spd1 YLR437C ​http://pfam.xfam.org/family/PF0859
• apm3 YBR288C PMID:14745133
• sst6 YCL008C PMID:14745133
• ker1 PMID:15647272
• cdt1 PMID:11836525
• nse1 PMID:12966087
• cox18 (pers. comm. Nathalie.Bonnefoy) not reciprocal best hits but SPCC1442.15c is the functional ortholog of S. cerevisiae COX18
• SPBC776.06c YOR129C ​http://pfam.xfam.org/family/PF07792
• SPAC23H4.08 YDL115C ​http://pfam.xfam.org/family/PF08574
• rap1 ​http://pfam.xfam.org/family/PF09197
• Hos3 HSK1 (directed search) ​http://pfam.xfam.org/family/PF08227
• slx4 YLR135W ​http://pfam.xfam.org/family/PF09494

• SPAC4D7.10c YOL148C (hAT subunit)
• SPACUNK4.15 YGR247W
• SPCC126.13c SAP18 family
• SPAC1F3.07c YLR033W
• SPACC11E10.04 YMR282C
• SPAC7D4.11c YLR440C
• SPBC2A9.04cYDR143c
• SPBC336.08 = spc24
• SPCC188.04c = spc25 Hiroshi PUB, I had an error
• rec10
• sgo1
• sgo2
• SPAC19D5.09c (ctf8)- the ortholog of YHR191C (CTF8),
• SPBC106.05c was identified in a targeted search for the ortholog of YDR322C-A
• SPAC1002.02|YLR018C (pers. comm. Maria Novatchkova) from Psi-blast, family included in Pfam PF08058
• SPC32A11.01|YOR188W (pers. comm. Maria Novatchkova) from Psi-blast, family submitted to Pfam
• SPCC417.02 | YKL138C-A (S. pombe Hos3 identified as ortholog of
• kinetochores DASH complex component HSK3, targeted search for ortholog of new S. cerevisiae gene YKL138C-A), family submitted to Pfam
• shf1
• swi5/sus1
• qci9
• sds3

other egs

• 1. Book chapter
• 2. ortholog table diffs