Version 14 (modified by val_wood, 9 years ago) (diff)


Known pombe gene losses


  • YAT1 YAR035W carnitine O-acetyltransferase
  • CYS4 YGR155W cystathionine beta-synthase
  • TAZ1 YPR140W TAfaZzin
  • YJL055W involved in the metabolism of purine and pyrimidine base analogues
  • HMO1 YDR174W rDNA-binding component of the Pol I transcription system
  • YPC1 YBR183W
  • HHO1 YPL127C histone H1
  • STE18 YJR086W gamma subunit of G protein
  • PDE2 YOR360C high affinity 3',5'-cAMP phosphodiesterase

Glycogen metabolism

  • GLC3 YEL011W glycogen branching enzyme
  • GDB1YPR184W glycogen debranching enzyme
  • GPH1, YPR160W glycogen debranching enzyme
  • GPH1 YPR160W Glycogen PHosphorylase
  • GDB1,
  • GLG1,
  • GLG2,
  • GSY1,
  • GSY2,
  • FPS1

Tryptophan degradation/ de novo NAD biosynthesis

  • BNA1 YJR025c tryptophan met 3-hydroxyanthranilate 3,4-dioxygenase activity
  • BNA2 YJR078W tryptophan 2,3-dioxygenase activity
  • BNA4 YBL098W tryptophan met kynurenine 3-monooxygenase
  • BNA5 YLR231C tryptophan met kynureninase
  • BNA6 YFR047C biosynthesis of NAD from tryptophan via kynurenine

peroxisomal proteins and components of the fatty acid oxidation pathway

  • PEX8
  • PEX21
  • PXA2
  • FOX1
  • FOX3
  • SPS19
  • DCI1
  • ECI1
  • FAA2
  • TES1
  • CAT2
  • EEB1 YPL095c medium-chain fatty acid ethyl ester biosynthesis during fermentation
  • EHT1 YBR177c medium-chain fatty acid metabolic process
  • YMR210w medium-chain fatty acid metabolic process

biotin synthesis enzymes

  • BIO4
  • BIO3
  • + one?

May be conserved but not yet detected

  • YDl156W (WD repeat)
  • YML129C COX14
  • YGR008C
  • YJL131C AIM23? mitochondrial IF3
  • tom6 (small)
  • RSF1 YMR030W (yeast only)
  • YCL044C

Distant orthologs not picked up by most ortholog predictors