Version 21 (modified by vw253, 7 years ago) (diff)


Known pombe gene losses


  • YAT1 YAR035W carnitine O-acetyltransferase
  • CYS4 YGR155W cystathionine beta-synthase
  • TAZ1 YPR140W TAfaZzin
  • YJL055W involved in the metabolism of purine and pyrimidine base analogues
  • HMO1 YDR174W rDNA-binding component of the Pol I transcription system
  • YPC1 YBR183W
  • HHO1 YPL127C histone H1
  • STE18 YJR086W gamma subunit of G protein
  • PDE2 YOR360C high affinity 3',5'-cAMP phosphodiesterase
  • KXD1 YGl079W
  • VID22
  • YGR071C
  • TOM6 (small) this paper links budding yeast to human, no pombe yet

Glycogen metabolism

  • GLC3 YEL011W glycogen branching enzyme
  • GDB1YPR184W glycogen debranching enzyme
  • GPH1, YPR160W glycogen debranching enzyme
  • GPH1 YPR160W Glycogen PHosphorylase
  • GDB1,
  • GLG1,
  • GLG2,
  • GSY1,
  • GSY2,
  • FPS1


Tryptophan degradation/ de novo NAD biosynthesis

  • BNA1 YJR025c tryptophan met 3-hydroxyanthranilate 3,4-dioxygenase activity
  • BNA2 YJR078W tryptophan 2,3-dioxygenase activity
  • BNA4 YBL098W tryptophan met kynurenine 3-monooxygenase
  • BNA5 YLR231C tryptophan met kynureninase
  • BNA6 YFR047C biosynthesis of NAD from tryptophan via kynurenine

peroxisomal proteins and components of the fatty acid oxidation pathway

  • PEX8
  • PEX21
  • PXA2
  • FOX1
  • FOX3
  • SPS19
  • DCI1
  • ECI1
  • FAA2
  • TES1
  • CAT2
  • EEB1 YPL095c medium-chain fatty acid ethyl ester biosynthesis during fermentation
  • EHT1 YBR177c medium-chain fatty acid metabolic process
  • YMR210w medium-chain fatty acid metabolic process

Autophagy and vesicle transport

  • YHR195W NVJ1
  • YDR357C CNL1
  • ATG10,16,18,21,23,27
  • SRN2 YLR119W Component of the ESCRT-I complex

biotin synthesis enzymes

  • BIO4
  • BIO3
  • + one?


  • TMA7,10,16,17,20,24,64,108

May be conserved but not yet detected

  • SPC12 PF06645
    • YDl156W (WD repeat)
    • YGR008C
    • YJL131C AIM23? mitochondrial IF3
    • RSF1 YMR030W (yeast only)
    • YCL044C
    • DLS1
    • IPT1
    • OGG1
    • HPA2 YPL123C

  • there are also 64 essential genes in budding yeast which do not appear to

have a fission yeast ortholog

Examples of distant orthologs not picked up by most ortholog predictors