Version 40 (modified by vw253, 7 years ago) (diff)


Known pombe gene losses


  • YAT1 YAR035W carnitine O-acetyltransferase (conserved in human, CPT2)
  • CYS4 YGR155W cystathionine beta-synthase (conserved in human, CBS)
  • TAZ1 YPR140W TAfaZzin (conserved in human , TAZ)
  • YPC1 YBR183W paralog YDC1 (conserved in human ACER3)
  • YDC1 YPL087W paralog YPC1 (conserved in human ACER3)
  • HHO1 YPL127C histone H1 (conserved in human H1F0)
  • AML1 adenine methyltransferase, has human, (conserved in human N6AMT2)
  • PDE2 YOR360C high affinity 3',5'-cAMP phosphodiesterase (family has human members, but no pombe member
  • OGG1 YML060W "CBF3 complex" base excision repair protein (conserved in human OGG1)

to check:

  • SRN2 YLR119W Component of the ESCRT-I complex

Glycogen metabolism

  • GLC3 YEL011W glycogen branching enzyme (conserved in human GBE1)
  • GDB1 YPR184W glycogen debranching enzyme (conserved in human AGL)
  • GPH1 YPR160W glycogen debranching enzyme (conserved in human PYGB)
  • GSY1 YFR015C (conserved in human GYS1)
  • GSY2 YLR258W (conserved in human GYS1)
  • FPS1 YLL043W (not sure about this)
  • GLG1 YKR058W (not sure about this)
  • GLG2 YJL137C (not sure about this)


Tryptophan degradation/ de novo NAD biosynthesis

  • BNA1 YJR025c tryptophan met 3-hydroxyanthranilate 3,4-dioxygenase activity (conserved in human HAAO)
  • BNA2 YJR078W tryptophan 2,3-dioxygenase activity (conserved in human IDO2)
  • BNA4 YBL098W tryptophan met kynurenine 3-monooxygenase (conserved in human, KMO)
  • BNA5 YLR231C tryptophan met kynureninase (conserved in human, KYNU)
  • BNA6 YFR047C biosynthesis of NAD from tryptophan via kynurenine (conserved in human, QPRT)

peroxisomal proteins and components of the fatty acid oxidation pathway

  • PXA2 YKL188C (possible human ABCD4)
  • POX1 YGL205W (human candidates ACOX1 and 2)
  • DCI1 YOR180C (conserved in human, PECI)
  • ECI1 YLR284C (conserved in human, PECI)
  • FAA2 YER015W (human ACSL1,5,6 ?)
  • TES1 YJR019C (conserved in human, ACOT8)
  • CAT2 YML042W (conserved in human, CRAT)
  • EEB1 YPL095c medium-chain fatty acid ethyl ester biosynthesis during fermentation
  • EHT1 YBR177c medium-chain fatty acid metabolic process
  • YMR210W similar to EEB1 and EHT1 medium-chain fatty acid metabolic process
  • POT1 (FOX3) YIL160C
  • SPS19 YNL202W SPAC922.06

Autophagy and vesicle transport

  • ATG21 YPL100W
  • ATG23 YLR431C
  • ATG27 YJL178C

BLOC1 complex (involved in endosomal maturation)

  • KXD1 YGL079W BLOC-1 complex (conserved in human KXD1)
  • CNL1 YDR357C BLOC-1 complex
  • VAB2 YEL005C ( NONE immediately detected but most likely conserved)
  • BLI1 YKL061W ( NONE immediately detected but most likely conserved)
  • BLS1 YLR408C ( NONE immediately detected but most likely conserved)
  • SNN1 YNL086W

biotin synthesis enzymes

check bio1,5,6,7,8

  • BIO4 YNR057C
  • BIO3 YNR058W
  • BIO5 YNR056C
  • BIO6 YAR069W-A (NOT IN 288C)
  • BIO7 YHR214W-G (NOT IN 288C) pseudogenic, highly degraded
  • BIO8 YHR214W-F (NOT IN 288C) pseudogenic, highly degraded

May be conserved but not yet detected

to check:

  • STE18 YJR086W gamma subunit of G protein (check)
  • YJL055W involved in the metabolism of purine and pyrimidine base analogues
  • YDl156W (WD repeat)
  • YGR008C
  • FUN26 YAL022C
  • DLS1 YJL065C DSL1 complex
  • ITC1 YGL133W CHRAC complex
  • ISW1 YBR245C isw1-a complex
  • ISW2 YOR304W CHRAC complex
  • HPA2 YPL123C
  • MGR1 YCL044C iAAA protease complex subunit (saccharomycetes only)
  • RSF1 YMR030W (yeast only)
  • AIM23 YJL131C? mitochondrial IF3 (saccharomycetes only)
  • SPP381 YBR152W (ascomycota only)
  • SHE1 YBL031W (ascomycota only)
  • NTC20 YBR188C (ascomycota only)
  • UTP8 YGR128C (ascomycota only)
  • NVJ1 YHR195W nuclear envelope protein (saccharomycetes only) (confirmed with PSI-blast)
  • VID22 YLR373C is paralog of ENV11 (ascomycota only)
  • ENV11 YGR071C is paralog of VID22 (ascomycota only)
  • TMA10 YLR327C ribosome associated (ascomycete only)
  • TMA16 YOR252W ribosome associated (ascomycete only)
  • TMA17 YDL110C (ascomycete only)
  • TMA24 YOL111C (ascomycete only variant or RAD23 paralog)
  • TMA108 YIL137C
  • PEX8 YGR077C (yeast only)
  • PEX21 YGR239C (yeast only)
  • there are also 64 essential genes in budding yeast which do not appear to have a fission yeast ortholog

Examples of distant orthologs not picked up by most ortholog predictors