wiki:PhenotypeTests

List any potential phenotype consistency checks

e.g.

  • Only mutants with phenotype A and B should have GO term C
  • All mutants with phenotype A and B should have phenotype term C
  • mutants with only phenotype A should not have GO term x unless also have phenotype B etc.
  • Should all mutant alleles which have both increased DNA content and decreased DNA content should have unequal chromosome segregation too?
    • Only one annotation to both at present check after V 33
  • should all mutant alleles that are multiseptate (cell phenotype) also have increased septation index (population phenotype)? (I'm not sure...what if incomplete penetrance?)
    • My gut feeling is that you can't infer either way -- multiseptate is about number of septa per cell and says nothing about the population, whereas increased septation index is about how much of a population is septating and says nothing about whether the septating cells have one or more septa.
  • queries for inviability
    • same allele/conditions combination can't be annotated to both viable cell and inviable cell
    • same allele/conditions combination can only be annotated to viable cell population and inviable cell if the inviable cell annotation has a penetrance extension (and the extension doesn't say "full/100%")
    • see if any cut are annotated as "viable" and then check if the correct penetrance qualifier is added
    • see which elongated vegetative aspetate are viable /inviable and check corretc penetrance qualifiers
Last modified 7 years ago Last modified on Aug 12, 2013, 12:55:37 PM