wiki:annotationSanityChecks

Version 3 (modified by val_wood, 9 years ago) (diff)

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GO already implements some sanity checks: http://geneontology.org/GO.annotation_qc.shtml

But we will have lots of home grown rules based on biology:

Start to list here, group by type

  • Extensions scope

tRNA as substrate is only possible with RNA pol III promoter

  • Matrix related Examples

Transmembrane transprot has no overlaps with DNA metabolism Transmembrane transprot has no overlaps with translation

I sent a test list to Amliea but I don't think any progress was made, dig out and add rules here

  • If A is true B is always true All transmembrane transporters should have integral to membrane EXCEPT (list complexes) Use for /if this then this F/P C/P is rules cannot be wired into ontology
  • Reciprocal annotations which are always true

reciprocal annotation GO/FYPO binding target of/ is substrate reciprocal annotation that can be inferred from extension i.e process dependent on localisation to -> component required_by process etc